ライフサイエンスコーパス: traction

1 al epiretinal membranes and/or vitreomacular traction.

2 ially in those without obvious vitreomacular traction.

3 ernal rounding forces and cell-intercalation traction.

4 ibroblasts were predominant in vitreomacular traction.

5 ascular vitreous veil with localized retinal traction.

6 ular hole after vitrectomy for vitreomacular traction.

7 ular hole after vitrectomy for vitreomacular traction.

8 hopsia in the right eye due to vitreomacular traction.

9 ive trend in identifying focal vitreomacular traction.

10 they are still small and have vitreomacular traction.

11 actile groups within clusters for generating traction.

12 ity and release of symptomatic vitreomacular traction.

13 s closure after vitrectomy for vitreomacular traction.

14 bstrate junctions with no apparent effect on traction.

15 ts to discover inhibitors have gained little traction.

16 ithout the need to explicitly determine cell tractions.

17 of variations in matrix stiffness with cell tractions.

18 s (57.1%), vasculitis (57.1%), vitreoretinal traction (57.1%), and chronic macular edema (ME) (71.4%)

19 Conversely, for focal vitreomacular traction (70 scans) and full-thickness MH (82 scans), 25

20 roduced by actin polymerization can generate traction across the plasma membrane by transmission thro

21 l motility, whereas the differences in their traction adhesion dynamics suggest that these two strain

22 lyzing the spatiotemporal evolution of their traction adhesions (TAs).

23 step-wise fashion, mainly forming stationary traction adhesions along their anterior-posterior axes a

24 e dynamics of the cell's mechanically active traction adhesions.

25 hanced iOCT imaging revealed strong vitreous traction and adhesion above the macula and optic disc.

26 dynamics, thus increasing cell motility and traction and enabling chemotaxis.

27 is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types

28 al fluid and, when applicable, vitreomacular traction and MH.

29 Using traction and monolayer stress microscopy, we show that S

30 ography showed the release of vitreo-macular traction and multifocal electroretinogram responses show

31 n injections in patients with vitreo-macular traction and reduced central visual acuity.

32 c retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens

33 hat NAs transmit a distinguishable amount of traction and that NA maturation depends on traction grow

34 rylation and the CSD promotes focal adhesion traction and, thereby, cancer cell motility.

35 Four of the 8 patients with traction and/or rhegmatogenous RD developed recurrent de

36 ng the magnitude and spatial distribution of tractions and cell speed on confined cells.

37 tral serous chorioretinopathy, vitreomacular traction, and full-thickness MH.

38 We also find that 90% of neutrophil tractions are in the out-of-plane axis, and this may be

39 Patient-funded trials (PFTs) are gaining traction as a means of accelerating clinical translation

40 Exon skipping by ASOs is gaining traction as a therapeutic strategy, and the use of ASOs

41 ptical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision m

42 ime correlated random walks" are now gaining traction as models of scale-finite animal movement patte

43 Ca(2+) oscillations induced by laser-tweezer-traction at the plasma membrane, providing a model to st

44 M) revealed that cells produced the greatest tractions at the cell periphery, where distinct types of

45 forces in motile tissues and show that such traction-based stresses match those calculated from inst

46 clinical practice who had possible UIP with traction bronchiectasis on HRCT and had not undergone su

47 f nintedanib if they had honeycombing and/or traction bronchiectasis plus reticulation, without atypi

48 patterns supporting a potential mechanism of traction by Muller cells in the CB.

49 ore susceptible to damage from vitreomacular traction by rotational and/or acceleration-deceleration

50 thick stage 3 membranes with anteroposterior traction concerning for progression to stage 4 ROP (3 ey

51 acting rheological information directly from traction data.

52 Vitreous traction does not seem to play a significant pathogenic

53 s with small macular holes and vitreomacular traction during vitrectomy after intravitreal ocriplasmi

54 this study was to evaluate the extension and traction effects of posterior vitreous detachment (PVD)

55 The strength of the traction exerted by the vitreous on the fovea seems to b

56 The method allows computing the traction field from the substrate displacements within t

57 quisition of continuous in- and out-of-plane traction fields with high sensitivity.

