Evolution and diversification of the basal transcription machinery

Trends Biochem Sci. 2015 Mar;40(3):127-9. doi: 10.1016/j.tibs.2015.01.005. Epub 2015 Feb 5.

Abstract

Transcription initiation was once thought to be regulated primarily by sequence-specific transcription factors with the basal transcription machinery being largely invariant. Gradually it became apparent that the basal transcription machinery greatly diversified during evolution and new studies now demonstrate that diversification of the TATA-binding protein (TBP) family yielded specialized and largely independent transcription systems.

Keywords: TATA-binding protein (TBP); TBP-related factor (TRF); basal transcription machinery; diversification; evolution; gene regulation; system factors; transcription.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Humans
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcription, Genetic*

Substances

  • Transcription Factors