ライフサイエンスコーパス: oxy

1 6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin- 4-yl}oxy)-1-piperidinecarboxylate (GSK1104252A) (3), a potent

2 -tert-butyl-1,2-quinone-(3,5-di-tert-butyl-2-oxy-1-phenyl)imine) to give five-coordinate (X)(Y)Si(ON[

3 xy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmeth oxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (11j) is

4 nyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzo ic acid, 42 (MK-3903).

5 ble 2',2''-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclod odecane-1,4,7-t

6 N-{trans-3-[(5-Cyano-6-methylpyridin-2-yl)oxy]-2,2,4,4-tetramethylcyclobutyl}imid azo[1,2-a]pyrimi

7 d analog of [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride (McN-A-343).

8 -beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-20-[(6-O-beta-d-xylopyra nosyl-beta-d-glucopyranosy

9 g the construct specific of the canola event Oxy-235 (3'-junction Nitrilase/Tnos) and the canola endo

10 n and the quantification of the canola event Oxy-235.

11 9i (LMK235) (N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide) showed similar effects compa

12 s shown that the polarizing agent 1-(TEMPO-4-oxy)-3-(TEMPO-4-amino)propan-2-ol (TOTAPOL) has a strong

13 inhibitor, N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-pheny l-2,3-di

14 -dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide (carboxy-PTIO, an NO scavenger), 1H-[1,2,4]-

15 l)-oxy]-ethyl-4-methoxy-4-2-[(4-methylpentyl)oxy]-3,4-dihydr o-2H-6-pyranylbutanoic acid (2) and 3-((

16 eta-d-glucopy ranosyl)-beta-d-glucopyranosyl]oxy]-(3beta)-lanost-9(11)-en-24-one; 4-(2Z)-2-decen-1-yl

17 nthren-3-yl]o xy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol], an alkaloid iso

18 (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1, 3]oxazine (PA-824)

19 (2-(5-bromofuran-2-yl)-4-oxo-4H-chromen-3-yl)oxy)acetamide (CB7993113), was further tested for its ab

20 a non-natural substrate, benzaldehyde imino-oxy acetic acid (BIAA).

21 tor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859).

22 potent P2Y4R-selective N(4)-(3-phenylpropyl)oxy agonist was phenyl ring-substituted or replaced with

23 Employing a copper-catalyzed oxy-alkenylation strategy, a range of readily available,

24 icient strategy involving a copper-catalyzed oxy-alkynylation of diazo compounds with ethynylbenziodo

25 ped using the long-established principles of oxy-allyl cation chemistry.

26 tonation step to form an enantiodiscriminant oxy-allyl cation prior to the stereodefining nucleophili

27 alpha-Oxy amides are prepared through enantioselective synthes

28 Overall, this approach to alpha-oxy amides provides an innovative complement to alternat

29 acetoxybenzyl-based, 4-(5-(((4-acetoxybenzyl)oxy)amino)-2-carboxy-5-oxopentyl)benzoic acid, 12, provi

30 cts of medications containing oxymetazoline (OXY), an alpha1-adrenoceptor (AR) agonist of the imidazo

31 The potent N(4)-(3-(4-methoxyphenyl)-propyl)oxy analogue 19 (EC50: P2Y2R, 47 nM; P2Y4R, 23 nM) was f

32 ther, these results indicate that both the 3-oxy and 4'-benzylamide positions in (R)-1 can accommodat

33 n successfully applied to a variety of alpha-oxy and alpha-amino acids, as well as simple hydrocarbon

34 ic reactions of PAH lead to the formation of oxy and nitro derivatives, reviewed here, too.

35 The substrate specificities of OxyS and OxyR were shown to influence the relative ratio

36 Here we report two redox enzymes, OxyS and OxyR, are sufficient to convert 3 to 1.

37 ds, including hydrocarbon-substituted, alpha-oxy, and alpha-amino acids, provides a versatile CO2-ext

38 Our data indicate that RoxY, OxyS, and AhpD play a role in the mycobacterial oxidativ

39 166, we found that it encodes a repressor of oxyS, and therefore we have renamed the gene roxY.

