染色体不分離
染色体不分離
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/06/27 20:06 UTC 版)
染色体不分離（せんしょくたいふぶんり、英: nondisjunction）とは、細胞分裂（有糸分裂/減数分裂）時に相同染色体または姉妹染色分体が適切に分離しない現象である。不分離には、減数第一分裂において相同染色体対が分離しない場合、減数第二分裂において姉妹染色分体が分離しない場合、有糸分裂において姉妹染色分体が分離しない場合の3つのケースがある[1][2][3]。不分離の結果、異常な染色体数（異数性）を持つ娘細胞が生じる。
- ^ a b Simmons, D. Peter Snustad, Michael J. (2006). Principles of genetics (4th ed.). New York, NY [u.a.]: Wiley. ISBN 9780471699392
- ^ a b c d e f g h i Bacino, C.A.; Lee, B. (2011). “Chapter 76: Cytogenetics”. In Kliegman, R.M.; Stanton, B.F.; St. Geme, J.W. et al.. Nelson Textbook of Pediatrics, 19th Edition (19th ed.). Philadelphia: Saunders. pp. 394–413. ISBN 9781437707557
- ^ a b c d Strachan, Tom; Read, Andrew (2011). Human molecular genetics (4th ed.). New York: Garland Science. ISBN 9780815341499
- ^ Thomas Hunt Morgan (August 31, 2012). Sex-Linked Inheritance in Drosophila. Ulan Press. pp. 10–11
- ^ a b c Nagaoka, SI; Hassold, TJ; Hunt, PA (Jun 18, 2012). “Human aneuploidy: mechanisms and new insights into an age-old problem.”. Nature Reviews Genetics 13 (7): 493–504. doi:10.1038/nrg3245. PMC 3551553. PMID 22705668.
- ^ a b c Jones, K. T.; Lane, S. I. R. (27 August 2013). “Molecular causes of aneuploidy in mammalian eggs”. Development 140 (18): 3719–3730. doi:10.1242/dev.090589. PMID 23981655.
- ^ a b eds, Charles R. Scriver ... [] (2005). The online metabolic & molecular bases of inherited disease (8th ed.). New York: McGraw-Hill. ISBN 9780079130358
- ^ Quevedo, O; García-Luis, J; Matos-Perdomo, E; Aragón, L; Machín, F (2012). “Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.”. PLOS Genetics 8 (2): e1002509. doi:10.1371/journal.pgen.1002509. PMC 3280967. PMID 22363215.
- ^ Banks, P (Feb 1977). “Pulp changes after anterior mandibular subapical osteotomy in a primate model.”. Journal of Maxillofacial Surgery 5 (1): 39–48. doi:10.1016/s0301-0503(77)80074-x. PMID 403247.
- ^ Holm, C; Goto, T; Wang, JC; Botstein, D (Jun 1985). “DNA topoisomerase II is required at the time of mitosis in yeast.”. Cell 41 (2): 553–63. doi:10.1016/s0092-8674(85)80028-3. PMID 2985283.
- ^ Sun, S.-C.; Kim, N.-H. (14 November 2011). “Spindle assembly checkpoint and its regulators in meiosis”. Human Reproduction Update 18 (1): 60–72. doi:10.1093/humupd/dmr044. PMID 22086113.
- ^ a b Eichenlaub-Ritter, Ursula (2012). “Oocyte ageing and its cellular basis”. The International Journal of Developmental Biology 56 (10–11–12): 841–852. doi:10.1387/ijdb.120141ue. PMID 23417406.
- ^ a b c d Gleason, H. William, ed (2005). Avery's diseases of the newborn (8th ed.). Philadelphia, Pa.: W.B. Saunders. ISBN 978-0721693477
- ^ Koehler, KE; Hawley, RS; Sherman, S; Hassold, T (1996). “Recombination and nondisjunction in humans and flies.”. Human Molecular Genetics 5 Spec No: 1495–504. doi:10.1093/hmg/5.Supplement_1.1495. PMID 8875256.
- ^ Tartaglia, NR; Howell, S; Sutherland, A; Wilson, R; Wilson, L (May 11, 2010). “A review of trisomy X (47,XXX).”. Orphanet Journal of Rare Diseases 5: 8. doi:10.1186/1750-1172-5-8. PMC 2883963. PMID 20459843.
- ^ Harper, JC; Harton G (2010). “The use of arrays in preimplantation genetic diagnosis and screening”. Fertil Steril 94 (4): 1173–1177. doi:10.1016/j.fertnstert.2010.04.064. PMID 20579641.
- ^ “Karyotyping”. National Institute of Health. 2014年5月7日閲覧。
- ^ van der Ven, Katrin; Montag, Markus; van der Ven, Hans (2008-03). “Polar body diagnosis - a step in the right direction?”. Deutsches Arzteblatt International 105 (11): 190–196. doi:10.3238/arztebl.2008.0190. ISSN 1866-0452. PMC 2696746. PMID 19629197.
- ^ Montag, M; van der Ven, K; Rösing, B; van der Ven, H (2009). “Polar body biopsy: a viable alternative to preimplantation genetic diagnosis and screening”. Reproductive Biomedicine Online 18 Suppl 1: 6–11. doi:10.1016/s1472-6483(10)60109-5. PMID 19281658.
- ^ Parnes, YM (Mar–Apr 1989). “RCT controversy.”. Journal of Obstetric, Gynecologic, & Neonatal Nursing 18 (2): 90. doi:10.1111/j.1552-6909.1989.tb00470.x. PMID 2709181.
- ^ Yu, Y; Zhao, Y; Li, R; Li, L; Zhao, H; Li, M; Sha, J; Zhou, Q et al. (Dec 6, 2013). “Assessment of the risk of blastomere biopsy during preimplantation genetic diagnosis in a mouse model: reducing female ovary function with an increase in age by proteomics method.”. Journal of Proteome Research 12 (12): 5475–86. doi:10.1021/pr400366j. PMID 24156634.
- ^ “Cigarette smoking and aneuploidy in human sperm”. Mol. Reprod. Dev. 59 (4): 417–21. (2001). doi:10.1002/mrd.1048. PMID 11468778.
- ^ “Smoking cigarettes is associated with increased sperm disomy in teenage men”. Fertil. Steril. 70 (4): 715–23. (1998). doi:10.1016/S0015-0282(98)00261-1. PMID 9797104.
- ^ “Chronic alcohol exposure induces genome damage measured using the cytokinesis-block micronucleus cytome assay and aneuploidy in human B lymphoblastoid cell lines”. Mutagenesis 26 (3): 421–9. (2011). doi:10.1093/mutage/geq110. PMID 21273273.
- ^ “Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human”. Ann. N. Y. Acad. Sci. 1310 (1): 74–83. (2014). Bibcode: 2014NYASA1310...74M. doi:10.1111/nyas.12382. PMC 3978411. PMID 24571325.
- ^ “Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate”. Toxicology 203 (1–3): 49–60. (2004). doi:10.1016/j.tox.2004.05.018. PMID 15363581.
- ^ “Genotoxic effects on spermatozoa of carbaryl-exposed workers”. Toxicol. Sci. 85 (1): 615–23. (2005). doi:10.1093/toxsci/kfi066. PMID 15615886.
[続きの解説]
「染色体不分離」の続きの解説一覧
- 1 染色体不分離とは
- 2 染色体不分離の概要
- 3 影響
- 4 診断
- 染色体不分離のページへのリンク
