ライフサイエンスコーパス: inhibit

1 in which host protein synthesis is globally inhibited.

2 , is dragged 75 A apart, and is irreversibly inhibited.

3 ine dinucleotide phosphate oxidases are also inhibited.

4 ive capacity as assessed by their ability to inhibit Ab responses in vitro.

5 rectly interacting with the Abeta peptide to inhibit Abeta42 fiber formation.

6 GBPs inhibit actin-dependent motility and cell-to-cell spread

7 portant kinases in the BCR signaling pathway inhibit activation of lytic viral expression but do not

8 ed JNJ0966, a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent gen

9 HSCs and that neutralizing antibody to CCL5 inhibited activation.

10 serum divalent cations eliminate myotonia by inhibiting AfD and NaPIC.

11 f TNFalpha was inhibited by LDN193189, which inhibits ALK2 but not ALK1.

12 Gedatolisib also inhibited ALL proliferation in ABL/platelet-derived grow

13 cell transformation and leukemogenesis, and inhibits all-trans-retinoic acid (ATRA)-induced AML cell

14 Fractions X1C and X2C notably inhibited alpha-glucosidase, with IC50=9.89 and 8.05mug/

15 oposed oncometabolite that can competitively inhibit alphaKG-dependent enzymes.

16 te that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necroptosis.

17 amide/oleamide, and phosphatidylethanolamine inhibit and phosphatidic acid and sphingomyelin enhance

18 xamples resulting from these efforts in both inhibiting and stabilizing specific 14-3-3 protein compl

19 ed transcription elongation factor that both inhibits and stimulates transcription elongation in meta

20 However, the growth of MRSA was inhibited, and a significant protection in mice against

21 VEGFR1-STAT3 signaling by VEGF165a and hence inhibits angiogenesis and perfusion recovery in PAD musc

22 e report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback lo

23 r drugs (DREADDs) to selectively activate or inhibit ArcN NPY neurons expressing agouti-related pepti

24 Unlike IL-1beta, which inhibits B lymphopoiesis by acting on early lymphoid pro

25 acting on early lymphoid progenitors, S100A9 inhibits B lymphopoiesis by acting on myeloid cells and

26 E) by in situ minerals, and C2H2 is known to inhibit bacterial dechlorination.

27 enantiomer that is structurally incapable of inhibiting BET bromodomains, which resulted in a minimal

28 lectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mic

29 Finally, targeted IL8 shRNA inhibited BM-MSC-induced AML survival.

30 ich activating mutations in the FGF receptor inhibit bone growth.

31 to isolate RNA aptamers that can potentially inhibit both AMPA and kainate receptors.

32 : BI-D1870 and BRD7389, for their ability to inhibit both proliferation and protein synthesis in pati

33 hain-only Ab (VHH or nanobody) significantly inhibited both phosphoantigen-dependent and -independent

34 can fuel low-frequency synaptic function and inhibiting both underlies loss of synaptic transmission

35 es copper levels and MAPK signaling, thereby inhibiting BRAF(V600E)-driven melanoma tumor growth.

36 are rapidly degraded when DNA replication is inhibited by a 3' to 5' pathway that requires extensive

37 type I signaling, and both mechanisms can be inhibited by administering specific molecules to prevent

38 of fs120, but not fs188 cells, in vitro was inhibited by B20-4.1.1.

39 and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentratio

40 ent with doxorubicin, was also significantly inhibited by FKBP12.

41 OVCa cells, p-Akt Thr-308 was significantly inhibited by intracellular Ca(2+)i chelation or CaM inhi

42 n (MTD), which, in unstressed conditions, is inhibited by intramolecular binding to the Vms1 leucine-

43 s by BMP9/10 in the presence of TNFalpha was inhibited by LDN193189, which inhibits ALK2 but not ALK1

44 an increase in the protein amount, which was inhibited by p300 RNAi.

45 However, the increase was inhibited by pertussis toxin as well as by wortmannin bu

46 se and ATP-dependent helicase activities are inhibited by Rev in a dose-dependent manner, although AT

47 to non-physiological low pH in vitro and is inhibited by small molecule compounds, such as the drug

48 moted by a regulatory protein that is itself inhibited by the cell-cycle activator, their interaction

49 latent HIV-1 infection in CD4(+) T could be inhibited by viral-specific CD8(+) T cells, a result wit

50 e RMTg reduced both the number of DA neurons inhibited by, and the duration of inhibition resulting f

51 In tumoral pituitaries, BIM-23A760 also inhibited Ca(2+) concentration, hormone secretion/expres

52 utralization of 5RK promotes spontaneous and inhibits Ca(2+)-triggered release events.