58 s mediate adhesive interactions that provide traction for cell migration.

59 ented organic electronics from gaining rapid traction for sensing applications.

60 al cells on stiff substrates decreased their traction force (from 300 nN to 100 nN) and spread area (

61 ls with inhibited myosin II motors increased traction force (from 41 nN to 63 nN) and slightly reorie

62 , to our knowledge, a novel method to assess traction force after long-term (24 h) uniaxial or biaxia

63 stretch, the cells had similar decreases in traction force and area and reoriented perpendicular to

64 g network, simulations predict the resulting traction force and FN fibril formation.

65 study, we examined the relationship between traction force and vinculin-paxillin localization to sin

66 However, the study of how cell-generated traction force changes in response to stretch is general

67 le-particle tracking (MPT) microrheology and traction force cytometry to probe how genetic induction

68 In addition, the traction force developed by cells has to reach a minimal

69 Interestingly, the absolute level of traction force did not correlate with growth cone advanc

70 hanism by which FN fibril assembly regulates traction force dynamics in response to mechanical stimul

71 The traction force exerted by the growth cone was measured b

72 model that predicts the dynamics of cellular traction force generation and subsequent assembly of fib

73 inding, vinculin was necessary for efficient traction force generation in 3D collagen without affecti

74 he talin rod R3 subdomain decreases cellular traction force generation, which affects talin and vincu

75 , with reduced YAP/TAZ nuclear shuttling and traction force generation.

76 ronments by increasing cell-ECM adhesion and traction force generation.

77 s may be a fundamental element of neutrophil traction force generation.

78 range over which FAs can accurately adapt to traction force generation.

79 imental approaches, we quantified retrograde traction force in Aplysia californica neuronal growth co

80 HspB1 is recruited to sites of increased traction force in cells geometrically constrained on mic

81 combined results indicate that the change in traction force in response to external cyclic stretch is

82 to determine how cells actively alter their traction force in response to long-term physiological cy

83 dies introduce a new model for regulation of traction force in which local actin assembly forces buff

84 eover, our results suggest that the level of traction force is directly correlated to the stiffness o

85 and paxillin FA area did not correlate with traction force magnitudes at single FAs, and this was co

86 In this article, we present single-cell traction force measurements using breast tumor cells emb

87 trate adhesion strength and myosin activity, traction force measurements, and mathematical modeling t

88 ments provided results consistent with total traction force measurements.

89 Conventional force-to-strain based cell traction force microscopies have low resolution which is

90 Cell traction recorded via traction force microscopy (TFM) commonly takes place on

91 Traction force microscopy (TFM) enables determination of

92 Traction force microscopy (TFM) revealed that cells prod

93 Traction force microscopy (TFM) was used to establish th

94 Using three-dimensional traction force microscopy and a double hydrogel sandwich

95 e whole-mount imaging, genetic ablation, and traction force microscopy and atomic force microscopy, w

96 igh nuclear tension that matches trends from traction force microscopy and from increased lamin-A,C.

97 Using traction force microscopy and microfluidic invasion devi

98 Traction force microscopy and time-lapse imaging reveal

99 ey are increasingly used in combination with traction force microscopy on soft elastic substrates.

100 Traction force microscopy revealed that tumor-associated

101 Traction force microscopy shows that lowering cholestero

102 y, a robust finite-element-method-based cell traction force microscopy technique is developed to esti

103 We introduce a new type of traction force microscopy that in contrast to traditiona

104 netic control of RhoA, live-cell imaging and traction force microscopy to investigate the dynamics of

105 Here we use traction force microscopy to measure the forces exerted

106 Traction force microscopy was carried out on primary hum

107 These cell forces can be measured with traction force microscopy which inverts the equations of

108 mp recording, phase contrast microscopy, and traction force microscopy).

