KEGG   ORTHOLOGY: K15746
Entry
K15746                      KO                                     
Symbol
crtZ
Name
beta-carotene 3-hydroxylase [EC:1.14.15.24]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00372  Abscisic acid biosynthesis, beta-carotene => abscisic acid
Reaction
R07530  alpha-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07558  beta-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07559  beta-cryptoxanthin,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07561  echinenone,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07562  echinenone,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07568  canthaxanthin,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07569  3'-hydroxyechinenone,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07570  3-hydroxyechinenone,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R07572  phoenicoxanthin,reduced ferredoxin [iron-sulfur] cluster:oxygen 3'-oxidoreductase
R07851  alpha-cryptoxanthin,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
R09747  beta-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K15746  crtZ; beta-carotene 3-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.24  beta-carotene 3-hydroxylase
     K15746  crtZ; beta-carotene 3-hydroxylase
Other DBs
GO: 0052611
Genes
ATH: AT4G25700(BETA-OHASE_1) AT5G52570(BETA-OHASE_2)
ALY: 9300260 9303669
CRB: 17875800 17877995
CSAT: 104717685 104722390 104725769 104727661 104730850 104761269
EUS: EUTSA_v10014816mg EUTSA_v10025794mg
BRP: 103844746 103861586(BCH) 103863442
BNA: 106347114 106405085 106406976 106421444 106421466 106442750 106442837
BOE: 106302033 106316293 106323808 106324977
RSZ: 108833660 108849035 108849036
THJ: 104800269 104811957
CPAP: 110810314
CIT: 102578021(chyB) 102617763
PVY: 116107134
GMX: 100785541(BCH2) 100802778(BCH4) 100813368(BCH5) 547758(BCH3)
LJA: Lj0g3v0299729.1(Lj0g3v0299729.1) Lj2g3v1902110.1(Lj2g3v1902110.1) Lj5g3v1988680.1(Lj5g3v1988680.1)
ADU: 107491106
AIP: 107644881
PCIN: 129319019
CSAV: 115716368
VVI: 100232875(BCH1) 100268009
SLY: 544133(CrtR-b1) 544297(CrtR-b2)
NTA: 107789701 107809222(CrtR-b1) 107822278(BCH2)
INI: 109189248(CHYB)
ITR: 116021238
SMIL: 130993429
HAN: 110912807
ECAD: 122587205
LSV: 111918038
CCAV: 112509279
CSIN: 114310406
BVG: 104888376
SOE: 110784117
ATRI: 130806171
MOF: 131146015
NNU: 104595976
DOSA: Os03t0125100-01(Os03g0125100) Os04t0578400-01(Os04g0578400) Os10t0533500-00(Os10g0533500)
TUA: 125529683
AOF: 109837875
VCN: VOLCADRAFT_68369(chyB)
MNG: MNEG_1351
APRO: F751_1825
MPP: MICPUCDRAFT_38006(CRTR)
ESA: ESA_00341
PSTS: E05_04180(crtZ)
EGE: EM595_0216(crtZ)
PAM: PANA_4163(crtZ)
PLF: PANA5342_p10304(crtZ)
PAJ: PAJ_p0121(crtZ)
PAQ: PAGR_p229
PVA: Pvag_pPag30170(crtZ)
PSTW: DSJ_25955
PPU: PP_3246(crtZ)
PPF: Pput_2516
PPT: PPS_2732
PPB: PPUBIRD1_2531(crtZ)
PPI: YSA_10718
PPX: T1E_5632(crtZ)
PPUH: B479_13325
PPUT: L483_17455
PPUN: PP4_25760(crtZ)
PPUD: DW66_2991
PMON: X969_13000
PMOT: X970_12645
PVD: CFBP1590__2677(crtZ)
PEN: PSEEN3115(crtZ)
PDW: BV82_2968
PSA: PST_3871(crtZ)
PSZ: PSTAB_3822(crtZ)
PSR: PSTAA_3964(crtZ)
PSTT: CH92_19200
ACX: Achr_15260(crtZ)
RTA: Rta_07680
MVAR: MasN3_17880(crtZ)
XAU: Xaut_4535
RVA: Rvan_0152
CAK: Caul_1710
NAR: Saro_1168
SAL: Sala_2128
SPHP: LH20_13675
SMAZ: LH19_01990
SPHU: SPPYR_3342(crtZ)
SPHI: TS85_19965
SSAN: NX02_21750
SPKC: KC8_14900
SJP: SJA_C1-06860(crtZ)
SINB: SIDU_10345
SSY: SLG_38860(crtZ)
SPMI: K663_01820
SPHB: EP837_01682(crtZ)
SPHR: BSY17_1741
SPHT: K426_03985
BLAS: BSY18_170
SMIC: SmB9_24720(crtZ)
ALB: AEB_P3199
AAY: WYH_00011
ELI: ELI_03325
RAP: RHOA_2894(crtZ)
SCL: sce0583(crtZ)
AFO: Afer_0482
AYM: YM304_38780(crtZ)
CPI: Cpin_5618
FLN: FLA_3500
SEDT: TEGAF0_22830(crtZ)
SGN: SGRA_1065(crtR)
PHE: Phep_2089
MUC: MuYL_4807
CHU: CHU_2038(crtZ)
SLI: Slin_5702
PSEZ: HME7025_02277(crtZ)
DFE: Dfer_2033
FAE: FAES_0647
HSW: Hsw_1151
FLM: MY04_1511
FAX: FUAX_08040(crtZ)
PPSV: PEPS_24420(crtZ)
ATK: AUTU_23730(crtZ)
GFO: GFO_2501(crtZ)
GFL: GRFL_0484
FPS: FP1451(crtZ)
FJO: Fjoh_0059
FBR: FBFL15_2142(crtZ)
FIN: KQS_04640(crtZ)
FAO: SHINM13_12070(crtZ)
FAN: GENT5_11530(crtZ)
FOK: KK2020170_00890(crtZ)
ZPR: ZPR_0874
MARM: YQ22_13890
CBAL: M667_09580
CBAT: M666_09505
DOK: MED134_13066(crtZ)
DDO: I597_1408
ZGA: ZOBELLIA_2972(crtZ)
NDO: DDD_2395(crtZ)
NMF: NMS_0120
POM: MED152_02565(crtZ1) MED152_02665(crtZ3)
WIN: WPG_0039
TJE: TJEJU_1860(crtZ)
TMAR: MARIT_0424
MARF: CJ739_2846
MESQ: C7H62_2006
MLT: VC82_2329
SPON: HME9304_02556(crtZ)
FBA: FIC_01508
FBU: UJ101_02156(crtZ)
EAO: BD94_2900
CHZ: CHSO_3057(crtZ)
PTO: PTO1531
CDIV: CPM_0972
SSO: SSO2906(crtZ)
SOL: Ssol_0702
SSOA: SULA_0695
SSOL: SULB_0697
SSOF: SULC_0695
SAI: Saci_1733(crtZ)
SID: M164_0447
MSE: Msed_1074
MEMJ: MJ1HA_1202
MCN: Mcup_1040
ACIH: HS5_02320(crtZ)
CSTY: KN1_09420(crtZ)
STEP: IC006_2248
SAHS: HS7_13530(crtZ)
AG: AAD54243(crtZ) ACF21782(BHY) CAA70427(CA1) CAA70888(CA2)
 » show all
Reference
  Authors
Choi SK, Matsuda S, Hoshino T, Peng X, Misawa N
  Title
Characterization of bacterial beta-carotene 3,3'-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli.
  Journal
Appl Microbiol Biotechnol 72:1238-46 (2006)
DOI:10.1007/s00253-006-0426-2
Reference
PMID:8798688
  Authors
Sun Z, Gantt E, Cunningham FX Jr
  Title
Cloning and functional analysis of the beta-carotene hydroxylase of Arabidopsis thaliana.
  Journal
J Biol Chem 271:24349-52 (1996)
DOI:10.1074/jbc.271.40.24349
  Sequence
[ath:AT4G25700]
Reference
  Authors
Linden H
  Title
Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation.
  Journal
Biochim Biophys Acta 1446:203-12 (1999)
DOI:10.1016/S0167-4781(99)00088-3
  Sequence

