ライフサイエンスコーパス: open

1 approach (including procedures converted to open).

2 a depolarized conformation, and the pore is open.

3 he membrane deformation changes upon channel opening.

4 rmation by alamethicin or Ca(2+)-induced PTP opening.

5 ane ODH after thermal activation under O2 to open a cobalt coordination site and to oxidize Co(II) to

6 encourage undergraduate physics students to open a discussion on the fundamental assumptions in ther

7 These results open a new platform for the additive manufacturing techn

8 ient separation is the formation of Jupiter, opening a gap in the disk and preventing the exchange of

9 smoprotective emergency valve in bacteria by opening a large, water-filled pore in response to change

10 species co-occurs with other cuckoo species, opening a new avenue for standardized citizen science on

11 e used to identify drug-target interactions, opening a new research direction in target identificatio

12 a class of hybrid supramolecular composites, opening a window into fiber technology through low-energ

13 can readily be adapted to other species and opens a door to detailed investigations of inelastic or

14 This method opens a rapid access to gamma-substituted propyl-1,1-die

15 Our work opens a venue for the expansion of the classification of

16 re present in solution, where Dcp2 adopts an open, a closed, or a catalytically active state.

17 IMG/M allows open access interactive analysis of publicly available d

18 CTGU-5 which has coordinates water and more open access to the cobalt site has higher electrocatalyt

19 rated and made publicly available through an open access website.

20 egmentation phenotypes, which we share in an open-access annotated database.

21 p for substrate guidance and have an unusual open-access copper site, yet they can still react with s

22 l global plant predictions from a handful of open-access field measurements.

23 ort to enroll many participants to create an open-access repository of genome, health and trait data

24 ARTEMIS showing DNA-PKcs-independent hairpin opening activity.

25 The discovery of Neandertals at open-air sites during the late MP reinforces the view th

26 tion results in increased retro-Bergman ring opening, allowing C(1)-C(5) cyclization to become a comp

27 F56Bpa and F57Bpa KCNE1 were cross-linked in open and closed states, respectively, which suggests tha

28 sted by the U.S. government have fostered an open and collaborative environment for the development o

29 Participants had their eyes open and fixated on a point in the dark.

30 eve better outcomes, and explain why we need open and international discussions concerning a technolo

31 tumors (Siewert I), were randomized between open and MI esophagectomy with curative intent.

32 disease-free and overall 3-year survival for open and MI esophagectomy.

33 ing exocytotic fusion pores that can flicker open and shut multiple times.

34 ion of the nucleotide binding domains drives opening and closing of the MacB periplasmic domains via

35 n-sulfur cluster cofactors in reductive ring opening and hydroxy-group elimination.

36 uctural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template strand.

37 that indicate it is in equilibrium between "open" and "closed" conformational states.

38 culoplasty (SLT) as sole therapy for primary open-angle glaucoma (POAG) in an Afro-Caribbean populati

39 rine transporter inhibitor, in patients with open-angle glaucoma and ocular hypertension.

40 ent of patients with ocular hypertension and open-angle glaucoma.

41 The open aortic cohort comprised 16391 men (71.9%), had a me

42 ed in the study, 22836 (25.3%) had undergone open aortic surgery and 67467 (74.7%) had had infraingui

43 e codes were used to determine the either an open approach or a laparoscopic approach (including proc

44 verity of complications as compared with the open approach.

45 beginning of 2010 to 39 (71%) of 55 centres open at the end of 2014.

46 Cdt1 stabilizes MCM in a left-handed spiral open at the Mcm2-5 gate.

47 models, that will deepen our understanding, open avenues for research and provide an important refer

48 al coherence tomography (OCT) Bruch membrane opening (BMO) algorithm and stereoscopic optic disc phot

49 lution to the bryostatin supply problem also opens broad, facile, and efficient access to derivatives

50 higher open probability due to more frequent opening bursts.

