ライフサイエンスコーパス: imbalance

1 wer CD4/CD8 T-cell ratios (suggesting immune imbalance).

2 ct, which can lead to a synergistic chemical imbalance.

3 -level iron status and risk factors for iron imbalance.

4 riptional bursting causing temporary allelic imbalance.

5 owing metabolic stress imposed by nucleotide imbalance.

6 iovascular and behavioral responses to fluid imbalance.

7 xacerbates cardiac dysfunction and autonomic imbalance.

8 C proteins can result in deafness and severe imbalance.

9 r, had lower AMA titers, and lower sex-ratio imbalance.

10 (55%) with KRAS mutations exhibited allelic imbalance.

11 y downstream of mTORC1 triggered by anabolic imbalance.

12 icits associated with nutritional n-3 PUFAs' imbalance.

13 es (movement vs. no movement) to reduce data imbalance.

14 dered breathing patterns, and sympatho-vagal imbalance.

15 rval responses have many zero values and are imbalanced.

16 oid overtreatment and control of sex hormone imbalances.

17 es regarding potential excitation/inhibition imbalances.

18 and resource availability create additional imbalances.

19 instem is a useful circuit for testing these imbalances.

20 ne expression, splicing patterns and allelic imbalances.

21 is and lactic acidosis, and neurotransmitter imbalances.

22 han classical stoichiometric protein complex imbalances.

23 .0 vs. 9.7 +/- 2.6 events h(-1) ), autonomic imbalance [0.6 +/- 0.2 vs. 0.2 +/- 0.1 low/high frequenc

24 To account for risk imbalances, 1:1 propensity score matching based on 16 ba

25 Focusing on Kras allelic imbalance, a feature shared by all three models, we disc

26 y monitoring board detected an unanticipated imbalance across blinded groups in the number of hematol

27 iterature examining neural correlates of E/I imbalance across children and adults with ASD and adults

28 icularly computational models predicting E/I imbalance across disorders.

29 eads reduce the position-specific nucleotide imbalance across reads and improve the utility of these

30 bles were constructed via random forests and imbalance-adjustment strategies using two of the four co

31 as overrepresented due to allelic expression imbalance (AEI).

32 Yet, imbalanced alleles, especially from diploid genome regio

33 and sensory information, but whether such an imbalance also influences auditory-perceptual processes

34 Whether this imbalance also occurs in bronchial epitheliumof asthmati

35 provides a distinct contribution to a chiral imbalance, an effect known as the mixed axial-gravitatio

36 eptide YY3-36 can reverse this neurochemical imbalance and acutely restore sleep composition.

37 on cardiomyocytes (CMs), resulting in redox imbalance and cardiac dysfunction that can be functional

38 of a direct relationship between tau isoform imbalance and defects in axonal transport, which induce

39 order characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction.

40 havioral responses that mitigate homeostatic imbalance and ensure survival.

41 ought to characterize morphea serum cytokine imbalance and IFN-related gene expression in blood and s

42 hannel disorder characterized by episodes of imbalance and incoordination.

43 By addressing the data-imbalance and location-correlation issues, the GLMM effe

44 iastolic dysfunction, worsens sympatho-vagal imbalance and markedly increases the incidence of cardia

45 euronal integrity losses to neurotransmitter imbalance and metabolite dysregulation, leading to the r

46 activation (ZGA), the combination of genomic imbalance and partial genome loss disrupts the normal pa

47 in CHF and that they contribute to autonomic imbalance and progression of CHF.

48 he OVLT and MnPO that are activated by fluid imbalance and show that stimulation of these neurons is

49 tauopathic disease, including a tau isoform imbalance and tau hyperphosphorylation in the absence of

50 , emerging pathologies, fueled by complement imbalance and therapy-skewing genetic variance, undersco

51 justment as a way of dealing with prognostic imbalance and to the basic principles and relative trust

52 t showed preserved sagittal balance, coronal imbalance and valgus knee deformity.

53 ession of the angiopoietins becomes markedly imbalanced and Tie2 signaling is greatly attenuated.