53 ssion and caused myofibril disarray, whereas inhibiting Calcineurin activity attenuated FoxO-mediated

54 Acylation and suppression of O-GlcNAcylation inhibits cancer invasion and metastasis.

55 y binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in mice.

56 SH/GSSG in three breast cancer cell lines by inhibiting CBS.

57 These data demonstrate that BCD inhibits CC-induced inflammatory responses, which may be

58 We observed that miR-874 inhibits CCNE1 expression in primary osteoblasts, but in

59 These data suggest that zinc may inhibit cell proliferation of esophageal cancer cells th

60 ns ranging from 12 to 18 mg/L, significantly inhibited cell proliferation, reduced cell viability, an

61 of a catalytically inactive form of METTL3, inhibits cell differentiation and increases cell growth.

62 Vgll4 inhibits cell proliferation and tumor growth by competin

63 matin mutants could be partially restored by inhibiting cep-1/p53, endogenous meiotic double strand b

64 aken together, these data suggest that SMase inhibits CFTR channel function by locking channels into

65 TP interact with the KATP channel complex to inhibit channel activity.

66 odels of inflammation yet was less potent at inhibiting chemotaxis in vitro with an IC50 of 21 nm Fur

67 ) mice, emphasizing the importance of PTH in inhibiting Cldn14.

68 Only ascorbic acid showed some ability to inhibit colour fading during storage, although EDTA had

69 icance: This provocative study suggests that inhibiting complement activation may heighten immunother

70 TNF inhibited completion of the HCV infectious cycle in hepa

71 nstrate a novel mechanism by which antimycin-inhibited complex III generates significant amounts of R

72 forts are now underway to develop DOACs that inhibit components of the intrinsic and extrinsic coagul

73 cal analysis suggests that it neutralizes by inhibiting conformational changes required for entry.

74 PDZ1i inhibited crucial GBM signaling involving FAK and mutant

75 ion of RO5166017 into the NAc core and shell inhibited cue- and drug-induced cocaine-seeking, respect

76 POL5551 inhibited CXCR4 binding to its ligand, stromal cell-deri

77 Of them, 14 drugs inhibited CYP27A1 by >/=75% and were evaluated for in vi

78 (MitoQ) reduced intracellular superoxide and inhibited cyst epithelial cell proliferation through ext

79 In mice, the compound inhibited cytokine production induced by injection of se

80 We investigated whether inhibiting cytokinesis in the liver slows tumor growth w

81 Addictive and therapeutic psychostimulants inhibit DA reuptake and multiple DAT coding variants hav

82 on conveyed by GABA and ACh corelease, which inhibited DA neurons.

83 oth to maintain TA cell proliferation and to inhibit differentiation.

84 ntopolar cortex, we were able to selectively inhibit directed exploration while leaving random explor

85 AEE788 treatment inhibits DNA replication in the kinetoplast (mitochondri

86 Tetradocosahexaenoyl-CL inhibited domain organization due to favorable Gibbs fre

87 number of Tmem was only reduced when FAS was inhibited during T cell priming and not during the Tmem

88 Homologous recombination is inhibited during the G1 phase of the cell cycle, but bot

89 as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechan

90 A significant increase of the ACE-inhibiting effect was observed following butanol extract

91 -3-O-glucoside and delphinidin-3-O-glucoside inhibited EGFR (IC50=0.10 and 2.37microM, respectively).

92 them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic c

93 TDP-43 inhibits endocytosis, and co-localizes strongly with end

94 rimary culture, both Nanobodies were able to inhibit endogenous EphA4-mediated growth-cone collapse i

95 nd stem-like properties of tumor cells, also inhibit endothelial phenotypes of breast cancer cells ad

96 c hearts, suggest that HYAL2 is important to inhibit endothelial-to-mesenchymal transition.

97 cking externalized PS or suppressing TMEM16F inhibited Env-mediated fusion.

98 ls from GTPs and BSp are highly effective in inhibiting ERalpha-negative breast cancer due at least i

99 terference mechanism that is responsible for inhibiting expression of the coding NDC80 mRNA isoform.

