ライフサイエンスコーパス: necessitate

1 Marked BPE does not necessitate a BI-RADS 3 assessment.

2 Furthermore, the patterns observed necessitate a degree of selection driven by the introduc

3 These findings thus necessitate a fundamental change in our conception of th

4 Unavoidable imperfections necessitate a means to improve remote entanglement by lo

5 We demonstrate how these limitations necessitate a new, integrated analytical approach to pne

6 These findings necessitate a re-investigation of the nature of charge o

7 The data necessitate a reformulation of the dominant textbook def

8 Our findings now necessitate a shift in thinking about the biological imp

9 This has generally necessitated a switch to new drugs and the discontinuati

10 ejection 56 days after transplantation which necessitated a transplantectomy.

11 lds most of the polycyclic architecture, but necessitates a challenging C-H functionalization, which

12 the role of immune dysregulation in ASD thus necessitates a deeper understanding of the interaction b

13 ed with marked inter-individual variability, necessitates a deeper understanding of the relationship

14 ies both in basic and translational research necessitates a method that can be applied to a wide rang

15 of novel therapeutics against these bacteria necessitates a molecular level understanding of the stru

16 same dynamics as the conservative tracer and necessitates a more stochastic framework for modeling eD

17 agement of patients is often challenging and necessitates a multidisciplinary approach.

18 Ultimately, conserving many of these species necessitates a paradigm shift in conservation toward a h

19 ecialised architecture of neuronal processes necessitates a properly regulated transport network of m

20 spatial location while making eye-movements necessitates a rapid, saccade-synchronized shift of atte

21 duation limits infants' numerical skills and necessitates a reliance on continuous magnitudes.

22 Their abrupt nature necessitates a similarly short-lived trigger, and large

23 hese novel compounds for chronic hepatitis B necessitates a standardized appraisal of the efficacy an

24 create an efficient thermoelectric material necessitates a thorough understanding of the relationshi

25 efined as worsening disease-related symptoms necessitating a change in anticancer therapy and/or dete

26 erentially regulated by individual isoforms, necessitating a deeper understanding of how the distinct

27 an also be costly when deployed excessively, necessitating a mechanism that regulates control engagem

28 ia two obligate intermediates, NH2OH and NO, necessitating a mediator of the third enzymatic step.

29 ng as potential barriers to viral infection, necessitating a more thorough understanding of their bas

30 ins more of the highly cell-permeable H2CO3, necessitating a substantial expenditure of energy on tra

31 lack defined DNA methylation patterns, thus necessitating a systematic re-evaluation of the mosquito

32 dications is limited by its short half-life, necessitating a three times daily dosing regimen.

33 e, size, and extent of the vascular anomaly, necessitating accurate diagnosis and classification.

34 dynamics and parasitic lifecycles, however, necessitate additional implementation research with more

35 y explained by the lack of synaptic cues but necessitates additional proteins to prevent spontaneous

36 ence of a multitude of resistance mechanisms necessitates administering drugs in combination, signifi

37 l technique failure increases significantly, necessitating advanced retrieval techniques to maintain

38 n the emergence of antimicrobial resistance, necessitating alternative treatment options.

39 mptoms related to neurological deterioration necessitate an appropriate and early palliative care app

40 However, these have limitations which necessitate an improved approach.

41 standardized management paradigms and which necessitate an individualized approach to treatment.

42 resources and the gravity of resulting harms necessitate an investigation of drivers to inform potent

43 pact on quality of life associated with FBDs necessitate an urgent need for improved understanding of

44 ermal conductance has been challenging as it necessitated an accurate measurement of very small tempe

45 ully duplicated before dissociation but also necessitates an active displacement mechanism for polyme

46 application of nanomaterials in biosciences necessitates an in-depth understanding of how they inter

47 further contributes to disease severity and necessitates an increase in maintenance corticosteroids.

48 cellular lifestyle of apicomplexan parasites necessitates an invasive phase underpinned by timely and

49 ased definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset

50 coronary artery abnormalities is essential, necessitating an increased frequency of assessments and

51 mage, viewed directly via a stereoendoscope, necessitating an uncomfortable operating position.

