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muscle (n.)

"contractible animal tissue consisting of bundles of fibers," late 14c., "a muscle of the body," from Latin musculus "a muscle," literally "a little mouse," diminutive of mus "mouse" (see mouse (n.)).

So called because the shape and movement of some muscles (notably biceps) were thought to resemble mice. The analogy was made in Greek, too, where mys is both "mouse" and "muscle," and its combining form gives the medical prefix myo-. Compare also Old Church Slavonic mysi "mouse," mysica "arm;" German Maus "mouse; muscle," Arabic 'adalah "muscle," 'adal "field mouse;" Cornish logodenfer "calf of the leg," literally "mouse of the leg." In Middle English, lacerte, from the Latin word for "lizard," also was used as a word for a muscle.

Musclez & lacertez bene one selfe þing, Bot þe muscle is said to þe fourme of mouse & lacert to þe fourme of a lizard. [Guy de Chauliac, "Grande Chirurgie," c. 1425]

Hence muscular and mousy are relatives, and a Middle English word for "muscular" was lacertous, "lizardy." Figurative sense of "muscle, strength, brawn" is by 1850; that of "force, violence, threat of violence" is 1930, American English. Muscle car "hot rod" is from 1969.

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muscle (v.)

1913, "to accomplish by strength," from muscle (n.). Meaning "coerce by violence or pressure" is by 1929 in U.S. underworld slang. Related: Muscled; muscling.

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muscled (adj.)

"having muscles (of a particular type)," 1640s, from muscle (n.).

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muscle-man (n.)

1929, originally "an underworld enforcer;" sense of "strong man" is attested by 1952; from muscle (n.) + man (n.).

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muscle-bound (adj.)

1879, from muscle (n.) + bound, past participle of bind (v.).

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amyotrophic lateral sclerosis (n.)

sclerosis of the spinal cord, causing atrophy of the muscles, 1874, in translations from French. Amyotropic is compounded from Greek elements: a- "not, without" (see a- (3)) + combining form of mys "muscle" (see muscle (n.)) + trophikos "feeding," from trophe "nourishment" (see -trophy). Also ALS, and often known in U.S. as Lou Gehrig's disease, after the New York Yankees baseball player who was diagnosed with it in 1939 and died of it in 1941.

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mouse (n.)

Middle English mous, from Old English mus "small rodent," also "muscle of the arm" (compare muscle (n.)); from Proto-Germanic *mus (source also of Old Norse, Old Frisian, Middle Dutch, Danish, Swedish mus, Dutch muis, German Maus "mouse").

This is from PIE *mus-, the old Indo-European name of the mouse, retained in several language families (source also of Sanskrit mus "mouse, rat," Old Persian mush "mouse," Old Church Slavonic mysu, Latin mus, Lithuanian muse "mouse," Greek mys "mouse, muscle").

Plural form mice (Old English mys) shows effects of i-mutation. As a type of something timid or weak, from late 14c. Contrasted with man (n.) from 1620s (nor man nor mouse).

The meaning "black eye" (or other discolored lump on the body) is from 1842. The computer sense of "small device moved by the hand over a flat surface to maneuver a cursor or arrow on a display screen" is from 1965, though the word was applied to other things resembling a mouse in shape since 1750, mainly in nautical use.

Parturient montes, nascetur ridiculus mus [Horace]
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mussel (n.)

"edible bivalve mollusk," Middle English muscle, from Old English muscle, musscel, from Late Latin muscula (source of Old French musle, Modern French moule, Middle Dutch mosscele, Dutch mossel, Old High German muscula, German Muschel), from Latin musculus "mussel," literally "little mouse," also "muscle;" like muscle, derived from mus "mouse" on the perceived similarity of size and shape (see mouse (n.)). The modern spelling, distinguishing the word from muscle, is recorded from c. 1600 but was not fully established until 1870s.

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myo- 

before vowels my-, word-forming element meaning "muscle," from combining form of Greek mys "muscle," literally "mouse" (see muscle (n.)).

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musculo- 

word-forming element meaning "involving or pertaining to muscles," from combining form of Latin musculus "muscle" (see muscle (n.)).

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