ライフサイエンスコーパス: host

1 ures that a virus experiences in its current host.

2 shmania parasites remain indefinitely in the host.

3 rogate growth of this bacterium in an insect host.

4 cterial dispersal, but is detrimental to the host.

5 type following microinjection into an insect host.

6 une responses for chronic persistence in the host.

7 result in communicable infections in the new host.

8 tive adaptation of B. pertussis to the human host.

9 asite and how it interacts with its ruminant host.

10 to alterations in the environment or in the host.

11 develop a persistent infection in the murine host.

12 non-pathogenic species, and select pathogen hosts.

13 interplay between papillomaviruses and their hosts.

14 photoautotrophic and heterotrophic bacterial hosts.

15 havioral changes of IJs towards the infected hosts.

16 cilli with invasive attributes for mammalian hosts.

17 in VP24 enable Ebola virus adaptation to new hosts.

18 by inflammatory responses in immunocompetent hosts.

19 te signalling proteins from plant and animal hosts.

20 form essential metabolic functions for their hosts.

21 ost used to produce virus inoculum for grass hosts.

22 ke ileitis following transfer into Rag1(-/-) hosts.

23 parasite size was intermediate in F1 hybrid hosts.

24 soil and plants to diverse tissues in human hosts.

25 drastic behaviour modifications in infected hosts.

26 port a self-assembled triple anion helicate (host 2) featuring a cavity resembling that of the cholin

27 ls identified from the headspace of infected hosts, 3-Methyl-2-buten-1-ol (prenol) and 3-Hydroxy-2-bu

28 tains two CDGSH motifs, and each CDGSH motif hosts a [2Fe-2S] cluster via three cysteine and one hist

29 to reconstitute, in a nonnative heterologous host, a minimal machinery capable of building Tfp.

30 c actin as bait to recruit and phosphorylate host actin-regulating proteins.

31 that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hep

32 ignificantly to GAS pathogenesis at multiple host anatomic sites.

33 idins have been described, some of which are host and cell specific.

34 Interactions between the host and its microbiota are of mutual benefit and promot

35 eplication in cells derived from its natural host and may be crucial not only to better understand Ch

36 ons in enterohepatic circulation, as well as host and microbiota bile acid metabolism, favor bile aci

37 tely, these complex interactions between the host and pathogen that lead to metal homeostasis provide

38 during the adaptation of the virus to a new host and that many mutations become fixed very early dur

39 s of filoviruses with natural and accidental hosts and for identification of factors that influence f

40 reconstructing the evolutionary histories of hosts and parasites, genes and species, and other interd

41 n all clone SA isolates derived from various hosts and times.

42 c circadian clock that is independent of the host, and which regulates parasite biology throughout th

43 surfaces of HIV-1 particles are targeted by host antibodies.

44 aimed to investigate the prognostic role of host antitumour immunity as represented by baseline quan

45 survival that is associated with pronounced host antiviral response and inflammasome activation toge

46 merous proteins that are dedicated to combat host antiviral responses.

47 plant recipients and other immunocompromised hosts are at particular risk for developing virus-relate

48 attern of Bd population growth on individual hosts, as well as population-level effects.

49 es and (iii) metagenomes from environmental, host associated and engineered microbiome samples.

50 access to a novel resource base rather than host-associated divergence.

51 , phagocytosis of the pathogen activates the host autophagy initiation complex (AIC) and the upstream

52 confers resistance to colibactin toxicity in host bacteria and which has been shown to be important f

53 This host binds specifically to the pyranine moiety, enabling

54 hyphal tips and lesion expansion on wounded hosts, but significantly promoted germ tube elongation a

55 Indeed, several recent challenges hosted by the U.S. government have fostered an open and

56 n this study, we report that noble gases are hosted by two major sites within the internal cavity.

57 site to balance the benefits of the enhanced host catabolic activity with the risk of being eliminate

58 This untimely egress depends on host cell acidification.

59 ew, we summarize the biochemical activities, host cell interaction partners, and physiological functi

60 Chlamydia-host cell interaction therefore constitutes a unique sys

61 s finding is important in understanding EV71-host cell interactions and has potential impact on under

62 al impact on understanding other enterovirus-host cell interactions.

63 Mycobacterium tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty

64 ions as an adapter between the virus and the host cell machinery.

65 stfusion (post-F) state at the time of virus-host cell membrane fusion.