40 ypes of regio- and enantioselective multiple oxy- and amino-functionalizations of terminal alkenes vi

41 In this context, oxy- and aminoalkynylation are especially important reac

42 ein, we report the first palladium-catalyzed oxy- and aminoalkynylation using aliphatic bromoalkynes,

43 A room-temperature intramolecular oxy- and aminoarylation of alkenes with aryldiazonium sa

44 t prediction of similar binding energies for oxy- and carbonmonoxymyoglobin.

45 te these results with measurements of tissue oxy- and deoxyhemoglobin concentration during oxygen dep

46 ut on an alert macaque demonstrate that both oxy- and deoxyhemoglobin concentrations in the frontal l

47 imaging of a targeted fluorescent agent and oxy- and deoxyhemoglobin gave functional information abo

48 scribed in detail the magnetic properties of oxy- and deoxyhemoglobin, as well as those of closely re

49 itrate and ferric ammonium citrate), against oxy- and met-hemoglobin erythrocytes used as controls.

50 a series of catecholic and non-catecholic 3-oxy- (and deoxy)-anthocyanidins.

51 ature survey showed surface complexation of (oxy)anions (As, B, and PO4) is consistently exothermic,

52 , and oxalic acids confirms the potential of oxy aromatics to produce light-absorbing aqueous seconda

53 ethyl 6-bromo-8-(4-((tert-butyldimethylsilyl)oxy)benzamido)-4-oxo-4H-chromene-2-carboxy late (19) wit

54 SHSAMs: ITO/IFL/poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][ 2-[[(2-eth

55 conducting PTB7 (poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluor o-2

56 ar-cell material poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro -2

57 cal to the double bond of 3-[(1-carboxyvinyl)oxy]benzoic acid.

58 lithiated (2S,2'S)-1,1'-(pentane-1,5-diylbis(oxy))bis(N-isopropyl-3-methylbutan-2-amine) 10 is a mono

59 e) 8, and (2S,2'S)-1,1'-(heptane-1,7-diylbis(oxy))bis(N-isopropyl-3-methylbutan-2-amine) 9 are dimers

60 including (2S,2'S)-1,1'-(butane-1,4-diylbis(oxy))bis(N-isopropylpropan-2-amine) 7, (2S,2'S)-1,1'-(pe

61 amine) 7, (2S,2'S)-1,1'-(pentane-1,5-diylbis(oxy))bis(N-isopropylpropan-2-amine) 8, and (2S,2'S)-1,1'

62 -[(Guanine-9H-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)}diphosphonic acid (compound 17) exhi

63 on prompts reaction with H2 to give a borane-oxy-borate derivative, the product of C-O bond cleavage.

64 ry and vas deferens are also desensitized by OXY, but not by NE or PE, indicating that this property

65 S)-N-isobutyl-3-methyl-1-((triisopropylsilyl)oxy)butan-2-amide forms both a 2:2 mixed aggregate and a

66 S)-N-isobutyl-3-methyl-1-((triisopropylsilyl)oxy)butan-2-amine and n-butyllithium are characterized b

67 nd the chlorine radical source for the alpha-oxy C(sp(3))-H arylation of cyclic and acyclic ethers.

68 -b']dithiophene-2,6-diyl][ 2-[[(2-ethylhexyl)oxy]carbonyl]-3-fluorothieno[3,4-b]thiophenediyl]]:pheny

69 -4-(trifluoromethyl-3H-diazirin-3-yl)ben zyl]oxy]carbonyl]nonanoyl]-sn-glycero-3-phosphocholine to th

70 -4-(trifluoromethyl-3H-diazirin-3-yl)ben zyl]oxy]carbonyl]nonanoyl]-sn-glycero-3-phosphocholine, the

71 y on the enantioselective synthesis of alpha-oxy carboxylic acids.

