ライフサイエンスコーパス: snail

1 ty of the SET9 promoter in coordination with Snail.

2 was specifically upregulated by Slug but not Snail.

3 ies of sequence-specific repressors, such as Snail.

4 ssociated with symmetry breaking in the pond snail.

5 dent degradation of the E-cadherin repressor SNAIL.

6 -34a and its direct targets Notch, Slug, and Snail.

7 directly facilitate capture by the predatory snail.

8 , and the epithelial-to-mesenchymal mediator Snail.

9 ion of HDAC1, DNMT3b, DNMT1, and mSin3A with SNAIL.

10 a known EMT regulator Slug, but not TWIST or Snail.

11 EndMT master regulatory transcription factor SNAIL.

12 cy, characterized by increased expression of Snail.

13 most obviously chiral animals, the gastropod snails.

14 rough contact with water containing infected snails.

15 a gondii was not detected in field-collected snails.

16 e and average life span of latently infected snails.

17 l T. gondii contamination in field-collected snails.

18 interactions with animals such as isopods or snails.

19 sustained were 0.006, 0.009, 0.028 and 0.020 snails/0.11 m(2), respectively.

20 control of stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homo

21 f stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homologs are

22 In SNAIL/293T cells, co-immunoprecipitation studies reveale

23 T cells, when stably transfected with SNAIL (SNAIL/293T), displayed suppressed transcription and tran

24 Our study reveals a critical Snail-4E-BP1 signaling axis in tumorigenesis, and provid

25 the developmental regulatory genes twist and snail [7-10].

26 s (HIV/HPs) displayed enhanced expression of SNAIL, a repressor of VDR.

27 Snail abundance fosters disease transmission, and thus t

28 ds based on model averaging provide reliable snail abundance projections.

29 iates that explain empirical observations of snail abundance under the actual climatic forcings exper

30 ng protein (AChBP), a humanized chimera of a snail AChBP, which has 71% sequence similarity with the

31 Methylmercury concentrations in clams and snails also declined with productivity, and consumer con

32 n expression pattern via reverting PI3K/Akt, Snail and beta-catenin expression.

33 xpression changes, including upregulation of Snail and beta-catenin, and increased cell migration and

34 high expression and nuclear accumulation of Snail and beta-catenin, which favor EMT.

35 BXL5 that was concurrent with suppression of snail and down-regulation of mesenchymal markers.

36 RNA) mediates a physical interaction between Snail and enhancer of zeste homolog 2 (EZH2), an enzymat

37 e often governed by the transcription factor Snail and entail the loss of apical junctions from epith

38 hosphorylation to promote the translation of Snail and Mmp-3 mRNAs, and the induction of epithelial-t

39 induced expression of cyclin-D1, cyclin-E1, snail and MMP2 and inhibited the expression of P53 and P

40 cells express conserved factors such as Msx, Snail and Pax3/7 and generate melanin-containing pigment

41 e when E-cadherin transcriptional repressors Snail and Slug are not implicated.

42 n MDA-MB-231 cells impaired the induction of Snail and Slug expression by EGF, and this effect was as

43 ty of E-cadherin transcriptional repressors, snail and slug, induced by transforming growth factor-be

44 dothelial-mesenchymal transition regulators: snail and slug.

45 There was increased binding of CUX1 to Snail and the E-cadherin promoter in mesenchymal cells c

46 ation of Cat L, decreased binding of CUX1 to Snail and the E-cadherin promoter, reversed EMT, and dec

47 d repertoire of EMT-related events including Snail and Twist expression, tumor cell motility, and ano

48 lated hypoxia-induced transcription factors, Snail and Twist1, leading to decreased transactivation o

49 of hypoxia-associated transcription factors, Snail and Twist1.

50 that miR-31 directly represses Pmar1, Alx1, Snail and VegfR7 within the PMC gene regulatory network

51 Snail and Zeb transcription factors induce epithelial-to

52 n of mesenchymal markers including Vimentin, Snail and ZEB1 are significantly elevated.

53 and transcription factors (N-cadherin, Slug, Snail and Zeb1), and upregulation of E-cadherin.

