Database: COMPOUNDEntry: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
LinkDB: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
ENTRY C02210 Compound
NAME beta-Endorphin
SEQUENCE Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr
Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu
ORGANISM Homo sapiens [HSA:5443]
TYPE Peptide
BRITE Compounds with biological roles [BR:br08001]
Hormones and transmitters
Peptide hormones
beta-Endorphin
C02210 beta-Endorphin
Bioactive peptides [BR:br08005]
Pituitary hormones
Proopiomelanocortin-derived peptide
C02210 Endorphin beta
DBLINKS CAS: 60617-12-1
PubChem: 5278
ChEBI: 10415
NIKKAJI: J39.450E
///
ENTRY C11684 Compound
NAME MET-enkephalin;
Methionine enkephalin
FORMULA C27H35N5O7S
EXACT_MASS 573.2257
MOL_WEIGHT 573.6611
SEQUENCE Tyr Gly Gly Phe Met
ORGANISM Homo sapiens [HSA:5179]
TYPE Peptide
BRITE Compounds with biological roles [BR:br08001]
Hormones and transmitters
Peptide hormones
Enkephalin
C11684 Met-enkephalin
Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C11684 Met-enkephalin
DBLINKS CAS: 58569-55-4
PubChem: 13849
ChEBI: 6618
NIKKAJI: J246.108K
ATOM 40
1 C8x C 17.2009 -20.4310
2 C8y C 15.9810 -19.7318
3 C8x C 15.9783 -18.3358
4 C8x C 17.1916 -17.6278
5 C8y C 18.4128 -18.3357
6 C8x C 18.4122 -19.7390
7 O1a O 14.7710 -20.4385
8 C1b C 19.6280 -17.6378
9 C1c C 19.6272 -16.2396
10 N1a N 18.4130 -15.5380
11 C5a C 20.8341 -15.5399
12 N1b N 22.0460 -16.2374
13 C1b C 23.2578 -15.5328
14 C5a C 24.4698 -16.2303
15 N1b N 25.6746 -15.5257
16 C1b C 26.8866 -16.2234
17 C5a C 28.0984 -15.5188
18 N1b N 29.3103 -16.2163
19 C1c C 30.5223 -15.5117
20 C5a C 31.7341 -16.2092
21 N1b N 32.9460 -15.5045
22 C1c C 34.1580 -16.2023
23 C6a C 35.3628 -15.4976
24 O5a O 20.8310 -14.1379
25 O5a O 24.4728 -17.6325
26 O5a O 28.0953 -14.1167
27 C1b C 30.5192 -14.1096
28 C8y C 31.7329 -13.4094
29 C8x C 32.9457 -14.1061
30 C8x C 34.1587 -13.4070
31 C8x C 34.1563 -12.0033
32 C8x C 32.9310 -11.3017
33 C8x C 31.7231 -12.0117
34 O5a O 31.7371 -17.6114
35 C1b C 34.1629 -17.5974
36 C1b C 32.9570 -18.2991
37 S2a S 32.9617 -19.6942
38 C1a C 31.7560 -20.3958
39 O6a O 36.5746 -16.1887
40 O6a O 35.3542 -14.1018
BOND 41
1 5 8 1
2 9 8 1 #Down
3 4 5 1
4 2 3 1
5 5 6 2
6 19 20 1
7 20 21 1
8 21 22 1
9 22 23 1
10 11 12 1
11 12 13 1
12 11 24 2
13 13 14 1
14 14 25 2
15 17 26 2
16 14 15 1
17 19 27 1 #Up
18 15 16 1
19 27 28 1
20 28 29 2
21 16 17 1
22 29 30 1
23 30 31 2
24 17 18 1
25 31 32 1
26 32 33 2
27 33 28 1
28 18 19 1
29 20 34 2
30 11 9 1
31 22 35 1 #Down
32 9 10 1
33 35 36 1
34 6 1 1
35 36 37 1
36 1 2 2
37 37 38 1
38 2 7 1
39 3 4 2
40 23 39 1
41 23 40 2
///
ENTRY C16041 Compound
NAME Leu-enkephalin
SEQUENCE Tyr Gly Gly Phe Leu
ORGANISM Homo sapiens [HSA:5179 5173]
TYPE Peptide
PATHWAY map04721 Synaptic vesicle cycle
BRITE Compounds with biological roles [BR:br08001]
Hormones and transmitters
Peptide hormones
Enkephalin
C16041 Leu-enkephalin
Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16041 Leu-enkephalin
DBLINKS PubChem: 47205351
ChEBI: 89656
NIKKAJI: J247.065I
///
ENTRY C16042 Compound
NAME Met-enkephalin-Arg-Gly-Leu
SEQUENCE Tyr Gly Gly Phe Met Arg Gly Leu
ORGANISM Homo sapiens [HSA:5179]
TYPE Peptide
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16042 Met-enkephalin-Arg-Gly-Leu
DBLINKS PubChem: 47205352
ChEBI: 80264
NIKKAJI: J374.467A
///
ENTRY C16043 Compound
NAME Met-enkephalin-Arg-Phe
SEQUENCE Tyr Gly Gly Phe Met Arg Phe
ORGANISM Homo sapiens [HSA:5179]
TYPE Peptide
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16043 Met-enkephalin-Arg-Phe
DBLINKS PubChem: 47205353
ChEBI: 80265
NIKKAJI: J374.466C
///
ENTRY C15890 Compound