72 OxyS catalyzes two sequential hydroxylations at C6 and C

73 the effect of the gases present in a typical oxy-coal combustion atmosphere on mercury speciation and

74 s desulfurization (WFGD) plants, focusing on oxy-coal combustion processes and differences when compa

75 (eta(1)-ONO(2)) demonstrating the ability of oxy coboglobin models to promote the nitric oxide dioxyg

76 The oxy-cobolglobin models of the general formula (NH(3))Co(

77 It was found that in an oxy-combustion atmosphere (mostly CO2), the re-emission

78 rries obtained from two limestones, under an oxy-combustion atmosphere.

79 res with H2O vapor concentrations typical of oxy-combustion conditions.

80 The oxy-combustion mechanisms available in the literature ca

81 uantify SOx and NOx emissions from gas-phase oxy-combustion systems.

82 otonation and hence further reduction of the oxy complex to the hydroperoxy intermediate resulting in

83 In the Y257F-4NC-oxy complex, the O(2) is bound side-on to the Fe(II), wh

84 ize the active-site structure of the ferrous-oxy complexes of human (hIDO) and Shewanella oneidensis

85 Probing the oxy-complexes of CYP19A1 poised for hydroxylase and lyas

86 ak area reproducibility were obtained for 14 oxy-compounds present in trace amount in the complex bio

87 r, allowing a quantitative determination for OXY concentrations as low as 30ng/mL.

88 We demonstrate that RoxY and OxyS contribute to M. smegmatis resistance to oxidative

89 developed leading to selective [2,3]-Wittig-oxy-Cope and isomerization-Claisen rearrangements.

90 odocyclohexenone followed by methylation and oxy-Cope rearrangement delivered enantiomerically enrich

91 lation of a cyclic enone followed by anionic oxy-Cope rearrangement delivered the ketone as a mixture

92 that relies on a diastereoselective anionic oxy-Cope rearrangement to set the relative configuration

93 f a three-step sequence comprising a thermal oxy-Cope rearrangement, an iridium-catalyzed hydrogenati

94 amura's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and the Lewis acid-promoted cycl

95 formation, [2,3]-sigmatropic rearrangement, oxy-Cope rearrangement, enol-keto tautomerization and fi

96 f the synthesis include a diastereoselective oxy-Cope rearrangement/oxidation sequence to install the

97 tion and subsequent annealing of the ternary oxy-cytochrome P450scc-cholesterol complex.

98 -beta-d-xylopyra nosyl-beta-d-glucopyranosyl)oxy]-dammar-24-en-19-al; (3beta)-28-oxo-28-(phenylmethox

99 Extended N(4)-(3-arylpropyl)oxy derivatives of uridine-5'-triphosphate were synthesi

100 urther, although the rate of autoxidation of oxy-DHP is somewhat enhanced by the presence of TCP, the

101 the absence of TCP, H(2)O(2) alone converts oxy-DHP to an inactive state (compound RH) instead of ox

102 substrate and H(2)O(2) are needed to convert oxy-DHP to the catalytically active ferric state.

103 henol (TCP) brings about facile switching of oxy-DHP to the enzymatically active ferric state via a p

104 the catalytically inactive oxyferrous state (oxy-DHP), we find that the combination of H(2)O(2) and t

105 hyrinato zinc(II) 1 and 5-(2,5-phenylene-bis(oxy)diacetamide)-10,15,20-tris(triphenylamino)porphyrina

106 ed base (BB) catalysis and the use of alpha'-oxy enones as enabling Michael acceptors with ambivalent

107 ones, thiazolones, and azlactones) to alpha'-oxy enones can afford the corresponding tetrasubstituted

108 rophenyl) piperazin-1-yl)-2-((4-fluorobenzyl)oxy)-ethanone, or DPFE, demonstrates improved solubility

109 ithium (R)-N-(1-phenyl-2-((triisopropylsilyl)oxy)ethyl)propan-2-amide.

