ライフサイエンスコーパス: small

1 enterocolitis, but the absolute reduction is small.

2 fficacy between antidepressant therapies are small.

3 erstand the ion-molecule growth mechanism of small acetylene clusters (up to hexamers).

4 Below 18 K, this small additional magnetic incommensurability disappears,

5 n cells representative of the trachea versus small airway bronchiolar cells.

6 rement of distal lung ventilation reflecting small-airway disease.

7 bunit that noncovalently associates with the small alpha subunit on the intermembrane space side of t

8 beta2 activation because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 bin

9 microtubule bundles remain stationary with a small amount of antagonizing force generated.

10 mplification, which hinders the detection of small amounts of genetic material.

11 otein binding partners simultaneously, using small amounts of starting material.

12 Small-amplitude motions within contact F-Q pairs, which

13 The method relies on the use of a small-amplitude pulse made prior to the FSCV sweep that

14 airy intake and fecundability were generally small and inconsistent across cohorts.

15 and Assembly Based ReAlignment are used for small and large indel detection, and results are present

16 selectively eliminated enteric glia from the small and large intestines, but caused no defects in epi

17 on of the complete RNA cargo, including both small- and long-RNAs, in a single library preparation st

18 Small angle X-ray scattering and ensemble modeling yield

19 Biophysical analysis, using small angle X-ray scattering and multi-angle light scatt

20 ion are analysed by simultaneous synchrotron small-angle X-ray scattering and Raman spectroscopy in a

21 ar weight of the complex was calculated from small-angle X-ray scattering data and was in good agreem

22 ate the RNA secondary structure information, small-angle X-ray scattering data, and any readily avail

23 tional profiling of LmnaH222P/H222P mouse, a small animal model of LMNA cardiomyopathy, suggested dec

24 In the small-animal PET experiments, LNCaP tumors were clearly

25 Small-animal SPECT/CT-based MMP-targeted imaging of the

26 In conclusion, Small aortic diameter (as opposed to large aortic diamet

27 f 50 (14%): here, rotation occurred around a small area of scar (<0.03 mV; 12+/-6 mm diameter).

28 Phantom imaging showed that features as small as 0.7 mm could be resolved.

29 The analysis of sample volumes as small as 50 muL is made possible using a microfluidic ce

30 We show here that a region as small as the first 32 amino acids of Swi1 (Swi11-32) can

31 aliana) have demonstrated that auxin-induced SMALL AUXIN UP RNA (SAUR) genes promote elongation growt

32 ile stoichiometric Ga2FeO4 NCs are intrinsic small bandgap semiconductors, off-stoichiometric GFO NCs

33 Isolated small bowel perforation following blunt abdominal trauma

34 h morbidity and mortality rates, and delayed small bowel perforation is even rarer.

35 morphological alterations in and around the small bowel, MDCTE seems to be an attractive modality fo

36 Phonological training resulted in a small but significant improvement in speech comprehensio

37 Conclusion A small but statistically significant dose-dependent T1-we

38 in STGD1 patients over a 12-month period was small, but varied depending on baseline BCVA.

39 Vps13p must be in complex with the small calcium-binding protein Cdc31p to be active.

40 ent protein fusions to the amino terminus of small capsid protein VP26 are the most widely used metho

41 of the most frequently mutated genes in non-small cell lung cancer (NSCLC) and is commonly comutated

42 a subcutaneous HER3 overexpressing H441 non-small cell lung cancer xenograft.

43 terogeneity and evolution in early-stage non-small cell lung cancer.

44 ntly in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this st

45 ogenic transcription and tumor growth in non-small-cell lung cancer (NSCLC).