66 navirus (CoV) S protein requires cleavage by host cell proteases to mediate virus-cell and cell-cell

67 Host cell proteins (HCP) are a major class of impurities

68 otein P36 as a major parasite determinant of host cell receptor usage.

69 ovel mechanisms, both rather associated with host cell survival.

70 zed a series of chemical analogs that reduce host cell toxicity while maintaining blood-stage and gam

71 e targeted by the autophagy machinery of the host cell, and the PV membrane (PVM) becomes decorated w

72 DPSC/HUVEC-filled RSs, and less cellularized host cell-derived pulp-like tissue was observed in the G

73 ich serves as a signaling interface with the host cell.

74 ticularly difficult to treat when it invades host cells and survive inside the cells.

75 Synthetic circuits embedded in host cells compete with cellular processes for limited i

76 racellular parasites must efficiently invade host cells in order to mature and be transmitted.

77 in which the cross talk between microbes and host cells is necessary for health, survival, and regula

78 ulatum minimizes detection of beta-glucan by host cells through at least two mechanisms: concealment

79 reted by fungal pathogens can spread between host cells via PD.

80 Here, we identify that infection of host cells with reovirus can result in necroptosis.

81 ngs of infected mice but not within cultured host cells, which indicates LegC4 augments bacterial cle

82 o an improved capacity of E11 to bind to its host cells, which was further attributed to two potentia

83 -associated molecular patterns released from host cells.

84 liver invasion as mutants fail to attach to host cells.

85 act at the interface between tumor cells and host cells.

86 us host ER/actin network for movement inside host cells.

87 velope spike (Env) mediates viral entry into host cells.

88 in, which facilitates bacterial adherence to host cells.

89 tial for effector protein translocation into host cells.

90 sible for inducing the expression of PTX3 in host cells.

91 fe cycle of HCV and its interaction with the host cells.

92 glycoproteins named "evasins," which bind to host chemokines, thereby inhibiting the recruitment of l

93 driven by the exchange of charge between the host [Co6Te8(P(n)Pr3)6][C60]3 and the intercalant TCNE.

94 lism represent a major energy source for the host colonic epithelium and enhance epithelial barrier f

95 by the viral proteins Vpx and Vpr to recruit host CRL4 (DCAF1) E3 ligase, which represents a target f

96 bacterial ubiquitin ligase secreted into the host cytosol.

97 The extent of Striga-induced host damage results from the interaction between parasit

98 r 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity.

99 present useful targets in the modulation of host defences against viral pathogens.

100 al nitrooxidative stress response suppresses host defences to facilitate the growth and development o

101 deltaT cells provide immune-surveillance and host defense against infection and cancer.

102 intestinal mucous layer provides a critical host defense against pathogen exposure and epithelial in

103 Inflammation is a host defense process against infection.

104 dy, we show that K6a network remodeling is a host defense response that directly up-regulates product

105 nd developing novel strategies for enhancing host defense to infections in newborns.

106 Neutrophils play a crucial role in host defense.

107 f the contribution of phagocytosis and other host defenses in the research for, and the design of, an

108 However, the ability of SCVs to resist host defenses is largely uncharacterized.

109 likely to play important roles in subverting host defenses, and constitute a valuable pool of anti-in

110 and the ability of a virus to counteract the host defenses.

111 These data suggest that the host defensive environment is supported by the productio

112 The newborn host demonstrates both quantitative and qualitative diff

113 s upon the interaction between Chlamydia and host dendritic cells.

114 epend on MPB dispersal, which decreases with host density.

115 ation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pse

116 Here we used mouse models to examine host determinants that affect H. pylori BabA expression.

117 ese pathways are potential novel targets for host directed therapy in CNS TB.

118 nd potent inhibitors could lead to promising host-directed therapeutic adjuvants for tuberculosis tre

119 ome in macrophages and indicates a potential host-directed therapeutic target to limit the damaging i

120 t SP110b may serve as a potential target for host-directed therapy aimed at manipulating host immunit

121 Host discrimination mechanisms that reduce the fitness o

122 Acute graft-versus-host disease (aGVHD) continues to be a frequent and deva

123 A history of graft-versus-host disease (GVHD) ( n = 27) was associated with higher

124 iated with an increased risk of graft-versus-host disease (GVHD).

125 tear washes of patients with ocular graft-vs-host disease (oGVHD).

126 blative conditioning, and acute graft-versus-host disease (P values < .01).

127 ptoms in animal models of acute graft-versus-host disease and multiple sclerosis.

