ライフサイエンスコーパス: helix

1 trimers, potentially via a coiled-coil alpha-helix.

2 in mechanism involving the amphipathic alpha-helix.

3 ed on the formation of a parallel DNA triple helix.

4 urbs the conformation of its DNA-recognition helix.

5 pendants positioned on the same side of the helix.

6 ellin monomers are arranged in a left-handed helix.

7 finding that human calcitonin forms an alpha-helix.

8 of the microparticles was of a V-type single helix.

9 ide chains arranged along one side of the 14-helix.

10 as if transitioning between the ends of the helix.

11 ond transmembrane segment and major coupling helix.

12 ural and dynamic perturbations in the double helix.

13 tolabeled residues (V954 and E969) in the S6 helix.

14 ered flexibility from the N terminus through helix 1 and modulated the RcnR-DNA interaction.

15 ing to RcnR orders its N terminus, decreases helix 1 flexibility, and induces conformational changes

16 (2)H uptake in helix 1 was suppressed in the Ni(II)- and Co(II)-bound R

17 vealed water penetration along transmembrane helix 1 with the cooperation of a polar residue (Y147 in

18 al aromatic and hydrophobic residues in pore helix 1, helices S5 and S6, and helix S6 of a neighbouri

19 include a distinct movement of transmembrane helix 2 (M2), from its position in the previously report

20 nalysis revealed that the flexibility of the helix 3, 7, and 11 regions represents the most important

21 four lipid-facing residues in transmembrane helix 4 (TM4) that is known to be important for dimeriza

22 a are antimicrobial, we synthesized IFN-beta helix 4 and found that it is sufficient to permeate mode

23 f the IFN-beta molecular surface (especially helix 4) are cationic and amphipathic, both classic char

24 on of a polar residue (Y147 in transmembrane helix 5) in the adjacent protomer.

25 a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular half outward to

26 To improve sampling of the helix 6-7 loop, we incorporated motion modes based on pr

27 xes further showed two distinct folds of the helix 6-7 region, classified as "open" and "closed", whi

28 two homologous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence homology to t

29 of the acceptor arm of deacylated tRNA with helix 68 of 23S rRNA.

30 Nmd3 and Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base f

31 ere, we identify a structural element, alpha-helix-7, in human Argonaute2 (Ago2) that is required for

32 ecognition of specific, structured RNAs like Helix 70.

33 s the helix-loop transition in transmembrane helix 8, which likely forms the structural basis for CFT

34 UT1 variant in which we substituted membrane helix 9 with the equivalent GLUT3 sequence.

35 on RTA and makes primary contacts with alpha-helix A (residues 18-32), alpha-helix F (182-194), as we

36 haped substrate pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-proline l

37 Instead of a canonical helix, a noncanonical herringbone helix is formed.

38 ngineered TGF-beta monomer, lacking the heel helix, a structural motif essential for binding the TGF-

39 he Swellix program presented here combines a helix abstraction with a combinatorial approach to the R

40 bind membrane and form an amphipathic alpha-helix (AH).

41 t mutations in loop L1c-FlapI, loop L6c, and helix alpha1c of the RFK module (positions K202, E203, F

42 Our data show that the two A3H alpha-helixes alpha3 and alpha4 represent the Vif-binding site

43 Multiple residues within the S1 helix also play an important role in fine-tuning the vol

44 hPg residues occupied opposite faces of this helix, an arrangement that minimized steric clashing of

45 g events in biogenesis is the formation of a helix, an elementary structure that is ubiquitously pres

46 is concentrated in regions between the alpha-helix and beta-sheet domains.

47 polycrystalline material in which the alpha-helix and beta-sheet regions of the protein are similar

48 Vps4 subunit to join the growing end of the helix and engage the substrate, while hydrolysis and rel

49 s bound at the channel-periphery near the M4 helix and exerts a long-range allosteric effect on the p

50 t degron, Deg1, also contains an amphipathic helix and exhibits 42% amino acid similarity with SM N10

51 e demonstrate that targeted helix-(pi-sheet)-helix and helix-(pi-sheet)-coil assemblies occur without

52 in intercalates between turns of the dynamin helix and impairs fission by preventing trans interactio

53 The alpha-helix and random coil contents of the 600 MPa treated sa

54 for the first time, both the helicity of the helix and the form of the herringbone.