51 lly controlled vascular gateway specifically opens by cleavage of NPY by CD26 signaling via NPY2 and

52 s a highly compact conformation in which its open Ca(2+)-activated C-lobe and closed N-lobe cooperate

53 and reducing multi-photon emission presented open challenges.

54 Importantly, we find that our open-channel model is consistent with the RyR1 and cardi

55 These motions result in a minimum open-channel pore radius of approximately 3 A formed by

56 sistent with the RyR1 and cardiac RyR (RyR2) open-channel structures reported while this paper was in

57 ered channel gating and current flow through open channels.

58 hat crossovers reside in genomic regions of "open chromatin", which were identified based on hypersen

59 ueisser limit, but they suffer from a larger open circuit voltage (VOC ) deficit than narrower bandga

60 The devices exhibit a high open circuit voltage of 1.08 +/- 0.01 V, attributed to t

61 We show the FEC condenses on the surface at open circuit voltage then is reduced to C-O containing p

62 electrochemical impedance analysis (EIS) and open-circuit potential decay transients (OCVD), which at

63 SAED, EDX, XPS, UV-visible spectroscopy, and open-circuit potential versus time experiments to unders

64 r-conversion-efficiency of 7.26% with a high open-circuit voltage of approximately 1 V and a striking

65 Thus, IOIC2-based OSCs show higher values in open-circuit voltage, short-circuit current density, fil

66 are beneficiaries undergoing laparoscopic or open colectomy between January 1, 2010, and December 31,

67 sence of calcium, are compacted but adopt an open conformation in the presence of calcium, enabling a

68 PK1 exhibits preferential binding toward the open conformation of vinculin, suggesting that the MAPK1

69 rganization requires the protein to adopt an open conformation that exposes the surfaces engaging in

70 post-chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP,

71 redoxin (Pdx), shows that P450cam adopts the open conformation.

72 The channel adopts an open conformation.

73 3-GK interaction, causing PSD-95 to adopt an open conformation.

74 thod and demonstrate pathways for the closed-open conformational transition in both directions by com

75 GMF induced two distinct open conformations of Arp2/3 complex, which correlated w

76 The ring-opening copolymerization of maleic anhydride and propyle

77 ed because the beta2 extension and headpiece opening could occur independently of the alphaI activati

78 ) or porous coordination polymers (PCPs) are open, crystalline supramolecular coordination architectu

79 METHODS AND In the OPEN CTO registry (Outcomes, Patient health status, and

80 A Bi(OTf)3-catalyzed ring-opening cyclization of (hetero)aryl cyclopropyl carbinol

81 ontrolled data sharing; or broad consent and open data sharing.

82 uxetics, using high-throughput computations, open databases, and efficient search algorithms.

83 mPTP opening decreases the mitochondrial membrane potential l

84 low cost and modular nature as well as fully open design of FlyPi make it a highly versatile tool in

85 k factors for adverse outcomes compared with open distal pancreatectomy (ODP).

86 Trabecular-iris angle (TIA), angle opening distance 500 mum from the scleral spur (AOD500),

87 aking roofs were repaired, windows screened, open eaves blocked with bricks and mortar, cement floors

88 experiment (metadata) is in the format of an open-ended, non-standardized textual description provide

89 ing the probability of L-Type Ca(2+) channel opening events.

90 Rearing animals in open-exchange cages permits the release of organic waste

91 ed interaction interface that results in the open "face-back" tunnel through the PD-L1 dimer.

92 Behavioral testing (handling and open field), continuous video-electroencephalographic (v

93 eneral increase in anxiety as measured in an open-field assay after intraperitoneal CGRP.

94 nd practical operation (ambient temperature, open flask, and undried solvents).

95 m complex was reused up to four cycles in an open-flask condition.

96 ere the aldol condensation, cyclopropyl ring opening followed by cyclization took place in a single-p

97 btained at different institutions and is now open for further validation in gliomas and other cerebra

98 est that as new regions of the genome become open for transcription during terminal differentiation,

99 e soft X-ray range with a laboratory source, opening, for example, the possibility of in-line or even

100 nstrated to control the thermal expansion in open-framework materials by adjusting the presence of gu

101 ry was most frequent (23 cases), followed by open globe injuries (8 cases).