128 No treatment-related death or graft-versus-host disease had been reported; 15 of the 17 patients (8

129 Grade II to IV acute graft-versus-host disease related to steroid treatment shows a trend

130 mage in a unique in vitro human graft-versus-host disease skin explant model.

131 0 years old and without chronic graft-versus-host disease, compared with the remaining patient cohort

132 ent central tolerance and limit graft-versus-host disease.

133 for Clinical Trials in Chronic Graft-Versus-Host Disease.

134 ion and replication rely on a limited set of host-dispensable genes and suggest that these pathways c

135 the stochastic minefield blocking access to host DNA.

136 osts suffered additional survival costs when hosting double infections.

137 lus and delivering the viral genome into the host during infection, but how the genome is organized a

138 resent a mathematical analysis of the within-host dynamics of plasma ZIKV burden in a nonhuman primat

139 endosymbiont Symbiodinium and its cnidarian hosts (e.g. corals, sea anemones) are the foundation of

140 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitinat

141 cales and the interplay of host-parasite and host-ecosystem interactions.

142 es is thought to reflect the capacity of the host-encoded cellular form of the prion protein (PrP(C))

143 livered VirE2 protein can use the endogenous host ER/actin network for movement inside host cells.

144 device with four embedded GaAs quantum wells hosting excitons that are spectrally matched to the A-va

145 -based control, which preferentially removes hosts expected to cause a high number of infections in t

146 tol 4-kinase IIIbeta (PI4KB) is an essential host factor for many positive-sense single-stranded RNA

147 creen with Haplobank identified PLA2G16 as a host factor that is required for cytotoxicity by rhinovi

148 Thus, our study reveals a role of ATM as a host factor that promotes chronic gammaherpesvirus infec

149 diagnostic techniques of both bacterial and host factors and high throughput screening of novel ther

150 or structural elements, small molecules, and host factors that alter these relatively conserved splic

151 roughput genome-wide siRNA screen identified host factors that prevent reproduction and spread of the

152 wo-dimensional Dirac semimetals are known to host fermionic excitations which can mimic physics usual

153 Promyeloperoxidase hosts five occupied glycosylation sites and six intracha

154 stack is showcased as suitable model cathode host for unveiling the challenging surface chemistry iss

155 lates vigorous immune responses in the human host; forcing selection of viral variants that escape ce

156 s of airway epithelial damage to protect the host from infections in patients with chronic rhinosinus

157 central engine is located in the core of the host galaxy.

158 We identified 4 host gene expression profiles, among which catabolic rem

159 ity is controlled and the function of L1s in host gene regulation are not completely understood.

160 Host-generalist pathogens sporadically infect naive host

161 alling pathway and an aberrant expression of host genes associated with pregnancy complications.

162 Total mRNA analysis identified a set of host genes that are upregulated in response to biofilm f

163 significant overlap in the most upregulated host genes.

164 )isophthalamide-barbiturate hydrogen-bonding host-guest complexes are separately incorporated into he

165 pling droplet morphology to enzyme activity (host-guest interactions with uncaging and molecular clea

166 gs with exciting applications in the area of host-guest organic chemistry, or to spectroscopically ev

167 e, which integrates unique information about host-gut microbiome interactions, gastrointestinal funct

168 treatment affects microbial communities and host health.

169 ivery as a potential strategy to augment the host immune response to prevent serious bacterial infect

170 Thus, augmenting host immune responses against Mycobacterium tuberculosis

171 ge ZIKV have different phenotypic impacts on host immune responses.

172 and infection of pathogens, and guiding the host immune system in response to foreign invasions.

173 ular parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a vari

174 eckpoint blockade immunotherapies enable the host immune system to recognize and destroy tumour cells

175 st interaction depends on the ability of the host immune system to suppress viral replication and the

176 es LegC4 augments bacterial clearance by the host immune system.

177 host-directed therapy aimed at manipulating host immunity against TB.

178 ty to withstand numerous stresses imposed by host immunity.

179 evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells.

180 tuberculosis (Mtb) can persist in the human host in a latent state for decades, in part because it h

181 4460 genes from 264 pathogens tested on 176 hosts in 8046 interactions.

182 emerging challenge in the immunocompromised host, in whom it may be asymptomatic or present as chron

183 phages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacte

184 uli that are potentially associated with the host, including extracellular magnesium limitation, low

185 erons (IFNs) are essential components of the host innate immune system and define first-line of defen

186 viruses, especially their interplay with the host innate immune system, have not been well investigat

187 HBV uses multiple pathways to harness host innate immunity to enhance its replication.

188 lytic surface that GAS employs to circumvent host innate immunity.

