ライフサイエンスコーパス: spine

1 in the dendrite and some are critical in the spine.

2 BMD at the forearm, femoral neck, and lumbar spine.

3 ulted in an interference with the kinase's R-Spine.

4 PKA-potassium channel signaling in dendritic spines.

5 with EB3 capped plus-ends transiently enter spines.

6 ly in dendrites and are present in dendritic spines.

7 with its localization in the small dendritic spines.

8 cells, such as synaptic clefts or dendritic spines.

9 ng their access to the dendritic surface and spines.

10 her reduce membrane-bound diffusion in these spines.

11 erminals and between CH and SR dendrites and spines.

12 he support of experimental results on cactus spines.

13 tic spines, consistent with other reports of spine abnormalities being associated with autism.

14 ive protein synthesis and corrects dendritic spine abnormality in Fmr1 knockout mice.

15 Under local dendritic voltage clamp, single-spine activation produced large spine head depolarizatio

16 ression failed to restore mushroom dendritic spines after EB3 knockdown, while in contrast EB3 overex

17 to progressive, clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramid

18 Similarly, changes in spine and femoral neck bone mineral contents (BMCs) were

19 herapies for treating BMD loss at the lumbar spine and femoral neck in estrogen-deficient women.

20 lated with the SUVmax in the axial skeleton (spine and iliac crests) and proximal limbs.

21 ination, and general knowledge of the lumbar spine and pelvic anatomy relevant to the child in their

22 ll-circumscribed fatty area between cervical spine and posterior muscles.

23 Dendritic spine and synapse impairments are features of many neuro

24 s dendrite arborization and causes dendritic spine and synapse loss in the cortex and hippocampus, co

25 mplant materials during injections for joint spine and tendon, aspiration biopsies and dermal fillers

26 Bone mineral density was measured at lumbar spine and the hip.

27 ential fracture risk, especially at the hip, spine and wrist.

28 ntly increased spine width and mushroom-type spines and also increased the cluster size and number of

29 assium channels (SK channels) are present in spines and can be activated by backpropagating action po

30 ay plays a key role in stability of mushroom spines and is compromised in different mice models of Al

31 y enriched in the neck and base of dendritic spines and largely absent from spine heads.

32 ng GSK2656157 prevents the loss of dendritic spines and rescues memory deficits after TBI.

33 cological inhibition of these NMDARs rescued spines and restored cognitive function.

34 ex where they form synaptic connections with spines and small-diameter dendrites.

35 atures, including the formation of dendritic spines and spontaneously active neuronal networks.

36 Recent studies tracking both spines and synaptic markers in vivo reveal that 20% of s

37 l in air-are the diaphragmatic, intercostal, spine, and neck muscles.

38 bone area for the total-body radius, lumbar spine, and total hip were observed between subjects who

39 neurite formation, maintenance of dendritic spines, and activity-dependent structural plasticity.

40 l three Nav subtypes on dendrites, dendritic spines, and axon terminals, but the proportion of pre- a

41 er at the total hip, femoral neck, or lumbar spine; and a history of fracture.

42 Given that synaptic spines are dynamic structures which regulate neuronal pl

43 neurites all bear spines, that some of these spines are immunopositive for glutamate receptor and pos

44 Only the smallest spines are lost in deep layer 3 of the primary auditory

45 Abnormalities in dendritic spines are manifestations of several neurodevelopmental

46 Dendritic spines are protrusions along neuronal dendrites that har

47 in subjects with schizophrenia, while larger spines are retained.

48 Dendritic spines are small postsynaptic compartments of excitatory

49 egeneration.SIGNIFICANCE STATEMENT Dendritic spines are small protrusions from neuronal dendrites tha

50 Dendritic spines are the major transmitter reception compartments

51 Dendritic spines are the primary site of excitatory synaptic input

52 compared the dissolution of test plates and spines as well as the spine mechanical properties (two-p

53 n-induced structural plasticity of dendritic spines, as well as for correct sensory learning and soci

54 PO-mediated enhancement in the thoracolumbar spine at 24 hours compared with the sham procedure.

55 ing endosomes (REs) located in dendrites and spines before reaching the plasma membrane.

