ライフサイエンスコーパス: osteophyte

1 s (IRF) scales (grades 0-3 for narrowing and osteophytes).

2 knees with a K/L score of 2 (i.e., definite osteophytes).

3 K/L) grade, joint space narrowing (JSN), and osteophytes.

4 teoclast recruitment to subchondral bone and osteophytes.

5 cular cartilage and in the abnormally formed osteophytes.

6 ith claw (P <.001) but not traction (P =.72) osteophytes.

7 OA as determined by the presence of definite osteophytes.

8 bone thickness, subchondral pseudocysts, and osteophytes.

9 ts as well as in the fibrocartilage covering osteophytes.

10 d with pain than were tomosynthesis-depicted osteophytes.

11 subchondral bone plate sclerosis and smaller osteophytes.

12 cartilage damage exhibited moderate to large osteophytes.

13 hich may be driven by the presence of spinal osteophytes.

14 sters, in middle and deep zone cells, and in osteophytes.

15 ting, eburnation, subchondral sclerosis, and osteophytes.

16 osteoarthritis (OA)-related JSN (OA-JSN) and osteophytes.

17 Of the 67 knees with large osteophytes, 54 (80.6%) exhibited severe cartilage damag

18 We found expression of active TGF beta in osteophytes, a prominent feature of the joint histology

19 by the presence of joint space narrowing or osteophytes alone produced similar results.

20 MR imaging depicted 171 osteophytes and 51 subchondral cysts.

21 sis is a key factor in new bone formation in osteophytes and at the osteochondral junction, thereby c

22 of JSW included markers associated with both osteophytes and BMD.

23 However, in most subjects, MRI revealed osteophytes and cartilage and bone marrow lesions in bot

24 s; disability was predicted by the number of osteophytes and depressive symptoms when pain and deform

25 elationship between both bone eburnation and osteophytes and generalized enthesophyte formation.

26 hs were graded on the presence or absence of osteophytes and joint space narrowing (JSN).

27 t RHOA phenotypes were defined as composite (osteophytes and joint space narrowing [JSN]), atrophic (

28 nimum joint space of < or = 1.5 mm, definite osteophytes and joint space narrowing, or > or = 3 radio

29 nd individual radiographic features, such as osteophytes and joint space narrowing, were scored from

30 nce (range, 0 to 4), and for the presence of osteophytes and joint-space narrowing (range, 0 to 3).

31 grade of >/=3, or both definite (score >/=2) osteophytes and JSN in the same hip.

32 Osteophytes and JSN were compared by Wilcoxon's signed r

33 grading of knee femoral articular cartilage, osteophytes and meniscal extrusion, and of radiographic

34 N were associated with increased severity of osteophytes and OA-JSN at baseline.

35 Presence of osteophytes and subchondral cysts in four locations of t

36 Tomosynthesis depicted more osteophytes and subchondral cysts than did radiography.

37 Subjects with tomosynthesis-depicted osteophytes and subchondral cysts were more likely to fe

38 Despite the presence of cartilage lesions, osteophytes and subchondral sclerosis were not observed

39 nts with knee OA (defined by the presence of osteophytes and symptoms) recruited from the community u

40 thirty-seven patients with knee OA (definite osteophytes and symptoms) underwent baseline gait observ

41 For the knee, only the PR for osteophytes and the adjusted mean number of knee joints

42 between findings using definitions based on osteophytes and those using definitions based on joint s

43 of both osteophytes (in particular, femoral osteophytes) and joint space narrowing would be recommen

44 int, there were no right-left differences in osteophytes, and for lone PF joint OA, there were no dif

45 10.8% for sclerosis, from 13.5% to 22.6% for osteophytes, and from 12.0% to 14.2% for bone mineral de

46 comes were 1) prevalence ratios (PRs) of OA, osteophytes, and joint space narrowing (JSN) per quartil

47 iographs were evaluated for global OA grade, osteophytes, and joint space narrowing (JSN).