189 ted PKs provides new insights into T. brucei-host interaction and reveals novel potential protein kin

190 in a proof-of-principle study how this virus-host interaction can be employed to enhance efficacy of

191 The outcome of a virus-host interaction depends on the ability of the host immu

192 o novel mitochondrial effectors in H. pylori-host interaction with links on gastric pathogenesis.

193 iral diversity, viral metagenomics and virus-host interactions in natural ecosystems.

194 Comprehensive understanding of capsid-host interactions that promote or impede HIV-1 infection

195 Thus, the viral SPI-1 protein and the host IRF2, FAM111A, and RFC complex likely form an inter

196 primary health centres in European countries hosting Latin American migrants.

197 port providing insight into the mechanism of host lipid catabolism by an M. tuberculosis enzyme, augm

198 emphasize that spatial determination of the host lipid components of the immune response is crucial

199 te where the association of HCV virions with host lipoproteins occurs.

200 ents target subcellular organelles to access host machineries required for replication and spread.

201 n-prophage varphi24B on its Escherichia coli host MC1061.

202 ST progressively disabled a host mechanism of protection by inducing endogenous neur

203 uring the relative expression levels of four host messenger RNAs, was developed to discriminate criti

204 In this issue of Cell Host & Microbe, Moguche et al. (2017) show that T cells

205 Host-microbe communication via small molecule signals is

206 3-D EEC model is a robust tool for studying host-microbe interactions and bacterial pathogenesis in

207 mising platform for the development of a new host modulation therapy in periodontitis.

208 Fibronectin (Fn), a ubiquitous host molecule targeted by many pathogens, promotes vascu

209 by access to the outdoors and carpeted rooms hosted more types of arthropods than non-carpeted rooms.

210 r relationship to control of parasitemia and host mortality.

211 e paired Pfaffian phase that is predicted to host non-Abelian anyons.

212 ily life, we rapidly and flexibly retrieve a host of biographical details about individuals in our so

213 e guiding principle for the development of a host of high strength structural alloys, in particular,

214 he best method for the identification of the hosts of contigs in metagenomic studies.

215 strategies used by phages to overcome their hosts, one can expect that the efficiency of protective

216 Intracellular pathogens manipulate host organelles to support replication within cells.

217 as a major determinant of the functioning of host organisms, affecting both health and disease.

218 r isolating GVs from native and heterologous host organisms, functionalizing these nanostructures wit

219 ncluding mediating parasite sequestration to host organs, phagocytic clearance of parasites, and regu

220 overlapping timescales and the interplay of host-parasite and host-ecosystem interactions.

221 e progression and outcome of disease-causing host-parasite interactions will be more clearly understo

222 stralia and Europe is a canonical example of host-pathogen coevolution.

223 ential to provide deeper insights into other host-pathogen interactions.

224 he TGN, causing delays in recruitment to the host-pathogen interface.

225 Here, we have examined the host pathways by which vMIA traffics from the ER to mito

226 rns (PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and activate p

227 l as leukocyte activation, without affecting host phagocytosis of E. coli RA101295 treatment reduced

228 Mtb infection upregulated expression of the host phosphatase PPM1A, which impairs the antibacterial

229 Exposure of hydrated cysts to host plant root exudates resulted in different transcrip

230 Using Arabidopsis as a host plant species, we conducted a comparative analysis

231 rulence and genetically determined levels of host-plant resistance and tolerance.

232 eted by filamentous fungi, are phytotoxic to host plants, but their functions have not been well defi

233 Individual prophages and the host pneumococcal genetic lineage were strongly associat

234 a high number of infections in the remaining host population.

235 s for subsequent cell-to-cell infection when host populations are expanded massively through fungicul

236 olutionary feedbacks of fungal parasitism on host populations is also limited.

237 neralist pathogens sporadically infect naive hosts, potentially triggering epizootics.

238 The dependence of adenovirus on the host pre-RNA splicing machinery for expression of its co

239 rties, neutrophils can contribute to optimal host protection by limiting the extent of endotoxin-indu

240 impaired bacterial clearance and eliminated host protection conferred by Gal-1 deficiency.

241 haping the inflammatory milieu that supports host protection during infection by fine-tuning NF-kappa

242 ers transcription of genes controlled by the host protein BACH1, and BACH1 knockdown reduces BZLF1 ex

243 ections cause host shutoff, a state in which host protein synthesis is globally inhibited.