56 African Americans lost more spine BMD than did Caucasians (-0.04 +/- 0.04 compared w

57 Lumbar spine bone mineral density showed a mean increase by day

58 long-term structural plasticity of dendritic spines by triggering MMP-9 activation and ECM remodellin

59 Based on a compartmental model of spine calcium dynamics, we propose that this biased dist

60 ciated with injuries of PLC in patients with spine cervical trauma.

61 n the absence of betaIII spectrin, dendritic spines collapse onto dendrites.

62 naptic transmission, and the extent to which spines compartmentalize voltage, specifically excitatory

63 synaptic NMDAR currents and fewer dendritic spines, consistent with other reports of spine abnormali

64 tomic specimen and in 10 healthy subjects on spine CT scans by three radiologists (readers 1, 2, and

65 n mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortica

66 ported by the fact that functional groups of spines defined by dimensionality reduction of receptive

67 small leftward shift in the distribution of spine densities plotted as a cumulative distribution, op

68 tenance of neuronal morphology and dendritic spine density (actin dynamics in particular) are essenti

69 h) neurons, including increases in dendritic spine density along with enhanced motivation for cocaine

70 ation was associated with an increase in NAc spine density and alpha-amino-3-hydroxy-5-methyl-4-isoxa

71 ic arborization and decreases both dendritic spine density and excitatory synaptic transmission.

72 tic cadherins-6 and -10 to regulate mushroom spine density and high-magnitude LTP in the SO layer.

73 re neurons resulted in the loss of dendritic spine density and impaired responses to activity-depende

74 GluN2B-containing NMDAR signaling suppresses spine density and impairs learning.

75 increased local p-tau, changes in dendritic spine density and morphology, and upregulation of the ad

76 METHOD: Primary auditory cortex deep layer 3 spine density and volume was assessed in 20 pairs of sch

77 Consistently, dendritic branching and spine density are reduced in cortical neurons of Ube3A 2

78 d receptors (CB1Rs) in memory impairment and spine density changes induced by nicotine withdrawal pre

79 time course of ifenprodil-induced rescue of spine density correlated with restoration of cognitive f

80 he major substrates of BACE1, causes reduced spine density in aged mice.

81 excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablatio

82 on decreased neuronal activity and dendritic spine density in striatopallidal medium spiny neurons (M

83 Ctcf CKO mice also had reduced dendritic spine density in the hippocampus and cerebral cortex.

84 a-mediated neuronal remodeling and dendritic spine density in the medial PFC.

85 with high-fat consumption reduced dendritic spine density in the PFC at both time points.

86 Microglia depletion significantly lowered spine density in young (developing) but not mature adult

87 However, spine density is (a) greater in young ASD cases compared

88 Drugs that restore spine density may have broad application for improving c

89 /inhibitory balance despite normal dendritic spine density on dentate granule cells.

90 Lower dendritic spine density on layer 3 pyramidal cells in the dorsolat

91 We also assessed spine density on WD36 in the dorsolateral striatum, a re

92 SNs, exposure to HIV-1 Tat reduced dendritic spine density significantly, increased dendritic damage

93 maging approach for longitudinal tracking of spine density that enabled correlation of synaptic chang

94 lation between memory performance and mature spine density was found.

95 ression analysis of all cases indicated that spine density was not associated with neuritic plaque sc

96 Spine density was similar among control and CAD cases bu

97 del was associated with changes in dendritic spine density without any signs of dendritic damage.

98 We observed significant loss of dendritic spine density, abnormal spine morphology, reduced dendri

99 reverses the sustained increase in dendritic spine density, an effect mediated by TrkB signaling path

100 B(P553T)-expressing neurons showed decreased spine density, concomitant with reduced NMDA-evoked curr

101 otivation for cocaine and reverses dendritic spine density, suggesting a potential target for the tre

102 Tomo-1 overexpression increased dendritic spine density, whereas Tomo-1 knockdown (KD) decreased s

103 ity, whereas Tomo-1 knockdown (KD) decreased spine density.

104 es, lower dendritic arborization and reduced spine density.

105 PSC frequency, likely resulting from reduced spine density.

106 aptic transmission, synaptic plasticity, and spine density.