109 vinculin localization at the cell membrane, traction force microscopy, and phosphorylated myosin lig

110 However, many experiments, e.g. traction force microscopy, rely on fluorescence microsco

111 Using Fourier traction force microscopy, we measured the spatiotempora

112 Using traction force microscopy, we show that cells exert sign

113 Using traction force microscopy, we show that increased bindin

114 d larger than was previously estimated using traction force microscopy-based methods.

115 l, we describe stimulated emission depletion traction force microscopy-STED-TFM (STFM), which allows

116 force and spatial resolution limitations of traction force microscopy.

117 This question is addressed here using traction force microscopy.

118 ctroscopy techniques may be smaller than the traction force of the unfoldase motor.

119 these observations, we propose that loss of traction force on ligand-bound integrin-beta3 causes rec

120 ntal data for shape, spreading dynamics, and traction force patterns of cells on micropatterned subst

121 Our model captures the traction force patterns of small clusters of nonmotile c

122 at may be responsible for the variability in traction force production.

123 cells cultured on soft gels increased their traction force significantly, from 15 nN to 45 nN, doubl

124 ation, increased focal adhesions, and higher traction force than controls.

125 icity of the FA structure and the associated traction force to accurately sense ECM stiffness.

126 of NM-II into actin stress fiber provides a traction force to promote actin retrograde flow and foca

127 ess (1100 nN) and exhibited a larger drop in traction force with uniaxial stretch, but the percentage

128 nce cell migration and for the modulation of traction force, spreading, and migration by ECM stiffnes

129 reduces the ability of PSCs to generate high traction forces and adapt to extracellular mechanical cu

130 t myosin inhibition led to a decrease in the traction forces and an increase in arc radius, indicatin

131 ntly and irreversibly remodelled by cellular traction forces and by macroscopic strains.

132 flow with rapid and pronounced increases in traction forces and cell-cell stresses.

133 h monolayers exhibit oscillatory patterns of traction forces and intercellular stresses that tend to

134 eton strain energy states and cell-generated traction forces and used a Forster resonance energy tran

135 sions are disordered, and cell spreading and traction forces are decreased.

136 In migrating Xenopus mesendoderm, traction forces are generated by cells through integrin-

137 We applied TPs to reveal that cellular traction forces are heterogeneous within focal adhesions

138 Engagement of CD28 increases traction forces associated with CD3 through the signalin

139 cellular biophysical state of cells generate traction forces at the basal side of the cells that are

140 e tumor cells exert higher integrin-mediated traction forces at the bulk and molecular levels, consis

141 und circular obstacles, and CIL accounts for traction forces at the edge.

142 ed of motion and magnitude of the associated traction forces at the level of a single cell.

143 ids and invaded the matrix while maintaining traction forces at the tips of persistent and newly form

144 zation, greater myosin activity and stronger traction forces compared to cells in the interior of the

145 Piezo1 activity triggered by traction forces elicited influx of Ca(2+), a known modul

146 Traction forces exerted by adherent cells on their micro

147 exhibit stress relaxation, so that cellular traction forces exerted by cells remodel the ECM.

148 knowledge, microfluidic technique to measure traction forces exerted by confluent vascular endothelia

149 twork stiffness, which in turn augmented the traction forces generated by human adipose stem cells (h

150 Here, we report that traction forces generated by T cells are regulated by dy

151 n of the E413K mutant desmin also alters the traction forces generation of single myoblasts lacking o

152 mosomal protein regulates actin dynamics and traction forces in motile keratinocytes.

153 tribution of cellular stresses from measured traction forces in motile tissues and show that such tra

154 We mapped the orientation of integrin-based traction forces in mouse fibroblasts and human platelets

155 showed that Aplysia growth cones can develop traction forces in the 10(0)-10(2) nN range during adhes

156 iderable variability in measurements of cell-traction forces indicates that they may not be the optim

157 aces, but other factors such as adhesion and traction forces may be equally important.