46 ly or histologically confirmed limited-stage small-cell lung cancer, Eastern Cooperative Oncology Gro

47 nd endowed all dendritic varicosities with a small-center, strong-surround receptive field, which var

48 We propose that small changes in the separation of the inner and outer n

49 uld be near a tipping point where relatively small changes to their fire regimes or their postfire fo

50 Mitochondria organelles have small circular genomes with substantial structural and g

51 ed effect of urban form on NO2 is larger for small cities (beta x IQR = -0.46 for cities < approximat

52 We find that a small component of field along the magnetic easy-axis me

53 ing delayed rectifier current (IKs ) and the small conductance Ca(2+) -activated potassium (SK) curre

54 inematic (e.g., velocity), but also showed a small contribution from the other motion kinematic (e.g.

55 This population also makes a small contribution to odontoblasts during primary dentin

56 ith a radius of 1.4 Earth radii transiting a small, cool star (LHS 1140) 12 parsecs away.

57 ts that show that proteins are assemblies of small cooperative units called foldons and that a number

58 Perovskite films composed of small crystallites show higher yields of superoxide and

59 Small cuticular drusen typically demonstrated a homogeno

60 Reactions between phosphines with small cyclohexyl- (Cy) or isopropyl- ((i)Pr) groups and

61 However, in the subgroup of small diameter stents (</=3 mm; n = 95), specificity(82%

62 Despite on-target activity in small-diameter dorsal root ganglia, spinal slices, and i

63 For small-diameter primary afferent neurons, it is unclear t

64 of Takanari than Koshihikari resulted in the small difference in evapotranspiration.

65 PFAS were cross-sectionally associated with small differences in markers of insulin secretion and be

66 bronchoalveolar lavage, large proximal, and small distal airway brushings were collected from patien

67 s to the light guiding in optical fibers and small distance between the fiber tips and trapped partic

68 Papillomaviruses are small, double-stranded DNA viruses that encode the E2 pr

69 determination of ligand selectivity both for small drugs and large proteins with nearly base-pair res

70 d from nonlinear mixed-effects models showed small early favorable changes in the first few months po

71 for primary care in rural Gambia had a very small effect on linear growth and did not reduce morbidi

72 Sex had a small effect on the mean (SD) number and severity of sym

73 isorder where multiple pleiotropic loci with small effects contribute to increased disease risk.

74 Age, sex, race, and ethnicity have small effects on the Z scores that are statistically sig

75 We discovered, however, that small electrolytic lesions in the midbrain severely impa

76 We establish small error rates in the identification of evoked spikes

77 In addition, the model results suggest that small external electrical signals play a greater role in

78 V)-encoded oncoprotein that is packaged into small extracellular vesicles (EVs) called exosomes.

79 hese effects and the characterization of the small F508del-CFTR subpopulation might be crucial for CF

80 se of a genome-wide analysis of members of a small family of immunoglobulin domain proteins, we found

81 crop essential to the food security of many small farmers in Asia and Africa and is a model system f

82 lp in screening patients for the presence of small fibre neuropathy and to assess disease progression

83 magnetic and paramagnetic states) using very small fields (smaller than 0.3 tesla).

84 f of Thailand, Bryde's whales, which feed on small fish species [3], predominantly anchovies, demonst

85 However, in applications where a small fluorescence reporter is required or desirable, th

86 with preterm birth (ARR, 1.16) but not with small for gestational age (ARR, 1.19), stillbirth (ARR,

87 (OR, 1.34 [95% CI, 1.18-1.52]) but not with small for gestational age (OR, 1.01 [95% CI, 0.81-1.25])

88 l nutritional status is a key determinant of small for gestational age (SGA), but some knowledge gaps

89 2.2 weeks; P<0.001), with increased rates of small for gestational age births (15% versus 8%; P=0.03)

90 evalence of preterm birth, low birth weight, small-for-gestational-age births, cesarean delivery, and

91 lation of selected candidate genes or a very small fraction of genomic CpG sites in human pancreatic

92 For many years, only a small fraction of the human genome was believed to regul

93 th will inevitably be appropriated by a very small fraction of the population unless effective wealth

94 , but known pigmentation loci explain only a small fraction of the variance.

95 100x higher than generic statins, and only a small fraction of their higher cost is likely to be reco

96 ditions were found to be concerted involving small free activation energies and are all exoenergonic.