100 Strategies to inhibit extracellular signal-regulated kinase 1/2, ribos

101 iology, which acts as a molecular brake that inhibits fatty acid metabolism and WAT browning.Histone

102 er Ca(2+) release in cardiac myocytes should inhibit further Ca(2+) release during the action potenti

103 9 pandemic H1N1 (pH1N1) virus is not able to inhibit general gene expression.

104 nction in the integrative stress response to inhibit general protein synthesis coincident with prefer

105 s the eukaryotic initiation factor 2alpha to inhibit global protein translation.

106 While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), th

107 se formation, and our data reveal that Wnt5a inhibits glutamatergic synapses formed via Celsr3.

108 decreased the expression levels of Glut1 and inhibited glycolysis in cancer cells.

109 r, THZ1 prevented Ser118 phosphorylation and inhibited growth of MCF7-Y537S cells.

110 These compounds are able to inhibit GSK3beta and induce the Nrf2 phase II antioxidan

111 rying shRNA against TGF-beta, though did not inhibit HBV replication alone, enhanced the antiviral an

112 There are currently no therapies to directly inhibit hepatic fibrosis.

113 Insulin inhibits hepatic glucose production and promotes lipogen

114 of Rab GTPase-activating proteins (RabGAPs) inhibited histamine-evoked, Ca(2+)-dependent WPB exocyto

115 DnaA activates transcription of sda, and Sda inhibits histidine protein kinases required for activati

116 cific CD8(+) T cells in elite controllers to inhibit HIV infection.IMPORTANCE The greater ex vivo ant

117 The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms.

118 As expected, only Ser5-001 strongly inhibits HIV-1 infectivity, whereas the other Ser5 isofo

119 ide fused with the TAT peptide significantly inhibited IAV replication and transmission.

120 or used for the treatment of AAT deficiency, inhibits IBMIR and cytokine-induced inflammation in isle

121 SCFAs inhibited IFN-gamma and IL-17A production in peripheral

122 rabbit sera were tested for their ability to inhibit IgE recognition of Cyp c 1, Cyp c 1-specific bas

123 itro analysis showed that PRN694 effectively inhibited IL-17A production from murine T helper type 17

124 ction of PGE2 We showed previously that PGE2 inhibits IL-27 production in murine bone marrow-derived

125 atic, since prior immunity to a scaffold may inhibit immune responses to the antigen-scaffold combina

126 Here we show that drugs that inhibit important kinases in the BCR signaling pathway i

127 A1 GLP-1R activation reduces food intake and inhibits impulsive operant responding for palatable food

128 mary tumors and metastases was both strongly inhibited in C3-deficient mice (C3(-/-) mice), with tumo

129 virus (IHNV), infectivity was significantly inhibited in vitro (using the epithelioma papulosum cypr

130 CH2 signaling was reduced but not completely inhibited, in response to JAG1(Ndr) compared with JAG1.

131 dly fragment when GTP hydrolysis of Sey1p is inhibited, indicating that network maintenance requires

132 ion, suggesting that restoring mitophagy and inhibiting inflammasome activation may serve as novel ta

133 CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses.

134 catecholamines in IUGR fetuses persistently inhibits insulin concentrations and secretion.

135 reby blocks the activity of these cytokines, inhibiting interleukin-23-dependent production of interl

136 itating oligomerization and negative charges inhibiting it.

137 at it can react rapidly with bGP and readily inhibits its glycogenolytic activity (kinact = 1.4 x 10(

138 STN HFS inhibited key brain regions, including the substantia ni

139 crystallographic analysis of allosterically inhibited L-lactate dehydrogenase.

140 ti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viability and by

141 uolar-type H(+)-ATPase inhibitors, which all inhibited LGR5 internalization by blocking clathrin-medi

142 dy examined the hypothesis that progesterone inhibits LH surge and pulsatile secretion via its recept

143 etion of tuberous sclerosis complex 2 (TSC2) inhibits lipophagy induction in DENV-infected cells and

144 MenA inhibiting, long chain-based compounds were designed, sy

145 lymphedema by promoting tissue fibrosis and inhibiting lymphangiogenesis.

146 osome rosette stability and is sufficient to inhibit macrophage invasion.

147 t for clean rooms and specialized skills has inhibited many biologists from pursuing new microfluidic

148 llular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover.

149 o, molecular beacons can also be employed to inhibit microRNAs in a specific manner.

150 Knockdown of C3 and CFB expression inhibited migration and proliferation of cSCC cells and

151 eutic effect of OEPCs is improved in vivo by inhibiting miR-17.