55 te pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-proline loop.

56 comprising six transmembrane helices, a pore helix, and a selectivity filter.

57 the converter, the SH1-SH2 helix, the relay helix, and the lever, abolishes nonmuscle myosin-2 speci

58 rate 2 SMS excitation in transmural myofiber helix angle, mean diffusivity (mean +/- standard deviati

59 ed in the monomeric state but forms an alpha-helix approximately 70 residues long in the self-associa

60 ed and shown to form well-defined helix-turn-helix architectures in which helical and sheet subcompon

61 nce-defined helix-sheet-coil and helix-sheet-helix architectures, are Nature-inspired synthetic mimic

62 nstructured in isolation but tends to form a helix as evidenced by CD and NMR studies.

63 nd conformation, instead of forming an alpha-helix as observed in the previously solved structure of

64 D IR spectroscopy, parallel and antiparallel helix associations were identified by vibrational coupli

65 anionic lipid membranes using an amphipathic helix at its unique N-terminus.

66 that covers one full turn of the nucleosome helix at seven different SHLs, and that the position of

67 The helix at the C-terminus binds to the well-known p53-bind

68 electrostatic interactions near the Cbeta H3 helix at the membrane-proximal face of the TCR, a region

69 es and show that the pore is most probably a helix barrel that contains eight D4 peptides arranged in

70 Such alpha-helix barrels engineered from peptides could find applic

71 linearly with the G:C content of the hairpin helix, being 50% longer for hairpins with only A:T base

72 TR structure reveals a previously unresolved helix belonging to the R domain docked inside the intrac

73 s (PIFs) are members of the basic helix-loop-helix (bHLH) family of transcription factors in Arabidop

74 e transcription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, development,

75 We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that

76 known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hopkins syndro

77 n anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tapetal d

78 ns in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase seam cell nu

79 This includes the basic helix-loop-helix (bHLH) transcription factors SPEECHLESS (SPCH), MU

80 ential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effect

81 enile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel

82 e maturation protein, which, with just a six-helix bundle and a six-stranded beta-sheet, forms a geno

83 rom the C112R substitution in the N-terminal helix bundle and likely relate to a reduced ability of a

84 wo interhelical loops of the C-terminal four-helix bundle appear to penetrate the membrane bilayer, s

85 a FPPase and CPPase are located within a six-helix bundle containing amino acids 53 to 241.

86 y replacing the loops and helices of the six-helix bundle from enzyme with those from the other.

87 r to Polalpha, p261C of Pol contains a three-helix bundle in the middle and zinc-binding modules on e

88 o heptad-repeat regions refold to form a six-helix bundle structure that can be specifically targeted

89 revealed the complete structure of the four-helix bundle that forms the C-terminal domain.

90 nds to model the formation of the SNARE four-helix bundle that mediates synaptic vesicle fusion and u

91 ported water-soluble self-assembled foldamer helix bundle to encapsulate simple guest molecules withi

92 on replacement of the first helix in the six-helix bundle.

93 e distinct conformational changes within the helix bundle.

94 he FAM3C proteins do not form classical four-helix-bundle structures as was initially predicted.

95 of WhiB1 reveals that Wbl proteins are four-helix bundles with a core of three alpha-helices held to

96 e fifth subunit approximately continues this helix but appears to be dissociating.

97 In contrast, mutants lacking the TAD alpha-helix but retaining the most distal C-terminal residues

98 s in K2hPg Further, the adoption of an alpha-helix by VKK38 upon binding to K2hPg sterically optimize

99 tonated Ex moves upward, out of the positive helix cage.

100 ructure of StnA can be described as an alpha-helix cap domain on top of a common alpha/beta hydrolase

101 In the latter, the slope along the helix changes its sign at least twice per turn.

102 fold and the alpha2 helices form a tight two-helix coiled-coil.

103 we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acc

104 al domain and an incipient amphipathic alpha-helix contained within it.

