ライフサイエンスコーパス: importance

1 ophysiology of DWMI is therefore of critical importance.

2 veloping Alzheimer disease (AD) is of utmost importance.

3 nogenicity appear to underlie their relative importance.

4 can activate microglia is thus of paramount importance.

5 ential of single cells is a task of critical importance.

6 e hypoxic tumor microenvironment is of major importance.

7 work centrality is often a good indicator of importance.

8 enes likely to affect traits of agricultural importance.

9 e air before it reaches the lungs are of key importance.

10 ty), and where the assembly rates are of key importance.

11 of this molecule in food samples is of great importance.

12 oth statically and dynamically) is of utmost importance.

13 t serves to classify roads in terms of their importance.

14 ognition of the Fab HM14c10 light chain CDRs.IMPORTANCE A chimeric yellow fever-dengue live-attenuate

15 ndings solely to attractiveness, and (3) the importance accorded attractiveness in mate preferences i

16 of individual residential changes and their importance among specific age and sex groups are still p

17 The results highlight the importance and functional consequence of these mutations

18 emical contaminants, but that their relative importance and interaction strength varied with the spat

19 f unidentified suppressors, highlighting the importance and power of strain validation and whole geno

20 ined a decision tree that shows the order of importance, and range of influence, of the physicochemic

21 In addition, RSV's importance as a largely unrecognized pathogen of debilit

22 Fast and direct detection of pyocyanin is of importance as it could provide important insights regard

23 Our data are of clinical importance, because they indicate that both CD19(+) cell

24 he presence of CD4(+) T cells is of critical importance but mast cells, antibodies, and basophils hav

25 Fisheries have an enormous economic importance, but reconciling their socio-economic feature

26 ication act on viruses lacking ExoN activity.IMPORTANCE CoVs encode multiple antagonists that prevent

27 tection against zoonotic infection with FeLV.IMPORTANCE Domestic exposure to gammaretroviruses such a

28 and regulation of EBOV VP40-mediated egress.IMPORTANCE Ebola virus (EBOV) is a high-priority, emergi

29 endogenous retroviruses on HIV-1 replication.IMPORTANCE Endogenous retroviruses inhabit big portions

30 This work is believed to be of importance especially for researchers working on the gro

31 fication of biothreat agents is of paramount importance for confirmation of the event and to mitigate

32 conductivity-a challenging mission of great importance for delivering affordable and environmentally

33 tic islets, the tissue of primary pathogenic importance for diabetes.

34 ent of these disorders to highlight areas of importance for future clinical trials.

35 for plant science research because of their importance for leaf growth and hence for plant fitness a

36 e discrepancies between models highlight the importance for policy makers to carefully evaluate the c

37 drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic tre

38 tion of ML to test whether ML is of critical importance for real-world face detection.

39 ective assembly of human genomes is of great importance for realizing the promise of precision medici

40 on raised by these findings is of particular importance for studies that seek to assign FP/LFP record

41 ydrogen evolution reaction (HER) is of great importance for sustainable energy conversion processes.

42 ion changes associated with fungi of medical importance for the years 2012 through 2015.

43 hronic gammaherpesvirus infection of B cells.IMPORTANCE Gammaherpesviruses infect a majority of the h

44 Parasites of medical importance have long been classified taxonomically by mo

45 n of HSC for liver fibrosis in HCV infection.IMPORTANCE HCV-associated liver fibrosis is a critical s

46 ites testing HIV-1 clade C-specific products.IMPORTANCE HIV-1 group M includes nine clades and many r

47 with T cell-dependent antibodies, and their importance in both humans and mouse models is still uncl

48 h a natural receptor molecule has tremendous importance in cell signaling, medical diagnostics, and t

49 Despite its fundamental importance in cellular processes and abundant use in bio

50 r computed tomography (MDCT) has also gained importance in diagnosing gastrointestinal bleeding, part

51 Despite its potential importance in Escherichia, Salmonella, Klebsiella, Shige

52 metal clusters are materials of ever-growing importance in fundamental and applied research.