52 Influenza viruses mutate rapidly, necessitating annual vaccine reformulation because tradi

53 opaque or physically inaccessible contexts, necessitating approaches other than direct imaging.

54 Thus, management decisions necessitate assessment of the individual risks for patie

55 nclusion criteria of these trials, our study necessitated at trial entry the presence of two distinct

56 Typically, multiplex platforms necessitate bath application of antibody cocktails, incr

57 achieved by consecutive lytic cycles, which necessitates biogenesis of significant energy and biomas

58 The rapid increase in sequenced genomes necessitates bioinformatics tools for finding gene clust

59 bable consequence of functional optimization necessitated by genomic reductions during the evolution

60 This adaptive mechanism is necessitated by increased PI4KA levels in Huh7 cells com

61 This is coupled with a high anabolic demand, necessitated by the diurnal turnover of a specialized me

62 ment at maximal speed, a feature that may be necessitated by the dynamic nature of Plasmodium actin f

63 In fMRI, this is necessitated by the fact that time resolution of a BOLD

64 em cells (FSCs) in the Drosophila germarium, necessitating careful control of signal generation, rang

65 d process requires a functional pool of SVs, necessitating cellular mechanisms for removing old or da

66 esentation and outcomes of patients with ICU-necessitating cellulitis and to compare them with patien

67 lities arising from the native RNA structure necessitate chemical modification for drug development.

68 rapid evolution of influenza A(H3N2) viruses necessitates close monitoring of their antigenic propert

69 anobacteria CO2-concentrating mechanism will necessitate co-introduction of the ancillary molecular c

70 sting whether this holds for all sea urchins necessitates comparative analyses of echinoid taxa that

71 ting and copolymerization/physical blending, necessitate compromise among nonfouling properties, dura

72 t-exposed in crystal structures of PLC-beta, necessitating conformational rearrangement to allow Gbet

73 Situations that ordinarily necessitate consideration of anticoagulation, such as ar

74 nuclear DNA has been found in cancer cells, necessitating consideration of these complex interaction

75 Influenza viruses mutate frequently, necessitating constant updates of vaccine viruses.

76 neutrophilic responses to fungal infections necessitate contact with the extracellular matrix (ECM).

77 hat reliably reduces the production of VEGF, necessitating continued neutralization by repeated intra

78 to exhibit genetic diversity in avian hosts, necessitating continuous efforts to monitor their pandem

79 ental factors associated with adulthood that necessitate control of lung ventilation.

80 Many animal bodies are inherently unstable, necessitating corrective locomotion to maintain stabilit

81 transduced into diverse functional outcomes necessitates correlated measurements at various stages.

82 rops daily, and/or recalcitrant inflammation necessitating corticosteroid-sparing immunosuppressive t

83 This situation would necessitate daily cycles of embolism repair to restore h

84 ) or mass spectrometry is time-consuming and necessitates databases of pre-existing structures for st

85 rom the VO-only group developed an infection necessitating DBS explantation, and was excluded from th

86 examining mechanical force generation either necessitate dedicated equipment or limit themselves to c

87 In many countries, the addition of IPV would necessitate delivery of multiple injectable vaccines (he

88 Implementation of these new models will necessitate delivery system transformation and will acti

89 ous (IV) iron for treatment of anemia in CKD necessitate development of safer therapies.

90 availability of genome-wide interaction data necessitates development of analytical methods to recove

91 sed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective a

92 h can lead to inflammatory tissue responses, necessitating development of minimally invasive approach

93 CI, 3.41-26.18; P < .001), new renal failure necessitating dialysis (OR, 14.48; 95% CI, 3.69-56.86; P

94 eans to perform association analyses without necessitating direct access to individual-level control

95 domonas aeruginosa was initiated, the former necessitating discontinuation of rifampicin.

96 lectronics, and hybrid and electric vehicles necessitates discovery of new lithium resources to meet

97 This necessitates early diagnosis and treatment.

98 odstuff can occur at very low concentrations necessitating early availability of sensitive and reliab

99 ering applications is rapidly increasing but necessitates efficacy and safety testing prior to clinic

100 regarding the diagnosis of tree-nut allergy, necessitating either their elimination or the performanc

101 nscriptionally inert PIC intermediate, which necessitates energy expenditure to complete the process.

