Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations

J Nucl Med. 2005 Apr;46(4):608-13.

Abstract

We investigated radiation exposure of patients undergoing whole-body 18F-FDG PET/CT examinations at 4 hospitals equipped with different tomographs.

Methods: Patient doses were estimated by using established dose coefficients for 18F-FDG and from thermoluminescent measurements performed on an anthropomorphic whole-body phantom.

Results: The most relevant difference between the protocols examined was the incorporation of CT as part of the combined PET/CT examination: Separate low-dose CT scans were acquired at 2 hospitals for attenuation correction of emission data in addition to a contrast-enhanced CT scan for diagnostic evaluation, whereas, at the other sites, contrast-enhanced CT scans were used for both purposes. Nevertheless, the effective dose per PET/CT examination was similar, about 25 mSv.

Conclusion: The dosimetric concepts presented in this study provide a valuable tool for the optimization of whole-body 18F-FDG PET/CT protocols. Further reduction of patient exposure can be achieved by modifications to the existing hardware and software of PET/CT systems.

Publication types

  • Evaluation Study

MeSH terms

  • Body Burden
  • Environmental Exposure / analysis
  • Fluorodeoxyglucose F18 / adverse effects
  • Fluorodeoxyglucose F18 / analysis*
  • Humans
  • Positron-Emission Tomography / adverse effects
  • Positron-Emission Tomography / methods*
  • Radiation Dosage
  • Radiation Injuries / etiology
  • Radiation Injuries / prevention & control
  • Radiation Protection / methods
  • Radiometry / methods*
  • Radiopharmaceuticals / adverse effects
  • Radiopharmaceuticals / analysis
  • Relative Biological Effectiveness
  • Risk Assessment / methods*
  • Risk Factors
  • Subtraction Technique*
  • Tomography, X-Ray Computed / adverse effects
  • Tomography, X-Ray Computed / methods*
  • Whole-Body Counting / adverse effects
  • Whole-Body Counting / methods*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18