[Effect of Alinamin F and Kakkontou on mucoid Pseudomonas aeruginosa chronic lower respiratory tract infection]

Nihon Kokyuki Gakkai Zasshi. 2009 Mar;47(3):218-21.
[Article in Japanese]

Abstract

In a 78-year-old woman with chronic respiratory tract infection caused by Pseudomonas aeruginosa with a mucoid phenotype, the organism was eliminated from the sputum by use of Kakkontou (Chinese herbal drug) and Alinamin F (Fursultiamine). Gram staining of a sputum smear showed mucoid micro-organisms were engulfed by neutrophils. Both drugs could change the mucoid character of this microorganism. It was suggested that polymorphonuclear leukocytes activated by Kakkontou could recognize this organism as a foreign body because of the changed mucoid character, and cleared it by phagocytosis.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Chronic Disease
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Pseudomonas Infections / drug therapy*
  • Respiratory Tract Infections / drug therapy*
  • Thiamine / analogs & derivatives*
  • Thiamine / therapeutic use

Substances

  • Drugs, Chinese Herbal
  • kakkon-to
  • prosultiamine
  • Thiamine