53 uildup of virions within dilated ER vesicles.IMPORTANCE In humans, symptoms of RVFV infection mainly

54 ther supporting previous observations on its importance in malignant transformation and development o

55 sporters in source and sink organs and their importance in regulating nitrogen movement in support of

56 the human transcriptome have revealed their importance in the development of colorectal cancer, and

57 e between different quantum states has great importance in the fields of chip-scale atomic clock and

58 hippocampal neurons as a novel substrate of importance in the higher-order regulation of feeding beh

59 novel cluster of amino acids with functional importance in the regulation of type I interferon signal

60 D4(+) T cell responses in natural infections.IMPORTANCE Increasing evidence suggests that virus-speci

61 ower the energetic barrier to pore expansion.IMPORTANCE Influenza A virus is an airborne pathogen cau

62 y reflect differences in geographical origin.IMPORTANCE New DNA sequencing technologies have made it

63 variation in drug metabolism pathways is of importance not only in livestock, but also in humans in

64 e ICD-11 framework, WHO has recognized their importance not only to clinicians but also to epidemiolo

65 To explore the functional importance of 5hmU, we develop a method for the genome-w

66 s, and public policy, and emphasize that the importance of a balanced diet may extend beyond the mere

67 Despite the importance of a cellular population of tubulin dimers, w

68 solid-state organic D-A blends and show the importance of a reduced relaxation energy, which we intr

69 This concept implies the importance of a three-dimensional (3D) culture model inc

70 nforming our understanding of the biological importance of A-to-I editing.

71 We propose the importance of accessing CT states for photoredox catalys

72 ur, and regulatory functions emphasizing the importance of accounting for environment in genetic anal

73 of reward and underscores the methodological importance of accounting for time of day in fMRI protoco

74 These findings underscore the importance of achieving widespread delivery of therapeut

75 Despite the socioeconomic importance of allergic rhinitis (AR), very few prospecti

76 Despite the physiological importance of aluminum (Al) phytotoxicity for plants, it

77 le demographic trajectories and the relative importance of anthropogenic stressors.

78 erse effect of the PIP/TAZO shortage and the importance of antibiotic stewardship when mitigating dru

79 In vitro studies have demonstrated the importance of apolipoproteins in HCV secretion and infec

80 Our results emphasize the importance of APP in AD and should stimulate new studies

81 Our results illustrate the importance of appropriate drought measures and, as a glo

82 he basis for ASO-FUS binding illustrated the importance of ASO backbone and hydrophobic 2' sugar modi

83 ly realistic conditions, and illustrated the importance of assessing exposure through all media in mi

84 explain biochemical and genetic data on the importance of B-subunit integrity in replisome function

85 In view of the functional importance of bacterial communities in the phyllosphere

86 is short review, we particularly discuss the importance of benchmarking stem cell-derived hepatocyte-

87 ificant differences in IC among centers, the importance of biliary strictures as a risk factor for gr

88 Given the importance of biting midges as vectors, a key area of fu

89 y help epidemiologists better understand the importance of both online and offline networks for popul

90 The importance of cell death in brain development has long b

91 These results highlight the importance of choosing cells lacking endogenous MA chann

92 ly modest correlations, leaving the relative importance of circulation and warming unclear.

93 n-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolut

94 The importance of climate-soil interactions to Se distributi

95 These methods highlight the importance of computational techniques in fMRI analysis,

96 variability relationships and highlights the importance of conserving regional species pools to help

97 rature dependence of GPP, and highlights the importance of considering physiological, ecological and

98 This analysis highlights the importance of considering the legacy of past ecosystem i

99 Our study highlights the importance of considering the packing when analyzing dyn

100 Our results emphasize the importance of continuing surveillance of sexual behavior

101 m of the phase transitions, highlighting the importance of cooperative multiscale processes.