102 l 3-year survival was 40.4% (SD 7.7%) in the open group versus 50.5% (SD 8%) in the minimally invasiv

103 This set-up was evaluated during open hepatic surgery.

104 that G100V/C103V retards initial fusion-pore opening, hinders its expansion and leads to premature cl

105 can pass directly through the endothelium by opening holes in endothelial cells, known as transcellul

106 These compounds crystallize to form robust open hydrogen-bonded networks with parallel indenofluore

107 tend our understanding of human CSF flux and open important clinical implications, including concepts

108 t changes and of circadian-mediated stomatal opening in constant light.

109 demonstrate that the mechanisms of pore gate-opening-induced and relaxation-induced voltage-sensor st

110 Here, we posit that open-innovation approaches are more successful when they

111 surgery at all US centers including our own (open kidney transplant).

112 controlled study involving 186 patients; an open label extension study performed after the phase 3.

113 isense oligonucleotide targeting exon 51: an open label study including 12 patients; a phase 3 random

114 lic blood pressure (130-149mmHg vs <130mmHg; open label) and to antiplatelet treatment (aspirin/clopi

115 Part B of these randomised, phase 2, open-label clinical trials enrolled individuals from 15

116 e open-label phase (-126.3 minutes at 1-year open-label end point).

117 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3).

118 Phase IV, multicenter, open-label extension study.

119 Both groups could receive open-label LAI for 84 additional days.

120 e frequently with cumulative exposure during open-label observation.

121 -time reduction was sustained throughout the open-label phase (-126.3 minutes at 1-year open-label en

122 SABRINA is a two-stage, randomised, open-label phase 3 study at 113 centres in 30 countries.

123 We conducted a single-arm, open-label study in which 15 virologically suppressed HI

124 ere randomly assigned (2:1) to switch to the open-label study regimen or continue the control regimen

125 ontrolled study for 16 weeks, followed by an open-label study with overall 40-week DHA treatment.

126 We conducted an open-label trial to evaluate the safety, tolerability, a

127 In this randomised, phase 3, open-label trial, patients were screened for eligibility

128 In this single-arm, open-label trial, we enrolled virologically suppressed,

129 gmatic, multicenter, randomized, controlled, open-label trials with blinded outcome evaluation: the P

130 n HIV-1 infected individuals (SWIFT-C) is an open-label, 2-cohort clinical trial in which the first c

131 he final analysis from GATSBY, a randomised, open-label, adaptive, phase 2/3 study, done at 107 centr

132 er, parallel-group, prospective, randomized, open-label, blinded end point trial, consenting patients

133 d an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants

134 is multicentre, parallel group, superiority, open-label, blinded-endpoint, randomised controlled tria

135 We did a phase 4, open-label, cluster randomised trial of 22 communities i

136 This was a phase 1, open-label, dose-escalating study done at four outpatien

137 ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomi

138 We did this single-arm, open-label, multicentre phase 3 study at 40 sites in Bel

139 In this ongoing, multicentre, open-label, phase 2 trial, we enrolled adults (aged >/=1

140 ACCL0431 was a multicentre, randomised, open-label, phase 3 trial that enrolled participants at

141 In this open-label, phase 3, multicentre, international study, a

142 Patients and Methods In this multicenter, open-label, phase III trial, 2,012 women with early TOP2

143 In this international, open-label, randomised, phase 3, multicentre trial, we e

144 on, we conducted a prospective, multicenter, open-label, randomized phase III trial that compared a b

145 We did a phase 2, open-label, single-arm study at six centres (hospitals a

146 Prospective open-label, unilateral single-dose, intravitreal injecti

147 evant included the repeated use of caves and open landscape sites.

148 The overall rate of conversion to open laparotomy was 10.1%: 19 of 236 patients (8.1%) in

149 over 18 years of age scheduled for elective open lobectomy or bilobectomy for malignancy were eligib

150 andom order: hyperinflation, 6 cm H2O above; open lung approach, 2 cm H2O above; and collapse, 6 cm H

151 bution of grafts in polymers via living ring-opening metathesis polymerization (ROMP).

