ライフサイエンスコーパス: necessary

1 or SE therapy and diagnosis is important and necessary.

2 ing behavior to adjust task performance when necessary.

3 emic control and therefore new therapies are necessary.

4 quence variation elsewhere in the protein is necessary.

5 apid, yet inexpensive, on-site monitoring is necessary.

6 and are of low cost, are becoming even more necessary.

7 works suggests that full coverage may not be necessary.

8 ssion level, detailed anatomical studies are necessary.

9 s that contain special adhesive monomers are necessary.

10 eir mechanical response to dynamic strain is necessary.

11 plexity of the lignin structure also impedes necessary and decisive information to understand the rea

12 It is both necessary and interesting to characterize the structural

13 ochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 b

14 TA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the

15 As E cell and gDN1 activity is necessary and sufficient for normal evening locomotor ac

16 nditioning, and cAMP signaling molecules are necessary and sufficient for normal memory in intrinsic

17 the identified transcription factors and are necessary and sufficient for PRE activity.

18 monstrate that mTORC1-regulated autophagy is necessary and sufficient for starvation-induced LD bioge

19 ACAP, and BNST PACAP receptor activation was necessary and sufficient for stress-induced reinstatemen

20 the oxidized sterol, ergosterol peroxide, is necessary and sufficient for Vms1 localization to mitoch

21 tween Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chr

22 SRB signaling is necessary and sufficient in these sensory neurons to inf

23 thesized that the conserved motif could be a necessary and sufficient minimal motif for translocation

24 40 via threonine 246 phosphorylation is both necessary and sufficient to cause exosome secretion with

25 family of helix-loop-helix proteins is both necessary and sufficient to direct cardiac mesoderm form

26 d in vivo targeting assays show that SecA is necessary and sufficient to direct the targeting and tra

27 Therefore, miR-338-3p depletion is necessary and sufficient to disrupt auditory TC signalin

28 We show that similar developmental stress is necessary and sufficient to extend Drosophila lifespan,

29 n conjunction with environmental cystine, is necessary and sufficient to increase glutamine catabolis

30 lasm and phosphorylates POS-1, which is both necessary and sufficient to increase POS-1 mobility.

31 olr1 knockdown in neural plate cells only is necessary and sufficient to induce NTDs.

32 Foxj1a is necessary and sufficient to specify motile cilia.

33 n unstructured N-terminal region of Tim10 is necessary and sufficient to target the substrate to the

34 results show that a minimum level of grip is necessary before the upper limb plays an active role in

35 OS, whose expression is ZHOUPI dependent, is necessary both for the formation of a normal embryo shea

36 to get rid of components that are no longer necessary but might continue to exert their effects on r

37 Improving quality of medical care may be necessary, but not sufficient, to improve the full range

38 being subject specific due to a lack of the necessary clinical data.

39 tion, and the transcription factor PqsR is a necessary component in the P. aeruginosa cell-to-cell si

40 Depletion of Atg7, a necessary component of the autophagy pathway, in beta ce

41 Audiovocal feedback not only is a necessary component of vocal learning but also guides th

42 value to each state, together capturing the necessary components for successful intertemporal choice

43 need to compile into discrete gate sets, the necessary computations can be performed in reasonable ti

44 at reaching a fixed threshold level is not a necessary condition for movement initiation.

45 tion, whose realistic reproduction appears a necessary condition for the onset of a convection collap

46 of declarative memory: Temporal binding is a necessary condition for the relational organization of d

47 ificantly alters the design criteria for the necessary conducting front electrode.

48 catalysts include V(5+) surface species as a necessary constituent to convert the alkane.

49 C4d deposition does not appear to be a necessary criterion for the diagnosis, and although some

50 o the neck of the budding virus to cause the necessary curvature for membrane scission.

51 nerate new propagons, the molecular entities necessary for [PSI(+) ] propagation in dividing cells an

52 Recalibration may be necessary for accurate risk assessment.

53 at genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia.