54 Blocking Snail and/or its associated gene expression program may

55 it has become a parasite of native European snails and deer.

56 Compatibility between snails and digeneans is often very specific, such that s

57 s that LDA is partially conserved in helicid snails and less in other molluscan species.

58 field experiment that tracked parasitism in snails and people at two matched villages after prawns w

59 ortion of large, warm-adapted species (i.e., snails and predatory dipterans) relative to small-bodied

60 ly related, euopisthobranch and panpulmonate snails and slugs.

61 n by parasites has also been shown for mice, snails and zebrafish as well as for insects.

62 prostate (ARCaP-M and ARCaP-E overexpressing Snail) and breast (MDA-MB-468, MDA-MB-231, and MCF-7 ove

63 ry circuits for both EMT (miR-200/ZEB/miR-34/SNAIL) and MAT (Rac1/RhoA).

64 find suitable intermediate hosts (freshwater snails) and mature larvae, definitive hosts (ungulates).

65 vated the expression of mRNA for N-cadherin, Snail, and GHRH GHRH antagonist reduced the average volu

66 kton/filter feeding clam, periphyton/grazing snail, and leaves/shredding amphipod (Hyalella azteca).

67 mal transition (EMT) markers vimentin, Zeb2, Snail, and Twist.

68 ically in the venom glands of predatory cone snails, animals that synthesize a remarkably diverse set

69 The immune cells (hemocytes) of a snail are sentinels that act as a crucial barrier to inf

70 Results suggest that turban snails are competent transport hosts for T. gondii.

71 ed and spread into novel areas where Bulinus snails are endemic, and how hybridisation could increase

72 aeological shellmounds, many species of land snails are found abundantly distributed throughout the o

73 Biomphalaria snails are instrumental in transmission of the human blo

74 We conclude that snails are not 'picky' eaters at the microbial level, bu

75 Cone snails are predatory marine gastropods characterized by

76 Here we identify Snail as a strong transcriptional repressor of 4E-BP1.

77 GF-beta target genes such as PAI1, MMP9, and Snail as well as augmented TGF-beta1 secretion in mesenc

78 phalaria glabrata granulin (BgGRN)] from the snail B. glabrata, a natural host for the human blood fl

79 Snail binds to three E-boxes present in the human 4E-BP1

80 provide timely and important information on snail biology.

81 to-snail transmission in the epidemiology of snail-borne diseases are also discussed.

82 Snail-borne lungworms exert an enormous toll on the heal

83 Schistosomiasis is a snail-borne parasitic disease endemic in several tropica

84 etical studies on the ecology of the aquatic snails (Bulinus spp. and Biomphalaria pfeifferi) that se

85 eem likely that malleodectids specialised on snails but probably also consumed a wider range of prey

86 we demonstrate that susceptible B. glabrata snails can be made resistant to infection with S. manson

87 ch patterns, like the Levy walks made by mud snails, can have their mechanistic origins in chaotic ne

88 MB-468, MDA-MB-231, and MCF-7 overexpressing Snail) cancer cells expressed lower E-cadherin activity,

89 Silencing XPO1 or snail caused re-expression of FBXL5 as well as EMT rever

90 rces for aquatic consumers like tadpoles and snails, causing bottom-up effects on wetland ecosystems.

91 Marine cone snails contain a high diversity of toxins in their venom

92 liminate schistosomiasis, it is time to give snail control another look.

93 Snail control can complement preventive chemotherapy by

94 present ideas for modernizing and scaling up snail control, including spatiotemporal targeting, envir

95 em by 2025, there is now renewed emphasis on snail control.

96 Two fish-hunting cone snails, Conus geographus and Conus tulipa, have evolved

97 results suggests the use of ad hoc models of snail demography depending on habitat type (e.g., natura

98 Shoreline cleanup further reduced adult snail density as well as snail size.

99 mean of estimated thresholds of Oncomelania snail density below which the schistosomiasis transmissi

100 sed to estimate the threshold of Oncomelania snail density for interrupting schistosomiasis transmiss

101 m the periphyton to the water column in high-snail density/high-infection ponds were up to 50% higher

102 factor-beta and transglutaminase 2 stimulate Snail-dependent invadosome formation in rat and human sy

103 ctility can strengthen junctions to override Snail-dependent junctional disassembly and postpone EMT

104 s direct evidence of gain of resistance in a snail-digenean infection model using a defined factor to

105 g/kg) and BAF values (0.05) obtained for the snail directly exposed to contaminated soil were lower t

106 e without microplastics, indicating that the snails do not recognize solid nonfood particles in the s

107 utrient excretion in their intermediate host snails (dominant grazers).