107 social interactions, and decreased dendritic spine density.

108 increased Tomo-1 protein level and dendritic spine density.

109 lly, the relatively immobile G-actin pool in spines depends on the phosphoinositide PI(3,4,5)P3 and i

110 her find that this G-actin pool functions in spine development and its modification during synaptic p

111 mers (G-actin) in dendritic spines regulates spine development and plasticity.

112 ed to defects in dendritic growth, dendritic spine development and radial migration during cortical d

113 a7A promotes dendrite growth, complexity and spine development through beta1-subunit-containing integ

114 oring notochord function and allowing normal spine development.

115 rs four principal assessments of a patient's spine disease: NOMS (neurologic, oncologic, mechanical i

116 The maintenance of new spines driven by mitogen-activated protein kinase intera

117 e plasticity of prelimbic cortical dendritic spines during the formation of new action-outcome memori

118 participate in tuning synaptic efficacy and spine dynamics by precise regulation of neuronal Tomo-1

119 We discuss distinct roles that spine dynamics can play in circuit remodeling depending

120 Ns, normal texture discrimination, and L5 PN spine dynamics similar to unstressed EE mice.

121 ffective for most excitatory synapses due to spine electrical compartmentalization.

122 Using simultaneous somato-spine electrical recordings, we find that back propagati

123 ocular deprivation (BD), increased dendritic spine elimination over 3 days in the binocular region of

124 ependent LTP recruits recycling endosomes to spines, enhances synaptic recycling of AMPA receptors to

125 y, LTP and LTD are correlated with dendritic spine enlargement and shrinkage that are accompanied by

126 Increased spine extent distinguished CAD cases from controls and A

127 ical for the effects of cocaine on dendritic spine formation and for cocaine-mediated behavioral sens

128 s is necessary for cocaine-induced dendritic spine formation by using either localized TrkB knockout

129 Repeated cocaine exposure produces new spine formation in striatal projection neurons (SPNs) of

130 ed cocaine administration, de novo dendritic spine formation occurs in NAc MSNs.

131 ons influence cocaine's effects on dendritic spine formation remain unclear.

132 ulated kinase (ERK) activation and dendritic spine formation through Rabex-5/platelet-derived growth

133 ar-events sequence responsible for the rapid spine formation.

134 xpression of EB3 causes increase of mushroom spines fraction and is able to restore their deficiency

135 plications for synaptic plasticity rules and spine function.

136 e electronic origin of the curious "kinked'" spine geometries that are common in such species.

137 lease prevented the maintenance of dendritic spine growth induced by Hebbian activity.

138 Spine growth required extracellular signal-regulated kin

139 ory postsynaptic potentials are large in the spine head (mean 26 mV) but are strongly attenuated at t

140 lamp, single-spine activation produced large spine head depolarizations that severely distorted measu

141 Sodium removal from the spine head is through rapid diffusion out to the dendrit

142 spine neck width and neck length, as well as spine head size.

143 first intracellular recordings from targeted spine heads under two-photon visualization.

144 selectively prevented their upregulation in spine heads, but not bases and necks, during consolidati

145 nt regulation of actin polymerization within spine heads.

146 of dendritic spines and largely absent from spine heads.

147 oskeleton compartment presented in dendritic spines, however, recent studies demonstrated that dynami

148 odiscitis include: involvement of the lumbar spine, ill-defined paraspinal abnormal contrast enhancem

149 Repair of spines, important for both buoyancy and feeding, was als

150 -energy x-ray absorptiometry scans of lumbar spine in 39 KTR and 77 controls.

151 T) trabecular texture analysis of the lumbar spine in patients with anorexia nervosa and normal-weigh

152 Strikingly, lysosomes traffic to dendritic spines in an activity-dependent manner and can be recrui

153 ronal compartments, such as single dendritic spines in brain slices.

154 examined the density and volume of dendritic spines in deep layer 3 of the auditory cortex of 20 schi

155 Furthermore, there were fewer dendritic spines in GluN2B S1413L-expressing neurons.

156 d calcium imaging to examine ion dynamics in spines in hippocampal pyramidal neurons.

