Despite a substantial literature examining personality, prejudice, and related constructs such as Right-Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO), there have been no systematic reviews in this area. The authors reviewed and meta-analyzed 71 studies (N = 22,068 participants) investigating relationships between Big Five dimensions of personality, RWA, SDO, and prejudice. RWA was predicted by low Openness to Experience but also Conscientiousness, whereas SDO was predicted by low Agreeableness and also weakly by low Openness to Experience. Consistent with a dual-process motivational model of ideology and prejudice, the effects of Agreeableness on prejudice were fully mediated by SDO, and those of Openness to Experience were largely mediated by RWA. Finally, the effects of Agreeableness and Openness to Experience were robust and consistent across samples, although subtle moderating factors were identified, including differences in personality inventory (NEO Personality Inventory-Revised vs. Big Five Inventory), differences across prejudice domain, and cross-cultural differences in Conscientiousness and Neuroticism. Implications for the study of personality and prejudice are discussed.