Abstract
By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Cell Line, Tumor
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Cell Proliferation
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Chromosomal Proteins, Non-Histone / genetics
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Computational Biology
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Gene Expression Regulation*
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Genome, Human / genetics
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HeLa Cells
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Humans
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Mice
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Microfilament Proteins / genetics
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Models, Genetic
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Molecular Sequence Data
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NIH 3T3 Cells
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Nucleic Acid Conformation
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RNA Polymerase III / metabolism
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RNA Processing, Post-Transcriptional
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Small Nuclear / chemistry
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RNA, Small Nuclear / genetics*
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RNA, Small Nuclear / metabolism
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Sequence Analysis, DNA
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Species Specificity
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TATA Box / genetics
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Transcription, Genetic / genetics*
Substances
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Chromosomal Proteins, Non-Histone
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Microfilament Proteins
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RNA, Messenger
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RNA, Small Nuclear
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centromere protein F
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RNA Polymerase III