110 amine, (R)-N-(1-phenyl-2-((triisopropylsilyl)oxy)ethyl)propan-2-amine, or (S)-N-isobutyl-3-methyl-1-(

111 hydroxybenzoate (1), 2-2-[(4-hydroxybenzoyl)-oxy]-ethyl-4-methoxy-4-2-[(4-methylpentyl)oxy]-3,4-dihyd

112 Crystallography of oxy-F33Y-CuBMb reveals an extensive H-bond network invol

113 ort EPR spectroscopic studies of cryoreduced oxy-F33Y-CuBMb, a functional model of HCOs engineered in

114 ormation following binding to either met- or oxy(Fe(2+))-alpha.

115 accelerates the rate of decay of the ferrous-oxy/ferric-superoxo species in substrate turnover.

116 nd applied it to study the properties of the oxy-ferrous complex of a human membrane bound P450, CYP1

117 on submicrometer fly ash at higher levels in oxy-firing than in air-blown combustion.

118 This oxy form is found to react with monophenols, indicating

119 spF, we have generated and characterized the oxy form of its active site.

120 the oxidized met form but not in the reduced oxy form.

121 nd higher N2O formation were observed in the oxy-fuel atmosphere.

122 ab-scale in a relevant environment) and full oxy-fuel combustion (TRL 4 being the component and syste

123 oncentrations were considerably higher under oxy-fuel combustion compared to that in the air combusti

124 Oxy-fuel combustion conditions utilize an oxygen-enriche

125 n coal in a 10 kWth fluidized bed unit under oxy-fuel combustion conditions.

126 SO(2) and SO(3), is considerably high during oxy-fuel combustion even though the sulfur content in Mo

127 rities--typical of flue gas from natural gas oxy-fuel combustion processes--the measured dew point pr

128 Hg(2+) is similar regardless of whether CO2 (oxy-fuel combustion) or N2 (air combustion) are the main

129 erefore, for Morwell coal utilization during oxy-fuel combustion, additional sulfur removal, or polis

130 For application at cement plants, partial oxy-fuel combustion, amine scrubbing, and calcium loopin

131 nder three different atmospheres: pyrolysis, oxy-fuel combustion, and carbon dioxide gasification con

132 fur was found to be converted to SO(3) under oxy-fuel combustion, whereas SO(3) was undetectable duri

133 ion of those species was also assessed under oxy-fuel condition.

134 e boiler and CO2 separation units during the oxy-fuel fluidized-bed combustion using this coal.

135 d for the first time as means to evaluate an oxy-fuel power plant with CO(2) capture.

136 S(2) are the major species during pyrolysis, oxy-fuel, and gasification.

137 We report that SeO2 catalyzes the facile oxy-functionalization of (CO)5Re(I)-Me(delta-) with IO4(

138 This represents a new strategy for the oxy-functionalization of M-R(delta-) polarized bonds.

139 table catalyst for the selective, high yield oxy-functionalization of methane.

140 tituted pyrimidine derivatives armed with an oxy-functionalized acetate chain at the ring is describe

141 iyama-Michael reaction of 2-[(trimethylsilyl)oxy]furan with diverse alpha,beta-unsaturated ketones is

142 Thus, an extended N(4)-(3-arylpropyl)oxy group accessed a structurally permissive region on t

143 FM-300(V(IV)) shows CO2 bound side-on to the oxy group and sandwiched between two phenyl groups invol

144 pectroscopy data on solution and crystalline oxy-Hb indicate both geometric and electronic structure

145 ies, the electronic structure description of oxy-Hb remains elusive, with at least three different de

146 riptions are correct for the Fe-O2 center in oxy-Hb.

147 with triplet O2, forming diamagnetic (S = 0) oxy-Hb.