105 etween these potassium and water sites and a helix controlling the cytoplasmic gate of KdpA is linked

106 trate, while hydrolysis and release promotes helix disassembly and substrate release at the lagging e

107 in the A. thaliana kinome found that alphaC helix disorder may be a common feature of plant kinases.

108 Importantly, a helix-disrupting mutation of W50R into residues 44-65 re

109 epair (BER) recognizes and repairs minimally helix-distorting DNA base lesions induced by both endoge

110 proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukar

111 rial outer membrane via its N-terminal alpha helix domain and hosts a redox-active [2Fe-2S] cluster i

112 egion consists of a zinc domain and a winged helix domain and plays an important role in enzyme activ

113 domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlapping location.

114 It contains one long, imperfect double helix (domain I), one branched domain (domain II) contai

115 ke domains forming one layer, and the winged-helix domains (WHDs) forming a top layer.

116 raphy, we show that Cdt1 contains two winged-helix domains in the C-terminal half of the protein and

117 que secondary structure that we term an "eta-helix" due to its repeating turns, which are highly remi

118 ation, AU/GU internal loop closure and AU/GU helix end parameters were particularly important.

119 s with alpha-helix A (residues 18-32), alpha-helix F (182-194), as well as the F-G loop.

120 fferences that alter the conformation of the helix F through helix G region in the upper portion of t

121 of At2g44920 as a representative of the beta-helix family to determine if it had exceptional global s

122 ion factors, members of the basic helix-loop-helix family, play crucial roles in mesoderm development

123 rties of mutations within an overlooked hERG helix, finding important contributions to channel functi

124 ructure immediately adjacent to the SecA two-helix finger subdomain before channel entry.

125 selectivity, which correlates strongly with helix folding, the system we report here is also highly

126 210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexamers and pentamers.

127 ally, the N- and C-terminal halves of the TM helix form trimeric cores of opposite nature (hydrophobi

128 ngaged on cellulose, as models predict alpha-helix formation and decreased cellulose interaction for

129 Thus, reversible alphaS amphipathic helix formation and dynamic multimerization regulate a n

130 nd on the other hand, they can promote alpha-helix formation in certain peptides.

131 an important role in the zipper-like triple-helix formation in collagen.

132 , without any signs of intramolecular triple helix formation or fiber-fiber aggregation.

133 rwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, whereas pept

134 esistant to conformational collapse or alpha-helix formation upon the addition of the osmolyte trimet

135 cle binding via membrane-induced amphipathic helix formation, and '3K' further enhances this effect.

136 oupling between membrane partitioning, alpha-helix formation, and electrostatic repulsions between ac

137 onds is the rate-limiting step during triple-helix formation.

138 s (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wide range of ex

139 Our results show that the short 310-helix from D580 to S584 is critical for proper biogenesi

140 domains induces protection of the Nef alphaB-helix from deuterium uptake, consistent with a role for

141 gest that the formation of an extended alpha-helix from the disordered carboxy-terminal region of nuc

142 lter the conformation of the helix F through helix G region in the upper portion of the cavity and io

143 to a transient unfolding and dissociation of helix H that becomes more prominent at higher temperatur

144 Polymerization assays using Lmod2 mutants of helix h1 and the WH2 domain support this conclusion.

145 rms were observed on the heme-proximal side (helix H5), at the dimerization interface (helices H6 and

146 haracterize the substrate preferences of the helix-hairpin-helix (HhH) domains of XPF and ERCC-XPF an

147 conformational transitions in the C-terminal helix have specific functional involvements in PtdIns tr

148 ubiquitination-resistance were positioned at helix-helix interfaces, likely preventing the hepcidin-i

149 a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain.

150 e substrate preferences of the helix-hairpin-helix (HhH) domains of XPF and ERCC-XPF and show that th

151 Cyanobacteria possess a family of one-helix high light-inducible proteins (Hlips) that are hom

152 Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators controlled by MYT

153 x/loop regions, as well as of the C-terminal helix; (iii) the energy barrier of phospholipid extracti

154 obe cooperate to recognize a mixed alpha/310 helix in AKAP79.

