スピンドルチェックポイントとは？ わかりやすく解説

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紡錘体チェックポイント

(スピンドルチェックポイント から転送)

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/13 14:41 UTC 版)

紡錘体チェックポイント（ぼうすいたいチェックポイント、英: spindle checkpoint）は、有糸分裂または減数分裂において、複製された各染色体が紡錘体に正しく接着する（後期）まで染色体の分離を防ぐ、細胞周期チェックポイントである。スピンドルチェックポイント、紡錘体（スピンドル）形成チェックポイント（英: spindle assembly checkpoint、略称: SAC）、有糸分裂チェックポイント（英: mitotic checkpoint）とも呼ばれる。適切な染色体分離（英語版）を行うためには、姉妹染色分体上の2つのキネトコアはそれぞれ反対側の紡錘体極と接着していなければならない[1]。この接着パターンのときのみ、各娘細胞が染色体の1つのコピーを受け取ることが保証される。このチェックポイントの生化学的特徴はM期サイクリン/CDK複合体による後期促進複合体の刺激であり、これによってサイクリンや姉妹染色分体をつなぎとめているタンパク質の分解が引き起こされる[2]。


出典
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