54 precipitating circuit inhibition-excitation imbalances and in some cases lethality.

55 Importantly, neurobehavioral deficits, E/I imbalance, and histological damage are all ameliorated b

56 ported here could contribute to this circuit imbalance, and may be a key point to consider for therap

57 ncy leads to abnormal brain development, E/I imbalance, and neurobehavioral dysfunction, which may be

58 ificant age-dependent EFA, lipid composition imbalance, and reduced animal longevity on a high-fat di

59 way" SPNs (iSPNs); their firing rates became imbalanced, and they disparately engaged in network osci

60 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated

61 extreme temperatures, water deficit, and ion imbalance are projected to exacerbate and jeopardize glo

62 We identified 247 genes in which splicing imbalances are associated with clinical patients' outcom

63 How organ-shaping mechanical imbalances are generated is a central question of morpho

64 Force imbalances are primarily thought to arise from within ce

65 Importantly, these dNTP imbalances are strongly mutagenic in genetic backgrounds

66 How imbalances arise in disease states is poorly understood.

67 display irregular breathing, sympatho-vagal imbalance, arrhythmias and diastolic dysfunction.

68 ave proposed excitation and inhibition (E/I) imbalance as a possible mechanistic, network-level hypot

69 Obesity typically is linked to caloric imbalance as a result of overnutrition.

70 owever, most methods of detecting an allelic imbalance assume diploid genomes.

71 Not surprisingly, reciprocal genomic imbalances at this locus confer some of the highest know

72 We present a novel method that adopts imbalance-aware learning strategies based on resampling

73 e-art ML-based methods do not adopt specific imbalance-aware learning techniques to deal with imbalan

74 We show that imbalance-aware ML is a key issue for the design of robu

75 g log-binomial regression, adjusting for the imbalanced baseline characteristics between the groups.

76 This imbalance between adipocytes and stromal cells was accom

77 The pathophysiology reflects an imbalance between alpha- and beta-globin chains with an

78 human bipolar susceptibility may arise from imbalance between AnkG function in interneurons and prin

79 The imbalance between apoB and apoA-I as well as between LDL

80 rning model and PSSM-RT to better handle the imbalance between binding and non-binding residues in da

81 Osteoporosis results from the imbalance between bone resorption and bone formation, an

82 eoclast differentiation, thereby creating an imbalance between bone resorption and bone formation.

83 Our data suggest that there is an imbalance between cardiac and peripheral responses to CS

84 allmark of solid cancers, resulting from the imbalance between cellular O2 consumption and availabili

85 otype-independent test to detect methylation imbalance between chromosomes.

86 An imbalance between cortical excitation and inhibition cou

87 ked to abnormal synaptic transmission and an imbalance between cortical excitation and inhibition.

88 ked to abnormal synaptic transmission and an imbalance between cortical excitation/inhibition.

89 dal projections might result over time in an imbalance between direct and indirect pathways for prope

90 a neurological disorder characterized by an imbalance between excitation and inhibition leading to s

91 subtype 5-HT2C contributes critically to the imbalance between excitatory and inhibitory drive of amy

92 Arid1b haploinsufficiency also led to an imbalance between excitatory and inhibitory synapses in

93 Some emerging hypotheses are an imbalance between indirect and direct basal ganglia path

94 We present evidence for the imbalance between inflammatory and resolving lipid media

95 rogrammed effects will potentially create an imbalance between insulin secretion and insulin-stimulat

96 s in the corneal epithelium, followed by the imbalance between metalloproteinases and their physiolog

97 Several lines of emerging data point to an imbalance between neuronal excitation and inhibition in

98 in sensitivity leads to a proatherosclerotic imbalance between NO and superoxide.

99 in sensitivity leads to a proatherosclerotic imbalance between NO and superoxide.

100 Imbalance between NSP activity and endogenous protease i

101 balance model, work stress was defined as an imbalance between perceived high efforts and low rewards

102 ive inflammation, a second-hit insult, or an imbalance between pro- and anti-inflammatory pathways.