108 SNAIL downregulation and E-cadherin upregulation mediate

109 ply that myosin-mediated tension can prevent Snail-driven EMT.

110 anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, dr

111 asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry.

112 microbial ecology of microbes grazed by tree snails enables effective management when conservation re

113 Gene silencing also revealed that Snail enhanced the permeability of endothelial monolayer

114 (Zn) associated with natural particles using snails enriched with a less common Zn stable isotope.

115 tions in aquatic snails with measurements of snail excretion and tissue stoichiometry to show that pa

116 mal Snail expression in mesoderm, or ectopic Snail expression in ectoderm, is sufficient to drive ear

117 hen contractile myosin is absent, the normal Snail expression in mesoderm, or ectopic Snail expressio

118 Furthermore, Snail expression is associated with an epithelial-mesenc

119 n complex 2 (mTORC2) and thereby upregulates Snail expression.

120 flow revealed that low shear stress induced Snail expression.

121 ncoding snail family zinc finger 1, known as Snail) expression is sufficient to promote prolonged TGF

122 to Snail2/P-cadherin in the chick, but both Snail factors and Zeb2 fulfil a similar role in chick an

123 To address these questions, we collected 102 snail faecal samples as a proxy for diet, and 102 matche

124 structure was significantly distinct between snail faeces and leaf samples, but the same microbes occ

125 rming putative T. gondii oocysts detected in snail faeces and tissues by microscopy.

126 ater, oocysts were detected by microscopy in snail faeces and tissues for 10 and 3 days respectively.

127 etalloproteinases (Mmp3 and -9; P < 0.01), a snail family member (Snai3; P < 0.001), and osteopontin

128 Snail family members regulate epithelial-to-mesenchymal

129 Members of the Snail family of transcription factors are required for c

130 Ingression is independent of the Snail family of transcriptional repressors and down-regu

131 factor 1, known as Twist) or Snai1 (encoding snail family zinc finger 1, known as Snail) expression i

132 how that the reactivation of Snai1 (encoding snail family zinc finger 1, known as Snail1) in mouse re

133 anscription factor (EMT-TF), a member of the Snail family, serves as a master regulator of the gland-

134 transition-like mechanism that required the Snail-family member Escargot and, in subdomains, Decapen

135 Schistosomiasis or snail fever is an endemic parasitic infection caused by

136 the Cavu River, with many Bulinus truncatus snails found in both locations.

137 With the snails found, we carried out snail-parasite compatibilit

138 y, genetic and pharmacological inhibition of Snail function restores 4E-BP1 expression and sensitizes

139 pment of most digeneans takes place within a snail (Gastropoda).

140 of MMPs as well as the presence of twist and snail genes in TS Huh-7 cells were reversed by LDE225, a

141 More than 100 species of venomous cone snails (genus Conus) are highly effective predators of f

142 d by studies of predator-induced shell form, snail growth rates and life history parameters of a few

143 both the ecological niche and the species of snail (Helix aspersa) acting as intermediate host.

144 sts, or of the interactions occurring at the snail-helminth interface.

145 ld and may define this species as a suitable snail host for S. mansoni.

146 o control due to a broad distribution of its snail hosts and range of animal reservoir hosts.

147 nvestigating schistosomes in their human and snail hosts and the development of therapeutics and vacc

148 s is often very specific, such that suitable snail hosts define the geographical ranges of diseases c

149 nd T. brevior L3s to infect new, susceptible snail hosts following their release from experimentally

150 ty, depends on the formation of a tripartite Snail/HOTAIR/EZH2 complex.

151 As expected from a reduction in infected snails, human schistosomiasis prevalence was 18 +/- 5% l

152 tic dynamics in the movement patterns of mud snails (Hydrobia ulvae) moving in controlled experimenta

153 tivated expression of the EMT regulator gene Snail in a SMAD3/Stat3-dependent manner.

