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1 colonies performed poorly at the flower poor site).

2 l peptides and residues of the ACE catalytic site.

3 independently regulated, co-agonist-binding site.

4 ting the neutralizing epitope (NE) antigenic site.

5 espect to the substrate in the enzyme active site.

6 blocks of 3 and 6), and stratified by study site.

7 proximately 100-300 mum away from the injury site.

8 a pyridine-like nitrogen across the vacancy site.

9 ly to beta-tubulin at the colchicine binding site.

10 s reduced after mutation of the Sp-1-binding site.

11 as progesterone, likely binding to the same site.

12 the number of intergenic SNPs per intergenic site.

13 ther sites, and below a factor of 1.3 at one site.

14 fectively disassemble the adenylation active site.

15 oglycan-synthesizing enzymes to the division site.

16 ajor autolysin LytA and occurs at the septal site.

17 -ring for recruitment to the future division site.

18 of the COX2 C-tail that contains the apo-CuA site.

19 4 per 100000 in NETs with an unknown primary site.

20 or are immediately upstream of the cleavage site.

21 on's disease but not in controls at a single site.

22 lysis revealed four resolved factors at each site.

23 gatively affected by herbivores in subarctic sites.

24 or under-represented among different cancer sites.

25 enation and moderate to strong Bronsted acid sites.

26 are adapted to colonize different metastatic sites.

27 , 11.2% in the oral cavity, and 8.8% at both sites.

28 e able to identify six T-bet phosphorylation sites.

29 opic bone formation above the mesh in 72% of sites.

30 nts in pockets of enzymes stabilizing active sites.

31 he stabilizing effect at many of the mutated sites.

32 conversion of amines to quaternary ammonium sites.

33 r targeting amplicons with conserved priming sites.

34 maximize CO2 uptake within and above storage sites.

35 ott scenario without real charge order on Ni sites.

36 , AU-rich sequences, and Pumilio recognition sites.

37 ing a mutation(s) at the transmitter-binding sites.

38 eractions and identify their genomic binding sites.

39 ent of the strength and number of competitor sites.

40 can bind pre-acetylated nucleosome-depleted sites.

41 o GAS pathogenesis at multiple host anatomic sites.

42 d more likely to contain nonconsensus splice sites.

43 alter metal uptake by blocking key reactive sites.

44 tchener), including three upstream reference sites.

45 Confirmation that Sites 1 and 2 function in trans was demonstrated by exam

46 were created in healed maxillary extraction sites 1) by drilling or 2) by drilling followed by stepw

47 lutamate of the canonical nucleotide binding site 2 was mutated to glutamine.

48 Sunburn on all exposed body sites 22 to 24 hours after sun exposure.

49 hydrogen-bonded pi-complex at Bronsted acid sites, -36 kJ/mol.

50 vation MI versus MI not related to a stented site (59% vs. 26%, p = 0.001).

51 d the functional importance of S-nitrosation sites across the mammalian proteome, remain largely unch

52 of 39 kb that contains DNAse hypersensitive sites active at a restricted time window during retinal

53 t evident upon re-inspection of one of these sites after 18 months, indicating how evidence of distur

54 he impact was more marked at the flower-rich site (all colonies performed poorly at the flower poor s

55 y AXO from unplanned explosions at munitions sites, although the grey literature suggests that AXO is

56 Individual sites analysed structural T1-weighted MRI brain scans wi

57 Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding prot

58 (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co-agonist

59 In all seven lines the exact integration site and breakpoint sequences were identified.

60 nese and cobalt can bind to the same nonheme site and confer HCO activity in a heme-nonheme biosynthe

61 ed for in vitro binding to the enzyme active site and for inhibition constants.

62 potential existence of an additional binding site and provide new insights into GB1:IgG complex struc

63 se Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial.

64 eless, the evolution of the receptor-binding site and the stem region on HA is severely constrained b

65 ation under O2 to open a cobalt coordination site and to oxidize Co(II) to Co(III), as evidenced by o

66 0ng to 1microg due to the increased reactive sites and distance.