54 ylls into chlorophyll a and chlorophyll b is necessary for advanced monitoring of plant growth.

55 In conclusion, TSG-6 is necessary for AHR in response to ozone or sHA, in part b

56 Clarifying this central concept is necessary for assessing Burkart et al.'s proposal that t

57 We found that PRMT1 activity was necessary for c-Myc binding to the acetyltransferase p30

58 leptomeningeal metastatic models and proved necessary for cancer growth within the leptomeningeal sp

59 We found that Ca(2+) influx through TRPV1 is necessary for capsaicin-induced ablation of nociceptive

60 nt on the C. elegans PINK1 homolog, which is necessary for cellular resistance to chronic malfunction

61 Strikingly, PIKfyve is necessary for chemotaxis, ROS production, and stimulatio

62 maged tissues upon acute sterile injuries is necessary for clearance of necrotic debris and for coord

63 ocytic response and elevation of Trem2, both necessary for clearing damaged myelin, were markedly red

64 The neural circuitry necessary for context-driven salt-seeking behavior is un

65 d five upstream adenylates, and H4a/Psi3 was necessary for cooperative association of two other hairp

66 vide evidence that the mPFC-->NAc pathway is necessary for cue-induced reinstatement of alcohol seeki

67 GA and FS area could be determined for BCVA necessary for daily activity.

68 hat, unlike the axolotl, Pax3 is present and necessary for development and that contrary to mammals,

69 ndesired effect on lactic bacteria which are necessary for development of aroma and chemical properti

70 Finally, although serum exposure was not necessary for drusen formation, COL4 accumulation in ECM

71 her, this work identifies Actr10 as a factor necessary for dynactin-mitochondria interaction, enhanci

72 Glycolysis is necessary for early gene transcription, while glutaminol

73 gene transcription, while glutaminolysis is necessary for early gene translation but not transcripti

74 CaM is shown to be absolutely necessary for efficient activity of eEF-2K, and Ca(2+) i

75 egulator of the cellular ESCRT machinery, is necessary for efficient entry and egress of Autographa c

76 ar metabolic profiling revealed that PknG is necessary for efficient metabolic adaptation during hypo

77 In neoplastic PanIN cells, pERK was not necessary for either TGFbeta-induced pSMAD2 phosphorylat

78 These results indicate that NUMB is necessary for establishing polarity in CE cells, and tha

79 The biological factors necessary for ethanol-induced overeating remain unclear,

80 ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthet

81 homozygous variants in WNT7A and SMARCA4 are necessary for expression of TH and selection against the

82 werful, the process of tissue homogenization necessary for flow cytometry analysis introduces bias an

83 both S1-S2 and S3-S4 of NaV channels may be necessary for functional modulation, and that targeting

84 mechanisms that control the plant processes necessary for fungal colonisation and arbuscule developm

85 e positive charge of the lysine residues was necessary for fusion regulation, as alanine substitution

86 that sensory neurons express major proteins necessary for GABA synthesis and release and that sensor

87 ry to activate all the transcription factors necessary for gene transcription and hypertrophy.

88 in this study that mitochondrial fission is necessary for glucose-stimulated insulin secretion in mo

89 gest that therapeutic anticoagulation is not necessary for grade 1 and 2 arterial and grade 1 venous

90 ross talk between microbes and host cells is necessary for health, survival, and regulation of physio

91 yocytes (CMs) generate the mechanical output necessary for heart function through contractile mechani

92 repopulation ability, indicating that Erf is necessary for hematopoietic stem cell maintenance or dif

93 n, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and as

94 whether Dam1, a known substrate of Mps1, was necessary for its critical meiotic role.