152 Sulfide inhibits mitochondria and reduces ROS production.

153 ddC treatment inhibited mtDNA replication, oxidative phosphorylation,

154 t stability can be significantly restored by inhibiting mTORC1 or p70S6 kinase (p70S6K), downstream k

155 (ROCK) prevented cytoskeletal defects, while inhibiting myosin light chain kinase or phosphorylation

156 CHAF1A inhibits NEIL1 initiated repair in vitro Subsequent rest

157 nant-negative mutants of ATL1 in PC-12 cells inhibit nerve growth factor (NGF)-induced neurite outgro

158 Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a

159 RNAi knockdown of either Cbx3 or Med26 inhibits neural differentiation while up-regulating gene

160 geting of SPHK1 or YAP/TAZ was sufficient to inhibit neuroblastoma metastasis in vivo Overall, we ide

161 signaling pathway promotes neurogenesis and inhibits neurodegeneration.

162 -independent contributions by activating or inhibiting neurogenic activity with veratridine and tetr

163 icroglia, and microglial exosomal miR-124-3p inhibited neuronal inflammation in scratch-injured neuro

164 effect on hippocampal proliferative cells by inhibiting neuronal proliferation and triggering the for

165 Metoprolol inhibits neutrophil-platelet interactions in AMI patient

166 , because suppression of UNC5A significantly inhibited NF-kappaB p65(ser536) phosphorylation, c-Myc u

167 ORTANCE The vaccinia virus (VACV) K1 protein inhibits NF-kappaB activation among its other antagonist

168 lysates, confirming that exon 23a inclusion inhibits Nf1 RasGAP activity in vivo as it does in cultu

169 Cleavage of syntaxin 17 inhibits not only autophagy but also staurosporine-induc

170 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.

171 These results suggest that carbofuran inhibits NSC proliferation and neuronal differentiation

172 m-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer

173 nale for development of CXCR2 antagonists to inhibit or prevent metastatic spread of disease.

174 lection of opposing allosteric features that inhibit or promote photoconversion and reversion of Pfr

175 ic differentiation further but significantly inhibited osteoblast-regualted osteoclastic differentiat

176 rhamnolipid, and pyocyanin) and successfully inhibit P. aeruginosa infection in murine model of impla

177 licited by natural Pf exposure that potently inhibited parasite transmission and development in vivo.

178 th-ligand 1 (PD-L1) monoclonal antibody that inhibits PD-L1 and programmed death-1 (PD-1) and PD-L1 a

179 e modulator of TLRs that we detected in PDE, inhibited PDE-induced, TLR2- or TLR4-mediated profibroti

180 These studies revealed that the agent inhibited pERK1/2 phosphorylation in all tumours, caused

181 When spliceosome components were depleted or inhibited pharmacologically, the steady-state levels of

182 e, we report in vitro and in vivo effects of inhibiting PI3Kdelta in APDS.

183 Pnldc1 mutation in mice inhibits piwi-interacting RNA trimming and causes accumu

184 In addition, pTRS1 binding to PKR inhibited PKR kinase activity.

185 Together our data suggest that pTRS1 inhibits PKR by binding to conserved amino acids in the

186 upting actin filament regulation processes - inhibiting polymerization-promoting signaling through se

187 y a key role in PM H(+)-ATPase activation by inhibiting PP2C.D family protein phosphatases.

188 tion of cannabinoid (CB1) receptors known to inhibit presynaptic GABA release was significantly reduc

189 ASXL3 silencing inhibited proliferation, clonogenicity, and teratoma for

190 ession of virus-specific B cell responses by inhibiting proliferation of germinal center (GC) B cells

191 Unexpectedly, T124N/T174I IN substitutions inhibited proteolytic processing of HIV-1 polyproteins G

192 in vitro analysis showed directly binds and inhibits purified ppGalNAc-T3 with no detectable activit

193 we demonstrate that flavonoids specifically inhibit quorum sensing via antagonism of the autoinducer

194 The koose inhibited radical-induced oxidative cellular and DNA dam

195 ning gangliosides enriched in lipid rafts to inhibit raft-dependent PI3K signaling.

196 und that partial APC/C inactivation severely inhibits retinal differentiation independently of cell-c

197 ein Sun1 antagonizes Sun2 LINC complexes and inhibits RhoA activation and focal adhesion assembly.

198 lassical m(7)G cap that promotes rather than inhibits RNA decay.

199 most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic

200 yielded two attractive chemotypes capable of inhibiting S1P formation in cells.