157 mice produced a 17 +/- 1% loss of dendritic spines in layer 1 of retrosplenial cortex.

158 detail using sequential synaptic input onto spines in morphologically, electrically, and chemically

159 development of dendrite arbors and dendritic spines in newly generated dentate gyrus granule cell neu

160 ssion resulted in a lower density of smaller spines in primary neuronal cultures.

161 nt manner and can be recruited to individual spines in response to local activation.

162 ted with structural alterations of dendritic spines in the CeA and, moreover, whole-cell patch clamp

163 induced loss of total and mushroom dendritic spines in the hippocampal CA1 region.

164 Lphn2 was specifically targeted to dendritic spines in the stratum lacunosum-moleculare, which form s

165 s and ifenprodil-mediated rescue of synaptic spines in vivo would predict impairment and rescue of co

166 er bone diseases with near-normal MRI of the spine, in whom plain radiographs revealed subtle finding

167 copy identified postsynaptic mGluR2/3 in the spines, in addition to the traditional presynaptic and a

168 ll as the detailed architecture of dendritic spines, in mouse brain circuitry.

169 expression and elicits structural changes in spines, including increased growth and maturation.

170 ed both AMPAR and NMDAR EPSCs and eliminated spines, indicative of a synapse elimination.

171 Astrocytes can eliminate dendritic spines, induce synapse formation, and regulate neurotran

172 f LTP and structural LTP (sLTP) of dendritic spines inhibited these forms of plasticity in hippocampa

173 The axon-spine interface (ASI) decreased 18% after sleep compare

174 Signaling events in spines involve a signaling network composed of hundreds

175 scitis included: involvement of the thoracic spine, involvement of 2 or more adjacent vertebral bodie

176 skeleton, and the skeleton of their primary spines is in direct contact with seawater.

177 synaptic markers in vivo reveal that 20% of spines lack PSD-95 and are short lived.

178 would compromise the structural stability of spines, leading to their loss.

179 M), we show that F-actin depolymerization in spines leads to a breakdown of the nano-organization of

180 iation in the key female antagonistic trait (spine length, a defence against males), as well as body

181 esses, meningeal enhancement at the affected spine level.

182 lysis was performed for 30 randomly selected spine levels.

183 h PIP2 is also concentrated at the dendritic spines, little is known about the direct physiological f

184 tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing reco

185 ort that sickness-induced cortical dendritic spine loss and impaired memory formation is mediated by

186 Blocking PERK phosphorylation rescues spine loss and memory deficits independently of phosphor

187 bly, TGF-beta1 reduced hippocampal dendritic spine loss and memory impairment in mice that received i

188 how that axotomy causes retrograde dendritic spine loss at directly injured pyramidal neurons followe

189 s (PNs) in the mouse barrel cortex, and such spine loss closely associates with deteriorated performa

190 eleton supporting dendritic spines, produced spine loss in cortical pyramidal cells and striatal hype

191 ild-type GRASP1, but not ID mutants, rescued spine loss in hippocampal CA1 neurons in Grasp1 knockout

192 Dendritic spine loss is recognized as an early feature of Alzheime

193 ce fear conditioning experiments showed that spine loss predicted learning deficits and that the time

194 synaptic AMPA receptors (AMPARs), dendritic spine loss, and synaptic depression.

195 channel subunit protein expression linked to spine loss.

196 The bulbous head of a mushroom-shaped spine makes the synapse, whereas the narrow neck transmi

197 Upf3b-null mice display deficient dendritic spine maturation in vivo.

198 affolding protein PSD95, promoting dendritic spine maturation.

199 ignal transduction in the muscles within the spine may lead to the development of vertebral fusions.

200 dependent membrane-bound diffusion in mature spines may contribute to spine-specific compartmentaliza

201 ion of test plates and spines as well as the spine mechanical properties (two-points bending tests) i

202 Most spine mechanisms are linear.

203 gnificantly reduced the (18)F-FTT AUC in the spine (median difference before and after treatment and

204 ed to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement.

205 was discontinued 45 minutes later, dendritic spine morphology and AMPA to NMDA ratios were restored a

206 zed to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GA

207 Here, we examine the connection between spine morphology and membrane-bound diffusion through a

208 tivation in operant conditioning, as well as spine morphology and phospho-CaMKIIbeta in the striatum.