102 hallow CO2-rich hydrothermal systems and the importance of coupling highly specific process indicator

103 pharmacological and genetic data suggest the importance of delta-opioid receptors.

104 Our data emphasize the importance of dental disease and tooth extraction in ONJ

105 nds, which may indicate standard of care and importance of developing methods of treatments.

106 e, the model was used to assess the relative importance of different pathways in metal bioaccumulatio

107 ed structural equation modelling to test the importance of direct and indirect (via floral resources)

108 These results underscore the importance of documenting head injuries even within the

109 ovement on estimator accuracy emphasizes the importance of effective post-hoc calculation of area sam

110 the generalizability of this effect and the importance of encouraging older adults to engage in thes

111 cell receptor-blind viruses demonstrated the importance of epithelial cell infection for clinical dis

112 In this review, we evaluate the importance of ERs in bone metastasis and discuss new ave

113 temperatures, and to understand the relative importance of factors that contribute to heat generation

114 ys ferulic acid can be present in maize, the importance of ferulic acid derivatives and the methodolo

115 Therefore, our data underscore the importance of finely regulated endosomal traffic in TCR

116 el (an elastic network model) highlights the importance of flexibility in the entrance region.

117 ID for structured substrates and uncover the importance of G4 recognition and oligomerization of AID

118 By documenting the importance of geographies of synchrony, advancing concep

119 uting stent use within SVG, and the relative importance of high platelet reactivity (HPR) in SVG PCI

120 Limitations of calculation methods and the importance of high quality food composition data are dis

121 between the two, few studies have tested the importance of hippocampal-OFC interactions.

122 lyses of CRC tissues further corroborate the importance of histone H4K16 acetylation in CRC.

123 rstanding will be disentangling the relative importance of host tree mortality from changes in soil c

124 and P inputs, respectively, underscoring the importance of household actions in influencing urban wat

125 een unreported, even though evidence for the importance of HSV-2 antigen-specific CD8 T cells is moun

126 Understanding the importance of human activities on TOC changes requires k

127 eported for IAPP fibrils and demonstrate the importance of hydrogen bonding and hydrophobic interacti

128 microrefugia insufficiently accounts for the importance of hydrologic processes and changing water av

129 dd to a growing literature demonstrating the importance of identifying normative trajectories of func

130 Our findings underscore the importance of IL-10R signaling in preventing T-cell- and

131 ples still exceeded 10 mug/L, reflecting the importance of implementing full LSL replacement and effi

132 pathetic tone respectively, highlighting the importance of individual neural and autonomic difference

133 orter system to quantitatively determine the importance of individual receptors in HCV cell-free and

134 Given the importance of insulin and its related peptide hormones a

135 These findings reveal the importance of intracellular transport in steady-state ly

136 Our findings show the importance of investigating non-coding regulatory varian

137 Despite the importance of ions in fungal decay mechanisms, the spati

138 strategy, but with geography, revealing the importance of isolation-by-distance dynamics in the area

139 Our results highlight the importance of kinesin-3 based axonal transport in synapt

140 Our study highlights the importance of lifelong monitoring of cardiovascular risk

141 We used it to probe the importance of lipid peroxidation in progression of NASH

142 This finding highlights the importance of macrocyclization in combination with rigid

143 major unmet need in this population and the importance of maintaining or improving quality of life f

144 This work points out the importance of matching the charge transport layers in pe

145 gnatures are not intuitive, exemplifying the importance of mathematical modelling approaches.