152 ckpoint is the conformational conversion of "open" mitotic arrest deficient 2 (O-MAD2) into "closed"

153 Using a constitutively open mutant of ENaC, we demonstrate that the augmentatio

154 pericardial resection in normal canines with open (n=3) and closed chest (n=5) and in a pig model wit

155 tructures of nanoclusters and is expected to open new avenues for designing nanoclusters with novel s

156 imaging using (89)Zr-Df-ALT-836 promises to open new avenues for improving future diagnosis, stratif

157 This may open new avenues for the study of ion pumps and similar

158 eir chemical versatility for adaptation will open new opportunities for applications built upon diver

159 e cell-cell communication structure - it may open new opportunities for identifying molecular signatu

160 The properties of graphene open new opportunities for the fabrication of composites

161 These findings open new possibilities to measure maximal absolute coron

162 These findings could open new research avenues to help design chronopharmacol

163 These insights open new vistas on the neural basis of social behavior a

164 nvironment in planar chromatography but also opened new avenues and new perspectives for tailor-made

165 (TMDs) as atomically thin semiconductors has opened new frontiers in semiconductor heterostructures e

166 Recent advances in optogenetics have opened new routes to drug discovery, particularly in neu

167 n via altering its charge distribution, thus opening new possible roles for betaS in Parkinson's and

168 Our design approach opens new avenues for optically controlling enzyme funct

169 This opens new avenues for the exploration of adaptation of m

170 e machines recently introduced in the market opens new expectations in the field of espresso brewing.

171 ence of empirical and computational advances opens new frontiers of scientific inquiry, including net

172 This study opens new opportunities for understanding the mechanisti

173 Our work opens new perspectives for PAM in biomedical sciences.Ph

174 d functions of differentiated cell types and opens new research avenues into epithelial trafficking.

175 printing of functional materials and devices opens new routes for the biointegration of various senso

176 isrupted regulatory metal coordination in an open non-DNA-binding conformation.

177 on of the vocal behaviour of penguins in the open ocean and discuss the function of their vocal commu

178 doles via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having subs

179 butadiene with ethylene, electrocyclic ring-opening of cyclobutene, electrocyclic ring-closing of Z-

180 ient low-cost method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH

181 structural changes occur in the ATP-induced opening of Hsp70 to allow substrate exchange.

182 chable following the reversible ring closure/opening of the central dithienylethene via irradiation w

183 epressive disorder were randomly assigned to open or placebo-controlled citalopram treatment.

184 tula, has yet to be adequately compared with open pancreatoduodenectomy (OPD).

185 pensity score-matched analysis of robotic vs open pancreatoduodenectomy to date, and it demonstrates

186 S. admonitor trees to paternity in seed from open-pollinated flowers of S. subcuneata decreased rapid

187 d reduced Ca(2+) sensitivity, single-channel open probability and tamoxifen sensitivity.

188 .1 in giant liposomes, resulting in a higher open probability due to more frequent opening bursts.

189 mistry, a novel C-N bond activation and ring-opening process is described for these increasingly impo

190 National examination of open proctectomy (OP), laparoscopic proctectomy (LP), an

191 an experimentally study phase transitions of open quantum systems.

192 arbon nanotubes (CNTs) has been an important open question since the first reports of the strong modu

193 triggers metabolon formation has remained an open question.

194 llite subsequently inserts into the NE is an open question.

195 ick required for error-prone synthesis is an open question.

196 al stimuli and simplified behaviors, leaving open questions about nervous system function in the cont

197 ll also point out some of the most important open questions in the field and emerging evidence sugges

198 Our analysis of the key uncertainties and open questions of and beyond the inventory shows that, a

199 Finally, we discuss major challenges and open questions related to the application of SERS for un

200 domonas, and Stentor coeruleus Although many open questions remain, elucidating how cells repair them

201 bserved tonic signaling heterogeneity remain open questions today.