95 The LIM domains of Rga1 are necessary for its interaction with Nba1, and loss of thi

96 phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

97 , Nedd8 binding site in Smurf is shown to be necessary for its ubiquitin ligase activity towards the

98 , and RNAs present at active centromeres are necessary for kinetochore assembly and cell-cycle progre

99 SLC38A9 is necessary for leucine generated via lysosomal proteolysi

100 Nutrients are necessary for life, as they are a crucial requirement fo

101 is a conserved Rhadinovirus protein that is necessary for long-term chronic infection by these virus

102 l stem cell quiescence and exhaustion and is necessary for long-term maintenance of the mammary gland

103 s key to the alteration of synaptic strength necessary for long-term potentiation, learning, and memo

104 These results argue that TbSmee1 is necessary for maintaining HC morphology, which is import

105 tantly, dose adjustments for tacrolimus were necessary for maintaining sufficient trough levels.

106 priate methods of post-harvest treatment are necessary for maintaining these bioactive phytochemicals

107 Mast cell activation is common and possibly necessary for maintenance of survival.

108 gulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and ide

109 Furthermore, lysine 9 on histone H3 is necessary for maximal pol II pause release through SEC a

110 emonstrated that the first two cysteines are necessary for McpM to inhibit susceptible cells.

111 We also found that FDXR was necessary for mitochondrial iron homeostasis and proper

112 cell cycle regulators and that the KDM5s are necessary for mitotic clonal expansion in 3T3-L1 cells,

113 Therefore, polysomnography is not necessary for most patients with suspected sleep apnea.

114 y Purkinje cells with contextual information necessary for motor learning, but how they encode this i

115 Thus, although IH is not necessary for MPR in this neuron type, it contributes in

116 rentiation and early myelination, but is not necessary for myelin maintenance.

117 abolic labeling, we found that TbPSS2 (i) is necessary for normal growth of procyclic trypanosomes, (

118 These studies demonstrate that DDR2 is necessary for normal TMJ condyle development and homeost

119 hemical and physical component, and both are necessary for optimal barrier restoration.

120 lse-labeling experiments showed that RAD6 is necessary for overcoming cisplatin-induced replication f

121 fied the GLASSY HAIR 1 (GLH1) gene, which is necessary for papillae formation.

122 ANTXR1 is necessary for permissivity in vitro and in vivo.

123 Though REC phosphorylation is necessary for PhyR function in vivo, we did not detect e

124 Ezrin links CFTR and TLR4 signaling, and is necessary for PI3K/AKT signaling induction in response t

125 cell, which organizes polarity determinants necessary for plant cell invasion.

126 tendon thickness, indicating that mTORC1 is necessary for postnatal tendon development.

127 nd a minimal fusogenic peptide motif that is necessary for promoting cell-cell fusion with myomaker.

128 dicate that Tcf1-beta-catenin interaction is necessary for promoting thymocyte survival to maintain t

129 ate time and location in polarizing cells is necessary for proper establishment of epithelial polarit

130 found that miR-155 expression by T cells is necessary for proper tumor-associated macrophage express

131 es (NAbs) targeting distinct epitopes may be necessary for protective immunity.

132 FSS expressed higher levels of key proteins necessary for PT function, including ion transporters, r

133 ch1 signaling and primary cilium maintenance necessary for radial progenitor functions.

134 d tested the hypothesis that macrophages are necessary for regeneration.

135 Thus, Treslin-MTBP is collectively necessary for replication.

136 transiently binds the basic Sm core residues necessary for RNA annealing.

137 Controlled human feeding studies are necessary for robust nutritional biomarker development a

138 S hot spots and the plasmonic nanostructures necessary for SM detection, the past and current methodo

139 The nuclear receptor LXR is necessary for Srebf-1c transcription.

140 ic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune

141 The properties of organic chromophores necessary for successfully driving water oxidation in a

142 three core multivalent molecular components necessary for such assembly: specific RNA molecules that

143 h an abundance of virulence factors that are necessary for survival within a host, including the prod

144 rotein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memor

145 nits, largely dispensable early in life, are necessary for terminating contraction (systole) in aged

146 ductal adenocarcinoma (PDAC) PAR2 protein is necessary for TGF-beta1-dependent cell motility.