102 coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure.

103 nesis and drug-resistant epilepsy in humans, necessitating evaluation in larger-scale prospective stu

104 atient-centered strategies and interventions necessitate evidence about patients' decision-making pro

105 Cell growth necessitates extensive membrane remodeling events includ

106 We demonstrate that this behavior necessitates full-length tandem G3T monomers directly co

107 atory adaptation is the most crucial change, necessitating functional adaptations of the gills, kidne

108 Incidental findings at brain MR imaging that necessitate further diagnostic evaluation occur in over

109 d interactions in HWF compared to IWG doughs necessitate further investigation to establish their imp

110 light harvesting and charge collection have necessitated further advances in photoelectrode design.

111 subphylum of Dikarya) sparked curiosity but necessitated further efforts to obtain appropriate refer

112 ular structures has become a bottleneck that necessitates further algorithmic improvements and develo

113 es with high spatial and temporal complexity necessitates further joint development of light-delivery

114 This necessitates further understanding of how T follicular h

115 cer care in a sustainable health system will necessitate future oncologists, investigators, and polic

116 The familial pattern noted in this report necessitates future studies to investigate the role of g

117 capacity to consciously process information, necessitating gating of information.

118 st have large brains, and (iii) large brains necessitate having even more altricial offspring.

119 TTLBs (17.1%); five of the 1175 TTLBs (0.4%) necessitated hemorrhage-related admission.

120 ed for human confidence in our tasks without necessitating heuristic operations.

121 rived cardiomyocytes and other biologics all necessitate high-throughput (HT), cellular-level electro

122 tion steps, and RNA fragmentation, which can necessitate higher levels of starting RNA, increase expe

123 Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain te

124 Serious adverse reactions necessitating hospitalisation occurred in 33 infants (16

125 TCR binding necessitates hot-spot burial, yielding high energetic pe

126 Progressive decline in neurological function necessitated immunotherapy cessation and allograft remov

127 ries of some species of Pacific salmon could necessitate imprinting prior to the PST.

128 ntly relapses after complete remission (CR), necessitating improved detection and phenotypic characte

129 nd slow kinetics of this primitive electrode necessitated improvements.

130 hich O2 serves as a chemical oxidant without necessitating incorporation of oxygen into reaction prod

131 nd and cardiomyocyte size during hypertrophy necessitate increased fuel and oxygen delivery and stimu

132 ether results in decreased reactivity, which necessitated increased temperatures for reaction to occu

133 plemented, legacy contamination will remain, necessitating increased awareness of e-waste as a major

134 e their preparation a substantial challenge, necessitating innovative chemical solutions.

135 sting is prevalent in many chronic diseases, necessitating inquiries into molecular regulation of mus

136 social sustainability because sustainability necessitates integrating environmental, economic, and so

137 -influenza Abs, regardless of their epitope, necessitates interactions with FcgammaRs on effector cel

138 ize severe sepsis care, an approach that may necessitate interhospital patient transfers.

139 d outer chloroplast envelopes, respectively, necessitating intermembrane lipid transfer.

140 er, rigorous quantification of these effects necessitates interrogating longitudinal data on macrofil

141 nt experienced abdominal cramps and diarrhea necessitating interruption of brincidofovir and none dev

142 e dose related, and are transient and rarely necessitate intervention.

143 ented hemoptysis, and bleeding complications necessitating intervention.

144 and that ERT for metabolic diseases may not necessitate introduction of the deficient enzyme into it

145 Such a critical innate immune function necessitates ion participation.

146 2000 bp) surrounding each genome edit, which necessitates laborious in vitro DNA splicing.

147 , such as respiratory tract infections, this necessitates large panels of tests and has limited yield

148 e, the H3K36me3-mediated increase in H4K16ac necessitated lens epithelium-derived growth factor p75 s

149 the development of chronic health conditions necessitates life-long risk-based monitoring of the BMT

150 s a barrier to long-term graft survival that necessitates lifelong immunosuppressive therapy after re

151 vels but does not eliminate latent HIV, thus necessitating lifelong therapy.