202 rgy funnel", the carotenoids still pose many open questions.

203 mide is unprotected, the characteristic ring-opening reaction is completely silenced, which explains

204 which explains that the majority of the ring-opening reactions reported in the literature invoke N-al

205 P24), angiopoietin 4 (ANGPT4), chromosome 11 open reading frame (C11orf30/EMSY), and exocyst complex

206 The nonclassical open reading frame in the FCGR2C gene (FCGR2C.nc-ORF) wa

207 ransmembrane protease, serine 2) gene to the open reading frame of ERG, encoding an ETS family transc

208 on enhancing factor (PTEF) relieves upstream open reading frame repression and thereby facilitates VA

209 s operational when combined with an upstream open reading frame.

210 Ribo-TISH can also predict novel open reading frames (ORFs) from regular ribosome profili

211 iversity leading to the formation of altered open reading frames (ORFs) that appear to be under relax

212 s responsible for modulating myocardial mPTP opening remain unclear.

213 ation where the DNA enters the pore from the open reservoir.

214 An open scanner design may potentially improve tolerance of

215 ication of nanoparticle-based drug delivery, opening several exciting avenues for selective and prolo

216 Measuring the opening shape of the epidermal actin cortex after laser

217 Mindboggle is an open source brain morphometry platform that takes in pre

218 It is released under an Open source MIT license.

219 Here, we present an open source R package 'twoddpcr', which uses Poisson sta

220 lipidomics, we developed LipidHunter, a new open source software for the high-throughput identificat

221 they produce for data analysis and modeling open source, and are actively encouraging their colleagu

222 k-loop mode, and are highly customizable and open source.

223 oduce analytical chemists who are new to the open-source movement to best practices and concepts in t

224 epts in this area and to survey the state of open-source research in analytical chemistry.

225 ation in single particle cryo-EM and present open-source software for rapidly assessing orientation d

226 rowing need for a user-friendly, extensible, open-source solution for digital pathology and whole sli

227 We provide an open-source tool, xiFDR, that implements our observation

228 Here we present PLUMED-ISDB, an open-source, freely-available module of the popular PLUM

229 ed within 100 m of each location when it was open (spatiotemporal coverage) for Toronto overall and d

230 Failure of this closure process leads to open spina bifida, a common cause of severe neurologic d

231 nel lymph node mapping were performed during open standard oncological resection.

232 sted that F56Bpa interacts with KCNQ1 in the open state, whereas F57Bpa interacts predominantly in re

233 ity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I su

234 The SGC plants showed a loss of ability to open stomata in anticipation of daily dark-to-light chan

235 -cost surface microfluidic mixing devices on open substrates.

236 chnique (RKT) versus patients performed with open surgery at all US centers including our own (open k

237 Nonetheless, in 2012, open surgery still remained the preferred surgical treat

238 However, compared with open surgery, laparoscopic surgery imposes greater ergon

239 prohibitive surgical risk and, therefore, an open surgical procedure may not be feasible or appropria

240 N-terminal acidic region of Ng peptide pries open the beta-sheet structure between the Ca(2+) binding

241 Approaches such as those presented here may open the door for accurately determining intermolecular

242 amino acid at POmega, which enabled them to open the F pocket and expose their C-terminal extension

243 This metabolic imbalance may open the therapeutic window for challenge with metabolic

244 nterferometer Gravitational-wave Observatory opened the door to alternative probes of stellar and gal

245 These data have opened the window to a diverse array of novel targets wh

246 ins are targetable by dietary interventions, opening the avenue to a precision intervention for patie

247 y is possible in other chalcogenide spinels, opening the door for the realization of other magnesium

248 observation of Bi-B double and triple bonds, opening the door to design main-group metal-boron comple

249 gahertz response of metallic nanostructures, opening the door to new optomechanical device strategies

250 timulates a depolarizing chloride current by opening the olfactory Ca(2+)-activated chloride channel

251 ins similar antigenicity to wild-type virus, opening the possibility for its use as a live-attenuated

252 human biomonitoring at the community scale, opening the possibility to assess population-wide exposu

253 veral orthogonal split intein pairs, thereby opening the way to the creation of multiplexed sensor sy

254 This work opens the door to a detailed atomistic understanding of

255 ther optically/IR-transparent organisms, and opens the door to high-resolution systematic analyses of

256 The sequenced genome opens the door to molecular analysis of single-cell rege

257 nd mannose without triggering allostery that opens the lectin/EGF domain hinge.