103 In many cell types, imbalance between protein synthesis and degradation can

104 he NRF2 antioxidant pathway have a metabolic imbalance between supporting increased antioxidant capac

105 Imbalance between T regulatory (Treg) and T effector (Te

106 reinvigoration, but rather resulted from an imbalance between T-cell reinvigoration and tumour burde

107 hat UVB irradiation of the cornea caused the imbalance between the antioxidant and prooxidant enzymes

108 e considered the most aberrant example of an imbalance between the cost and benefit of an immune resp

109 ation, and therefore there is necessarily an imbalance between the small set of available disease-ass

110 Weight changes are accompanied by imbalances between calorie intake and expenditure.

111 There were no large imbalances between drug groups on baseline factors.

112 the GABABR agonist (R)-baclofen rescued the imbalances between excitatory and inhibitory neurotransm

113 Emerging evidence indicates that imbalances between specialized proresolving mediators an

114 y between cohorts likely contributed to this imbalance, but some increase in risk cannot be excluded.

115 The mutation induces Ca(2+) imbalance by depressing RyR2 channel activity during exc

116 Previous reports have shown that dNTP pool imbalances can be caused by mutations altering the allos

117 h may, to some extent, counteract the genome imbalance caused by gene loss.

118 he distal convoluted tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate

119 transcriptional response indicative of iron imbalance, causing the induction of genes that are requi

120 This imbalance created strong interocular suppression in deep

121 lance-aware learning techniques to deal with imbalanced data that naturally arise in several genome-w

122 argued as suitable metric for comparison for imbalanced datasets similar to the one studied here.

123 Consequently, this metabolic imbalance decreased biosynthesis of the critical compone

124 2CR knockdown in the amygdala normalizes the imbalance, decreases neuronal activity, and inhibits neu

125 ratiometric sensing, balance detection, and imbalance detection.

126 Adjusting for energy imbalances did not alter these findings.

127 ributed to the exploitation of nutritionally imbalanced diets such as plant saps or vertebrate blood.

128 In contrast, baseline imbalance (difference in ES = 0.01, 95% CI: -0.09 to 0.1

129 nts (CNVs) are major contributors to genomic imbalance disorders.

130 However, an imbalanced distribution of multiple myeloma is frequentl

131 he activation of the DNA damage response and imbalanced dNTP pools.

132 ectivity could enhance the representation of imbalance during nose-up postures while preserving gaze

133 Imbalanced early-stage sound level processing could part

134 Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated disea

135 amined the association between effort-reward imbalance (ERI) exposure at work and unsuccessfully trea

136 ons arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical netw

137 Imbalanced expression in 3R-tau and 4R-tau has been foun

138 Hyperphosphorylation of tau and imbalanced expression of 3R-tau and 4R-tau as a result o

139 to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na(+)-K(+)-2Cl(-) cotranspo

140 of this "NOTCH2-BCR axis" in cGVHD revealed imbalanced expression of the transcription factors IRF4

141 RNAs, one-third of which showed allelically imbalanced expression.

142 iWAT of B6x129 F1-intercrossed mice, with an imbalance favoring the 129-derived alleles, demonstratin

143 imilarity to that of a regular 3D population imbalanced Fermi gas, but with a more drastic departure

144 ton imaging analyses identified elevated and imbalanced glucose metabolism in the Igf2 null mouse.

145 balance." We find that parasites form highly imbalanced groups, and that concomitant predation, in wh

146 the sensitivity of reproduction to metabolic imbalance has significant public health implications.

147 ntly and the taxonomic drivers of functional imbalances have not been systematically identified.

148 examining the mechanisms underlying the E/I imbalance hypothesis across neurodevelopmental disorders

149 stinal bleeding in 1, and severe electrolyte imbalance in 1, all of which were associated with reject

150 This frequent, naturally arising imbalance in 19S regulatory complex composition is achie

151 NKT cell alterations were associated with an imbalance in B-cell subsets, including a significant dec

152 Our results highlight an imbalance in brain ceramide and sphingosine in the early

153 a correction of the pathologic globin chain imbalance in cells from patients with beta-thalassemia.