152 eading cause of end-stage liver disease that necessitates liver transplantation.

153 lization of clusters onto micropillars which necessitates long residence times and causes damage to c

154 th and development, the homeostasis of which necessitates long-distance transport processes that have

155 d damage inside intraerythrocytic parasites, necessitating macromolecule degradation.

156 n, is a typical case of a human protein that necessitates mammalian systems to obtain functional expr

157 r children with acute myeloid leukemia (AML) necessitate maximally intensive therapy.

158 ate changes in annual event rates that could necessitate medical attention.

159 ive bestrophinopathy closely resemble AEPVM, necessitating medical and hereditary evaluation to exclu

160 Incidence of OM necessitating middle-ear fluid culture (predominantly co

161 ively poor pharmacokinetic properties, which necessitate molecule modifications and complex delivery

162 elopment of disease-modifying therapies will necessitate monitoring programs to determine the long-te

163 tation in mice by classic vaccine paradigms, necessitating more iterative testing of new vaccine conc

164 sed on Bayesian computations would minimally necessitate multiple priors.

165 tep if high false positive or negative rates necessitate multiple rounds of enrichment.

166 d topological diversity of membrane proteins necessitates multiple insertion pathways that remain inc

167 ountries with a low incidence of the disease necessitates multiple interventions, including innovatio

168 fety at the expense of immunogenicity, often necessitating multiple doses and boosters.

169 ation of the therapeutics at the tumor site, necessitating multiple injections of both therapeutics.

170 cus, thus limiting membrane availability and necessitating NE breakage.

171 roliferation and expansion of security risks necessitates new measures to ensure authenticity and val

172 mplicated the management of chronic UTIs and necessitates new preventative strategies.

173 the high mortality despite these medications necessitates new treatment strategies.

174 fective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic p

175 rug-resistant (MDR) bacterial infections has necessitated novel antibacterial strategies.

176 increasing availability of metabolomics data necessitates novel methods for deeper data analysis and

177 ealth care, undermining therapy outcomes and necessitating novel approaches to drug design.

178 rs of images and sensor data into knowledge, necessitating novel methods of data handling and modelli

179 in occlusion the procedure was unsuccessful, necessitating pars plana vitrectomy, while in a case wit

180 This necessitates personalized immunosuppression to avoid kno

181 ncation products, which introduce biases and necessitate population-average assessments of RNA struct

182 r cells and the retinal pigmented epithelium necessitate precise gene regulation to maintain their ho

183 of highly targeted biological hybrid agents, necessitates precise control of conjugation reactivity.

184 this drug on humans even in low dosage which necessitates preventive efforts to reduce the chance of

185 ent of uncomplicated malaria, severe malaria necessitates prompt detection and referral to facilities

186 ental finding of a bronchial artery aneurysm necessitates prompt treatment.

187 s of NL trimeric conformers vary among Envs, necessitating purification by monoclonal antibodies (MAb

188 But data generated by NGS platforms necessitate quality control, genome assembly and sequenc

189 testing methods and a modern transplant era necessitate re-examination of this role to more accurate

190 integrator of three major types of GPCRs and necessitate reconsideration of classic models used to pr

191 outside the capacity of most clinical labs, necessitating reference laboratory testing and thereby d

192 leads to temporary deactivation of catalyst, necessitating regeneration steps, affecting throughput,

193 plantable electronic device implantation and necessitates removal of all hardware for optimal treatme

194 w drug development in kidney transplantation necessitated repurposing drugs initially developed in on

195 ufficient efficacy and lead to side effects, necessitating research of novel targets against pain.

196 years ago, many new results have been found, necessitating revision of the original interpretations.

197 e due to late manifestation of its symptoms, necessitating rigorous treatment following diagnosis.

198 show that achieving a desired outcome often necessitates roundabout steps.