158 ges in length and spatiotemporal dynamics of traction forces measured in chemotaxing unicellular amoe

159 T cells generated traction forces of 100 pN on arrays with both antibodies

160 d molecular tension probes (TPs) that report traction forces of adherent cells with high spatial reso

161 ermined the three-dimensional spatiotemporal traction forces of motile neutrophils at unprecedented r

162 their actin cytoskeletons in order to exert traction forces on and move directionally over the dermi

163 Mouse cells expressing the 5C.C7 TCR exerted traction forces on pillars presenting peptide-loaded MHC

164 ing wild-type tandem pairs, each cell exerts traction forces on stationary sites ( approximately 80%

165 matrix through adhesive sites, and can exert traction forces on the local matrix, causing its spatial

166 Indeed, the magnitude of cell traction forces on the underlying extracellular matrix i

167 lts suggest the profound impacts of cellular traction forces on their host ECM during development and

168 s using a method that does not depend on the traction forces or material properties.

169 Strikingly, FA traction forces oscillate in time and space, and govern

170 When actomyosin-dependent traction forces overcome substrate resistance, platelets

171 scopy technique is developed to estimate the traction forces produced by multiple isolated cells as w

172 tment of actin and myosin but also increased traction forces that rapidly propagate across the cell v

173 ECM) elasticity by gauging resistance to the traction forces they exert on the ECM.

174 hich cells exert actin cytoskeleton-mediated traction forces to sense the ECM stiffness.

175 d on a surface or to crawl, cells must apply traction forces to the underlying substrate via adhesion

176 ansion and contraction and apply coordinated traction forces to their environment.

177 Cell traction forces transmitted by FAs and integrin tensions

178 rcellular stress in monolayers from measured traction forces upon the substrate.

179 ovel method, to our knowledge, for measuring traction forces using an atomic force microscope (AFM) w

180 Combining measurements of cell-scale normal traction forces with FA monitoring, we show that the cel

181 lity of this method to correlatively overlap traction forces with spatial localization of proteins re

182 behaviors and parameters (e.g., adhesion and traction forces) to the collective migration of small gr

183 symmetric distribution of basal protrusions, traction forces, and apical aspect ratios that decreased

184 antly and irreversibly remodeled by cellular traction forces, as well as by macroscopic strains.

185 eases cytoskeletal remodeling, intracellular traction forces, cell migration and invasion, and anchor

186 n over a substrate by generating alternating traction forces, of up to 1.4 kPa, at each flank of the

187 ayers on stiffer substrates showed increased traction forces, vinculin at the cell membrane, and vinc

188 or receptor alpha-mediated contractility and traction forces, which are transduced to Fn through alph

189 in driving polarized motility and generating traction forces, yet little is known about how tension b

190 ate characterized by a broad distribution of traction forces.

191 d Fn fibres from being stretched by cellular traction forces.

192 cytoplasmic mobility, cellular movement, and traction forces.

193 ening coupled with increases in cell-exerted traction forces.

194 ns independent of cell spread area and total traction forces.

195 tor the dynamics of peripheral arc radii and traction forces.

196 hereby constraining the transmission of cell traction forces.

197 owever, most ice-sheet models estimate basal traction from satellite-derived surface velocity, withou

198 ns still maintain a regulatory role for cell traction generation and cell locomotion under the physic

199 rectional migration directly correlates with traction generation and is mediated by transforming grow

200 s the elongation, directional migration, and traction generation of breast cancer cells.

201 n (HFR) as well as movement trajectories and traction generation of individual HPCs, we find that the

202 The resulting traction gradient within the growing FA favors SF format

203 f traction and that NA maturation depends on traction growth rate.

204 Twitching bacterial groups also produce traction hotspots, but with forces around 100 pN that fl

205 ution, these technologies are likely to gain traction in cutaneous oncology research and practice.