154 Metabolic imbalance in chronic diseases such as type-1 diabetes ma

155 netics of BiOCl in neutral conditions and an imbalance in Cl and Na storage (i.e., Cl storage require

156 study are two potential sources of bias: an imbalance in cluster size (mean practice size 7,397 [int

157 ing with propensity scores to adjust for the imbalance in covariate baseline values between these two

158 read misregulation of gene expression and an imbalance in cytosolic redox balance.

159 d that Tregs could restore the immunological imbalance in DED.

160 There appears to be an imbalance in dopaminergic receptor and transporter expre

161 cycle pathways, which were reflective of an imbalance in energy metabolism.

162 pathways for energy metabolism and oxidative imbalance in exponentially growing and stationary growth

163 Moreover, this imbalance in eye dominance can also be induced by prior,

164 The resulting imbalance in gene dosage is corrected by increased expre

165 protein that may contribute to transcriptome imbalance in HCC through the regulation of MYC signaling

166 tans is a powerful exotoxin, which can cause imbalance in host response.

167 ivated with the beta-lactam hapten and/or an imbalance in immune regulation.

168 Loss-of-function of the NALCN creates an imbalance in ions, including K(+) and Ca(++) , that inte

169 Imbalance in MMP activity can result in many diseases, s

170 This mitochondrial redox imbalance in mutant Hsp27 motor neurons is likely to cau

171 The DNA methylation imbalance in p53-deficient (p53(-/-)) mESCs is the resul

172 The connections between the redox imbalance in post-mortem muscle, early protein oxidation

173 bundance was uncovered which consisted of an imbalance in protein abundance of inhibitory and activat

174 Bone loss results from an imbalance in remodeling, the physiological process where

175 tion of the glucocorticoid and catecholamine imbalance in SCI patients could be a strategy to prevent

176 is characterized by T helper type 1 cytokine imbalance in serum, particularly CXCL9, which is associa

177 An early imbalance in TE events in the PAG arm led to a clinical

178 We also found an imbalance in Th17/Treg ratio known to control tissue hom

179 The disease hallmarks include imbalance in the alpha/beta-globin chain ratio, ineffect

180 ignited on the lagging electrode, causing an imbalance in the generated forces and consequently a var

181 An imbalance in the lineages of immunosuppressive regulator

182 This imbalance in the role played by the response of the infe

183 potential danger is critical to survival and imbalance in this system may contribute to psychopatholo

184 y reversed high-fat diet (HFD)-induced M1-M2 imbalance in white adipose tissue (WAT) and blocked HFD-

185 itory ratio of synaptic transmission becomes imbalanced in a manner that correlates highly with the l

186 re balanced in the normal adult human brain, imbalances in 3R:4R ratio have been tightly associated w

187 - and mania-like complications of SD through imbalances in cortical levels of neuroactive steroids.

188 We additionally find that similar functional imbalances in different diseases are driven by both dise

189 ted with various HCA risk factors, including imbalances in estrogen or androgen hormones.

190 nhibition may be an important contributor to imbalances in excitation and inhibition in FXS and that

191 eurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circ

192 teinases and their physiological inhibitors (imbalances in favour of prooxidants and metalloproteinas

193 that are mutated in autism is showing us how imbalances in fundamental cellular processes can lead to

194 tification for baseline antibody status, and imbalances in male/female ratio are the main limitations

195 Imbalances in our food can lead to deficiency diseases o

196 We find that imbalances in regulation of actin bundling lead to chaot

197 We determined how imbalances in regulation of actin cytoskeletal dynamics

198 tions in the autonomic nervous system prompt imbalances in sympathetic-parasympathetic activity, whil

199 system, six tau isoforms are expressed, and imbalances in tau isoform ratios are associated with pat

200 ears ago) are thought to have been driven by imbalances in the rates of formation of North Atlantic a

201 ome (FXS) are widely believed to result from imbalances in the relative strengths of excitatory and i

202 Imbalances in the synthesis of individual subunits resul

203 models that can overcome the stoichiometric imbalance, including quaternary organization of P450 and

204 approaches that address the underlying chain imbalance, ineffective erythropoiesis, and iron dysregul

