Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia

Casey Curtis; Princess U Ogbogu

doi:10.1016/j.iac.2015.04.001

Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia

Immunol Allergy Clin North Am. 2015 Aug;35(3):387-402. doi: 10.1016/j.iac.2015.04.001. Epub 2015 Jun 23.

Authors

Casey Curtis¹, Princess U Ogbogu²

Affiliations

¹ Section of Allergy & Immunology, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center at the Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: curtis.159@osu.edu.
² Section of Allergy & Immunology, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center at the Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA.

PMID: 26209891
DOI: 10.1016/j.iac.2015.04.001

Abstract

Peripheral blood eosinophilia is commonly encountered in clinical practice. The causes of peripheral blood eosinophilia are varied, ranging from benign eosinophilia to malignancy. A careful history and physical examination along with directed clinical evaluation may help determine the cause. When uncontrolled, peripheral blood eosinophilia may result in end-organ damage and life-threatening complications. This article summarizes the differential diagnosis and evaluation of persistent marked eosinophilia.

Keywords: Eosinophilia; FIP1L1-PDGFRA; Hypereosinophilic syndrome; Lymphocytic hypereosinophilic syndrome (L-HES); Myeloproliferative hypereosinophilic syndrome (M-HES).

Publication types

Review

MeSH terms

Cytokines / metabolism
Eosinophils / cytology*
Humans
Hypereosinophilic Syndrome / diagnosis*
Hypereosinophilic Syndrome / etiology*
Hypereosinophilic Syndrome / pathology
Molecular Diagnostic Techniques / methods*

Substances

Cytokines