209 ential for brain functions, because aberrant spine morphology is associated with many neuropsychiatri

210 n filaments, leading to changes in dendritic spine morphology of NAc medium spiny neurons (MSNs).

211 were assayed during reinstatement: dendritic spine morphology, alpha-amino-3-hydroxy-5-methyl-4-isoxa

212 5T variant on dendritic branching, dendritic spine morphology, protein and messenger RNA stability, a

213 nt loss of dendritic spine density, abnormal spine morphology, reduced dendritic arborization, and ex

214 r MeCP2, bringing to disruption of dendritic spine morphology, synaptic plasticity and plasticity-rel

215 ting and marble burying as well as dendritic spine morphology.

216 ects on NADPH oxidase activity and dendritic spine morphology.

217 t EB3 is involved in regulation of dendritic spines morphology, in part due to its association with S

218 and Methods A total of 121 consecutive whole-spine MR imaging examinations (63 men; mean age +/- stan

219 tistics from the GEFOS consortium for lumbar spine (n = 31,800) and femoral neck (n = 32,961) BMD, an

220 neralized shape factor calculated using both spine neck width and neck length, as well as spine head

221 id diffusion out to the dendrite through the spine neck with a half-removal time of approximately 16

222 their mobility and also decreases dendritic spine number.

223 ptic deletion of Lphn2 selectively decreased spine numbers and impaired synaptic inputs from entorhin

224 tic transmission and synapse density but not spine numbers, suggesting that these effects reflect a g

225 9-29 S20G may serve as a model for the toxic spine of hIAPP.

226 ty of protein segments composing the amyloid spine of hIAPP.

227 increased the density of long/thin dendritic spines of layer 5 pyramidal neurons in the adult PrL-C.

228 in the nuclei, dendrites and near dendritic spines of mouse dorsal hippocampal CA1 neurons.

229 glutamate receptor, GluRdelta2, in dendritic spines of Purkinje cells.

230 d that polyribosomes accumulate in dendritic spines of the adult rat lateral amygdala (LA) during con

231 On the contrary, spines of the T. ventricosus were significantly etched a

232 Mature dendritic spines on CA1 pyramidal hippocampal neurons decreased 4

233 nces the density and morphology of dendritic spines on medium spiny neurons (MSNs) in the nucleus acc

234 re were also fewer and less mature dendritic spines on OGT knockout neurons.

235 t pathway accompanied by decreased dendritic spines on the indirect pathway medium spiny projection n

236 Dendritic spines on the principal pyramidal neurons of the orbitof

237 Chaetognath grasping spines, originally reported as conodonts, occur worldwid

238 d implants in the femoral head, sternum, and spine (P = 0.01, 0.01, and 0.03, respectively).

239 sitol (3,4,5)-triphosphate (PIP3) within the spine plasma membrane.

240 riptional changes, restores MeCP2 levels and spine plasticity and ameliorates cognitive defects in IL

241 However, the relationship between spine plasticity and craving remains unclear.

242 nce to support the hypothesis that dendritic spine plasticity is a mechanism of cognitive resilience

243 otor learning and learning-related dendritic spine plasticity through tumor necrosis factor (TNF)-alp

244 ted tomography (CT) of an injury of cervical spine posterior ligamentous complex (PLC).

245 the actin cytoskeleton supporting dendritic spines, produced spine loss in cortical pyramidal cells

246 ent of actin monomers (G-actin) in dendritic spines regulates spine development and plasticity.

247 ies of CaMKII that mediate Ca(2+) signals in spines remain elusive.

248 ivation and subsequent recovery on dendritic spine remodeling of layer 5 pyramidal neurons in the mou

249 ese data argue that TBI elicits pathological spine remodeling that contributes to behavioral deficits

250 By contrast, LTD-induced spine removal of AKAP79/150 required its depalmitoylatio

251 pulations at single-cell or single dendritic spine resolution in awake monkeys, the techniques report

252 neous sodium and calcium imaging with single-spine resolution in pyramidal neurons in rat hippocampal

253 EB3 overexpression rescued loss of mushroom spines resulting from STIM2 depletion.

254 scale, organization was evident: neighboring spines separated by less than 10 mum shared similar spat

255 Fin spines serve as a major deterrent to predators and enhan

256 ng dendrites show an inverse distribution of spine size and NMDAR-driven calcium signals along dendri

257 shed basal dendritic branching and dendritic spine size, compared with wild-type Kal9.