146 studies, our findings further emphasize the importance of measures to reduce the global epidemic of

147 The importance of mechanical forces in influencing cell beha

148 Due to the great importance of medicinal plants for health, we need to fi

149 ntial for riboswitch function, revealing the importance of metastable states for RNA-based gene regul

150 pathogenic CNVs in this study highlights the importance of microarray analysis in adults with unexpla

151 The importance of microwave irradiation in organic synthesis

152 this thematic series discusses the relative importance of mitochondrial sites for ROS production, RO

153 To better assess the importance of mobile technologies in rhinitis control, t

154 dant and Aerosol Study (SOAS) emphasizes the importance of modeling the whole system to understand th

155 ltatory migration in vivo and highlights the importance of MT flexibility in N-C coupling and neurona

156 with recent preclinical studies showing the importance of multiple neuropeptides in reinstatement of

157 First, we theoretically model the importance of multiple scattering effects and computatio

158 These studies highlight the importance of multiscale imaging of HIV-1-infected tissu

159 This work demonstrates the importance of MXene electrode architecture on the electr

160 Given the importance of N recycling, an important but underestimat

161 ex III, and by piericidin, demonstrating the importance of NADH-related ubiquinone reduction for ROS

162 nflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflamm

163 Although the importance of neuronal progenitors in vascular developme

164 ls reproduce these results and highlight the importance of neurons coding feature values for parallel

165 Despite the importance of neurovascular disease and subsequent injur

166 Methods for ranking the importance of nodes in a network have a rich history in

167 Our studies further illustrate the importance of normal membrane trafficking in the physiol

168 Collectively, these studies highlight the importance of nucleobase desolvation as a key physical f

169 By doing so, it suggests the biological importance of optogenetic follow-up of less-publicized e

170 The study findings underscore the importance of organizational safety practices and cultur

171 The central importance of oxygen, energetics, and redox homeostasis

172 The functional importance of palmitoylation results in part from a dram

173 ncy with ID in offspring and investigate the importance of parental mental illness for such an associ

174 Within this broader pattern, the relative importance of particular routes also fluctuates over the

175 d PDLIM5 levels, underscoring the functional importance of PDLIM5 for proper kAE1 membrane residency,

176 etwork-based cellular signatures.Despite the importance of pharmacological and functional genomic scr

177 We also document the importance of PKR, TRIF, and TBK1 in cytokine secretion

178 Our previous studies demonstrated the importance of PLCgamma2 in osteoclast (OC) differentiati

179 homeostatic regeneration, and highlight the importance of postmitotic cell growth in gut epithelial

180 fy key players in liver regeneration and the importance of posttranslational regulation of growth fac

181 ic and psychiatric diseases, emphasizing the importance of precise neuronal control of effector pathw

182 These data suggest the importance of preventing severe forms of DR to mitigate

183 ect in the aversive procedure, revealing the importance of procedural differences to the demonstratio

184 These findings highlight the importance of prompt diagnosis, care engagement, and opt

185 tion of hunters and the public regarding the importance of proper preparation of wild game prior to i

186 n Ksp-cre;Pth1r(fl/fl) mice, emphasizing the importance of PTH in inhibiting Cldn14.

187 Taken together, our results highlight the importance of RALY as an indirect regulator of transcrip

188 These results demonstrate the importance of reactivation of AR-regulated lipid biosynt

189 Our data not only highlight the importance of regulating the epigenetic landscape during

190 Our findings underscore the importance of retroviral structural proteins for integra

191 But how this occurs, and the functional importance of S-nitrosation sites across the mammalian p

192 These results highlight the importance of seagrass ecosystems to the health of human

193 This highlights the importance of selecting from both chemo- and biocatalyst

194 Given the importance of selective information processing in nearly

195 Thus, our study highlights the importance of SENP8 in maintaining proper neddylation le

196 These results highlight the importance of sequence context for alt-EJ repair and hav

197 Moreover, our approach reveals the relative importance of sequence-based features coming from both w

198 ivity underwent evaluation of the diagnostic importance of serum anti-BP180 IgE.