155 at fibrillar exon1 has a partly mobile alpha-helix in its aggregation-accelerating N terminus, and se

156 ults support a model whereby the amphipathic helix in SM N100 attaches reversibly to the ER membrane

157 ed a deletion mutant lacking only this alpha-helix in stable cell lines and Xenopus laevis photorecep

158 Furthermore, we showed that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a mem

159 res of these three factors revealed an alpha-helix in the C-terminal inhibitory domain that packs aga

160 ties were lost upon replacement of the first helix in the six-helix bundle.

161 connecting helices, as well as the short 310 helix initiating the CTD.

162 G530 stabilizes the cognate codon-anticodon helix, initiating step-wise 'latching' of the decoding c

163 regulating signal sequence and transmembrane helix insertion in a substrate-dependent manner.

164 mall molecule stabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ri

165 ecific factors such as Cwc25 lock the branch helix into position for nucleophilic attack of the branc

166 due volume at the Phe position in the alpha1-helix is critical for alphaLbeta2 activation because tri

167 ding on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic pa

168 canonical helix, a noncanonical herringbone helix is formed.

169 For example, a central helix is more frequently populated within the A2T-bound

170 the cleft closes, and the amphipathic alpha-helix is released to bind to the carrier domain via its

171 econdary structure with a low content of PII helix is remarkably efficient at promoting calcium adsor

172 This helix is required for association with actin as truncati

173 The FtsL helix is thus a candidate for acting as a potential mech

174 y residues in the S5, S6, and the first pore helix; isoflurane competitively disrupts A-967079 antago

175 l parameters of adjacent rungs in the triple-helix ladder and developed statistical potentials by ext

176 cription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein.

177 ein, Gp5.7, which adopts a winged helix-turn-helix-like structure and specifically represses transcri

178 CFTR from all other ABC transporters is the helix-loop transition in transmembrane helix 8, which li

179 TING FACTORs (PIFs) are members of the basic helix-loop-helix (bHLH) family of transcription factors

180 The transcription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, d

181 We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling fa

182 (TCF4 also known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hop

183 encoding an anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required fo

184 hat mutations in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase s

185 This includes the basic helix-loop-helix (bHLH) transcription factors SPEECHLESS

186 the differential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predi

187 insect juvenile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain prote

188 Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators contro

189 The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play

190 transcription factors, members of the basic helix-loop-helix family, play crucial roles in mesoderm

191 almia transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding p

192 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription fac

193 HAIR DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future root h

194 roaches, we discovered that the Id family of helix-loop-helix proteins is both necessary and sufficie

195 nd 5' RACE identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IRE1alph

196 p1 Inhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an impo

197 PK3 and MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the

198 Homeodomain and basic helix-loop-helix transcription factors are required for

199 is accompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix;

200 The key finding in the DNA double helix model is the specific pairing or binding between n

201 r an interesting semblance to the DNA double helix model.

202 a helical hairpin, and bipartite helix-turn-helix motif.

203 at least a factor of 60, confirming that TM helix motions are linked to the citrate-binding event.

204 ges that lead to asynchronous pore-lining M2 helix movements.

205 in the protein where the intersection of two helix N-termini creates a region with a strong, localize

206 th POTRA2 containing an additional elongated helix not observed previously in other POTRA domains.

207 ithin the hydrophobic half of the stabilized helix not only reversed the strong membrane interaction

208 lly conserved bulged uridine (U51) in the P4 helix of circularly permuted Bacillus subtilis P RNA wit

209 dulates the rate of Ziploc-ing of the triple helix of collagen in the rER.

210 Delta60) suggested that an 'accessory' alpha-helix of Complexin-I inhibits release by inserting into

211 The helix of FtsB is interrupted between the transmembrane a

212 olved for any linear peptoid, revealed a PPI helix of great regularity despite the presence of only 5

213 cysteine (Cys195) in the third transmembrane helix of Orai1.

214 talytically important interactions of the P4 helix of P RNA with metal ions, demonstrating that the b

215 substitutions, locating to the transmembrane helix of TatB that restored transport activity to Tat si

216 We also show that the C-terminal helix of the bHLH domain is involved in intermolecular i

217 ecular interactions with the DNA-recognition helix of the ETS domain to mediate autoinhibition.

218 main of one molecule bound to the C-terminal helix of the neighboring D1 domain.