205 rmalities and cortical excitation-inhibition imbalances involving loss of parvalbumin immunoreactive

206 Transcriptional R-loop imbalance is a novel molecular defect causative in TH1 i

207 AnkG isoform imbalance is a novel molecular endophenotype and potenti

208 Global transcriptomic imbalance is a ubiquitous feature associated with cancer

209 Amelioration of pre-rRNA imbalance is achieved through rescue of MRP RNA levels b

210 maintaining immune homeostasis and Th17-Treg imbalance is associated with inflammatory immunosuppress

211 This imbalance is particularly conspicuous within angiosperms

212 Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer.

213 ble learning can be used to address the data imbalance issue between binding and non-binding residues

214 Aneuploidy, an imbalanced karyotype, is a widely observed feature of ca

215 gly, Kinesin-5 inactivation results in force imbalance leading to monopolar spindle and chromosome se

216 This imbalance leads to nitric oxide synthase (NOS) uncouplin

217 ways and defense against pathogens and whose imbalance leads to pathological conditions.

218 ates a number of key issues including strand imbalance, library complexity, and signal enrichment of

219 This catecholamine imbalance may contribute to the particular vulnerability

220 This metabolic imbalance may open the therapeutic window for challenge

221 Conditions such as nutritional imbalance may therefore suppress puberty onset and ferti

222 fragile, whereby local transient biochemical imbalances may lead to permanent morphological changes a

223 rotein complexes, suggesting that regulatory imbalances may lead to stronger fitness effects than cla

224 oadly provides new evidence linking hormonal imbalances, metabolic disturbances, gut microbiota, and

225 higher numbers of apoptotic osteocytes, and imbalanced metabolism, leading to defective mineralizati

226 ts a nonthermal diffusion process-such as an imbalance mode between different bands-we show that the

227 We found that: (1) The E/I imbalance model cannot account for joint alterations in

228 The results support a developmental imbalance model of impulsivity and are consistent with t

229 These findings suggest that the basic E/I imbalance model should be updated to higher dimensional

230 According to the Effort-Reward Imbalance model, work stress was defined as an imbalance

231 This state is mediated by production of imbalanced molecules, and reactive dicarbonyl compounds

232 eservoir of carbon and energy in response to imbalanced nutritional conditions.

233 ls and breast cancer cells indicate that the imbalance of ASE and non-uniformity of gene isoform ASE

234 ichiometry in response to the stoichiometric imbalance of available resources.

235 e-10A (PDE10A) can map widespread functional imbalance of basal ganglia circuits in a mouse model of

236 al model can provide novel insights into the imbalance of brain states found in neuropsychiatric diso

237 To test the hypothesis that an imbalance of cardiac autonomic tone and increased system

238 rrent downregulation of PSI, resulting in an imbalance of energy distribution, decrease of photosynth

239 Mecp2 deletion in mice results in an imbalance of excitation and inhibition in hippocampal ne

240 Hyperexcitability and the imbalance of excitation/inhibition are one of the leadin

241 onorrhoeae infection and probably involve an imbalance of host extracellular matrix components and th

242 es are regulated in patients, suggesting the imbalance of immune and inflammatory cells in IgG4-relat

243 al roles for two OPN isoforms in causing the imbalance of leukocyte populations.

244 peractivate DDB motility and suggest that an imbalance of minus versus plus end-directed microtubule

245 le ocean fronts may explain the demonstrated imbalance of new production and sinking particle export

246 s propose that hallucinations result from an imbalance of prior expectation and sensory information,

247 f superoxide dismutase (SOD), magnifying the imbalance of redox status of E. coli O157:H7.

248 ila recapitulates the pathological polyamine imbalance of SRS and causes survival defects and synapti

249 o modulate cortical response gain creates an imbalance of suppression that favors the dominant eye.SI

250 Deletion of Mecp2 in mice results in an imbalance of synaptic excitation and inhibition in hippo

251 st parameter of CSHM is adapted to deal with imbalance of the dataset.

