インターフェロンγ
(IFN‐γ から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/05/20 00:14 UTC 版)
インターフェロンγ（英: interferon gamma、略称: IFN-γ）は、二量体型可溶性サイトカインであり、II型インターフェロンの唯一のメンバーである[5]。このインターフェロンは当初は免疫インターフェロン（immune interferon）と呼ばれており、E. F. Wheelockによってフィトヘマグルチニン刺激を受けたヒト白血球による産物として記載された[6]。また抗原刺激されたヒトリンパ球[7]やツベルクリン感作マウス腹膜リンパ球[8]でも産生されることが示され、水疱性口内炎ウイルスの増殖を阻害することが示された。こうした報告には、現在結核の検査に広く用いられているIFN-γ遊離試験の基礎をなす観察が含まれていた。ヒトでは、IFN-γタンパク質はIFNG遺伝子によってコードされる[9][10]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111537 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055170 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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[続きの解説]
「インターフェロンγ」の続きの解説一覧
- 1 インターフェロンγとは
- 2 インターフェロンγの概要
- 3 機能
- 4 生産
- 5 相互作用
- 6 調節
- IFN‐γのページへのリンク