NAME Endomorphin-1
SEQUENCE Tyr Pro Trp Phe-NH2
TYPE Peptide
PATHWAY map04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C15890 Endomorphin-1
DBLINKS PubChem: 47205210
ChEBI: 80156
NIKKAJI: J830.103D
///
ENTRY C15891 Compound
NAME Endomorphin-2
SEQUENCE Tyr Pro Phe Phe-NH2
TYPE Peptide
PATHWAY map04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C15891 Endomorphin-2
DBLINKS PubChem: 47205211
ChEBI: 80157
NIKKAJI: J454.979A
///
ENTRY C01574 Compound
NAME Dynorphin;
Dynorphin A
SEQUENCE Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
Gln
ORGANISM Homo sapiens [HSA:5173]
TYPE Peptide
BRITE Compounds with biological roles [BR:br08001]
Hormones and transmitters
Peptide hormones
Dynorphin
C01574 Dynorphin A
Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C01574 Dynorphin A
DBLINKS CAS: 74913-18-1
PubChem: 4731
ChEBI: 4727
///
ENTRY C16135 Compound
NAME Dynorphin B;
Rimorphin
SEQUENCE Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr
ORGANISM Homo sapiens [HSA:5173]
TYPE Peptide
BRITE Compounds with biological roles [BR:br08001]
Hormones and transmitters
Peptide hormones
Dynorphin
C16135 Dynorphin B
Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16135 Dynorphin B
DBLINKS CAS: 83335-41-5
PubChem: 47205445
ChEBI: 80347
NIKKAJI: J39.439D
///
ENTRY C01516 Compound
NAME Morphine
FORMULA C17H19NO3
EXACT_MASS 285.1365
MOL_WEIGHT 285.3377
REMARK Same as: D08233
REACTION R03591 R03592 R03697 R08262 R08263 R08265 R09402
PATHWAY map00950 Isoquinoline alkaloid biosynthesis
map00982 Drug metabolism - cytochrome P450
map01063 Biosynthesis of alkaloids derived from shikimate pathway
map01100 Metabolic pathways
map01110 Biosynthesis of secondary metabolites
map04080 Neuroactive ligand-receptor interaction
MODULE M00944 Morphine biosynthesis, (S)-reticuline => morphine
ENZYME 1.1.1.218 1.1.1.247 1.14.11.32 1.14.14.1
2.4.1.17
BRITE Phytochemical compounds [BR:br08003]
Alkaloids
Alkaloids derived from tyrosine
Isoquinoline alkaloids
C01516 Morphine
Secondary metabolites in pathway maps [br08011.html]
Biosynthetic pathways and modules of secondary metabolites
C01516
Prodrugs [br08324.html]
C01516
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA01 Morphine
D08233 Morphine (BAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00810 Morphine
D08233 Morphine
Analgesic
DG01984 Opioid analgesics
DG00810 Morphine
D08233 Morphine
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00810 Morphine
D08233 Morphine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D08233 Morphine (BAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08233
Prodrugs [br08324.html]
D08233
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Control Act Article 2 Table 1 (74 substances)
D08233
Opium and Cannabis
D08233
DBLINKS CAS: 57-27-2
PubChem: 4681
ChEBI: 17303
KNApSAcK: C00001889
PDB-CCD: MOI[PDBj]
3DMET: B04801
NIKKAJI: J2.323J
ATOM 21
1 C1z C 21.5384 -23.5506
2 C8y C 21.5384 -22.2288
3 C1y C 22.7210 -24.2462
4 C1y C 20.4253 -24.1767
5 C1x C 22.7210 -22.9245
6 C8y C 20.4253 -21.6027
7 C8y C 22.7210 -21.6027
8 C1y C 23.8341 -23.5506
9 C2x C 22.7210 -25.4984
10 O2x O 19.1036 -22.8548
11 C1y C 20.4253 -25.4984
12 C1x C 24.9471 -22.9245
13 C8y C 20.4253 -20.2809
14 C1x C 23.8341 -22.2983
15 C8x C 22.7210 -20.2809
16 N1y N 24.9471 -24.2462
17 C2x C 21.5384 -26.1941
18 O1a O 19.3123 -26.1941
19 C8x C 21.6080 -19.6549
20 O1a O 19.3123 -19.6549
21 C1a C 26.3437 -24.2462
BOND 25
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 2
17 11 18 1 #Down
18 13 19 2
19 13 20 1
20 6 10 1
21 8 14 1
22 11 17 1
23 12 16 1
24 15 19 1
25 16 21 1
///
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