154 Ectopic expression of Snail in cancer cell lines lacking Snail profoundly repr

155 A rats and RA patients, whereas knockdown of Snail in CIA joints prevents cartilage invasion and join

156 consistent with the role of beta-catenin and SNAIL in epidermal stem cell maintenance.

157 tigated the role of the transcription factor Snail in low shear stress-induced EndMT.

158 nternalized, despite the early expression of Snail in that primordium.

159 temic molluscicide for controlling slugs and snails in a wide range of agricultural and horticultural

160 tration and retention of T. gondii by marine snails in laboratory aquaria, and to test for natural T.

161 ers, as the majority ( approximately 75%) of snails in oiled habitats never reached standing unoiled

162 as dissected from non-endangered native tree snails in the same family as Achatinella to confirm that

163 uctural domains expressed by venomous marine snails in the superfamily Conoidea.

164 s increased chemoresistance-inducing factor, Snail, in recipient epithelial cells and promote prolife

165 key patterning genes-knirps, hunchback, and snail-in developing Drosophila embryos.

166 g expression of the EMT transcription factor Snail increased TF, coagulant properties, and early meta

167 lasticity and that miR302 regulates EZH2 and Snail independently.

168 Mechanistically, Snail induces extracellular matrix degradation in synovi

169 ercaria infective stages) and the parasite's snail intermediate host (growth and reproduction).

170 es that have complex life cycles involving a snail intermediate host.

171 nhoveni) that are voracious predators of the snail intermediate hosts for schistosomiasis.

172 nd also increased cercaria production by the snail intermediate hosts, causing opposing effects on ta

173 y elements of the biology and ecology of the snail intermediate hosts, together with an improved unde

174 a density- and trait-mediated effects on the snail intermediate hosts.

175 increased in more southeastern wetlands, and snail (intermediate host) community composition had stro

176 The transcription factor Snail is a master regulator of cellular identity and epi

177 eneral, since the unrelated beta-TrCP target Snail is also stabilized by ORF61.

178 We conclude that Snail is an essential driver of EndMT under low shear st

179 Although Snail is essential for disassembly of adherens junctions

180 Herein, we demonstrate that Snail is essential for the formation of extracellular ma

181 Of significance, Snail is overexpressed in synovial cells and tissues of

182 cal mechanism of action within the recipient snail is to close off the entrance to the sperm digestio

183 ions: movements of an endangered raptor, the snail kite (Rostrhamus sociabilis plumbeus), and human m

184 geographic range of an endangered bird, the snail kite (Rostrhamus sociabilis plumbeus).

185 r an endangered, wetland-dependent bird, the snail kite (Rostrhamus sociabilis plumbeus).

186 ignificant modularity in annual dispersal of snail kites (all adults, males only, females only, and j

187 For snail kites, our method reveals substantial differences

188 al population structure (i.e. modularity) in snail kites.

189 4E-BP1 expression inversely correlates with Snail level in cancer cell lines and clinical specimens.

190 Periwinkle snails (Littoraria irrorata) are a critical component of

191 quencies in isolated populations of a marine snail (Littorina saxatilis), re-established with perturb

192 ntral nervous system (CNS) of the freshwater snail Lymnaea stagnalis was conducted.

193 the central nervous system of the freshwater snail Lymnaea stagnalis.

194 erin, and decreased those of vimentin, Slug, Snail, matrix metalloproteinase (MMP)-2, -9, and activit

195 erin protein levels; increased expression of SNAIL, matrix metalloproteinase 2, and integrin beta1; a

196 By concentrating oocysts in faecal pellets, snails may facilitate entry of T. gondii into the nearsh

197 these results suggest that marsh periwinkle snails may have been adversely affected following exposu

198 Snail-mediated downregulation of AJ component E-cadherin

199 highlight HOTAIR as a crucial player in the Snail-mediated EMT.

200 ing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

201 thicknesses of 0.1 and 0.5 cm, while 73% of snails moved in unoiled chambers after 4h.