201 that controls iron export from vacuoles and inhibits Salmonella growth in macrophages.

202 ivation of lytic viral expression but do not inhibit several other lytic activation pathways.

203 utant that does not bind to eIF4A, failed to inhibit Sin1 translation, and consequently failed to rep

204 n initiation factor 4A (eIF4A), sufficiently inhibited Sin1 translation, and thus suppressed mTORC2 k

205 f CXCR6 with its ligand CXCL16 significantly inhibited SIVagmSab replication in sabaeus PBMC and had

206 t encompasses RAS and RAF, MEK, and ERK that inhibits SOS via phosphorylation.

207 Mechanistic studies showed that HNK inhibited Stat3-phosphorylation/activation in an LKB1-de

208 ole antifungal drugs showed that CYP126A1 is inhibited strongly by azoles containing an imidazole rin

209 NAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation.

210 THB is shown to bind and inhibit SULT1A3 with high affinity, 23 (+/-2) nM, and to

211 irst two cysteines are necessary for McpM to inhibit susceptible cells.

212 Moreover, Neto2 Ser-409 phosphorylation inhibited synaptic targeting of GluK1 because, unlike WT

213 regimens in organ transplantation primarily inhibit T cells.

214 Concurrent helminth infection potently inhibits T cell immunity; however, whether helminthes pr

215 tween TAM Ig1 domain and Gas6 Lg1 domain can inhibit TAM activation, and support the further developm

216 itical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling.

217 outcompetes DNA polymerase I to successfully inhibit template strand extension.

218 rcuitry via 5-HT and glutamate co-release to inhibit the BA output.SIGNIFICANCE STATEMENT The modulat

219 nd that H9e hydrogel could not significantly inhibit the diffusion of camptothecin encapsulated insid

220 f PPP1R11 to prevent activation of STAT3 and inhibit the EMT and metastasis.

221 Metabolites can inhibit the enzymes that generate them.

222 a short-lived transcription factor that can inhibit the growth, or stimulate the death, of developin

223 Because statins inhibit the production of isoprenoid intermediates in th

224 etermined that many of these small molecules inhibit the protein-protein interactions through covalen

225 Using transcranial magnetic stimulation to inhibit the right frontopolar cortex, we were able to se

226 el signaling pathway that can be targeted to inhibit the secretion of cytokines by modulating either

227 Besides, all compounds inhibit the trophozoite proliferation in amoebic liver a

228 cal analyses revealed that UbVs specifically inhibited the activity of UBE4B or phosphorylated CBL by

229 ion of the GluA1 ubiquitin-deficient mutants inhibited the adverse effects of Abeta on the surface ex

230 ome contrast, activation of PZ(Vgat) neurons inhibited the behavioral, but not electrocortical, arous

231 of LRP6, including JNK and WNT/beta-catenin, inhibited the biologic activity of domain 4.

232 tolerogenic activity of MDSCs in tumors, and inhibited the expression of immunosuppressive factors ar

233 We determined that chrysophanol inhibited the functional and morphological features of M

234 ritoneal administration of S17 significantly inhibited the growth of MGC803 cells in vivo in a xenogr

235 CK1alpha and the proteasome synergistically inhibited the growth of multiple RAS-mutant human cancer

236 type, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in

237 n or pharmacological inhibition of DDR2 also inhibited the MT1-MMP-dependent cellular degradation of

238 nin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated p

239 of antifungal activity by tissue Mvarphi and inhibited the production of tumor necrosis factor alpha

240 It significantly inhibited the proliferation in HEY, A2780, and A2780/Tax

241 Moreover, MSA effectively inhibited the sprouts of mouse aortic rings and neoangio

242 ous 2-AG and their actions were prevented by inhibiting the 2-AG-synthesizing enzyme diacylglycerol l

243 POP2 also impairs macrophage priming by inhibiting the activation of non-canonical IkappaB kinas

244 lecules or monoclonal antibodies that act by inhibiting the activity of specific proteins that drive

245 tively induces PEL cell cycle arrest through inhibiting the activity of the nuclear factor-kappaB pat

246 cceptance was the most commonly cited factor inhibiting the adoption of ATS, and a variety of technic

247 onstitutive activities of odorant receptors, inhibiting the basal spike firing in olfactory sensory n

248 re internalized by active transport and that inhibiting the caveolae-mediated pathway significantly r

249 L-21 receptor signaling in donor T cells and inhibiting the elimination of thymic ILCs improved thymo

250 Inhibiting the fall of plasma FFAs in these mice prevent

251 that ANI-7 is up to 263-fold more potent at inhibiting the growth of breast cancer cell lines (MCF7,

252 Inhibiting the nuclear receptor's activity using a chemi

253 induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.

