Should women of childbearing potential be prescribed valproate? a call to action

J Clin Psychiatry. 2016 Apr;77(4):525-6. doi: 10.4088/JCP.15com09958.

Abstract

Prescribing medications during pregnancy can be complicated by a serious negative outcome-harm to the fetus. Probably the 2 best-known examples of medications that can cause severe teratogenicity are thalidomide and isotretinoin. Thalidomide, used for anxiety, insomnia, and tension, was associated with phocomelia (malformation of limbs that many children did not survive).

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Abnormalities, Drug-Induced / prevention & control*
  • Bipolar Disorder / drug therapy*
  • Contraception Behavior / psychology
  • Epilepsy / drug therapy*
  • Female
  • Humans
  • Infant, Newborn
  • Migraine Disorders / drug therapy*
  • Neural Tube Defects / chemically induced
  • Neural Tube Defects / prevention & control
  • Patient Compliance
  • Practice Patterns, Physicians'*
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Risk Factors
  • Valproic Acid / adverse effects*
  • Valproic Acid / therapeutic use

Substances

  • Valproic Acid