67 eting of Fli1 to favour nearby Sox consensus sites and enhances the vascular function of converted ce

68 Published data reveal TET2 binding sites and hydroxymethylcytosine proximal to KLK3.

69 reduced editing at 38 mitochondrial editing sites and increased editing at 24 sites; therefore the a

70 predict the CO binding at a large number of sites and select four exhibiting CO binding stronger tha

71 NFkappaB dimers bind to a myriad of genomic sites and switch the targeted genes on or off with preci

72 s in the methyl esterification of all acidic sites and the conversion of amines to quaternary ammoniu

73 ng to the multiple potential phosphorylation sites and their clustering in the Tau sequence.

74 acid protein containing five F-actin-binding sites and two G-actin-binding sites, and interacts with

75 markably, the glycan patterns, glycosylation site, and their occupancy by N-glycans are all detected

76 g, 3.56 per 100000 in gastroenteropancreatic sites, and 0.84 per 100000 in NETs with an unknown prima

77 between a factor of 1.5 and 1.8 at six other sites, and below a factor of 1.3 at one site.

78 -actin-binding sites and two G-actin-binding sites, and interacts with wheat (Triticum aestivum) Acti

79 distinct kinetic profiles, even for proximal sites, and this suggests that target sequence and chroma

80 region abolishing the N-linked glycosylation site; and 2 variants represented the head domain, 1 comp

81 Nase-seq, DNase hypersensitive site mapping, site annotation and motif identification for DNase-seq,

82 ative regulatory influences at each promoter site are integrated to modify pqsR expression.

83 The fact that these sites are associated with enhanced oxidative stress and

84 Five of these are novel, and four sites are consistently dephosphorylated in both Rheb-def

85 a shared core protein fold but whose active sites are located in entirely different regions, illustr

86 uired for efficient Ede1 localization at CME sites are the third EH domain, the proline-rich region,

87 ccurs through an unusual ground state active site arrangement or by thermally sampling conformational

88 omoter constructs, we identified a NF-kappaB site as critical in this activation.

89 se of synaptic activity occurring in distant sites as well.

90 tein adducts requires ATP hydrolysis at both sites, as does the stimulation of ATM kinase activity.

91 We further identify a naturally polymorphic site at Nef position 9 that contributes to the MHC-B dow

92 The phosphorylation site at serine 14 of TRPC6 is embedded in a basophilic k

93 e transmembrane helices and effector docking sites at the intracellular surface of the beta1AR, but t

94 heostoma caeruleum) were collected from nine sites at varying distances from two major municipal wast

95 h/branch-site models and unrestricted branch-site-based models (BS-REL, BUSTED and RELAX)), our resul

96 ide of a membrane system and seal the defect site because of increased hydraulic drag through damage

97 r to T1 closure such that the U5-A6 cleavage site becomes embraced to achieve its cleavage competent

98 are naturally curved at each of the cellular sites believed to engage in autophagosome formation, rev

99 biased low by more than a factor of 2 at six sites, between a factor of 1.5 and 1.8 at six other site

100 ctures, which binds choline in a unique dual-site-binding mode.

101 1 in APP from the Glu(11) site to the Asp(1) site both in male and female transgenic mice in vivo and

102 f the adenine subpocket of the AcCoA binding site by an aromatic ring.

103 nzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD and LAVP,

104 on and the core H-bond network in the active site by relocating to replace the missing Arg85' sidecha

105 the immediately preceding and older division sites by interacting with Nba1 and Nis1.

106 the hetero-tetramer interface and the active sites can abolish Pseudomonas aeruginosa growth in a def

107 Among others, we identified sites catalyzed at faster rates with potential critical

108 nd identifies surface features, H(+) binding sites, Ce(3+) locations, and O vacancies on (100) facets

109 ions with individual and primary health-care site characteristics, using mixed models.