148 The [oxy-Hb] change during the sustained attention task (SAT)

149 We found that the [oxy-Hb] change during the verbal fluency task (VFT) was

150 Notably, [oxy-Hb] change in the left dorsolateral prefrontal corte

151 Our results suggest that [oxy-Hb] change in the prefrontal cortex during the susta

152 the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex.

153 eoxy), CO-inhibited (carboxy), and O2-bound (oxy) hemes in myoglobin (MB) and hemoglobin (HB) solutio

154 xide dioxygenation (NOD) reaction similar to oxy-hemes.

155 concentrations of deoxy-hemoglobin (ctHHb), oxy-hemoglobin (ctHbO2), water (ctH2O), lipid, and TOI (

156 lectronic structure of the Fe-O(2) center in oxy-hemoglobin and oxy-myoglobin is a long-standing issu

157 We describe an alternative oxy-hemoglobin assay that eliminates dithionite and sugg

158 The oxy-hemoglobin concentration change and the beta band po

159 A sharp increase of the oxy-hemoglobin concentration change, together with a dra

160 d (3S)-(15-methyl-3-((13-methyltetradecanoyl)oxy)hexadecanoyl)glycyl-l-serine, abbreviated as l-serin

161 indicated the contribution of reductive Mn (oxy)hydoxide dissolution with Mn eventually becoming a t

162 f calcium phosphate, calcium carbonate, iron(oxy)(hydr)oxide, silica, and also amino acids as an exam

163 hat is, the growth of a self-assembled metal oxy(hydroxide) active layer.

164 Layered (oxy) hydroxide minerals often possess out-of-plane hydro

165 and reactivity of floc amorphous Fe((III))-(oxy)hydroxide (FeOOH) phases under ice ([FeOOH](summer)

166 critical component of record-activity Ni/Fe (oxy)hydroxide (Ni(Fe)OxHy) oxygen evolution reaction (OE

167 rce of orthophosphate to WEOM-adsorbed iron (oxy)hydroxide AFM tips suggesting that the molecular mas

168 s TCE by Fe(II) associated with the Fe(III) (oxy)hydroxide coating is substantially slower than that

169 also lead to transformation of the Fe(III) (oxy)hydroxide coating to more crystalline phases, the ra

170 d a reference peat soil material to an iron (oxy)hydroxide mineral surface.

171 of dissolved organic matter (DOM) to metal (oxy)hydroxide mineral surfaces is a critical step for C

172 rganic matter (WEOM) for adsorption to iron (oxy)hydroxide mineral surfaces is an important factor in

173 ental ligands on the dissolution of Cr(III)-(oxy)hydroxide solids and associated Cr isotope fractiona

174 Iron (oxy)hydroxide solids in the shallowest sediments likely

175 be induced by biological reduction of iron (oxy)hydroxide solids.

176 nding force between orthophosphate and iron (oxy)hydroxide that was coated onto atomic force microsco

177 he phase transformation from amorphous iron (oxy)hydroxide to goethite, resulting in pyrite surface p

178 he aqueous AlAl12(7+) ion to solid aluminum (oxy)-hydroxide phases, we found that this ion lies close

179 The development of a single-phase Fe/Mn oxy-hydroxide (delta-Fe0.76Mn0.24OOH), highly efficient

180 r performance in comparison to the pure iron oxy-hydroxide (FeOOH) catalysts, originate from the bran

181 adsorption capacity for As(V) of a single Fe oxy-hydroxide combined with enhanced As(III) removal bas

182 According to this structuration, the oxy-hydroxide maintains the high adsorption capacity for

183 vior of the anodic peak for amorphous nickel oxy/hydroxide (a-NiOx) films in basic media was investig

184 t the ratio of ZnS and Zn associated with Fe oxy/hydroxide depended on the redox state and water cont

185 s are important as Fe-containing Co- and Ni-(oxy)hydroxides are the fastest OER catalysts known.

186 n of a family of thin-film transition metal (oxy)hydroxides as OER catalysts.

187 waters due to reductive dissolution of Fe/Mn(oxy)hydroxides below the SWI.