199 hannels in platelets is unclear, despite the importance of shear stress in platelet function and life

200 sing temperature for all densities, with the importance of short-range impurity scattering resulting

201 To reliably predict the functional importance of single isolated UMCs across the genome, wh

202 These results highlight the importance of soil- and leaf-P in defining the photosynt

203 Comparison to previous studies indicates the importance of some key model aspects including climatic

204 These findings underscore the importance of specific combinations of transcription fac

205 ously, we have begun to understand the vital importance of splicing in disease, which offers a new pl

206 Our analysis reveals that the importance of spreaders is fixed by the subcritical path

207 Given the importance of STEM careers as drivers of modern economie

208 d disorders; however, only recently have the importance of sterile inflammatory processes in this eff

209 ese uterine leiomyoma subtypes emphasize the importance of subtypes and genotypes in designing nonsur

210 Yet, despite the importance of such experiments for translational medicin

211 Recent studies have highlighted the importance of such metabolic regulation in the endotheli

212 diet-induced obese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weig

213 rate enhancements, our study highlights the importance of the atomistic and chemical nature of the t

214 We demonstrate the importance of the barley reference sequence for breeding

215 These results demonstrate the importance of the CeA in regulating responses to rewardi

216 taining site-directed mutations revealed the importance of the conserved DDE motif and a W residue.

217 cer-type mer-C,N,S ligation, emphasizing the importance of the fac-C,N,S-iron(II) motif in promoting

218 To elucidate the importance of the GPB and GPC receptors relative to the

219 Not only do our results highlight the importance of the gut microbiome in honeybee health, but

220 red as L35<F68<L64<F127<P123, indicating the importance of the hydrophobic environment for the colori

221 Furthermore, we analyze the importance of the pair-relationships extracted by PSSM-R

222 der threat of extinction, thus revealing the importance of the preservation of the natural Sardinian

223 This study addresses the importance of the structural changes in P10 during infec

224 the morning, which accounts for the possible importance of the studied process.

225 on housing stability and STIs highlight the importance of the supportive housing program for youths

226 Despite broad recognition of the importance of the third dimension5,6, current lithograph

227 The relative importance of the tumor microenvironment and cancer cell

228 The results showed the importance of the volatile compounds produced from amino

229 Although the importance of these cells is clearly recognized, their e

230 sitivity for fibril formation supporting the importance of these charged side chains in fibril format

231 The importance of these diseases as well as the proliferatio

232 Despite the potential importance of these factors, few studies have directly t

233 To more fully understand the importance of these findings for conservation and manage

234 The importance of these findings translated to the natural h

235 The individual importance of these pathways for the generation of essen

236 umer ('top-down') controls, but the relative importance of these selective forces is unknown.

237 However, the actual importance of these to collective migration remains circ

238 Despite the biological importance of this layer of complexity, relatively littl

239 accade-related accumulation, emphasizing the importance of this parameter in biologically plausible m

240 Technological importance of this pigment emerged from various studies

241 lated at lysine 14 (H3K14Ac), validating the importance of this specific acetylation mark for PBRM1 b

242 Despite the importance of this structure, it is unknown which factor

243 itional approach to diagnosis emphasises the importance of thorough clinical and laboratory evaluatio

244 The importance of thymic epithelial cells (TECs) is evidence

245 ffected neuronal migration, highlighting the importance of tightly regulated CAMK2 auto-phosphorylati

246 behaviour is widely recognized, whereas the importance of tissue material properties, in particular

247 Staff highlighted the importance of training, but staff training appeared main

248 The importance of understanding patient preferences for life

249 Our results underscore the importance of understanding the interplay among disposit

250 We demonstrate the importance of undervaccinated subpopulations, using an e

251 Our data further demonstrate the importance of Vascular Endothelial Growth Factor (VEGF)

252 Despite the importance of vasodilation in cardiovascular homeostasis

253 The importance of VEGF produced by ALL cells in mediating le

254 habitats and demonstrates the complexity and importance of vertical structures.

