GSK-3
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/05/12 05:12 UTC 版)
GSK-3 (glycogen synthase kinase 3) は、セリンとスレオニンのアミノ酸残基へのリン酸分子の付加を媒介するセリン・スレオニンプロテインキナーゼである。グリコーゲンシンターゼキナーゼ-3、グリコーゲン合成酵素キナーゼ-3などとも呼ばれる。なお直訳すると「グリコーゲンシンターゼ(グリコーゲン合成酵素)をリン酸化する酵素(キナーゼ)」という意味である。GSK-3は、1980年にグリコーゲンシンターゼを調節するキナーゼとして発見され、それが名前の由来となっている[2]。それ以降、GSK-3は様々な経路の40種類以上のタンパク質に対してキナーゼとして機能することが示されている[3]。哺乳類では、GSK-3は2つの遺伝子GSK3A (GSK-3α)、GSK3B (GSK-3β) にコードされていることが知られている。近年、GSK-3は2型糖尿病、アルツハイマー病、炎症、がん、双極性障害など多数の疾患との関連が示唆され、多くの研究の対象となっている。
- ^ PDB 1J1B; “Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta”. Acta Crystallographica Section D 60 (Pt 3): 439–46. (March 2004). doi:10.1107/S090744490302938X. PMID 14993667.
- ^ a b “Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase”. European Journal of Biochemistry 107 (2): 519–27. (June 1980). doi:10.1111/j.1432-1033.1980.tb06059.x. PMID 6249596.
- ^ a b c “The glamour and gloom of glycogen synthase kinase-3”. Trends in Biochemical Sciences 29 (2): 95–102. (February 2004). doi:10.1016/j.tibs.2003.12.004. PMID 15102436.
- ^ “Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition”. Cell 105 (6): 721–32. (June 2001). doi:10.1016/S0092-8674(01)00374-9. PMID 11440715.
- ^ “Regulation and functions of the glycogen synthase kinase-3 subfamily”. Seminars in Cancer Biology 5 (4): 269–75. (August 1994). PMID 7803763.
- ^ “Judging a protein by more than its name: GSK-3”. Science's STKE 2001 (100): re12. (September 2001). doi:10.1126/stke.2001.100.re12. PMID 11579232.
- ^ “Glycogen synthase kinase-3: properties, functions, and regulation”. Chemical Reviews 101 (8): 2527–40. (August 2001). doi:10.1021/cr000110o. PMID 11749387.
- ^ a b c d “Glycogen synthase kinase 3: more than a namesake”. British Journal of Pharmacology 156 (6): 885–98. (March 2009). doi:10.1111/j.1476-5381.2008.00085.x. PMC 2697722. PMID 19366350 .
- ^ “Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling”. The Journal of Biological Chemistry 280 (6): 4422–8. (February 2005). doi:10.1074/jbc.M410610200. PMID 15574412.
- ^ “Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression”. Diabetes 50 (5): 937–46. (May 2001). doi:10.2337/diabetes.50.5.937. PMID 11334436.
- ^ a b c d e f g “Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics”. Neurochemical Research 32 (4-5): 577–95. (Apr–May 2007). doi:10.1007/s11064-006-9128-5. PMC 1970866. PMID 16944320 .
- ^ a b “Glycogen synthase kinase 3: a point of convergence for the host inflammatory response”. Cytokine 53 (2): 130–40. (February 2011). doi:10.1016/j.cyto.2010.10.009. PMC 3021641. PMID 21095632 .
- ^ “Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors”. Frontiers in Molecular Neuroscience 4: 47. (2011). doi:10.3389/fnmol.2011.00047. PMC 3223722. PMID 22275880 .
- ^ “Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage”. Proceedings of the National Academy of Sciences of the United States of America 99 (12): 7951–5. (June 2002). doi:10.1073/pnas.122062299. PMC 123001. PMID 12048243 .
- ^ “CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium”. Journal of Neurochemistry 78 (6): 1219–32. (September 2001). doi:10.1046/j.1471-4159.2001.00495.x. PMC 1947002. PMID 11579131 .
- ^ a b “Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation”. Cancer Research 68 (16): 6643–51. (August 2008). doi:10.1158/0008-5472.CAN-08-0850. PMC 2585745. PMID 18701488 .
- ^ “GSK-3β: A Bifunctional Role in Cell Death Pathways”. International Journal of Cell Biology 2012: 930710. (May 2012). doi:10.1155/2012/930710. PMC 3364548. PMID 22675363 .
- ^ “GSK-3: tricks of the trade for a multi-tasking kinase”. Journal of Cell Science 116 (Pt 7): 1175–86. (April 2003). doi:10.1242/jcs.00384. PMC 3006448. PMID 12615961 .
- ^ “Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria”. NeuroReport 14 (18): 2415–9. (December 2003). doi:10.1097/00001756-200312190-00025. PMID 14663202.
- ^ “Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions”. European Journal of Medicinal Chemistry 144: 843–858. (January 2018). doi:10.1016/j.ejmech.2017.11.103. PMID 29306837.
- ^ “Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock”. Science 311 (5763): 1002–5. (February 2006). doi:10.1126/science.1121613. PMID 16484495.
- ^ “Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder”. Journal of Affective Disorders 159: 80–4. (April 2014). doi:10.1016/j.jad.2014.02.024. PMID 24679394 .
- ^ “GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals”. Neurobiology of Disease 33 (2): 193–206. (February 2009). doi:10.1016/j.nbd.2008.10.007. PMC 4313761. PMID 19038340 .
- ^ “Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy”. Nature 455 (7217): 1205–9. (October 2008). doi:10.1038/nature07284. PMC 4084721. PMID 18806775 .
- ^ “Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms”. Carcinogenesis 33 (3): 529–37. (March 2012). doi:10.1093/carcin/bgr309. PMID 22201186.
- ^ “GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats”. Molecular Neurobiology 53 (10): 7028–7036. (December 2016). doi:10.1007/s12035-015-9607-2. PMC 4909586. PMID 26671619 .
- ^ a b “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses”. Immunity 44 (2): 274–86. (February 2016). doi:10.1016/j.immuni.2016.01.018. PMC 4760122. PMID 26885856 .
- ^ “GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS”. Frontiers in Molecular Neuroscience 4: 32. (2011). doi:10.3389/fnmol.2011.00032. PMC 3204427. PMID 22065134 .
- 1 GSK-3とは
- 2 GSK-3の概要
- 3 疾患との関連
- 4 阻害剤
- 5 関連項目
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