206 pigenetic alterations has gained significant traction in overcoming cancer cell resistance to various

207 gamification" of science has gained a lot of traction in recent years, and games that convey scientif

208 ch to decreasing cancer mortality has gained traction in recent years, evidenced by its inclusion in

209 n, we find that individual cells exert local traction in small hotspots with forces on the order of 5

210 Amyloid PET is gaining traction in the clinical arena, but validity and cost-ef

211 This pursuit has recently found traction in the field of optomechanics in which a mechan

212 mpact of microbes on plants have gained much traction in the research literature, supporting diverse

213 an patient aged 67 years with vitreo-macular traction in the right eye, treated with Ocriplasmin, at

214 onstruction algorithm that resolves cellular tractions in diffraction-limited nascent adhesions (NAs)

215 c vitreomacular adhesion (VMA)/vitreomacular traction, including full-thickness macular hole (FTMH).

216 remained at the VMT stage, the mean angle of traction increased by only 1 degree throughout follow-up

217 auses a rapid and local increase in cellular traction, intercellular tension and tissue compaction.

218 However, traction is amplified approximately fivefold in groups.

219 oncept that has recently gained considerable traction is that micronutrients modulate gene expression

220 ased applications in food safety are gaining traction, it is crucial that we consider the effect the

221 s MH (82 scans), 25-line raster missed focal traction (<1500 mum) and MH in 5 scans (P=.07) and 7 sca

222 of foveal detachment in patients with myopic traction maculopathy without posterior vitreous detachme

223 mality associated with retinoschisis, myopic traction maculopathy, epiretinal membrane, vitreoretinal

224 d with PVD can occur in cases of high myopic traction maculopathy, especially in those without obviou

225 ich suppresses noise without underestimating traction magnitude.

226 Traction maps reveal that local cell responses to slow s

227 Removal of the anterio-posterior vitreous traction may play the main role and may help the spontan

228 istance or remodeled fibers at a distance by traction-mediated reorientation or aligned deposition ga

229 resonance (MR) imaging (MR arthrography and traction MR arthrography).

230 cystoid retinal edema (n = 6; 13%), retinal traction (n = 11; 23%), intralesional cavities (n = 28;

231 None of the cases involved traction of the vitreomacular interface or posterior vit

232 retinal break (P <0.005) or visible vitreous traction on a retinal break (P = 0.04).

233 Inferior breaks and visible vitreous traction on a tear predicted failure.

234 hyaloid membrane creates anterior-posterior traction on the fovea, and, during detachment, retinal l

235 These actuators have recently gained traction on the one hand due to the technology push from

236 No preoperative evidence for vitreous traction on the optic disc or macula was seen in any eye

237 s are isolated, gliding produces low average traction on the order of 1 Pa.

238 of white vascularized tissue with associated traction on the retina and sometimes hemorrhage.

239 Retinal tear location and persistent traction on the retinal flap was evaluated with B-scan u

240 ultrasonography and OCT revealed persistent traction on the retinal tear flap in 19 and 15 eyes, res

241 ulopathy, epiretinal membrane, vitreoretinal traction, optic or scleral pit, or advanced glaucomatous

242 eal ocriplasmin injection without release of traction or closure of macular holes during follow-up.

243 reatment of retinoblastoma and may result in traction or rhegmatogenous retinal detachment along with

244 sistent despite CS or in case of threatening traction or visually significant epimacular membrane (28

245 However, precisely how and why the FA traction oscillates is unknown.

246 This underpins the observed FA traction oscillation and, importantly, broadens the ECM

247 growth and maturation thus culminate with FA traction oscillation to drive efficient FA mechanosensin

248 her stabilizes the FA and generates a second traction peak near the center of the FA.

249 oximal growth of the FA and contributes to a traction peak near the FA's distal tip.

250 tomyosin contractility, resulting in central traction peak oscillation.

251 motion of membrane components and acting as traction points for cell motility.