110 ly Treatment Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coor

111 ompared to controls across single- and multi-site cohorts, and increased over 1 year in Parkinson's d

112 ice dislocation, and femoral vascular access site complications.

113 Free-energy simulations elucidate the active site conformations in the AppA (activation of photopigme

114 We also mapped phage 9 g DNA packaging (pac) site containing two 21-bp direct repeats and a major ter

115 Nevertheless, European sites containing well-dated human remains associated wit

116 FR tyrosine phosphorylation, particularly of sites corresponding to the binding specificity of the ov

117 op is relocated by pressure was validated by site-directed mutagenesis and by inhibition by small pep

118 sible spectroscopy, heme quantification, and site-directed mutagenesis of histidine residues, we demo

119 Site-directed mutagenesis was performed by partial gene

120 t and its implications for heme transfer via site-directed mutagenesis, resonance Raman (RR), hydroge

121 e of increased hydraulic drag through damage site during filtration.

122 The discovery of Neandertals at open-air sites during the late MP reinforces the view that Neande

123 At a site early in the Salmonella flgM gene, the effects on t

124 icient quantity and delivered to restoration sites efficiently.

125 c rNMP (rAP site) or a ribose 8oxoG (r8oxoG) site embedded in DNA.

126 Effective target sites fall within two domains, which are conserved in se

127 nd divisive, to split groups when functional site features suggest distinct functionally-relevant clu

128 add sequences containing similar functional site features, and divisive, to split groups when functi

129 all NMR parameters: Starting as a nucleation site for monomer-monomer contacts, this six-residue sequ

130 on to the Orai C terminus, the main coupling site for STIM1, the Orai N terminus is indispensable for

131 The intestinal epithelium is a major site for the conversion of dietary beta-carotene to reti

132 a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, thereby dir

133 was predicted to disrupt a consensus binding site for the transcription factor ETS within an enhancer

134 mal treatment yields silica-supported M(III) sites for a broad range of metals.

135 ch correlated with the two suggested binding sites for GMF.

136 on, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome cofactors Mt

137 ifs enriched in the PREs are cognate binding sites for the identified transcription factors and are n

138 xygen diffusion channels, but also preferred sites for the induced oxygen vacancies.

139 resent models for how MRX-Sae2 creates entry sites for the long-range resection machinery.

140 s and support the use of tonsils as lymphoid sites for the study of germinal center reactions after v

141 predominantly in liver and small intestine, sites for triglyceride-rich lipoprotein biogenesis and e

142 ciated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year

143 fy canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked ImmunoP

144 This site has been neglected in previous HIV-1 vaccine studie

145 e based on DNA methylation at 329 unique CpG sites, has a median absolute error of 3.33 weeks and has

146 proteins from the scPDB database of binding sites have been evaluated using both a distance and a vo

147 nism of cyclization within the enzyme active site; however, there is evidence that conformational res

148 ysis of clonal abundance in several anatomic sites identified 2 types of anatomic asymmetry.

149 ensed antibody palivizumab, which recognizes site II on both the pre-F and post-F proteins, is restri

150 izing a compound known to block the H3K27me3 site in EED discovered by in-house screening, Novartis s

151 mary amino acid sequence in the SOD2-binding site in hsp70.

152 the complete glycosylation profile at every site in multiple HIV-1 Env trimers, accomplishing two go

153 ezo1 in adult endothelium, the major control site in physical activity.

154 Furthermore, Nedd8 binding site in Smurf is shown to be necessary for its ubiquitin

155 econd (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests that nucleotide bin

156 analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which b

157 irect repeats and a major terminase cleavage site in the phage genome.

158 -arm, phase 3, multicentre study done at 143 sites in 17 countries.

159 s consistent with coalescence of the 5 and 3 sites in a complex (I, initial), but if this cannot form

160 ar factor kappa B (NFkappaB) from DNA target sites in a process we have termed molecular stripping.