48 luated included the Kellgren/Lawrence score, osteophytes, and joint space narrowing.

49 The PRs for OA, osteophytes, and JSN and adjusted mean number of joints

50 t space narrowing [JSN], presence/absence of osteophytes, and Kellgren/Lawrence [K/L] score).

51 the assessment of femoral medial and lateral osteophytes, and medial meniscal extrusion.

52 e OA was defined by the presence of definite osteophytes, and patients had to have at least a little

53 icular cartilage lesions, subchondral cysts, osteophytes, and synovial herniation pits was recorded.

54 hs were read by a single reader for anterior osteophytes (AO) and disc space narrowing (DSN) using th

55 Subchondral bone volume and osteophyte area were measured by histomorphometric analy

56 The prevalence of grade > or = 2 osteophytes assessed using the 2 IRF scales were similar

57 were strongly associated with eburnation and osteophytes at other joint sites not commonly thought to

58 ences, and was strongest for the presence of osteophytes at the TF joints (odds ratio [OR] 3.57, 95%

59 hough the tennis players tended to have more osteophytes at the TF joints and hip, but the runners ha

60 e in both age groups developed periarticular osteophytes at the tibial plateau in response to the 9.0

61 men who develop incident knee OA, defined by osteophytes, BMD is higher and of a magnitude similar to

62 The presence of osteophytes, bone sclerosis, and subchondral cysts and t

63 biochemical marker profiles associated with osteophytes compared with those associated with subchond

64 In situ hybridization in osteoclastoma and osteophyte confirmed that cathepsin K mRNA was highly ex

65 ssion analysis showed that both age and hand osteophytes contributed to the increase in baseline RA-J

66 the adjusted mean number of knee joints with osteophytes decreased significantly with increasing plas

67 s of articular cartilage, formation of large osteophytes, decreased production of proteoglycans, and

68 < or =1.5 mm, definite femoral or acetabular osteophytes, definite superolateral joint space narrowin

69 Tomosynthesis had a higher sensitivity for osteophyte detection in left and right lateral femur (0.

70 tosis at day 5, synovitis present at day 14, osteophytes, ectopic calcification, and meniscus patholo

71 interval [95% CI] 1.18-3.17, P = 0.009), new osteophyte formation (OR 1.70, 95% CI 1.03-2.88, P = 0.0

72 d twenty-one genes were associated with both osteophyte formation and cartilage damage in the STR/Ort

73 The age-dependent severity of osteophyte formation and extent of cartilage damage were

74 ere available for 353 knees without baseline osteophyte formation and for 446 knees without baseline

75 s based on individual radiographic features (osteophyte formation and joint space narrowing) supporte

76 The osteophyte formation appears to be derived from prolifer

77 Eburnation and osteophyte formation at the hand, hip, and knee were str

78 beta-catenin in disc cells led to extensive osteophyte formation in 3- and 6-month-old beta-catenin

79 graphic scores for joint space narrowing and osteophyte formation in the knee were also assessed.

80 and focal resorption of bone, together with osteophyte formation in the tibiotarsal joint.

81 ced MDSCs demonstrated better repair without osteophyte formation macroscopically and histologically

82 e, these factors might selectively influence osteophyte formation more than joint space narrowing.

83 plateau in response to the 9.0N load, but no osteophyte formation occurred in adult mice subjected to

84 s a change in joint space narrowing (JSN) or osteophyte formation of 1 grade according to a standardi

85 racteristic curve) but was not predictive of osteophyte formation or progression of JSN in the latera

86 cant inhibition of joint space narrowing and osteophyte formation was achieved in groups of animals t

87 , cartilage damage, synovial thickening, and osteophyte formation were measured histologically.

88 e, and the development of bony outgrowths or osteophyte formation within joint space.

89 e visually scored for joint space narrowing, osteophyte formation, and calcification of tendons.