202 In a second movement assay, there was no snail movement standing unoiled structure in chambers wi

203 Here, we have shown that oil impeded snail movement to clean habitat over a short distance an

204 In the first movement assay, snail movement to standing unoiled vegetation was signif

205 The snails (n = 10 snails) were exposed for 10 days to incre

206 ly proteins and confirmed the suppression of snail network.

207 uggest that a positive feedback loop between Snail-nuclear Cat L-CUX1 drives EMT, which can be antago

208 Snails of conspicuous colours (white, red, banded) are n

209 Snails of conspicuous colours (white, red, banded) are n

210 ive accumulation and speciation in different snail organs.

211 With the snails found, we carried out snail-parasite compatibility experiments by exposing sna

212 , together with an improved understanding of snail-parasite interactions, will aid to identify, plan,

213 ignificance, and review current knowledge of snail-parasite interplay.

214 s the BBB encapsulating the analgesic marine snail peptide ziconotide (Prialt(R)).

215 uce human schistosomiasis have evolved from 'snail picking' campaigns, a century ago, to modern wide-

216 sease transmission, and thus the dynamics of snail populations are critically important for schistoso

217 k of it) of ecological growth rates of local snail populations by contrasting novel ecological and en

218 sing gene silencing it was demonstrated that Snail positively regulated the expression of EndMT marke

219 verished asexual populations of a freshwater snail, Potamopyrgus antipodarum, from distinct habitats

220 ession of Snail in cancer cell lines lacking Snail profoundly represses 4E-BP1 expression, promotes c

221 nfirmed occurrence of H3K4 trimethylation on SNAIL promoter.

222 s in breast and skin epithelia indicate that Snail proteins promote an undifferentiated state.

223 Our results identify the Snail-PTEN platelet-derived growth factor receptor/phosp

224 Of the 3544 snails recovered across all sites, none were naturally i

225 Our findings demonstrate that SNAIL recruits multiple chromatin enzymes to form a repr

226 E treatment resulted in nuclear retention of snail regulator FBXL5 that was concurrent with suppressi

227 enhance ADM development, the contribution of Snail-related protein Slug (Snai2) to ADM development is

228 a correlation between mitotic silencing and Snail repression.

229 The Snail-repressive activity, here monitored on genes with

230 on experiments confirmed the presence of the SNAIL repressor complex at the VDR promoter.

231 f HIV on expression of molecules involved in SNAIL repressor complex formation and demonstrated that

232 employ live-imaging methods to visualize the Snail repressor, which establishes the boundary between

233 derm due to transcriptional quenching by the Snail repressor, which precludes recruitment of CBP and

234 ction model using a defined factor to induce snail resistance to infection.

235 ayer exploit the paralogous EMT-TFs Slug and Snail, respectively, which induce distinct EMT programs.

236 rm hunting to fish hunting among marine cone snails, resulting in the adaptive radiation of fish-hunt

237 fish, making them easier to engulf with the snail's distended false mouth, which functions as a net.

238 ations of W compartmentalization were in the snail's hepatopancreas based on wet chemistry and synchr

239 calculations of (66)Zn assimilation into the snail's soft tissues.

240 ies with host plant or location, nor whether snails selectively consume microbes.

241 Bivalve, ammonite and snail shells are described by a small number of geometri

242 rther reduced adult snail density as well as snail size.

243 ell motility and expression of beta-catenin, Snail, Slug, Zeb1 and N-cadherin, and upregulated E-cadh

244 overexpression of key transcription factors (Snail, Slug, Zeb1) or by acquiring drug resistance produ

245 of the critical EndMT transcription factors Snail/Slug in involuting hemangiomas.

246 in is downregulated during tumorigenesis via Snail/Slug-mediated E-cadherin transcriptional reduction

247 ependence 1 (GFI1) is comprised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated

248 . elegans include migration vectors (such as snails, slugs and isopods) and pathogens (such as micros

249 izing a cis-regulatory module (CRM) from the snail (sna) gene, sna-DP (for dorsal primordia).