199 Regarding ESRD due to multiple myeloma necessitating RRT in the United States, we evaluated tem

200 e and research studies is often impractical, necessitating short-item if not single-item measures wit

201 of the sample and low analyte concentration necessitates signal enhancement using culture-based or m

202 Robust differentiation protocols necessitate single cell cultures that are achieved by us

203 Retrieving this information necessitates single-particle experiments which simultane

204 s and microstructure on the nanometre scale, necessitating spatially resolved high-resolution studies

205 are often made of biofouling materials that necessitate special coatings, rely on electrical connect

206 ercialization of wearable diagnostic sensors necessitates stability in detection of analytes over pro

207 In young children with asthma necessitating Step 2 treatment, phenotyping with aeroall

208 ow collection efficiencies, has continued to necessitate stringent experimental conditions for the ob

209 to estimate effects in multiple populations, necessitating stronger assumptions.

210 This necessitates structural insight into how BSs interact wi

211 r lymphoma (FL) experience multiple relapses necessitating subsequent lines of therapy.

212 editing is executed via multiple paths that necessitate successive re-modification of junction regio

213 er spatial scales in anaerobic environments, necessitating sulfur isotopic measurement techniques tha

214 itis, arthralgia, and fatigue are common and necessitate systematic follow-up.

215 exacerbations of their autoimmune condition necessitating systemic treatment; all were managed with

216 rt in nano- and meso-scale junctions, but it necessitates that any variation of the junction with tim

217 The opposite strand polarity of duplex DNA necessitates that the leading strand is replicated conti

218 plex interactions of interconnected neurons, necessitating that links between connectivity and dynami

219 ower than comparable volcanoes on Earth, and necessitating that Mars was far more volcanically active

220 tes and the idiosyncrasies of tRNA sequences necessitate the development and use of methodologies tha

221 ion and the increased use of marginal livers necessitate the development of accurate pretransplant te

222 vel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine

223 osomal deletions and loss of heterozygosity, necessitate the development of inference methods that ut

224 d the emergence of antiviral drug resistance necessitate the development of new potent antiviral drug

225 onal design of potent DBP-based vaccines and necessitate the identification of globally conserved epi

226 ese 2 major signaling pathways in humans may necessitate the identification of more refined, cancer-s

227 c and antigenic evolution of existing agents necessitate the improvement of technology for the rapid

228 The method does not necessitate the pairing of samples that must be performe

229 transient events expected in fusion devices) necessitate the study of other comparable materials.

230 e phenotypically heterogeneous and therefore necessitate the use of high-dimensional phenotyping to o

231 and interactions that drive soil C dynamics necessitate the use of proxy variables to represent soil

232 owth and potential of global aquaculture has necessitated the adoption of sustainable and welfare-ori

233 in executable models and their analysis has necessitated the borrowing of terms and methods from com

234 Realization of this objective necessitates the ability to control the structural featu

235 romosome's relatively small size (16,569 bp) necessitates the ability to detect extremely focal event

236 requires active calcineurin whereas eCB-tLTP necessitates the activity of presynaptic PKA.

237 sequential mechanism and that BldD function necessitates the assembly of the BldD2-(c-di-GMP)4 compl

238 that asthma is mostly a chronic disease and necessitates the avoidance of allergens, prevention of i

239 This role necessitates the design of highly active, stable, yet ea

240 ing the unique mechanisms of human oogenesis necessitates the development of an in vitro system of st

241 variation observed between individual cells necessitates the development of methods that measure chr

242 h as vancomycin-resistant enterococci (VRE), necessitates the development of new antimicrobials.

243 tion, coupled with emerging drug resistance, necessitates the development of new drugs to treat influ

244 hed molecular heterogeneity of human cancers necessitates the development of new paradigms to serve a

245 of fungal strains exhibiting drug resistance necessitates the development of novel antimicrobial ther

246 of resistance to current antimalarial drugs necessitates the development of novel therapeutics.