254 nst DN by increasing glucose metabolic flux, inhibiting the production of toxic glucose metabolites a

255 ins," which bind to host chemokines, thereby inhibiting the recruitment of leukocytes to the location

256 Here we challenged rRNA 2'-O-Me globally by inhibiting the rRNA methyl-transferase fibrillarin in hu

257 We find, for example, that inhibiting the set of four kinases AURKB, NEK1, TTK, and

258 Interestingly, inhibiting the TOR signaling pathway rescued the midgut

259 on followed by sequencing indicates that ERG inhibits the ability of ERF to bind DNA at consensus ETS

260 hesis are inferred to increase DegU-P, which inhibits the expression of ComK, the master regulator fo

261 optimal dual drug conjugate more effectively inhibits the growth of an aggressive, orthotopic 4T1 tum

262 Loss of IKBKE inhibits the initiation and progression of pancreatic tu

263 rmore, we demonstrate that CX-4945 treatment inhibits the maturation of Th17 cells into inflammatory

264 eedback from differentiated tumor cells that inhibits the rate of tumor stem cell division.

265 tin ligase or affect chromatin organization, inhibits the transcriptional activation activity of PHYT

266 eraction surfaces and, thus, that they could inhibit their ligands.

267 zed Pt NPs induced nanoparticle aggregation, inhibiting their catalytic activity.

268 uppresses replication of X4 HIV-1 strains by inhibiting their entry.

269 fuses to growing other immature neurites and inhibits their outgrowth.

270 ivation and may benefit more from complement-inhibiting therapy than patients with AMD in general.

271 at SOD delivery to caveolae may specifically inhibit this pathological pathway, we conjugated SOD wit

272 We found that AICAR inhibited TNF-alpha-induced CFB expression in ARPE-19 an

273 NO2-OA inhibited TNFalpha-induced NF-kappaB transcriptional act

274 , which causes acute promyelocytic leukemia, inhibits TNFalpha induced gene expression and phosphoryl

275 assay indicated that XWL-1-48 significantly inhibited topoisomerase II activity in a concentration-d

276 decreased charge density, the AMPs exhibited inhibited toxicity against mammalian cells.

277 toxicity, only SA-15 and SA-17 significantly inhibited toxin association with the cell surface.

278 f Myc, but not the mutant p53, significantly inhibited tumor cell proliferation.

279 et of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft

280 optosis in KRAS-mutant lung cancer cells and inhibited tumor growth in murine models.

281 f these two subtypes with targeted therapies inhibited tumor growth only in the subtype of tumor wher

282 Genetic depletion of p62 robustly inhibited tumor-initiating frequencies, as well as growt

283 the effect of anti-PD-1 antibody therapy on inhibiting tumor growth in the BRAF V600E/PTEN-null mela

284 The depletion of KDM3 inhibits tumorigenic growth and chemoresistance of human

285 Enzyme kinetic analysis revealed that BA inhibited tyrosinase activity non-competitively.

286 Being able to focus on a complex task and inhibit unwanted actions or interfering information (i.e

287 Verinurad specifically inhibits URAT1 with a potency of 25 nM.

288 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS) and conse

289 Honokiol application also inhibited UVB-induced DNA hypermethylation and its eleva

290 Mechanistically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK)

291 bromarone, sulfinpyrazone and probenecid all inhibit verinurad binding via a competitive mechanism.

292 show that deubiquitination of ILV cargoes is inhibited via Doa4 binding to Vps20, which is the subuni

293 inase protein kinase R (PKR), which potently inhibits virus replication.

294 romotes mitotic entry by phosphorylating and inhibiting Wee1.

295 Ex vivo serum CP activity was profoundly inhibited when TNT009 concentrations exceeded 20 mug/mL.

296 same protocol was used for 20 mL of RBC AChE inhibited with a soman model compound.

297 tically, RARRES2 overexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting

298 o and in vivo, while esculetin significantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

299 nial mouse xenograft models of glioblastoma, inhibiting Wnt5a activity blocked brain invasion and inc

300 Moreover, we show that the OrzO sRNA can inhibit zorO translation via base pairing to the of the