161 nces of CRISPR/Cas9-mediated deletions at 17 sites in four loci of the mouse genome.

162 These fossils were collected at two sites in Germany, Neumark-Nord and Weimar-Ehringsdorf, a

163 location frequency to IGH and AID off-target sites in human chronic lymphocytic leukaemia and mantle

164 (MAbs) that recognize known major antigenic sites in MeV-H, we identified a D4 genotype variant that

165 rengthen connections between separate neural sites in motor cortex (MC).

166 ement based estimates of annual means at 179 sites in Tehran megacity, Iran.

167 to identify pathways and their postsynaptic sites in the amygdala in rhesus monkeys, we found that t

168 y, we found that methylation at multiple CpG sites in the HOXA4 promoter region was associated with h

169 sed distribution towards transcription start sites in the promoters of co-expressed genes.

170 of enriched transcription factor DNA-binding sites in the promoters of differentially expressed genes

171 venting its recruitment to canonical binding-sites in the promoters of Nanog, Oct4 and Sox2.

172 species between peri-implant and periodontal sites in the same individuals, suggesting similar pathog

173 studies of the beta1AR define ligand-binding sites in the transmembrane helices and effector docking

174 Responses obtained in contaminated sites included inductions of vitellogenin-like proteins

175 a interactions within primary and metastatic sites, including the lung.

176 Specific ion binding to such sites induces changes in the filter conformation, which

177 With bacterial contamination, surgical site infections (SSI) are a serious complication that ca

178 ther nutrient starvation or use of an active site inhibitor reduces Skp2 levels and stabilizes LT, le

179 anslation through an internal ribosome entry site (IRES).

180 l adenosine generated by cells at the injury site is critical for protection from IRI through bone ma

181 Results demonstrated that a miR398 binding site is eliminated in AhCSD1-2.2 as a consequence of alt

182 ylation of STAT5B on the JAK2-dependent Y699 site is significantly reduced in the liver and skeletal

183 n immediately downstream of the S2' cleavage site is the FP (amino acids 798-818 SFIEDLLFNKVTLADAGFMK

184 coordination of Ni(II) at the hexahistidine site is thermodynamically preferred over Zn(II).

185 ion of cholinergic and glutamatergic release sites is also possible.

186 from multiple interdependent phosphorylation sites is required for a GC-A conformation capable of tra

187 revealed subspecies clades specific to body sites; it also quantified species with phylogenetic dive

188 nkage for alpha5 and alphaIIb is the synergy site located in close proximity to the RGD motif.

189 PtdInsPs interact with the polyanion-binding site located on an inner chamber wall of the enzyme.

190 wly created islands and five nearby mainland sites located in the Brazilian Cerrado, a biodiversity h

191 rthritis (RA) infiltrate non-lymphoid tissue sites, maneuver through extracellular matrix and form la

192 itioning for MNase-seq, DNase hypersensitive site mapping, site annotation and motif identification f

193 athrin-mediated endocytosis (CME), endocytic-site maturation can be divided into two stages correspon

194 mulation, acupuncture at local versus distal sites may improve median nerve function at the wrist by

195 acer, were also found to have many more sst2 sites measured with the antagonist.

196 iety of approaches (restricted branch/branch-site models and unrestricted branch-site-based models (B

197 sion was affected by CNOT3 loss, and also at sites modulated in certain types of colorectal cancers.

198 POP levels varied significantly among sites, more than 36-fold on a mass basis.

199 ly, analysis of transcription factor-binding site motifs of differentially dysregulated genes uncover

200 te recessive allele is due to a splice donor site mutation in the scavenger receptor B1 (SCARB1; also

201 rotubules through a novel dynein interacting site near its C terminus.

202 on energy is weak because only a few binding sites near the collision point contribute significantly

203 efractory disease, mediastinal primary tumor site, nonseminoma histology, intermediate- or poor-risk

204 f chronic pain can also induce a generalized site-nonspecific enhancement in the aversive response to

205 these tasks, they neither die at the injury site nor are phagocytosed.

