Abstract
[structure: see text] Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods. Compound 1 is based on an unprecedented stilbenolignan skeleton in which a stilbene moiety is linked with a phenylpropane unit through a dioxane bridge. Compounds 1 and 2 exhibited significant inhibitory activities against cyclooxygenases-1 and -2.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / isolation & purification*
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Cyclooxygenase Inhibitors / pharmacology
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Luteolin
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plants, Medicinal / chemistry*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Seeds / chemistry
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology
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Structure-Activity Relationship
Substances
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Flavonoids
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Isoenzymes
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Stilbenes
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aiphanol
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isorhapontigenin
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3,3',4,5'-tetrahydroxystilbene
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Cyclooxygenase 1
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Luteolin