KEGG   ENZYME: 1.14.13.129
Entry
EC 1.14.13.129    Obsolete  Enzyme                                 
Name
Transferred to 1.14.15.24
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Comment
Transferred entry: beta-carotene 3-hydroxylase. Now EC 1.14.15.24, beta-carotene 3-hydroxylase.
History
EC 1.14.13.129 created 2011, deleted 2017

KEGG   REACTION: R07558
Entry
R07558                      Reaction                               
Name
beta-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase
Definition
beta-Carotene + 2 Reduced ferredoxin + H+ + Oxygen <=> beta-Cryptoxanthin + 2 Oxidized ferredoxin + H2O
Equation
Comment
the first step of two-step reaction (see R09747, R07558+R07559)
Reaction class
RC00478  C02094_C08591
Enzyme
1.14.13.-       1.14.15.24      1.14.-.-
Pathway
rn00906  Carotenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00372  Abscisic acid biosynthesis, beta-carotene => abscisic acid
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R07558  beta-Carotene + 2 Reduced ferredoxin + H+ + Oxygen <=> beta-Cryptoxanthin + 2 Oxidized ferredoxin + H2O
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.24
     R07558  beta-Carotene + 2 Reduced ferredoxin + H+ + Oxygen <=> beta-Cryptoxanthin + 2 Oxidized ferredoxin + H2O
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-
     R07558  beta-Carotene + 2 Reduced ferredoxin + H+ + Oxygen <=> beta-Cryptoxanthin + 2 Oxidized ferredoxin + H2O
Orthology
K02294  beta-carotene hydroxylase [EC:1.14.13.-]
K15746  beta-carotene 3-hydroxylase [EC:1.14.15.24]
K15747  beta-ring hydroxylase [EC:1.14.-.-]
K22492  beta-carotene 3-hydroxylase [EC:1.14.15.24]
K23037  beta-carotene 4-ketolase/3-hydroxylase [EC:1.14.99.63 1.14.15.24 1.14.99.-]
Other DBs
RHEA: 30326

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