147 Consequently, the condition necessary for the "flat/steep" band model for supercondu

148 role in chloroplast redox regulation, being necessary for the activity of diverse Trxs with unrelate

149 Mechanical loading is necessary for the development and maintenance of the mus

150 s sufficient but does not show whether it is necessary for the effects of exogenous GLP-1R agonists (

151 vergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity.

152 Bcp1 has been shown to be necessary for the export of Mss4, a phosphatidylinositol

153 ial fluctuations in outcomes, whereas BLA is necessary for the facilitation of learning in response t

154 in which Bmpr1a signaling in chondrocytes is necessary for the formation of a pool or niche of osteop

155 PDZD8 was necessary for the formation of ER-mitochondria contacts

156 pid transporter activity of ALA1/ALA2 may be necessary for the formation of similar invaginations for

157 se promotes the complete disassembly of MCC, necessary for the inactivation of the mitotic checkpoint

158 pression and/or repression of genes that are necessary for the initiation of gametocyte development i

159 not GATOR2, to the lysosomal surface; and is necessary for the interaction of GATOR1 with its substra

160 Hence, SPA proteins are necessary for the light-controlled change in COP1 subcel

161 tionships in fitness-related traits, (3) are necessary for the maintenance of sexual dimorphism, (4)

162 changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over

163 ur data indicate that O-glycosylation is not necessary for the natural replication cycle of HIV and S

164 umour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cance

165 Neuronal survival is necessary for the proper function of cochlear prosthetic

166 f these activities are generally accepted as necessary for the provision of quality care, but have no

167 sting that the enzymatic activity of PARN is necessary for the release of 18S-E from Bystin-associate

168 lmacher et al. (2017) show that autophagy is necessary for the release of free fatty acids from intra

169 and cell composition prior to the injury is necessary for the repair macrophage phenotypic transitio

170 Thus, the expression of Ifnlr1 by IECs is necessary for the response to both endogenous and exogen

171 ndoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, th

172 HCFC2 was also necessary for the transcription of a large subset of oth

173 ck channel expression at the DRG membrane is necessary for their characteristic firing accommodation

174 iacidic motif (Asp-Glu) in these proteins is necessary for their export.

175 terial communities to maintain the functions necessary for their nutrition.

176 urons is endowed with specific cdhr proteins necessary for these cells to reach the developing AC.

177 ockout mice, demonstrating that GLUT4 is not necessary for these processes.

178 regulatory T cells (Tregs) were described as necessary for this M1 to M2 transition.

179 Cadherin-mediated homophilic adhesion is necessary for trans-endocytosis, and adhesive junctional

180 scribed genes, the reshaping of DNA topology necessary for transcription process stimulates secondary

181 enic cell lines implicated variants in genes necessary for transcriptional regulation and function of

182 uclear cluster transcription factor CLR-1 is necessary for utilization of cellulose, a major, recalci

183 The membrane fusion necessary for vesicle trafficking is driven by the assem

184 A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and

185 nge to the maintenance of cellular functions necessary for viral replication if continuous protein sy

186 gBcyt regulation is necessary for VZV pathogenesis, as the hyperfusogenic mu

187 The measurements here provide a necessary framework for understanding integrin activatio

188 taste perception modification, and point to necessary future directed sensory experiments needed to

189 ps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantati

190 While different binding modes could be necessary, given their roles in different secretory proc

191 ing device that can autonomously perform the necessary image processing.

192 The number of eligible patients necessary in each randomization arm was estimated to be

193 Further studies are necessary in moderate and heavy O. viverrini infections.

194 ide latitudinal and altitudinal gradients is necessary in order to gain a better understanding of pla

195 variability in climatic and biotic shifts is necessary in order to properly describe biodiversity res

196 abeled metabolites measured in two media are necessary: in a minimal medium containing only derivatiz

197 otoreceptors in the honey bee allows for the necessary input for an optimal color constancy solution

198 generation within soils and sediments is the necessary interaction of two low-solubility phases-Cr(II

199 f human cardiac progenitor cells (hCPCs) are necessary interventions to rejuvenate aged/diseased cell

200 tions include administration of oral and, as necessary, intravenous hydration; systematic monitoring

201 well (QW) has been developed to clarify the necessary means to achieve device quantum efficiency hig

202 In this Perspective, the "necessary nitrogen atom" is shown to be a versatile high

203 testinal signals-serotonin, CCK, and PYY-are necessary or sufficient for these effects.

