Objective To clarify the incidence, demographic features, and clinical characteristics of
polypoidal choroidal vasculopathy (PCV) in Japanese patients. Methods Consecutive patients …

Purpose: The programmed death-1 ligand/programmed death-1 (PD-L/PD-1) pathway has
been recently suggested to play a pivotal role in the immune evasion of tumors from host …

Purpose: The negative regulatory programmed death-1/programmed death-1 ligand (PD-1/PD-L)
pathway in T-cell activation has been suggested to play an important role in tumor …

Purpose: The aberrant expression of programmed cell death 1 ligands 1 and 2 (PD-Ls) on
tumor cells dampens antitumor immunity, resulting in tumor immune evasion. In this study, we …

Isono, Shiroh, John E Remmers, Atsuko Tanaka, Yasuhide Sho, Jiro Sato, and Takashi
Nishino. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects.J. …

Based on the follow-up evaluation of 350 patients in whom lumbar disc herniation was
treated by anterior discectomy and interbody fusion from 1955 to 1982, 94.3% of the patients …

… Hideki Ueno, Tatsuya Ioka, Masafumi Ikeda, Shinichi Ohkawa, Hiroaki Yanagimoto,
Narikazu Boku, Akira Fukutomi, Kazuya Sugimori, Hideo Baba, Kenji Yamao, Tomotaka …

A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using
gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer. …

Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool.
Here, we report mitocytosis, a migrasome-mediated mitochondrial quality-control process. …

To evaluate whether angiogenic factors are of clinical relevance to actual human pancreatic
cancers, we studied the intratumoral microvessel density (IMD), and PD-ECGF, VEGF …

BACKGROUND & AIMS: Little is known about factors that regulate intestinal epithelial
differentiation; microbial recognition receptors such as Toll-like receptor (TLR)4 might be involved. …

Vascular endothelial growth factor (VEGF), an established angiogenesis factor, is expressed
in allografts undergoing rejection, but its function in the rejection process has not been …

Recent basic and clinical studies have shown that the programmed death ligand (PD-L)/PD-1
pathway has a significant role in tumour immunity, and its blockade has a therapeutic …

This study investigated the effects of high flow and shear stress on the expression of matrix
metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase-2 (TIMP-2) during flow-…

This study addresses a mechanism by which lymphocytes may promote vascular endothelial
growth factor (VEGF) expression and angiogenesis in immune inflammation. Resting …

We investigated the effects of sequential and prolonged exposure to high and low wall shear
stress on arterial remodeling using a rabbit arteriovenous fistula (AVF) model. Blood flow …

The velopharynx is the most common site of obstruction in patients with obstructive sleep
apnea (OSA). Advancement of the mandible effectively reverses the pharyngeal obstruction. …

Recent success in functional recovery by photoreceptor precursor transplantation in dysfunctional
retina has led to an increased interest in using embryonic stem cell (ESC) or induced …

Purpose A multicenter survey was conducted to explore the role of adjuvant surgery for
initially unresectable pancreatic cancer with a long‐term favorable response to non‐surgical …

Therapeutic application of broadly reactive anti-T cell antibodies can lead not only to potent
immunosuppression but also to profound and long-lived T cell depletion. We reasoned that a …