252 Imbalance of these cues results in CC agenesis or dysgen

253 are capable of overcoming the immunological imbalance of Tregs and CD4(+) IFN-gamma(+) cells in the

254 on of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruct

255 Our studies indicate that an imbalance of two opposing transcriptional programs drive

256 gic interneurons, exhibit different regional imbalances of basal DA levels and fail to increase DA in

257 ABSTRACT: Imbalances of ionic currents can destabilize the cardiac

258 human embryos are aneuploid and genomically imbalanced, often as a result of meiotic errors inherite

259 However, inflammatory imbalance on day 4 was associated with development of IC

260 t of antibiotic-induced dysbiosis (microbial imbalance) on bee health and susceptibility to disease h

261 t-handed man presented with progressive gait imbalance over 6 years.

262 d bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA)

263 and bradykinesia, tremor, rigidity, postural imbalance, postural abnormalities) and non-motor feature

264 nsition probabilities and to solve the label-imbalance problem, we novelly incorporate the AUC (area

265 e cofactor transhydrogenase flux, correcting imbalanced production of NADPH and NADH, were enabled by

266 circuit model that pools such neurons in an imbalanced "push-pull" manner, to generate orientation-s

267 inucleotide phosphate (NADPH) production and imbalanced redox homeostasis in erythrocytes.

268 eviously reported Prevotella spp. population imbalances relative to other bacterial species in gut sy

269 Mechanisms that drive this imbalance remain largely unknown and will be discussed i

270 eveloped additional motor features (postural imbalance, rigidity, and postural abnormalities) and inc

271 SD in a warming world have increased because imbalanced sex ratios could potentially threaten populat

272 The mtDNA alterations led to an imbalanced stoichiometry of mitochondrial respiratory ch

273 raveled a previously unknown link between an imbalanced stoichiometry of the mitochondrial respirator

274 e foods (20-30% of all analysed) had mineral imbalance, such as not having the recommended ratio of C

275 ploidy and is partly due to gene copy number imbalances, suggesting that subtle changes in gene expre

276 orders of pregnancy often exhibit angiogenic imbalances, suggesting that the same mechanisms are invo

277 growth factor levels may imply an angiogenic imbalance that exists even after recovery and may thus p

278 Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increas

279 model of Fragile-X Syndrome, to test the E/I imbalance theory.

280 The excitatory influence of the two eyes is imbalanced to a degree that can be predicted from the se

281 Conversely, the imbalance toward the 4R isoform promoted a retrograde bi

282 In this study, inducing nutrient imbalance was investigated for controlling microbial gro

283 However, the degree of X-autosomal dosage imbalance was less than anticipated (1.14-fold to 1.36-f

284 This metabolic imbalance was reversed by mammalian target of rapamycin

285 inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from

286 ter in their own groups, using a measure of "imbalance." We find that parasites form highly imbalance

287 mprised 152 RPDs and 152 OPDs; all covariate imbalances were alleviated.

288 Furthermore, as cytosolic dNTP pool imbalances were transmitted equally well into the nucleu

289 splay KCC2/Na(+)-K(+)-2Cl(-) cotransporter 1 imbalance when implanted in a wild-type dam and prenatal

290 sed on the electrical conversion of the spin imbalance, where molecular materials are used to mimic t

291 ensory behavior concordant with the afferent imbalance, which is present at birth and nonprogressive,

292 t disorder, including motor coordination and imbalance, which is typical for a loss of DA release in

293 d in RNR substrate production can cause dNTP imbalances, which cannot be compensated by RNR or other

294 d pathways specifically affected by splicing imbalances whose perturbation would be hidden from a con

295 nd the impact of dehydration and electrolyte imbalance will improve health outcomes.

296 Imbalance will lead to conditions such as osteoporosis o

297 on of correlated lipids demonstrated overall imbalance with most prominent effect on cardiolipin mole

298 n analysis revealed a significant but modest imbalance with rs10995 and rs10156, a single-nucleotide

299 n APP dynamics, which might link tau isoform imbalances with APP abnormal metabolism in neurodegenera

300 Most forest nitrogen budgets are imbalanced, with nitrogen inputs exceeding nitrogen outp