188 Moreover, we found selective removal of Fe (oxy)hydroxides by aggregation at increasing salinity, wh

189 thus became more coupled to that of the iron(oxy)hydroxides downstream in the circumneutral streams.

190 Cobalt oxides and (oxy)hydroxides have been widely studied as electrocataly

191 terest because of its formation from Fe(3+) (oxy)hydroxides via dissimilatory iron reduction.

192 xes and precipitated as nanoparticulate iron(oxy)hydroxides which aggregated as the pH increased, wit

193 arosite and other minerals (e.g., clays, Fe-(oxy)hydroxides).

194 M but at pH >4.5 became associated with iron(oxy)hydroxides, and its transport thus became more coupl

195 to the abundance of precipitated iron(III) (oxy)hydroxides, are hot spots for the removal and rediss

196 vestigated the stability of Cr(III)-Fe(III)-(oxy)hydroxides, common Cr(VI) remediation products, with

197 organically complexed Fe, and colloidal Fe (oxy)hydroxides, stabilized by surface interactions with

198 ral organic matter (NOM) and suspended iron (oxy)hydroxides.

199 rted over longer distances compared to iron (oxy)hydroxides.

200 Specifically, the Co-doped iron oxy-hydroxides (Co0.54Fe0.46OOH) show the excellent elec

201 d is employed to fabricate well-defined iron oxy-hydroxides and transitional metal doped iron oxy-hyd

202 hydroxides and transitional metal doped iron oxy-hydroxides nanomaterials, which show good catalytic

203 biosolids with iron, aluminum, and manganese oxy/hydroxides has been advocated as a key mechanism lim

204 pecies, ZnS, Zn3(PO4)2, and Zn associated Fe oxy/hydroxides, also regardless of the form of Zn added.

205 Overexpression of oxyS in M. smegmatis reduced transcription of the ahpCD

206 pyl)-4-(((4-methoxyphenyl)(methyl) carbamoyl)oxy)indolin-1-ium hydrochloride) with IC50s of 0.4 and 1

207 dney-293 cells that the low-efficacy agonist OXY induces G protein-coupled receptor kinase 2-dependen

208 ational spectroscopy reveals that a furfuryl-oxy intermediate forms on TiO(2) as a result of a charge

209 This furfuryl-oxy intermediate is a highly active and selective precur

210 In addition, the oxy intermediate of the reaction cycle of Y257F-4NC + O(

211 rface activate the formation of the furfuryl-oxy intermediate via an electron transfer to furfuraldeh

212 y NE or PE, indicating that this property of OXY is not limited to recombinant receptors expressed in

213 Experiments show that the alpha'-oxy ketone moiety plays a key role in the above realizat

214 4- methyl-1-oxo-2-[(1-oxopropyl)amino]pentyl]oxy]-L-leucyl-N,O-dimethyl-,(7-->1)-lac tone (9CI)}, a n

215 LC-MS(3) analysis of intact esterified oxy-lipids and LC-MS(2) analysis of the hydrolysis produ

216 both fatty acids and acylcarnitines bind to oxy-Mb in 1:1 stoichiometry.

217 eal that: (i) the lipid binding affinity for oxy-Mb increases as the chain length increases (i.e. C12

218 gether, our results support a model in which oxy-Mb is a novel regulator of long-chain acylcarnitine

219 This suggests that oxy-Mb may play an important role in fuel delivery in Mb

220 of both fatty acids and acylcarnitines with oxy-Mb using molecular dynamic simulations and isotherma

221 ) fail to achieve a stable conformation with oxy-Mb.

222 of either fatty acids or acylcarnitines with oxy-Mb.

223 og, we developed the bis((isopropoxycarbonyl)oxy)methyl ester prodrug (ACT-281959, 45).

224 tion was carried out on the N1-(p-iodobenzyl)oxy]methyl derivative of compound 5 using propagyl alcoh

225 e isonitrile N-(2-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonitrile.

