制限酵素
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/29 04:30 UTC 版)
制限酵素（せいげんこうそ、英：Restriction enzyme; REase）は、制限部位として知られるDNAの特定の配列部位の内部、あるいはその近くでDNAを特異的に切断する酵素の一種である[1][2][3]。制限酵素はDNA切断活性を持つエンドヌクレアーゼと呼ばれる酵素群のうちの1つであり、特に制限エンドヌクレアーゼとも呼ばれる。タンパク質の複合体構造やDNA基質の認識部位、切断位置などの点から、一般的には5種類に分類される。すべての制限酵素は、DNA二重らせんの各糖リン酸骨格（つまり主鎖）を切断する活性を持つ。
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- ^ “The Nobel Prize in Physiology or Medicine”. The Nobel Foundation (1978年). 2008年6月7日閲覧。 “for the discovery of restriction enzymes and their application to problems of molecular genetics”
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- ^ “A bacterial clone synthesizing proinsulin”. Proceedings of the National Academy of Sciences of the United States of America 75 (8): 3727–31. (August 1978). Bibcode: 1978PNAS...75.3727V. doi:10.1073/pnas.75.8.3727. PMC 392859. PMID 3581986
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- ^ “Restriction Map”. bioweb.uwlax.edu. University of Wisconsin (2003年). 2021年5月10日閲覧。
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- ^ “S-Adenosyl-L-methionine-dependent restriction enzymes”. Critical Reviews in Biochemistry and Molecular Biology 39 (1): 1–19. (2004). doi:10.1080/10409230490440532. PMID 15121719.
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- ^ Types of Restriction Endonucleases | NEB
- ^ a b “Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle)”. Microbiology and Molecular Biology Reviews 64 (2): 412–34. (June 2000). doi:10.1128/MMBR.64.2.412-434.2000. PMC 98998. PMID 10839821.
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- ^ a b “Structure and function of type II restriction endonucleases”. Nucleic Acids Research 29 (18): 3705–27. (September 2001). doi:10.1093/nar/29.18.3705. PMC 55916. PMID 11557805.
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- ^ a b c d e “Structure and function of type II restriction endonucleases”. Nucleic Acids Research 29 (18): 3705–27. (September 2001). doi:10.1093/nar/29.18.3705. PMC 55916. PMID 11557805.
- ^ “Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI”. Nucleic Acids Research 40 (15): 7563–72. (August 2012). doi:10.1093/nar/gks428. PMC 3424567. PMID 22610857.
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- ^ “Structure and function of type II restriction endonucleases”. Nucleic Acids Research 29 (18): 3705–27. (September 2001). doi:10.1093/nar/29.18.3705. PMC 55916. PMID 11557805.
- ^ “Structure and function of type II restriction endonucleases”. Nucleic Acids Research 29 (18): 3705–27. (September 2001). doi:10.1093/nar/29.18.3705. PMC 55916. PMID 11557805.
- ^ “Nucleoside triphosphate-dependent restriction enzymes”. Nucleic Acids Research 29 (18): 3728–41. (September 2001). doi:10.1093/nar/29.18.3728. PMC 55918. PMID 11557806.
- ^ “Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage”. Nature 355 (6359): 467–9. (January 1992). Bibcode: 1992Natur.355..467M. doi:10.1038/355467a0. PMID 1734285.
- ^ “S-Adenosyl-L-methionine-dependent restriction enzymes”. Critical Reviews in Biochemistry and Molecular Biology 39 (1): 1–19. (2004). doi:10.1080/10409230490440532. PMID 15121719.
- ^ “Complex restriction enzymes: NTP-driven molecular motors”. Biochimie 84 (11): 1047–59. (November 2002). doi:10.1016/S0300-9084(02)00020-2. PMID 12595133.
- ^ Types of Restriction Endonucleases | NEB
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