Sterility tests were conducted on 15 kinds of ophthalmic solutions and 4 kinds of ophthalmic ointments used at Sapporo Medical College Hospital. Thioglycollate medium was used as culture medium for ophthalmic solutions and tryptone soya agar medium for ophthalmic ointments. It was found that the following 3 ophthalmic solutions were contaminated with Candidn Krusei, Escherichia coli, Staphylococcus epidermidis and. Gaffkya tetragena: Catalin, phospholine Iodide (Echothiophate Iodide) and Artificial Tear. Further, ophthalmic, ointments containing cortisone acetate and flavin adenine dinucleotide were contaminated with Staph. epidermidis, Bacillus subtilis, Flavobacterium and Moraxella. In the above tests no pathogenic microorganism was found, but it was reported that Bacillus and Moraxella are apt to cause an infection of the cornea.