204 ested that Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal

205 nt on a variety of substrates to achieve the necessary porosity.

206 during the care of diabetic retinopathy is a necessary precursor to fully understanding the underlyin

207 ng the robustness of these methods, which is necessary prior to use in drug development and regenerat

208 Our approach and results provide the necessary quantitative sleep phenotypes for large field

209 e for this conserved domain in providing the necessary stability to the envelope glycoprotein in orde

210 ancies that induce the incorporation of O as necessary stabilization of the crystal structure.

211 an inner-sphere adsorption complex may be a necessary step for the redox transformation via catalyti

212 Although it is reasonable and necessary that we question the relevance of such small e

213 however, ring-strain release can provide the necessary thermodynamic driving force to make such proce

214 , inactivation of both phoP and Sant_4061 is necessary to abrogate growth of this bacterium in an ins

215 We also characterize the read depths necessary to achieve sensitivity and specificity compara

216 The use of RBV may not be necessary to achieve SVR in this patient population.

217 Further development and improvement are necessary to achieve the ideal of a noninvasive image-ba

218 years old, a clinically guided protocol was necessary to achieve well-controlled INR.

219 actors, synergy between multiple pathways is necessary to activate all the transcription factors nece

220 However, further efforts are necessary to address the high rate of primary nonfunctio

221 stablishing a timeline for GRN evolution, is necessary to answer questions about the rate at which GR

222 r the control of a PBel(CGRP) switch that is necessary to arouse animals from hypercapnia.

223 erstanding the fate and transport of DNAN is necessary to assess the risk it may represent to groundw

224 ankton species and microbial biodiversity is necessary to assess water ecosystem health and the quali

225 ing structural controllability theory, it is necessary to balance the number of driver nodes and cont

226 rvational or experimental data, is therefore necessary to better understand observed cyclical pattern

227 developing immunomodulatory therapies, it is necessary to better understand the timing and complexity

228 In practice, it is usually necessary to calculate p-value by a permutation procedur

229 ons mediate word and face recognition, it is necessary to characterize how stimuli are represented an

230 Importantly, MEK1 activity was necessary to clear the pluripotency protein Ventx2 at th

231 tion, however two samples of paired sera are necessary to confirm the diagnosis, since using only one

232 knockdown resistance in An. funestus, it is necessary to continue to monitor the contribution of the

233 mprehensive study of individual mutations is necessary to create a realistic picture of the evolution

234 The percentage of transferred globin necessary to cure SCD is currently not known.

235 ral differences in intestinal microbiota are necessary to define applicability of new strategies targ

236 chanisms of cooperative ligand binding it is necessary to define at a microscopic level the structura

237 Large prospective trials are necessary to determine if these physiologic benefits tra

238 Specific validation studies will be necessary to determine the best combination of imaging m

239 Further studies are necessary to determine the efficacy of the intervention

240 Further studies will be necessary to determine which patients may benefit from e

241 ts and 83% of drug-resistant patients, it is necessary to develop a better understanding of where pat

242 oaccumulation in fish and seafood, making it necessary to develop methodologies to evaluate these com

243 However, it is necessary to develop strategies that reduce the formatio

244 icking of video-images (video-mosaicking) is necessary to display large areas of tissue.

245 ut this method lacks the temporal resolution necessary to distinguish pre- from poststimulus processe

246 Further studies are necessary to elucidate the causal direction of this asso

247 This efflux is necessary to ensure Fe(III) solubility and mobility in t

248 as well as the standardization of parameters necessary to ensure valid comparisons between different

249 patchy landscape of parasites in the skin is necessary to explain infectiousness.

