Abstract
In the present study, we investigated the antidepressive activity of opiorphin with central administration in the forced swim test in mice. Intracerebroventricular (i.c.v.) administration of opiorphin (1-6 μg/mouse) dose-dependently decreased the immobility time, which was reversed by nonselective opioid receptor antagonist naloxone, δ-selective naltrindole and μ-selective β-FNA. The data suggested that central administration of opiorphin produced an antidepressant-like effect by activating both μ and δ opioid receptors indirectly. In order to eliminate the possibility of a false-positive result in the forced swim test, locomotor activity was checked in both non-habituated and habituated mice. Opiorphin had no influence on non-habituated mice, though had weak effect on habituated mice. In addition, mice treated with opiorphin did not display any convulsive behaviors.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents / administration & dosage
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Antidepressive Agents / pharmacology*
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Dose-Response Relationship, Drug
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Habituation, Psychophysiologic
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Humans
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Injections, Intraventricular
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Male
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Mice
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Motor Activity / drug effects*
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Naloxone / pharmacology
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Naltrexone / analogs & derivatives
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Naltrexone / pharmacology
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Oligopeptides / administration & dosage
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Oligopeptides / pharmacology*
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Receptors, Opioid, delta / antagonists & inhibitors
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Receptors, Opioid, delta / physiology*
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Receptors, Opioid, mu / antagonists & inhibitors
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Receptors, Opioid, mu / physiology*
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Salivary Proteins and Peptides / administration & dosage
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Salivary Proteins and Peptides / pharmacology*
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Signal Transduction
Substances
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Antidepressive Agents
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Oligopeptides
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Receptors, Opioid, delta
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Receptors, Opioid, mu
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Salivary Proteins and Peptides
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glutaminyl-arginyl-phenylalanyl-seryl-arginine
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Naloxone
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Naltrexone
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beta-funaltrexamine