255 The importance of VPDant suggests that atmospheric drought i

256 Nonetheless, given their likely importance, phosphatases have recently become the focus

257 proteins may be critical for virion assembly.IMPORTANCE Poxviruses are unique among enveloped viruses

258 ciation of EFC proteins with viral membranes.IMPORTANCE Poxviruses comprise a large family that infec

259 nts may play in the prion conversion process.IMPORTANCE Prion conversion is likely influenced by lipi

260 protection against heterologous CDV strains.IMPORTANCE Rabies virus and canine distemper virus (CDV)

261 lity of anti-ZIKV drugs to cross the barrier.IMPORTANCE Recent outbreaks of ZIKV, a neglected mosquit

262 egy for EV71 to evade the antiviral response.IMPORTANCE Recently, it has been reported that GSDMD pla

263 or cyclin B1 inhibition during MVM infection.IMPORTANCE Replication of the parvovirus minute virus of

264 and is required for full MoMLV pathogenesis.IMPORTANCE Retroviruses are thought to spread primarily

265 developed as an intranasal pediatric vaccine.IMPORTANCE RSV and HPIV1 are major viral causes of acute

266 computational efficiency, we describe an new importance sampling scheme to perform model inference.

267 Despite their functional importance, several questions remain about how these pro

268 f attenuated viruses for vaccination studies.IMPORTANCE SFTS phlebovirus (SFTSV) and related tick-bor

269 ition and organization of the viral particle.IMPORTANCE Tailless viruses of the family Tectiviridae c

270 inding site and blocking PKR kinase activity.IMPORTANCE The antiviral kinase PKR plays a critical rol

271 transit, nuclear import, and mRNA synthesis.IMPORTANCE The fates of HIV-1 reverse transcription prod

272 n elite controllers to inhibit HIV infection.IMPORTANCE The greater ex vivo antiviral inhibitory acti

273 es than other, more attenuated DENV isolates.IMPORTANCE The lack of a known correlate of protection a

274 its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small nonenveloped icosa

275 ed particle can initiate infection in a cell.IMPORTANCE The pathways by which a virus enters a cell t

276 virulence evolution remain to be determined.IMPORTANCE The species jump of myxoma virus (MYXV) from

277 ction yet still elicited protective immunity.IMPORTANCE The vaccinia virus (VACV) K1 protein inhibits

278 mmunodeficiency virus (HIV) drug development.IMPORTANCE The Vpr and its paralog Vpx are accessory pro

279 Despite its scientific and technological importance, the interfacial structure of R5 during silic

280 Despite its importance, the mechanism and factors controlling MARCH5

281 Despite its fundamental importance, the mechanism(s) underlying this defect rema

282 Of importance, the risk of TLF and TLR for patients with BV

283 Despite its importance, the structural alignment problem has not bee

284 Of importance, these alterations in centrosome integrity do

285 ies of semiconducting materials are of great importance to a vast range of contemporary technologies.

286 nes for plastid transformation is of crucial importance to all efforts towards extending the species

287 aracterization of blood plasma is of central importance to clinical proteomics and particularly to bi

288 on aerosol particles is a process of crucial importance to Earth's climate and the environmental scie

289 The honey bee is of paramount importance to humans in both agricultural and ecological

290 ly modifiable condition, it is of particular importance to identify malnourished patients so that nut

291 y aspects of the 2016 update with particular importance to routine patient care and clinical trial de

292 ls to identify microenvironmental factors of importance to the development of improved regenerative m

293 ecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based th

294 erved in sequence/structure indicating their importance to the virus.

295 asy separation of the products lend a unique importance to this one-pot methodology.

296 facilitate the management of viral diseases.IMPORTANCE Tomato is an important source of micronutrien

297 uated annually for inclusion on the basis of importance, validity, and performance gap.

298 thicity and host transcriptional suppression.IMPORTANCE Viruses must suppress host antiviral response

299 mRNA via conserved residues whose functional importance was unknown.

300 e approach for assessing disease progression.IMPORTANCE We report here that the HIV/SIV-associated B