FADD
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/06 02:53 UTC 版)
FADD（Fas-associated protein with death domain）は、ヒトでは11番染色体の11q13.3領域のFADD遺伝子によってコードされるタンパク質である[4]。MORT1（mediator of receptor-induced toxicity）とも呼ばれる。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168040 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ a b “TRAIL receptor-2 signals apoptosis through FADD and caspase-8”. Nature Cell Biology 2 (4): 241–243. (2000). doi:10.1038/35008667. PMID 10783243.
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- ^ Yeh, W. C.; De La Pompa, J. L.; Mccurach, M. E.; Shu, H. B.; Elia, A. J.; Shahinian, A.; Ng, M.; Wakeham, A. et al. (1998). “FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis”. Science 279 (5358): 1954–1958. Bibcode: 1998Sci...279.1954Y. doi:10.1126/science.279.5358.1954. PMID 9506948.
- ^ “Multiple functions of FADD in apoptosis, NF-kappa B-related signaling, and heart development in Xenopus embryos”. Genes to Cells 17 (11): 875–896. (2012). doi:10.1111/gtc.12004. PMID 23025414.
- ^ “SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma”. Human Molecular Genetics 16 (20): 2482–2493. (2007). doi:10.1093/hmg/ddm204. PMID 17656375.
- ^ a b c “Phosphorylation of FADD at serine 194 by CKI alpha regulates its nonapoptotic activities”. Molecular Cell 19 (3): 321–332. (2005). doi:10.1016/j.molcel.2005.06.024. PMID 16061179.
- ^ “Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1”. Nature 392 (6673): 296–300. (1998). Bibcode: 1998Natur.392..296Z. doi:10.1038/32681. PMID 9521326.
- ^ “The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells”. Journal of Immunology 176 (11): 6852–6861. (2006). doi:10.4049/jimmunol.176.11.6852. PMC 3110081. PMID 16709845.
- ^ “Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)”. Journal of Biological Chemistry 275 (32): 24357–24366. (2000). doi:10.1074/jbc.M000811200. PMID 10823821.
- ^ a b c d “FADD: a regulator of life and death”. Trends in Immunology 31 (7): 260–269. (2010). doi:10.1016/j.it.2010.05.005. PMID 20576468.
- ^ Balachandran, S.; Venkataraman, T.; Fisher, P. B.; Barber, G. N (2007). “Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7”. Journal of Immunology 178 (4): 2429–2439. doi:10.4049/jimmunol.178.4.2429. PMID 17277150.
- ^ “Regulation of Protein Kinase C Inactivation by Fas-associated Protein with Death Domain”. Journal of Biological Chemistry 287 (31): 26126–26135. (2012). doi:10.1074/jbc.M112.342170. PMC 3406696. PMID 22582393.
- ^ “Domain-containing Protein (FADD) Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation”. Molecular & Cellular Proteomics 12 (10): 2689–2700. (2013). doi:10.1074/mcp.M113.029306. PMC 3790283. PMID 23828893.
- ^ “Molecular evidence for the nuclear localization of FADD”. Cell Death and Differentiation 10 (7): 791–797. (2003). doi:10.1038/sj.cdd.4401237. PMID 12815462.
- ^ a b “FLICE-inhibitory proteins: Regulators of death receptor-mediated apoptosis”. Molecular and Cellular Biology 21 (24): 8247–8254. (2001). doi:10.1128/mcb.21.24.8247-8254.2001. PMC 99990. PMID 11713262.
- ^ a b Scaffidi, C.; Schmitz, I.; Krammer, P. H.; Peter, M. E. (1999). “The role of c-FLIP in modulation of CD95-induced apoptosis”. Journal of Biological Chemistry 274 (3): 1541–1548. doi:10.1074/jbc.274.3.1541. PMID 9880531.
- ^ “Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis”. Journal of Biological Chemistry 276 (48): 44944–44952. (2001). doi:10.1074/jbc.M104919200. PMID 11581255.
- ^ a b “Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis”. Nature Communications 3: 978. (2012). Bibcode: 2012NatCo...3..978L. doi:10.1038/ncomms1981. PMID 22864571.
- ^ “FADD is upregulated in relapsing remitting multiple”. Neuroimmunomodulation 21 (5): 221–225. (2014). doi:10.1159/000356522. PMID 24603611.
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- ^ a b Razaghi, Ali; Villacrés, Carina; Jung, Vincent; Mashkour, Narges; Butler, Michael; Owens, Leigh; Heimann, Kirsten (2017). “Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells”. Experimental Cell Research 359 (1): 20–29. doi:10.1016/j.yexcr.2017.08.014. PMID 28803068.
- ^ “FADD expression is associated with regional and distant metastasis in squamous cell carcinoma of the head and neck”. Histopathology 63 (2): 263–270. (2013). doi:10.1111/his.12174. PMID 23763459.
- ^ “FADD protein release mirrors the development and aggressiveness of human non-small cell lung cancer”. British Journal of Cancer 106 (12): 1989–1996. (2012). doi:10.1038/bjc.2012.196. PMC 3388563. PMID 22669160.
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- ^ “FADD phosphorylation is critical for cell cycle regulation in breast cancer cells”. British Journal of Cancer 94 (4): 532–539. (2006). doi:10.1038/sj.bjc.6602955. PMC 2361184. PMID 16450001.
- ^ “A Novel Kinase Inhibitor of FADD Phosphorylation Chemosensitizes through the Inhibition of NF-kappa B”. Molecular Cancer Therapeutics 10 (10): 1807–1817. (2011). doi:10.1158/1535-7163.mct-11-0362. PMC 3191281. PMID 21859840.
- ^ “Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein”. J. Biol. Chem. 277 (44): 41307–10. (Nov 2002). doi:10.1074/jbc.C200436200. PMID 12235128.
- ^ “Identification and characterization of DEDD2, a death effector domain-containing protein”. J. Biol. Chem. 277 (9): 7501–8. (Mar 2002). doi:10.1074/jbc.M110749200. PMID 11741985.
- ^ “Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis”. Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5211–6. (Apr 2003). Bibcode: 2003PNAS..100.5211S. doi:10.1073/pnas.0431215100. PMC 154324. PMID 12702765.
- ^ “The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function”. Biochem. Biophys. Res. Commun. 303 (4): 1034–41. (Apr 2003). doi:10.1016/s0006-291x(03)00487-x. PMID 12684039.
- ^ “PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis”. Oncogene 18 (31): 4409–15. (Aug 1999). doi:10.1038/sj.onc.1202831. PMID 10442631.
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