90 ints, including articular cartilage lesions, osteophyte formation, and pathologic features, were exam

91 evidence of protection from bone resorption, osteophyte formation, and soft tissue swelling was appar

92 joints and neuromuscular function may cause osteophyte formation, but it has minimal, if any, effect

93 oglycans, collagen and aggrecan degradation, osteophyte formation, changes to subchondral bone archit

94 Loading also led to osteophyte formation, meniscal ossification, synovial hy

95 l joints, associated with varying degrees of osteophyte formation, subchondral bone change, and synov

96 tion of subchondral bone plate thickness and osteophyte formation.

97 resorption, on cartilage degradation and on osteophyte formation.

98 rarely occurred in the absence of associated osteophyte formation.

99 r ligament deterioration precedes or follows osteophyte formation.

100 here was a weak negative correlation between osteophyte grade and AP laxity.

101 aits (change over 10 years in the K/L score, osteophyte grade, and JSN grade), we found significant a

102 evidence of either joint space narrowing or osteophyte (grade 0, no structural changes).

103 ade>or=3), a summary grade>or=3, or definite osteophytes (grade>or=2) and JSN (grade>or=2) in the sam

104 space (odds ratio, 2.3 [Cl, 0.9 to 5.5]) and osteophyte growth (odds ratio, 3.1 [Cl, 1.3 to 7.5]).

105 also classified as having cartilage loss or osteophyte growth if their maximal joint space narrowing

106 th if their maximal joint space narrowing or osteophyte growth score increased by > or = 1 (range 0-3

107 Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a

108 include deformation of the femoral head and osteophyte growth, which are usually measured semiquanti

109 The 95 women with incident knee osteophytes had significantly higher baseline spine BMD

110 The hazard of incident knee osteophytes (HR 2.16 [95% CI 1.39-3.37]) and incident JS

111 rmore, ALN reduced the incidence and area of osteophytes in a dose-dependent manner.

112 itis was defined as the presence of definite osteophytes in at least 1 joint compartment of the index

113 6 +/- 9.6 y; BMI 27.8 +/- 4.8) with definite osteophytes in one knee (earlyROA, n = 32) and with ROA

114 The number of pairs concordant for definite osteophytes in the sample was too low to assess this fea

115 d definitions requiring the presence of both osteophytes (in particular, femoral osteophytes) and joi

116 imaging to identify disc space narrowing and osteophytes, in 5 population cohorts from Northern Europ

117 /Lawrence score and for individual features (osteophytes, joint space narrowing, and subchondral bone

118 graphs to determine the presence of marginal osteophytes, joint space narrowing, subchondral sclerosi

119 The sensitivity of marginal osteophytes, joint space narrowing, subchondral sclerosi

120 The specificity of marginal osteophytes, joint space narrowing, subchondral sclerosi

121 ally well in identification of tibio-femoral osteophytes, medial meniscal extrusion and medial femora

122 Subjects with tomosynthesis-depicted osteophytes (odds ratio, 4.2-6.4; P = .001-.011) and med

123 2 or medial JSN > or =3; 2) an IRF score for osteophytes of > or =2 in any location; or 3) a summary

124 radiologic OA (particularly the presence of osteophytes) of the knees and hips.

125 Osteophytes (OPH) and joint space narrowing (JSN) were a

126 essive OA (defined either by the presence of osteophytes or by joint space narrowing) and those with

127 was defined as being present when grade >/=1 osteophytes or grade >/=1 joint space narrowing was obse

128 ip OA defined as the development of definite osteophytes or new disease according to the summary grad

129 joints (OR 2.97, 95% CI 1.15-7.67), femoral osteophytes (OR 2.52, 95% CI 1.01-6.26), and hip joint n

130 pace narrowing [JSN]), atrophic (JSN without osteophytes), or osteophytic (femoral osteophytes withou

131 score, swollen joint count, and presence of osteophytes (osteoarthritis).