244 Although the important roles of co-opted host proteins in RNA virus replication have been appreci

245 e of evolution by the recruitment of diverse host proteins that became major virion components.

246 ents of Ef-Tu retain binding capabilities to host proteins.

247 l trajectories are significantly impacted by host proteostasis.

248 eages appear to be shared among heterologous hosts providing evidence of interspecies transmission ev

249 thers, this protocol makes powerful cryptand hosts readily available in gram quantities in good yield

250 ed by their functional roles in engaging the host receptor and in mediating membrane fusion, respecti

251 dN-conjugated beads to biochemically isolate host receptors for bacterial cdNs, and we identified the

252 e anion templation strategy, the [3]rotaxane host recognises dicarboxylates through the formation of

253 The microbiota and its larger host represent a metaorganism in which the cross talk be

254 Currently, microRNAs (miRNAs) involved in host resistance to APEC are unknown.

255 nstrated a major role for the HPA pathway in host resistance to endotoxin-induced septic shock.

256 mediated depletion of the microbiota reduces host resistance to infection.

257 mportant roles in the modulation of both the host response to infection and the replicative cycles of

258 ns unique to NS1 contribute to modulation of host responses, including inhibition of type I interfero

259 loss or removal of the endosymbiont from the host results in the death of both.

260 12%) CD25(-)CD4(+) T cells into RAG-knockout hosts revealed increased autoaggression activity against

261 the respiratory epithelium is crucial in the host's innate defence against primary alphaherpesvirus i

262 r constituents of pathogens and activate the host's innate immune responses.

263 Whole-genome sequencing of pathogens from host samples becomes more and more routine during infect

264 Host searching, pheromone communication, and microclimat

265 sensory neurons, plays a vital role in their host seeking and risk aversion processes.

266 ing infection-associated, short-term, within-host selection pressures.

267 Many viral infections cause host shutoff, a state in which host protein synthesis is

268 at regulate lung immunity, and delineate the host signaling axis they activate to protect against res

269 sRNA precursors of highly abundant viral and host siRNAs by the cellular RdRPs.

270 behaviorally accepted into their aggressive hosts' societies: emigrating with colonies and inhabitin

271 ferent lineages to prevail in the respective host species although some of these lineages appear to b

272 se-resistance, and that Bd prevalence and/or host species identity may impact the relative abundance

273 y of chytrids, their life cycles, phylogeny, host specificity and range.

274 At approximately 10,170 kelvin, the host star is at the dividing line between stars of type

275 In some instances, aphid hosts suffered additional survival costs when hosting do

276 er fibrosis manifested a beneficial role for host survival and apoptosis resistance.

277 ctivity blocked brain invasion and increased host survival.

278 mogenesis reduced tumor burden and prolonged host survival.

279 y hindered by the compatibility of different host-symbiont pairings.

280 ly expanding the scope and complexity of ChB host systems, we also demonstrate, by (1)H NMR and DFT c

281 The Jovian moon Io hosts the most powerful persistently active volcano in t

282 at some facultative symbionts directly alter host thermotolerance.

283 genetic differences between them may confer host tissue-specific virulence.

284 e cancer cells are transiently isolated from host tissue.

285 advantage in the immune systems of infected hosts to recall of memory B cells that recognized the la

286 63% of the phenotype variation, whereas the host traits considered here (age and previous carriage)

287 High-throughput screening of the host transcriptional response to various viral infection

288 The integration of information from the host transcriptomic, epigenetic and virus response also

289 be disentangling the relative importance of host tree mortality from changes in soil chemistry follo

290 netic resonators results in their ability to host two degenerate resonant modes.

291 and tubular ER function independently of the host ubiquitin machinery.

292 notably associated with a modulation of the host urinary metabolomics profile and intestinal energy

293 g a high titer of virus in this intermediate host used to produce virus inoculum for grass hosts.

294 iocompatible hydrogel-elastomer hybrids that host various types of genetically engineered bacterial c

295 colobus virus 1 (KRCV-1) and assessed within-host viral evolution.

296 ollectively, this study offers insights into host-virus interaction in tomato and provides valuable i

297 This effect is likely mediated by changes in host vitellogenin, insulin signaling, and gustatory resp

298 ntify the energetic cost of viruses to their hosts, we enumerated the costs associated with two very

299 of these findings translated to the natural host, where the AddAB system was found to be required fo

300 between microbes, their metabolites, and the host will be discovered.