Abstract
It has been previously well established that the use of dopaminergic agents in Parkinson's disease may contribute to behavioral disturbances such as dopamine dysregulation syndrome (DDS), impulse control disorders (ICD), and punding. ICD and punding have been most commonly addressed by reducing dose or by discontinuing the use of a dopamine agonist. Treatment of DDS has proven more challenging, and to date there has been no standard approach. In this paper, we review a series of four patients who met criteria for DDS, who were all refractory to medication adjustments. The DDS symptoms responded by the addition of valproic acid in all cases.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Akathisia, Drug-Induced / drug therapy*
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Akathisia, Drug-Induced / etiology
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Anticonvulsants / therapeutic use*
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Carbidopa / adverse effects
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Disruptive, Impulse Control, and Conduct Disorders / chemically induced
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Disruptive, Impulse Control, and Conduct Disorders / drug therapy*
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Dopamine Agents / adverse effects
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Drug Combinations
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Female
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Humans
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Levodopa / adverse effects
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Male
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Middle Aged
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Parkinson Disease / drug therapy
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Valproic Acid / therapeutic use*
Substances
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Anticonvulsants
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Dopamine Agents
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Drug Combinations
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carbidopa, levodopa drug combination
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Levodopa
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Valproic Acid
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Carbidopa