97 Quinoa starch has small granules with relatively low gelatinization temper

98 GAP (RASA1), a negative regulator of the Ras small GTP-binding protein.

99 Inhibition of LDH activity by small hairpin ribonucleic acid or expression of phospho-

100 Levels of NR1D1 were knocked down with small hairpin RNAs in human primary macrophages.

101 nder conditions promoting protein unfolding, small heat shock proteins (sHsps) prevent the irreversib

102 nsistent with STEMI at primary care clinics, small hospitals, and PCI hospitals in the southern state

103 was found although the sample size used was small; however, the results excluded greater than a smal

104 c telomere-length measurements in relatively small human cardiac samples and offers an attractive tec

105 The utility of these small hydrogels is demonstrated through the analysis of

106 0.65 for not worsening, 0.68 for at least a small improvement, 0.69 for at least a moderate improvem

107 ation in QoL, 9.2% had no change, 9.2% had a small improvement, 13.5% had a moderate improvement, and

108 WM pathways of AS model mice are abnormally small in caliber.

109 techniques, cataract surgery has evolved to small-incisional surgery with rapid visual recovery, goo

110 enatal exposure to PFASs was associated with small increases in adiposity measurements in mid-childho

111 countries but rather that this is driven by small indigenous companies.

112 scribed here to identify enhancer-associated small insertion variants provides a foundation for furth

113 de variants (SNVs), with the contribution of small insertions and deletions (indels) less well charac

114 of extreme facial features (e.g., very large/small inter-eye distance), and reduction of the gain of

115 Transfection of Sirtuin-1 small interfering RNA prevented hnRNP F stimulation of F

116 ajor histocompatibility complex molecules by small interfering RNA targeting of class II transactivat

117 h as nonsteroidal anti-inflammatory drugs or small interfering RNAs (siRNAs) against COX-1 and COX-2,

118 lncRNAs that produce trans-acting or phased small-interfering RNA (tasiRNA/phasiRNAs).

119 The individual small intestinal segments studied revealed comparable st

120 mation while having no discernable effect on small intestinal tumor formation.

121 d to the parental strain was observed in the small intestine and the liver.

122 enterocyte surface in the mid-region of the small intestine and translocate through the epithelial c

123 provides a noninvasive option to assess the small intestine, but its use with respect to endoscopic

124 6SF2 is expressed predominantly in liver and small intestine, sites for triglyceride-rich lipoprotein

125 ides, suggestive of a role for TM6SF2 in the small intestine.

126 l role in looping morphogenesis of the avian small intestine.

127 deltaN/N for CP-AFM junctions is remarkably small (</=2%) and that the largest contributions to delt

128 iron (<0.025 mum) at pH 4 but principally as small (<0.45 mum) iron oxyhydroxide particles at pH 8 wi

129 n addition, it remains challenging to access small luminal organs or pass through narrow luminal sect

130 ents with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at

131 the underlying lattice, as evidenced by the small magnitude of the magnetostriction anomaly at H*.

132 ed tight UF hollow fibers not only possess a small mean pore diameter of 1.0-1.3 nm with a molecular

133 l modification of cellular proteins with the small modifier, ubiquitin (Ub), regulates virtually ever

134 nts an advancement toward the development of small molecule activators of tumor suppressor proteins.

135 al plus-strand RNA viruses that binds to the small molecule ADP-ribose.

136 recognition that are orthogonal to classical small molecule and protein-based approaches.

137 The initial screen of small molecule compound libraries identified more than t

138 We investigated the small molecule crystal structure of lead molecule 7 and

139 ver fibrosis, we sought to identify improved small molecule functional mimetics of H2-RLX with select

140 tion, and support the further development of small molecule Gas6-TAM interaction inhibitors as a nove

141 ion of the drebrin/EB3 pathway using BTP2, a small molecule inhibitor of drebrin binding to actin fil

142 between GAS6 and AXL and the promiscuity of small molecule inhibitors represent important challenges

143 , we performed phenotypic screens on a NINDS small molecule library of 1040 drugs.

