Combinatorial chemistry is among the most recent topics in synthetic organic chemistry. A key feature is diversification in the development of organic reactions and in the synthesis of organic compounds. A crucial chemistry is solid-phase synthesis, which is a powerful method in order to optimize reaction conditions, to investigate scope and limitations of new reactions, and to synthesize a variety of compound libraries. Solid-supports, linkers, and strategies for the combinatorial chemistry are described. Synthetic methods (parallel synthesis and mix-and-split synthesis), analysis, and purification in the solid-phase synthesis are also described.