258 by a gradual, distance-dependent decline in spine size, which we visualized using serial block-face

259 Furthermore, we found that average dendritic spine sizes were decreased and increased following 3-day

260 A receptors.SIGNIFICANCE STATEMENT Dendritic spines, small structures that are difficult to investiga

261 diffusion in mature spines may contribute to spine-specific compartmentalization of neurotransmitter

262 nt active discopathy on MRI at 12 months and spine-specific limitations in activities, health-related

263 conical wire-like structures, such as cactus spines, spider silk, and water striders' legs.

264 ar signal-regulated kinase activation, while spine stabilization involved transcription-independent p

265 idely distributed lacustrine fish, the three-spine stickleback (Gasterosteus aculeatus).

266 both timing and frequency of breeding; three-spine stickleback spawned earlier and more often in resp

267 We employed the three-spined stickleback and three ecologically relevant paras

268 (pea clams Pisidium sp.), 131 +/- 105 (three-spined sticklebacks: Gasterosteus aculeatus), 41 +/- 38

269 t into the regulation of PSD-95 in dendritic spine structural plasticity through phosphorylation-medi

270 nase A (PKA) play important roles in LTP and spine structural plasticity.

271 fascinated by the small protrusions, termed spines, studding many neuronal dendrites.

272 all muscles joining the neural arches of the spine suggesting that loss of myosin function in these m

273 nesis of presynaptic terminals and dendritic spines, suggesting that glutamatergic neurotransmission

274 tion of the AROM inhibitor letrozole reduced spine synapse density in the BL of adult female mice but

275 rapidly increases the number and function of spine synapses in the apical dendritic tuft of layer V p

276 eatment with letrozole significantly reduced spine synapses in the BL only in cultures derived from f

277 The formation of functional spine synapses is thought to be critically dependent on

278 ynapses and an increased number of dendritic spines that are not in contact with a presynaptic termin

279 k propagating action potentials fully invade spines, that excitatory postsynaptic potentials are larg

280 cose outer plexiform layer neurites all bear spines, that some of these spines are immunopositive for

281 he lack of direct electrical recordings from spines, the influence that the neck resistance has on sy

282 retory trafficking in neuronal dendrites and spines through a specialized GA-independent trafficking

283 and type of surgery performed for metastatic spine tumors.

284 ow that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the lo

285 Here, we measured CaMKII activity in spines using fast-framing two-photon fluorescence lifeti

286 Dendritic spines usually have a mushroom-like shape, which is esse

287 neral density (BMD) loss at the L2-L4 lumbar spine vertebra (P < 0.05), femoral neck (P < 0.01), and

288 his effect had reversed: the density of thin spines was lower in cocaine rats compared with saline ra

289 synaptic glutamatergic boutons and dendritic spines was performed on SPNs 1 hour and 1 week after a s

290 r (NMDAR)-driven calcium responses in single spines, we provide a spatial map of synaptic calcium sig

291 ophoretically filled with Lucifer yellow and spines were analyzed with NeuronStudio software.

292 tion induces translocation of Septin7 to the spine, where it associates with and stabilizes the scaff

293 is typically induced by Ca(2+) elevation in spines, which activates a variety of signaling pathways.

294 related to initial larynx distance from the spine, while hyoid elevation was predicted by pharyngeal

295 ific inhibitor AMI-1 significantly increased spine width and mushroom-type spines and also increased

296 in, and promoted regeneration of bone in the spine with a protein dose that is 100-fold lower than th

297 Cap-independent upregulation was specific to spines with small, astrocyte-associated synapses.

298 mice had a severely deformed curved thoracic spine, with an associated loss of trabecular bone volume

299 ial receptive fields of individual dendritic spines within individual layer 2/3 neuron dendrites.

300 We compared dendritic spines within layer II and III pyramidal neuron dendrite