144 ated that extracellular matrix organization, small molecule metabolic process, cell adhesion (GO IDs:

145 biological and pharmacological diversity of small molecule metabolites.

146 Host-microbe communication via small molecule signals is important for both symbiotic a

147 Small molecule splicing modifiers have been previously d

148 nantly sandwich assays) are not suitable for small molecule targets.

149 We identified a small molecule, AC1903, that specifically blocks TRPC5 c

150 y-enabled high-throughput screen to identify small-molecule agonists of TFEB and discover three novel

151 rokaryotes and eukaryotes, and recognized as small-molecule binding proteins.

152 Intraperitoneal injection of the HuR small-molecule inhibitor MS-444 in AOM/DSS mice, a model

153 he molecular effects of a recently developed small-molecule inhibitor of the KDM5 family of proteins

154 , summarizes the current status of exogenous small-molecule inhibitors of RAGE and concludes by ident

155 We discuss how small-molecule inhibitors of the tryptophan (Trp) catabo

156 The discovery of nonnucleoside, reversible, small-molecule inhibitors with greater specificity again

157 Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery

158 Existing small-molecule modulators of V-ATPase either are restric

159 thod for rapid identification of synergistic small-molecule pairs, the overlap2 method (O2M).

160 erent types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-v

161 In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer i

162 y was to develop and characterize a specific small-molecule tracer for PET imaging that binds with hi

163 a consistent cleft palate phenotype to test small-molecule Wnt agonist therapies.

164 ribing their application to the detection of small molecules (haptens).

165 compounds and efforts toward development of small molecules and biologics that could be of therapeut

166 sults establish potent Sirt6 activation with small molecules and provide a structural basis for furth

167 tates the coordinated discovery of bioactive small molecules and their molecular targets.

168 ptors, was optimized using CCS values of 205 small molecules and validated using a set of 131 pestici

169 Thus, small molecules applied locally to the skin can be used

170 ing mass spectrometry, we generated a map of small molecules differentially expressed in the Drosophi

171 ) as a label-free approach to chemically map small molecules in aggregated and single Escherichia col

172 icularly in the gut, and at least 20% of the small molecules in human blood are products of the micro

173 e efforts also determined that many of these small molecules inhibit the protein-protein interactions

174 raises the possibility that HMBA or related small molecules may be explored as therapeutic adjuvants

175 These small molecules of the heterocyclic diamidine family dis

176 y accurate quantifications of the effects of small molecules on specific microscopic steps in Abeta42

177 Here, we screened a panel of small molecules targeting epigenetic modulators against

178 Together, these observations establish that small molecules that bind to the interface between TAM I

179 ruggable targets and identify a new class of small molecules that may be further optimized for the re

180 Small molecules that target Bcl-2 are used in the clinic

181 Small molecules with novel and defined mechanisms of inh

182 roperties (e.g., self-assembling ability) of small molecules with the efficacy of a molecule process

183 d be used to screen for structural elements, small molecules, and host factors that alter these relat

184 ervations indicate that the self-assembly of small molecules, as multifaceted entities and processes

185 ilizing specific 14-3-3 protein complexes by small molecules, peptide mimetics, and natural products.

186 d by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are

187 ein interactions, are difficult to target by small molecules.

188 broaden sequence recognition of DNA-targeted-small-molecules to include both A.T and G.C base pairs,

189 exRNA is enriched in small ncRNAs, such as miRNAs in exosomes, and precisely

190 A small network incorporating neighboring insular regions

191 ly, this elastic behavior is transferable to small networks, where we found the surprising effect tha

192 A variety of small neutral guest molecules with complementary sizes a

193 There was a small non-clinically relevant but statistically signific

194 NAs) are 26-30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved

195 MicroRNAs (miRNAs) are small, non-coding RNAs that play critical roles in the p

196 neuroimaging research, most studies recruit small, non-representative samples.