252 le performing a vitrectomy for vitreomacular traction posterior hyaloid membrane creates anterior-pos

253 pathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern(R) (PPP) guidelines,

254 PATHIC EPIRETINAL MEMBRANE AND VITREOMACULAR TRACTION PREFERRED PRACTICE PATTERN(R) GUIDELINES: New e

255 pontaneous resolution (defined by release of traction), progression to full-thickness macular hole, a

256 Cell traction recorded via traction force microscopy (TFM) co

257 VMT stage was significantly associated with traction resolution (nasally P = .001, temporally P < .0

258 Besides traction retinal detachment, vision loss in IP can occur

259 acterized by fibrotic membrane formation and traction retinal detachment.

260 retinal surface and prevented development of traction retinal detachment.

261 le outcomes, but eyes undergoing surgery for traction/rhegmatogenous RD carry a more guarded prognosi

262 itize safety and strive to minimize vitreous traction, stabilize anterior chamber volume, maintain ca

263 The critical value of compressive traction stress at the transition from a protease-indepe

264 dent of matrix stiffness, suggesting that 3D traction stress is a key factor in triggering protease-m

265 fibroblasts impedes enhanced cell spreading, traction stress, and fibronectin fiber formation.

266 strate that the cytoskeletal stiffness, cell traction stress, and focal adhesion area were significan

267 organizing the distribution and size of high-traction-stress regions at the cell periphery.

268 ed the spatiotemporal evolution of shape and traction stresses and constructed traction tension kymog

269 microscopy (TFM) was used to establish that traction stresses are limited primarily to leading edge

270 influences the mode of cell invasion is the traction stresses generated by the cells in response to

271 the spatial and temporal evolution of the 3D traction stresses generated by the leukocytes and VECs t

272 ) with antisense morpholinos results in high traction stresses in follower row cells, misdirected pro

273 ment, consequently orchestrating anisotropic traction stresses that drive cell orientation and direct

274 cell motility is to govern the alignment of traction stresses that permit single-cell migration.

275 regulates the distribution and magnitude of traction stresses to maintain a constant strain energy.

276 At low 3D compressive traction stresses, cells utilize bleb formation to inden

277 es the spatial distribution and magnitude of traction stresses.

278 required for the anisotropic orientation of traction stresses.

279 developed by the International Vitreomacular Traction Study Group by 2 independent masked observers.

280 examine the natural history of vitreomacular traction syndrome (VMTS) in the absence of other ocular

281 Patients with vitreomacular traction syndrome, secondary ERM, or both were excluded.

282 shape and traction stresses and constructed traction tension kymographs to analyze cell motility as

283 The traction test (inverted grid with mice clinging to the u

284 at includes robust parameterisation of basal traction, the resistance to ice flow at the bed.

285 with 20/20 visual acuity and vitreo-macular traction treated with Ocriplasmin, and, for the first ti

286 itreomacular traction (VMT), vitreopapillary traction, vitreo-fold traction, vitreo-laser scar adhesi

287 (VMT), vitreopapillary traction, vitreo-fold traction, vitreo-laser scar adhesion, diminished foveal

288 y of patients with symptomatic vitreomacular traction (VMT) after Ocriplasmin treatment.

289 ent the management options for vitreomacular traction (VMT) and to recommend an individualized approa

290 at baseline and follow-up for vitreomacular traction (VMT) and vitreomacular adhesion (VMA), fluid,

291 al function in symptomatic VMA/vitreomacular traction (VMT) has not yet been documented, to our knowl

292 terior hyaloidal organization, vitreomacular traction (VMT), vitreopapillary traction, vitreo-fold tr

293 us studies have suggested that vitreoretinal traction (VRT) may contribute to the progression of neov

294 vitreoretinal interface (VRI), in particular traction (VRT), and the characteristics and progression

295 ical recovery with release of vitreo-macular traction was associated with a full functional recovery.

296 Vitreoretinal traction was found in 39 eyes (40%).

297 Patients with any degree of vitreomacular traction were excluded from the analysis.

298 ear-old woman with symptomatic vitreomacular traction who received intravitreal ocriplasmin and exper

299 e of MGS is caused primarily by the vitreous traction with further possible formation of the retinal

300 hanges (9 eyes, 69.2%), including tangential traction with temporal vessel straightening concerning f