A review of the available literature concerning sudden withdrawal of drugs shows that withdrawal syndrome have occurred with centrally antihypertensive drugs, beta-blockers on anginal patients, antiparkinsonian drugs and glucocorticoids. Because of a lack of controlled trials led among a large number of individuals, the correct frequency of this withdrawal syndrome is unknown. In most patients, it's hard to distinguish a return to a previous state from an overshoot phenomenon. In that way, gradual and supervised withdrawal of these agents should prevent the complication of sudden cessation of these therapy.