258 This opens the possibility for further studies of NSs and pot

259 to easily label pericytes in any mouse model opens the possibility of a broad range of investigations

260 Our work opens the way for the systematic study of temporal multi

261 When channels open, the tip links relax, reducing the hair-bundle stif

262 as been shown to promote CNG and HCN channel opening, the precise mechanism underlying gating remains

263 Modulation of flap opening through protease-Gag interactions fine-tunes the

264 ong shut times and a robust increase in mean open time.

265 g reaction is performed at room temperature, open to atmosphere, and without the need to rigorously e

266 ince the mid-1980s, but the term survivor is open to debate by people living with cancer and those ca

267 ticenter, phase 3, randomized clinical trial open to patients with biopsy-proven carcinoma of the eso

268 s left important aspects of ancient exchange open to speculation.

269 of related diols that were oxidatively ring-opened to afford cyclopentane dialdehydes.

270 peak twisting and untwisting at mitral valve opening (%untwMVO) using speckle-tracking echocardiograp

271 sound in one simple electronic device would open up a new world in acoustics.

272 on the in vivo transport of ultrasmall AuNPs open up a pathway to maximize their biomedical potential

273 This finding may open up an avenue to control Majorana fermions for imple

274 Such remote-controlled, smart films may open up new application possibilities in soft robotics a

275 large scale quantum information systems and open up new avenues for the design of artificial 2D mate

276 Moreover, they open up new avenues for the study of dynamic neurophysio

277 e detection of short RNA regions which could open up new opportunities in transcriptome analysis, vir

278 ree characterization of nanoscale structures open up new possibilities for assembly and control of na

279 These findings open up promising avenues in the design of a new generat

280 biological knowledge graph, and will thereby open up the increasing amount of Semantic Web based know

281 Together these tools open up the potential for automated analysis of this nat

282 y promising photonics-based chemical sensing opened up by the new guest@MOF composite systems is show

283 as revolutionized prenatal care globally and opened up new prospects for personalized medicine for th

284 In addition to opening up in meso crystallization to a broader range of

285 quids to afford permanent porosity, and thus opens up a new approach to prepare porous carbon liquids

286 of-plane field in thick magnetic multilayers opens up a new set of tools and materials to study the p

287 tatetraenyl via a single-collision event and opens up a versatile, unconventional path to access this

288 This tool opens up a wide range of possible studies to quantitativ

289 This development opens up avenues for pulse sequence design and lays a fo

290 This opens up new perspectives for the use of antioxidant tre

291 oping control of structural phase transition opens up new possibilities for developing phase-change d

292 The SCB model opens up opportunities to assess interactions of SCs wit

293 , by comparing the association of MAPK1 with open versus closed vinculin, we demonstrate that MAPK1 e

294 of kiri-kirgami, and their actuation of pore opening via both mechanical stretching and temperature,

295 An open water species displayed no response to DMS.

296 Notably, the overall radiative forcing of open-water fluxes (3.5 +/- 0.3 kg CO2 -eq m(-2) yr(-1) )

297 circadian-mediated anticipation in stomatal opening, we have generated SGC (specifically guard cell)

298 om closed with its orifice fully occluded to open with an orifice of approximately 10 A.

299 r approximately 200 kinases by (1) combining open with proprietary data, (2) choosing Random Forest o

300 terventional procedure consisting of fissure opening with linear cutting staplers buttressed with pai

301 nformations, one of which is most likely the open-X structure which has unpaired bases at the junctio