206 minus of chECL1, suggesting that the binding site of ALV-J gp85 on chNHE1 is probably located on the

207 tion, shifted the preferential beta-cleavage site of BACE1 in APP from the Glu(11) site to the Asp(1)

208 th tranexamic acid, with no heterogeneity by site of bleeding (p=0.5956).

209 cells and their progenitors are an important site of HCMV latency, and one viral gene expressed by la

210 olonization of the lower airways, the actual site of inflammation in asthma, which is hardly accessib

211 of EGP during a clamp, reaffirming that the site of insulin action to control EGP is extrahepatic.

212 The north African site of Jebel Irhoud contains one of the earliest direct

213 MYC ESE looping to the transcriptional stat site of MYC was dependent on EBNAs.

214 The site of pain depends on the pain type or underlying mech

215 Virus-specific CD8 T cells home to the site of recurrent infection and participate in viral cle

216 d the lipoprotein signal peptide recognition site of signal peptidase II (SpII).

217 At the molecular level, the sites of abnormal oral adhesions maintained periderm-lik

218 ssibly other microorganisms and form EETs at sites of airway epithelial damage to protect the host fr

219 e as important as platelets to thrombosis at sites of arterial injury and that platelets contribute t

220 We found FXR to bind to regulatory sites of genes encoding these proteins in control livers

221 eacon to target pathogens to their preferred sites of infection in vivo.

222 ground in many important tissues that may be sites of infection such as the lungs and soft tissues.

223 d the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge

224 f mutagenesis in the target protein-encoding sites of MSTN.

225 alf the identified proteins possess multiple sites of phosphorylation that are often clustered, where

226 -mediated endonucleolytic cleavage of DNA at sites of protein adducts requires ATP hydrolysis at both

227 dence of genes to the disparate, cytoplasmic sites of protein synthesis.

228 Coastal wetlands are sites of rapid carbon (C) sequestration and contain larg

229 Multiple hospital sites of the Aravind Eye Care System, India.

230 ell as be a reservoir for infection at other sites of the body.

231 ive in liver cells, enriched for the binding sites of the FOXA1, FOXA2 and HNF4A transcription factor

232 is relatively restricted in distribution to sites of tissue injury.

233 ally identifying the ampullae as the primary sites of viral persistence, combined with the fact that

234 DNA backbone specifically near the mismatch site on a 27-mer fragment, consistent with mismatch targ

235 Both the preprotein MTSs and their receptor site on SecA are essential for protein secretion.

236 activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease

237 ect of fuel loads (fat) acquired at stopover sites on the subsequent pace of migration has not been q

238 Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-prom

239 H2 is unable to process an abasic rNMP (rAP site) or a ribose 8oxoG (r8oxoG) site embedded in DNA.

240 tagonist AZ3451 binds to a remote allosteric site outside the helical bundle.

241 equencing analysis reveals that LSD1 binding sites overlap significantly with those bound by the S-ph

242 Ubiquitination of this site plays a role in AR stability and is critical for it

243 ng Ska complex, which enriches at attachment sites prior to anaphase onset to dampen chromosome motio

244 erTAD have a high enrichment of CTCF binding sites, promoter-related marks, and enhancer-related hist

245 and the higher number of hydrogen bond donor sites provides a remarkable enhancement of its binding e

246 Single site randomized control trial, 3 groupsx4 time points mi

247 ntrol, except for a higher rate of injection-site reactions with alirocumab.

248 similar when including all 210 patients with site-reported paired FFR data.