226 ognition, and these are connected through an oxy-methylene linker to cross the GC.

227 The usage of a diastereoselective oxy-Michael addition/benzylidene acetal formation couple

228 ies, Hf(OTf)4 was used to convert the double oxy-Michael product 28 into C1-C19 building block 10.

229 An intramolecular oxy-Michael reaction under basic conditions was used to

230 Ferric-oxy multimers, tetramers, and/or larger mineral nuclei f

231 of the Fe-O(2) center in oxy-hemoglobin and oxy-myoglobin is a long-standing issue in the field of b

232 Naphthenic (CnH2n+zO2) and oxy-naphthenic (CnH2n+zOx) acids represented the largest

233 Four sRNAs, ArcZ, OmrA, OmrB and OxyS, negatively regulated and one sRNA, McaS, positivel

234 ox active form of the protein in contrast to oxy-NGB.

235 cotinamide core structure, 5-((3-amidobenzyl)oxy)nicotinamides offered excellent activity against SIR

236 Therefore, 5-((3-amidobenzyl)oxy)nicotinamides represent a new class of SIRT2 inhibit

237 ular anionic cyclization of (2-alkynylbenzyl)oxy nitriles has been developed for the preparation of s

238 (20 mol %) to a solution of (2-alkynylbenzyl)oxy nitriles in tetrahydrofuran at room temperature in a

239 We clearly demonstrate that the OxyS non-coding RNA does not trigger an RNAi response in

240 irectly test the hypothesis that the E. coli OxyS non-coding RNA triggers the C. elegans RNAi pathway

241 Recently, the E. coli OxyS non-coding RNA was shown to regulate gene expressio

242 al to those of oxy-tyrosinase indicates that oxy-NspF contains a Cu(2)O(2) core where peroxide is coo

243 (2alpha,3beta-2,3-bis((thiophene-2-carbonyl)oxy)olean-12-en-28-oic acid (2a) (IZ=24mm).

244 erivatives: (3beta)-3-((thiophene-2-carbonyl)oxy)-olean-12-en-28-oic acid (1a) (IZ=22mm) and (2alpha,

245 his approach was applied to oxytetracycline (OXY), one of the antibiotics frequently used in aquacult

246 s (PAHs), PAH derivatives (nitro- (NPAH) and oxy-(OPAH)), organic carbon (OC), and particulate matter

247 Here, using 3d-M hydr(oxy)oxides, with distinct stoichiometries and morphologi

248 Most significantly, in the oxy-P450cam complex Gly248 adopts a position midway betw

249 tion that the cryoreduced ternary complex of oxy-P450scc-CH is catalytically competent and hydroxylat

250 reveals that the distal pocket of the parent oxy-P450scc-cholesterol complex exhibits an efficient pr

251 OOD), and a coke oven (COKE), and to PAH and oxy-PAH containing fractions of these.

252 Our results indicate that oxy-PAH containing mixtures can be as potent Ahr activat

253 AH fraction of the WOOD extract and with the oxy-PAH fraction of the COKE extract.

254 pecies known to be hazardous to health (PAH, Oxy-PAH, N-PAH, transition metals) were significantly hi

255 sly for PAHs but here for the first time for oxy-PAHs and N-PACs.

256 The effects of oxy-PAHs are, however, poorly known.

257 e included in such a study, oxygenated-PAHs (oxy-PAHs) and nitrogen containing heterocyclic PACs (N-P

258 f more polar PACs including oxygenated PAHs (oxy-PAHs).

259 ossible contributions to the ground state of oxy-pfp.

