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Potential anthelmintic: d-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans

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Abstract

No anthelmintic sugars have yet been identified. Eight ketohexose stereoisomers (d- and l-forms of psicose, fructose, tagatose and sorbose), along with d-galactose and d-glucose, were examined for potency against L1 stage Caenorhabditis elegans fed Escherichia coli. Of the sugars, d-psicose specifically inhibited the motility, growth and reproductive maturity of the L1 stage. d-Psicose probably interferes with the nematode nutrition. The present results suggest that d-psicose, one of the rare sugars, is a potential anthelmintic.

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Acknowledgments

The authors wish to thank Prof. Kazuhiro Fukada of Kagawa University for valuable discussions on this topic. This research was supported in part by a grant from the Glyco-Biocluster Plan Based on Rare Sugars of the Ministry of Education, Science, Sports and Culture of Japan.

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Authors and Affiliations

  1. Department of Applied Biological Science, Kagawa University, 2393 Miki-Ikenobe, Kagawa, 761-0795, Japan

    Masashi Sato, Hiroyuki Kurose & Toru Yamasaki

  2. Rare Sugar Research Center, Kagawa University, 2393 Miki-Ikenobe, Kagawa, 761-0795, Japan

    Ken Izumori

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  1. Masashi Sato
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  2. Hiroyuki Kurose
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  3. Toru Yamasaki
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  4. Ken Izumori
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Correspondence to Toru Yamasaki.

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Sato, M., Kurose, H., Yamasaki, T. et al. Potential anthelmintic: d-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans . J Nat Med 62, 244–246 (2008). https://doi.org/10.1007/s11418-007-0220-1

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  • DOI: https://doi.org/10.1007/s11418-007-0220-1

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