247 logical processes involved in NGS technology necessitates the development of statistically accurate m

248 ft and antigenic drift of influenza viruses, necessitates the development of the next-generation of i

249 iency virus (HIV) toward known drug regimens necessitates the discovery of structurally novel antivir

250 This tailored material property approach necessitates the establishment of relationships between

251 inding, and since non-stoichiometric binding necessitates the explicit choice of a statistical distri

252 associated with dysregulated MMP expression necessitates the imaging of distinct MMPs or MMP subgrou

253 Ever-increasing soybean consumption necessitates the improvement of varieties for more effic

254 nt of planar polarization by mammalian cells necessitates the integration of diverse signaling pathwa

255 Effectiveness of VNS in these models necessitates the integration of neural signals and alpha

256 ssessment for engineered nanomaterials (ENM) necessitates the knowledge about their environmental con

257 ssessment for engineered nanomaterials (ENM) necessitates the knowledge about their environmental emi

258 This necessitates the manipulation of molecular interactions

259 when the Universe was 1.5 billion years old) necessitates the presence of galaxies with star-formatio

260 This indiscriminate activation necessitates the presence of preformed regulators on aut

261 er populations of cells with this technology necessitates the production of smaller diameter hydrogel

262 Maintenance of this epigenetic landscape necessitates the transfer of parental nucleosomes to new

263 ilar damage across other reefs in the region necessitates the urgent development of cooperative manag

264 This situation necessitates the use of complementary hydrodynamic analy

265 st maintaining their structure and function, necessitates the use of different experimental and analy

266 l acceleration achievable in free space, and necessitates the use of dispersive structures or wavegui

267 cted to quadruple by the end of the century, necessitating the building of millions of homes.

268 ients benefit from antiangiogenic treatment, necessitating the development of criteria to predict the

269 ents tend to undergo structural degradation, necessitating the development of new amphiphilic agents

270 ave not improved the prognosis for patients, necessitating the development of new treatments.

271 erential growth of resistant subpopulations, necessitating the development of next-generation therapi

272 ncomplete and can generate loss of function, necessitating the development of novel treatment methods

273 tional exposure to H7N2 virus-infected cats, necessitating the evaluation of this virus for its capac

274 ing of infinity may persist for finite time, necessitating the introduction of buffer zones, within w

275 y impair responses to dietary interventions, necessitating the introduction of diet-responsive bacter

276 e degrades at elevated temperature, thereby, necessitating the need for heat extraction system.

277 ails a substantial energy penalty, typically necessitating the operation of energy-demanding low temp

278 of novel traits and trait functions without necessitating the origin of novel pathways.

279 usal increases interference effects in tasks necessitating the recruitment of cognitive control.

280 vo, were generated in mice performing a task necessitating the reporting of cue and noncue events.

281 re often not accessible in a direct fashion, necessitating the strategic decoupling of ring-formation

282 ular proto-oncogene activation and leukemia, necessitating the use of cellular promoters in "enhancer

283 e omics data are rapidly becoming available, necessitating the use of new methods to integrate differ

284 ochondria pose a lethal threat to cells that necessitates their prompt removal.

285 yeloid leukemia (AML) and its poor prognosis necessitate therapeutic improvement.

286 and up to one third of the observed episodes necessitated therapeutic intervention.

287 n potentially large numbers of exposures and necessitating time-intensive investigations.

288 This positioning necessitates tissue-level polarization of junctions and

289 6.86; P < .001), and new respiratory failure necessitating tracheostomy (OR, 23.92; 95% CI, 2.80-204;

290 is that the size and complexity of datasets necessitate trading speed for accuracy, or completeness.

291 IU), their natural history in mild cases not necessitating treatment and their response to treatment

292 n aged 12 to 59 months (n = 300) with asthma necessitating treatment with daily controller (Step 2) t

293 Controlling the costs of imaging necessitates understanding them at a procedural level an

294 This necessitates uptake of L-Cys that is predominantly in it

295 is a burgeoning global health epidemic that necessitates urgent action.

296 ment may lead to compressive symptoms, which necessitates urgent surgical decompression.

297 ly evolve to escape detection by antibodies, necessitating vaccine updates.

298 h-throughput sequencing remains error-prone, necessitating variant confirmation in order to meet the

299 ly evaluated since the high HLA polymorphism necessitates very large sample sizes, which have not bee

300 g for quantitative resistance will therefore necessitate whole-genome prediction models and selection