249 e lack of an appropriately positioned active site residue as a catalytic base leads us to propose an

250 manuscript, we have focused on OleTJE active site residues Phe(79), His(85), and Arg(245) to interrog

251 We mutated distinguishing active-site residues to generate enzymes that had a common Zn(2

252 complex hydrogen bond network of four active site residues, which was installed in the late stages of

253 and -230 mV, respectively, in the Q-binding site, respectively, suggesting that release of the Q tow

254 d constitutively phosphorylates a downstream site (S719) that accounts for 40% of basal NHE3 activity

255 Sterilized, impacted, spill-site sediment released minor amounts of cis- and up to 3

256 ic X-ray response can be explained with the "site-selective" Mott scenario without real charge order

257 Here, we describe site-selective, copper-promoted couplings of boronic aci

258 The simplicity and exquisite site-selectivity of the aza-Michael ligation described h

259 Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD

260 DNA in several modes that differ in occluded site size and cooperativity.

261 ely small samples in the dyadic analysis and site-specific analysis call for caution in interpreting

262 pping techniques is that they do not provide site-specific glycosylation information.

263 Combination of site-specific incorporation of a clickable p-azido-L-phe

264 They can catalyze site-specific RNA cleavage, and as a result, they have r

265 This new class of site-specifically metal-modified DNA films was character

266 ches to the previously identified HS binding site, suggesting a functional role.

267 teractions genetically and identified second-site suppressors of lethal mutations in SP.

268 te the formation of an intracellular binding site that enhances G-protein coupling.

269 As eosinophils typically accumulate at sites that are relatively hypoxic, particularly during p

270 Although located distant to the active site, the C2 domain greatly enhances catalytic turnover.

271 bility of neurotrophic factors in the lesion site, thereby promoting axonal regeneration and locomoto

272 al editing sites and increased editing at 24 sites; therefore the absence of MEF8 affects 11% of the

273 lease (step 4) of cyt c from the HCCS active site; thus, we term these "release mutants."

274 e alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, ABS2), Lmods lack TMBS2 and h

275 eavage site of BACE1 in APP from the Glu(11) site to the Asp(1) site both in male and female transgen

276 f the study include the exclusivity of study sites to India, lack of prior HIV/HCV diagnosis confirma

277 We also show that an active-site tryptophan, Trp-321, participates in off-pathway el

278 inding, CTCF quickly rebinds another cognate site unlike cohesin for which the search process is long

279 Splice site usage has been mapped exhaustively across different

280 after stroke was correlated with the lesion site using t-test statistics.

281 r prediction of transcription factor binding sites using an integrative energy function that combines

282 SNPs associated with DNase I-hypersensitive sites was also found in many tissue types, including bra

283 Spread at all sites was spatially heterogeneous, suggesting that envir

284 To better define the binding site, we used a series of decoy peptides derived from th

285 To identify active sites, we first predict the CO binding at a large number

286 Release sites were distributed throughout the AZ and underwent r

287 In 15 non-Hodgkin lymphomas, many more sst2 sites were labeled with the antagonist than with the ago

288 L3 regions, which flank the di-Zn(II) active site, were selectively (19) F-labeled using 3-bromo-1,1,

289 f the cofactor transiently enters the active site where it displaces the pterin ring of the THF produ

290 This study investigates the exact site where the association of HCV virions with host lipo

291 in particular the gut mucosa, are the major sites where immune cells traffic and reside.

292 With respect to sites where SNs were resected, remaining hotspots may ha

293 in the more recently designated Natura 2000 sites, which are subject to high human accessibility.

294 ce differences were revealed among the three sites, while specificity and NPV of MALDI-TOF MS for mal

295 Although it shares a binding site with other imide-based natural product translation

296 l electrograms had corresponding endocardial sites with BV <1.50 mV, and the remaining could be ident

297 rmed by neighboring tetrahedral interstitial sites, with analytical solutions for basin exiting time

298 We identified a centrin-binding site within H. sapiens Prp40 homolog A (HsPrp40A), which

299 The apparent diffusion coefficients of these sites within PEC films of poly(diallyldimethylammonium),

300 e protein scaffold that surrounds the active site, yet the exact nature of catalytically relevant pro