250 epithelial-mesenchymal transition regulator Snail (Snai1) can cooperate with Kras in acinar cells to

251 find that the gene for EMT master regulator Snail (SNAI1), but not Slug (SNAI2), shows evidence of P

252 293T cells, when stably transfected with SNAIL (SNAIL/293T), displayed suppressed transcription a

253 lly closely related to the fish-hunting cone snail specialists.

254 rm an in vitro screen of venoms from 18 cone snail species to identify toxins targeting ASICs.

255 n extrapolation from a random sample of land snail species via two independent approaches, that we ma

256 nstrumental to its activity are recruited to Snail-specific binding sites is unclear.

257 channels in the venom of a worm-hunting cone snail suggests that a closely related ancestral toxin en

258 A refreshing empirical experiment with snails supports this long-standing hypothesis.

259 Snail survival decreased with increasing exposure time,

260 Snail target enhancers were attached to an MS2 reporter

261 la mustelina is a critically endangered tree snail that subsists entirely by grazing microbes from le

262 rey capture by a subset of fish-hunting cone snails that use a net strategy to capture prey.

263 esis, and provides a rationale for targeting Snail to improve mTOR-targeted therapies.

264 explanation for the capacity of this asexual snail to spread by adaptive evolution or plasticity to d

265 py by reducing the risk of transmission from snails to humans.

266 oxicity assay was then conducted by exposing snails to oil coated Spartina stems in chambers for peri

267 rasite compatibility experiments by exposing snails to schistosome larvae recovered from the urine of

268 nia sea otters, the ability of kelp-dwelling snails to transmit terrestrially derived pathogens has n

269 The implications of snail-to-snail transmission in the epidemiology of snail

270 Cone snail toxins are well known blockers of voltage-gated so

271 n and decreased expression of N-cadherin and snail transcription factor -2 ( SNAI2) (also called SLUG

272 BR2 and the EMT inducers ZEB1, ZEB2, and the snail transcriptional repressor SNAI2, each crucial fact

273 INE) compounds results in reversal of EMT in snail-transduced primary human mammary epithelial cells

274 The implications of snail-to-snail transmission in the epidemiology of snail-borne di

275 ted by various signaling pathways, including Snail, Twist and transforming growth factor-beta1 as wel

276 CoCl2-induced EMT most likely via HIF1-alpha-Snail/Twist signaling pathway, and copper depletion may

277 enhanced expression of EZH2 coincident with Snail upregulation.

278 Vc1.1, a peptide from predatory marine cone snail venom, inhibits Cav2.2 channels by activating pert

279 no acid peptides present in predatory marine snail venoms that function as allosteric antagonists of

280 these delta-conotoxins from piscivorous cone snail venoms.

281 bpopulation expresses higher levels of SLUG, SNAIL, VIMENTIN and N-CADHERIN while show a lack of expr

282 expressed lower E-cadherin activity, higher Snail, vimentin, and Cat L activity, and a p110/p90 acti

283 Snail was also expressed in EC overlying atherosclerotic

284 Snail was also required for recovery.

285 d with flow-altering cuffs demonstrated that Snail was expressed preferentially at low shear stress s

286 The abundance of infected snails was 80% lower at that village, presumably because

287 i exposure and prey specialization on marine snails was identified in threatened California sea otter

288 Previously, research on snails was used to show that left-right signaling of Nod

289 The snails were exposed to the extract, the three most abund

290 Snails were placed in chambers containing either unoiled

291 Isotopically enriched snails were subsequently exposed to algae mixed with inc

292 The snails (n = 10 snails) were exposed for 10 days to increasing imidaclop

293 kingly, some early-recovery mRNAs, including Snail, were elevated first during apoptosis, implying th

294 y sub-additive behavior is also observed for snail, whereby removal of the proximal enhancer causes a

295 in, and decreased expression of vimentin and snail, which is partially attributed to inhibiting Akt/G

296 s of the Cavu River harbour many B truncatus snails, which are capable of transmitting S haematobium-

297 itual is the "love" dart shooting of helicid snails, which has courted many theories regarding its pr

298 ist assessment of 632 species of marine cone snails with human impacts and projected ocean thermal st

299 of trematode parasite infections in aquatic snails with measurements of snail excretion and tissue s

300 ures (no tumor rebound at 120 days) of HMLER-Snail xenografts.