197 miRNAs are evolutionarily conserved small noncoding RNAs that display important physiologica

198 RNA splicing.IMPORTANCE The Parvovirinae are small nonenveloped icosahedral viruses that are importan

199 collision experiments can be used to prepare small NP ensembles on a UME (i.e., UME-NPEs).

200 omes, all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs

201 However, only a small number of CCS values are available for drugs, whic

202 funding of career development grants, only a small number of early-career American College of Cardiol

203 se included, in particular, tuning to only a small number of facial features that were often related

204 jor predictor of transcriptomic variation; a small number of genes (n = 263) were differentially regu

205 Mutations in a small number of genes have been reported to cause PCH, a

206 Overall, we identified a small number of immunodominant regions, which were in fu

207 The abnormal aggregation of a small number of known proteins underlies the most common

208 Only a small number of leaf transcripts and metabolites were ch

209 roach we demonstrate that the frequency of a small number of linear motifs three amino acids in lengt

210 olution structures available, leaving only a small number of protein-ssNA crystal structures, while f

211 e process of route formation in detail for a small number of selected individuals.

212 Only a small number of weak interactions are formed at the tran

213 r remarkable aerodynamic agility with only a small number of wing muscles.

214 we use computational methods to investigate small numbers of bonds at the interface between two memb

215 tatistical power, most studies identify only small numbers of candidate genes that pass the conventio

216 n most natural infections or after recovery, small numbers of Leishmania parasites remain indefinitel

217 Small observational studies have indicated better outcom

218 and microencapsulate lipid fraction, so that small oil droplets are entrapped within a dry matrix of

219 erates short peptides, some of which are too small or uninformative for optimal analysis and which po

220 Here we identified a range of small organic molecules, drugs, drug metabolites and dru

221 ploring an ionization method that can ionize small organics and large biomolecules with different pro

222 he ion source, is useful for the analysis of small organics with low polarities.

223 We reasoned that small particle aerosols of virus would penetrate the low

224 M interacts with alphabeta-tubulin through a small peptide motif within its MT-binding domain.

225 te-directed mutagenesis and by inhibition by small peptides that mimic the loop residues.

226 n reduce sensitivity, such as probing only a small percentage of the nanoprobes present in the sample

227 advertising for mates by taking advantage of small, periodic decreases in the overall noise structure

228 of the hybrid mimic lines, whereas in the F6 small phenotype line, the 12 segments were each derived

229 with Lewy bodies cases mainly in the form of small phosphorylated alpha-synuclein aggregates that are

230 s developing disease in their twenties and a small portion of carriers surviving to their ninth decad

231 Dissolved N2O comprised a very small portion of the annual nitrogen outputs.

232 sis, although conventional regression gave a small positive association (0.02 higher grade, 95% CI: 0

233 The large brain and small postcanine teeth of modern humans are among our mo

234 ed strain sensors are incapable of resolving small pressure changes in the few kPa range, making them

235 er-feeding (enhancing foraging efficiency on small prey).

236 However, a small proportion of loci showed strong patterns of diffe

237 In contrast, small proportions of individuals are symptomatic (SYMP)

238 S1 (EXCESS MICROSPOROCYTES1) LRR-RLK and its small protein ligand TPD1 (TAPETUM DETERMINANT1) play a

239 Isolated in small quantities and shown to have promising antimicrobi

240 o be radical in nature, with the addition of small quantities of a radical initiator (azobis(isobutyr

241 double-blind randomised controlled trial of small-quantity lipid-based nutrient supplements (SQ-LNS)

242 tions can be performed in reasonable time on small quantum computers.

243 ibly confounded by the effect of anesthesia, small regional size, and tracer injection volume.

244 he many translational applications for these small regulatory RNAs in AML.