132 iochemical markers identifying patients with osteophytes overlapped with those correlated with a high

133 ul included endplate sclerosis and erosions, osteophytes, paraspinal soft-tissue mass, and decreased

134 Inclusion criteria were definite osteophyte presence (i.e., Kellgren/Lawrence radiographi

135 ifty-seven persons with knee OA (by definite osteophyte presence and symptoms) were evaluated.

136 ted weight loss, inflammation, or periosteal osteophyte production.

137 For the 33 women whose osteophytes progressed, no difference was seen compared

138 h and centroid position were associated with osteophyte progression (both P < 0.05).

139 N was highly correlated with the presence of osteophytes (r = 0.72).

140 were studied for evidence of eburnation and osteophytes, respectively, and the entire skeleton was e

141 dual radiographic features of OA (narrowing, osteophyte, sclerosis, and cysts) were graded, and an ov

142 Defects of cartilage, osteophytes, sclerosis, meniscal or ligamentous tears, j

143 with JSN score >/=3 and those with a femoral osteophyte score >/=2 and JSN score </=2.

144 2 (or when the JSN score was > or =2 and the osteophyte score was > or =1), and mixed OA when the kne

145 , patellofemoral OA on skyline view when the osteophyte score was > or =2 (or when the JSN score was

146 of radiographic findings, increase in total osteophyte score, decrease in MJS of > or =0.5 mm, total

147 were based on minimum joint space and total osteophyte score.

148 Osteophyte scores for the fingers were greater on the ri

149 ral compartment wider on the right side, and osteophyte scores were greater on the right side.

150 Immunolocalization in osteoclastoma and osteophyte showed intense punctate staining of cathepsin

151 tic bone lesions, subchondral sclerosis, and osteophyte size over periods of 6 weeks.

152 having severe cartilage damage according to osteophyte size were estimated using a logistic regressi

153 ge damage increased markedly with increasing osteophyte size.

154 s, including endplate sclerosis or erosions, osteophytes, spondylolisthesis, facet involvement (narro

155 with severe cartilage damage and concomitant osteophyte status were described.

156 e (P = .001); meniscal tears (P = .001); and osteophytes, subchondral cysts, sclerosis, joint effusio

157 fects of cartilage, bone marrow edema (BME), osteophytes, subchondral cysts, sclerosis, meniscal and/

158 Femoral osteophytes, superolateral JSN, and subchondral bone cha

159 The larger the osteophyte, the more likely was the presence of severe c

160 The size of osteophytes trended up with age, while the bone volume f

161 phic assessment of joint space narrowing and osteophytes, using MRI as a reference standard.

162 The presence of IDC, osteophytes, vertebral endplate abnormalities, and vacuu

163 was significantly higher, but the number of osteophytes was lower, in the ERT group compared with th

164 al sclerosis and the development of marginal osteophytes were also accurately represented.

165 Cartilage and osteophytes were assessed using the Whole-Organ Magnetic

166 Cartilaginous lesions and osteophytes were easily identified and were detected mor

167 Osteophytes were graded for each compartment, using a sc

168 A, and rheumatoid cartilage samples and from osteophytes were isolated, purified by gradient centrifu

169 However, radiography-depicted osteophytes were more strongly associated with pain than

170 Marginal osteophytes were the most sensitive radiographic feature

171 A, including articular cartilage lesions and osteophytes, were present in the medial tibial plateaus

172 8 weeks may be due to the maturation of the osteophytes which are thought to temporarily stabilize t

173 or beta (TGF beta) was expressed in marginal osteophytes, whose size and number were significantly in

174 do not suggest an association of early ROA (osteophytes) with cartilage composition, as assessed by

175 At baseline, 26% of patients had osteophytes, with a prevalence of 13% in the younger age

176 ithout osteophytes), or osteophytic (femoral osteophytes without JSN).

177 phenotype being defined as knees with large osteophytes (WORMS grade >/=5 on a 0-7 scale) but lackin

178 ng defined as knees with absent or only tiny osteophytes (WORMS grade </=2 on a 0-7 scale) in all 10