250 te that is, nonetheless, both sufficient and necessary to explain the speed of pCPI-17 dephosphorylat

251 losonate (Kdo)-lipid A domain in E. coli was necessary to facilitate chemical structure analysis and

252 allergic disease and delineating strategies necessary to fill these gaps.

253 ures below 233 K (-40 degrees C), conditions necessary to form cirrus clouds in the Earth's atmospher

254 ut for the chemical kinetic modeling that is necessary to fully extract physics from the observationa

255 Future prospective studies are necessary to further characterize potential causal links

256 stic target of rapamycin (mTOR) signaling is necessary to generate a mechanically induced increase in

257 m improve reproductive outcomes in women are necessary to guide public health policy for this emergin

258 esis in TBMs, and provides the critical data necessary to improve our ability to project the response

259 ir surrounding surface topographies, will be necessary to improve the yield of single quantum dot nan

260 umor activity from loss of self-tolerance is necessary to increase the therapeutic efficacy of checkp

261 otons, a fluence of 10(16) protons/cm(2) was necessary to induce a significant charge transfer from S

262 we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necropt

263 Both activities were necessary to maintain nuclear position in uncentrifuged

264 Additional evidence is necessary to make a definitive recommendation for or aga

265 cal association, so functional validation is necessary to make strong claims about gene function.

266 Early treatment may be necessary to maximize the benefit of the drug.

267 Significant discounts are necessary to meet conventional cost-effectiveness standa

268 ablish that complete structural integrity is necessary to observe single-molecule fluorescence of GFP

269 in both the excited and the ground states is necessary to obtain a photocontrolled system rather than

270 show proper Hamiltonian control is generally necessary to optimize the Fisher information.

271 of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues.

272 In addition, it was necessary to pool primary and secondary outcomes.INT tha

273 interacted directly and this interaction was necessary to position PTEN at the membrane.

274 rocesses and microbial community dynamics is necessary to predict microbial response to perturbation.

275 will spark the cross-disciplinary discussion necessary to produce a cognitively plausible model of li

276 ities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs aga

277 first time that both eIF2alphaP and ATF4 are necessary to promote erythroid differentiation and to re

278 t the genes linked to EDMD and CNM were each necessary to properly position nuclei.

279 Vaccination against all serotypes is necessary to protect susceptible animals and to prevent

280 date pathogen actually causes disease, it is necessary to provide additional evidence of causality.

281 Hence, it is necessary to record from neuronal dendrites, which can g

282 al but that additional constraints are still necessary to recover the observed growth rate distributi

283 ntify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo.

284 As more RGENs become available, it will be necessary to refine their activity before they can be tr

285 These findings suggest that it is necessary to rethink the dogma involving GAS pathogenesi

286 fragments, but multiple ligations, which are necessary to segmentally label proteins of more than two

287 t circulators and narrowband filters are not necessary to separate pump and signal waves.

288 vation efforts to protect intact forests are necessary to slow deforestation rates and to avert a new

289 HSPGs are necessary to stabilize microtubules in newly formed high

290 me with minimal or no instrumentation, it is necessary to streamline unit operations and store reagen

291 medical outcomes after live kidney donation necessary to support donor candidates in well informed d

292 oal of this strategy is to generate the data necessary to support US Food and Drug Administration cle

293 influx via plasma membrane channels is also necessary to sustain the oscillations over longer times.

294 ase, DNA ligase, DNA polymerase, and enzymes necessary to synthesize and incorporate dG(+).

295 The melting procedure necessary to transform the frozen solid into an injectab

296 ng that EGL-1 activity reaches the threshold necessary to trigger death only in daughter cells that a

297 of intracellular dynamics of IAV assembly is necessary to understand reassortment.

298 on observed in humans, and that EVHP appears necessary to unmask distinguishing features of severely

299 fferent connected reactions; it is therefore necessary to use mathematical models for holistic studie

300 When necessary (under low light conditions), photosynthetic o