Abstract
A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.
MeSH terms
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Animals
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CCAAT-Enhancer-Binding Proteins*
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Cholesterol / biosynthesis*
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DNA-Binding Proteins / metabolism*
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DNA-Binding Proteins / physiology*
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Fatty Acids / biosynthesis*
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Gene Expression Regulation*
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Liver / anatomy & histology
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Liver / pathology
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Mice
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Mice, Transgenic
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Models, Biological
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Nuclear Proteins / metabolism*
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Nuclear Proteins / physiology*
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors*
Substances
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CCAAT-Enhancer-Binding Proteins
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DNA-Binding Proteins
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Fatty Acids
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Nuclear Proteins
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Srebf1 protein, mouse
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors
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Cholesterol