The metabolically active and perpetually remodeling calcium phosphate–based endoskeleton
in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate …

The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast
growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of …

The klotho gene functions as an aging-suppressor gene that extends life span when
overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho gene …

A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive
traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho …

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due
to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient
mice exhibit a variety of aging-like phenotypes, many of which are similar to those …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification …

Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney
and influx from intestine and bone. FGF23 is a bone-derived phosphaturic hormone that acts …

The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23,
function as hormones that regulate bile acid, fatty acid, glucose, and phosphate metabolism in …

klotho is an aging suppressor gene and extends life span when overexpressed in mice.
Klotho protein was recently demonstrated to function as a hormone that inhibits insulin/insulin-…

Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho
affects phosphate homeostasis is unknown. We detected Klotho in the proximal tubule cell, …

Inactivation of theklotho(kl) gene in mice results in multiple disorders that resemble human
aging. The mouseklgene encodes a novel single-pass membrane protein with homology to β-…

Although members of the fibroblast growth factor (FGF) family and their receptors have well-established
roles in embryogenesis, their contributions to adult physiology remain relatively …

Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that stimulates glucose
uptake in adipocytes. Here, we show that FGF21 activity depends on βKlotho, a single-…

Fibrosis is a pathological process characterized by infiltration and proliferation of mesenchymal
cells in interstitial space. A substantial portion of these cells is derived from residing non-…

Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. …

Klotho is a mammalian senescence-suppression protein that has homology with glycosidases.
The extracellular domain of Klotho is secreted into urine and blood and may function as a …

Klotho is an antiaging substance with pleiotropic actions including regulation of mineral
metabolism. It is highly expressed in the kidney and is present in the circulation and urine but its …

Fibroblast growth factor (FGF) 23 inhibits renal phosphate reabsorption by activating FGF
receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is …