260 The ester 4-((tosyl-l-alanyl)oxy)phenyl tosyl-l-alaninate (TAPTA) was synthesized and

261 aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)(3- fluoro-4-hydroxypyrrolidin-1-yl)methanone

262 T. cruzi and N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4-((4-methyl-1,4-diazepan-1-yl)sulf onyl)

263 gen, such as 4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-(4-((4-methyl-1,4-diazepan-1- yl)sul

264 omatic)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}urea were identified as potent and selective

265 When overexpressed, four sRNAs, including OxyS, previously shown to repress rpoS, were observed to

266 ithium (S)-N-isopropyl-1-((triisopropylsilyl)oxy)propan-2-amide forms mostly a 2:2 ladder-type mixed

267 d from (S)-N-isopropyl-1-((triisopropylsilyl)oxy)propan-2-amine, (R)-N-(1-phenyl-2-((triisopropylsily

268 l-N-phenyl-2-{[2-(pyridin-2-yl)quinolin-4-yl]oxy}propanamide (22a; rat Ki=0.10 nM; human TSPO genotyp

269 from N-methylpyridone to a tetrahydropyranyl oxy-pyridine derivative.

270 Our results show that the Oxy-R fraction accurately quantifies tumor hypoxia nonin

271 Finally, Oxy-R fraction can detect dynamic changes in hypoxia ind

272 Furthermore, we show that Oxy-R fraction can quantify the hypoxic fraction in mult

273 challenge (lack of positive DeltaR1, termed "Oxy-R fraction") would be a robust biomarker of hypoxia

274 way is the cleavage of peroxide to the alpha-oxy radical (likely catalyzed by Cu), which is computati

275 high-spin Mn(V)-oxo complex and not a Mn(IV)-oxy radical as the most oxidized species.

276 alpha-Oxy radicals generated from benzylic acetals, TMSCl, and

277 DA by VMAT2 increase levels of DA-generated oxy radicals ultimately resulting in degeneration of DAe

278 aneous retinopathy in senescence-accelerated OXYS rats, an animal model of age-related macular degene

279 We found that sRNAs (GlmZ, OxyS, RyhB and SgrS) have equal preference for the nucle

280 OXY shows functional selectivity relative to NE and PE a

281 ied introduction of larger moieties at the 3-oxy site in (R)-1 was offset, in part, by including unsa

282 all nonpolar, nonbulky substituents at the 3-oxy site provided compounds with pronounced seizure prot

283 vity relationship (SAR) for the compound's 3-oxy site.

284 ectively functionalize alpha-amino and alpha-oxy sp(3) C-H bonds in both cyclic and acyclic systems.

285 multiple conformations of the binary ferrous-oxy species of the IDOs.

286 2 catalyst indicate the presence of a crotyl-oxy surface intermediate.

287 with the [(2,2,6,6-tetramethylpiperidin-1-yl)oxy] (TEMPO) stable free radical.

288 cluding 97 different parent, alkyl-, nitro-, oxy-, thio-, chloro-, bromo-, and high molecular weight

289 inct steps: 1) initial oxidation of ferrous (oxy) to ferryl Hb; 2) autoreduction of the ferryl interm

290 Phylogenetic analysis of oxy-tryptophan dimerization gene homologs found within a

291 For oxy, two unpaired Fe(d) spins and, thus by definition, a

292 n of spectral features identical to those of oxy-tyrosinase indicates that oxy-NspF contains a Cu(2)O

293 oxocyclohexa-1,4-dien-1-yl)methylene]-N-meth oxy-undecanamide (E3330-amide), a novel uncharged deriva

294 roups tethered by a 1,4-phenylenebis(butyl-4-oxy) unit (the strap) and carrying a methylbenzoic ester

295 The crystal structure of OxyS was obtained to provide insights into the tandem C6

296 fold and quaternary structure to MtmOIV and OxyS, which are enzymes in the mithramycin and oxytetrac

297 o EPR signal, in contrast to the cryoreduced oxy-wild-type (WT) Mb, which is unable to deliver a prot

298 nvolving H2O molecules, which is absent from oxy-WTMb.

299 ort the use of bis(((difluoromethyl)sulfinyl)oxy)zinc (DFMS) as a source of CF2H radical for a rapid

300 ioselective, with preferential deposition of oxy-Zn(II) species within the small pores of NU-1000.