245 ce on the electrical transport behavior of a small-resistance GaSb sample and explained the discontin

246 th most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic sys

247 The nict-1 locus contains a Piwi-interacting small RNA (piRNA) cluster; we observe that the Piwi Argo

248 EMB-4 as a direct and essential link between small RNA pathways and the transcriptional machinery in

249 tal RNA extracts with sensitivity similar to small RNA sequencing and northern blots.

250 scriptome structure and output of regulatory small RNAs (sRNAs) are incompletely understood.

251 t deep sequencing technology to sequence all small RNAs and degradome of sweetpotato for systematical

252 eir mechanism of action and show that mobile small RNAs generate sharply defined domains of target ge

253 Little is known about these small RNAs in litchi (Litchi chinensis), an economically

254 ysis of gene expression, DNA methylation and small RNAs in the rice endosperm and functional tests of

255 NMR metabolite profiling was achieved from a small sample of intact sausage after 0, 2, 4, 7, 11 and

256 s suffer from serious limitations, including small sample sizes.

257 irculating tumor cells requires manipulating small sample volumes without loss of rare disease-causin

258 Relatively small samples in the dyadic analysis and site-specific a

259 as state-of-the-art models, particularly at small samples.

260 When compared to small-scale diesel generators, PV-battery systems save 9

261 Small-scale disturbance of the plant canopy also had no

262 Small-scale heterogeneity of element distributions recen

263 nsors facilitates both rapid development and small-scale manufacturing.

264 ove cross-cultural life history datasets for small-scale societies for which reliable age records are

265 Small self-cleaving ribozymes have been discovered in al

266 e cardioverter-defibrillator (ICD) shocks in small series of patients with structural heart disease (

267 here is necessarily an imbalance between the small set of available disease-associated and the much l

268 ory-intensive, limiting their application to small, single data sets.

269 ovel molecular imaging in oncology have been small, single-center trials.

270 nsity (more than 10(24) per cubic metre) and small size (about 2.7 +/- 0.2 nanometres).

271 The stability, ease of production, small size and brightness of CpcA-PEB and CpcA-PCB demon

272 With the advantages of small size, high binding affinity, good stability, lack

273 Due to the relatively small size, SN-NPM possessed superior long tumor retenti

274 Arctic fish communities, mainly composed of small-sized bottom-dwelling benthivores, are being rapid

275 Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively

276 In this small study, no safety events were noted, but no safety

277 was probably influenced by publication bias/small-study effect.

278 oise ratio, thus optimizing visualization of small subcortical structures.

279 producible heat-dependent gene expression in small sublineages (one to four cells) without radiation

280 ed rapid and transient NPAS4 expression in a small subpopulation of FOS-positive neurons in the NAc.

281 NKT cells represent a small subset of glycolipid-recognizing T cells that are

282 its a very high level of selectivity towards small substrates including the natural indole-3-acetic a

283 identified as low performing with relatively small survival differences compared with expected.

284 rn to be wide ranging, holding for large and small synapses in the neocortex and brainstem.

285 as well as the energy density extracted from small synthetic samples allows planning potential uses o

286 Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplicat

287 however, the results excluded greater than a small to moderate benefit with 95% confidence.

288 ations for low back pain are associated with small to moderate, primarily short-term effects on pain.

289 e of benefit, but effect sizes are typically small to moderate.

290 Small ubiquitin-like modifier (SUMO) modification regula

291 We found that the SUMO (small ubiquitin-like modifier)-modification and ubiquiti

292 cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) and comprises an

293 Small variations on geometry and atomic charge were dete

294 beetles (Nicrophorus vespilloides) breed on small vertebrate carcasses, which they shave and smear w

295 he brain and may reflect underlying cerebral small vessel disease (SVD).

296 non-demyelinating disorders such as chronic small vessel disease and other inflammatory, granulomato

297 For small vessel occlusion (17.8%), outcomes tended to vary

298 of cardiovascular disease but lower odds of small-vessel cerebral vascular disease.

299 m the Vif-A3G and Vif-A3F interfaces, with a small Vif region being important for recognition of both

300 The area under the ROC for using small-window entropy imaging to classify tumors was 0.89