219 lular half outward to accommodate the alpha5-helix of the Ras-like domain of Gs.

220 The three-way junction and the P1 switch helix of the two apo conformers are notably different fr

221 the U2AF-homology motif (UHM) and the alpha6 helix of U2AF35, and was fine-tuned by exon Ab/3 variant

222 last 16 CCD residues, composing an "overlap helix" (OH), have been crystallized in two mutually excl

223 h helix rotations and movements toward a two-helix packing mode.

224 lated DNA local parameters, step parameters, helix parameters, and major/minor groove widths to exami

225 docked conformation and the preceding alpha6 helix partially melted.

226 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:B

227 the robust autophagy activity of the Kalpha2-helix peptide, the present study showed that treatment w

228 antiviral activities of synthesized Kalpha2-helix peptide, which was derived from the viral FLICE-li

229 ate that targeted helix-(pi-sheet)-helix and helix-(pi-sheet)-coil assemblies occur without compromis

230 We demonstrate that targeted helix-(pi-sheet)-helix and helix-(pi-sheet)-coil assembl

231 ane proteins with a single membrane-spanning helix play a plethora of vital roles in the cellular pro

232 SECM/optical microscope, generating a double helix point spread function at the image plane, which al

233 ing module, a membrane-inducible amphipathic helix present in a previously undescribed location in At

234 s steps involving unwinding-rewinding of the helix proceeded over the course of days.

235 as previously been employed to measure alpha-helix propensities among proteinogenic alpha-amino acid

236 rrounded by IDRs, individual intrinsic alpha-helix propensities varied as shown by CD spectroscopy.

237 d in nonphotochemical quenching, and the one-helix proteins and their cyanobacterial homologs designa

238 TIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future root hair cells (

239 discovered that the Id family of helix-loop-helix proteins is both necessary and sufficient to direc

240 dulating the position of the DNA recognition helix region relative to its major groove.

241 esulting in a rearrangement of the substrate helix register into a so-called "shifted" conformation t

242 ike movement of beta6-alpha7 loop and alpha7-helix, required for high-affinity ligand binding.

243 ge in a specific interaction with post-relay helix residue Glu-469, which affects the mechanics of th

244 Pore helix rotation by STIM1 also explains the dynamic coupli

245 onal amplitudes of the Tsr HAMP coupled with helix rotations and movements toward a two-helix packing

246 dues in pore helix 1, helices S5 and S6, and helix S6 of a neighbouring subunit, form a hydrophobic c

247 n to Survivin and Borealin, the single alpha-helix (SAH) domain of INCENP supports CPC localization t

248 ha1 and alpha2 helices are consistent with a helix scissors motion or a gearbox rotational model of H

249 inding pocket in mdm2 whereas the N-terminal helix serves as an affinity enhancer.

250 rgeted assemblies, a mix of sequence-defined helix-sheet-coil and helix-sheet-helix architectures, ar

251 mix of sequence-defined helix-sheet-coil and helix-sheet-helix architectures, are Nature-inspired syn

252 transcription are sufficient to give M2-seq helix signatures; these signals were previously overlook

253 amaterial consisting of interconnected metal helix slat structures with four-fold symmetry, which exh

254 The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play important

255 Helix stabilities are relatively low, 4 kcal/mol to 5 kc

256 Studies of F103 in the hinge of the inner helix suggest an important role for its bulky sidechain

257 mely Kite dimers (Kleisin interacting winged-helix tandem elements), interact with Smc-kleisin rings

258 secondary structural element is one turn of helix that binds the central portion of the CRM1 groove.

259 occurs at the N-terminus and the first alpha-helix that connects the HlyIIC domain to the HlyII-core

260 e six VAT subunits to constrict into a tight helix that grips an 80 A stretch of unfolded protein.

261 e the extended loop prior to the penultimate helix, the extended Omega-loop, and a beta-hairpin turn

262 ctions connecting the converter, the SH1-SH2 helix, the relay helix, and the lever, abolishes nonmusc

263 e (EC portion) to HL1 and to the neighboring helix TM2.

264 omote the pentapeptides transform from alpha-helix to beta-sheet conformation.

265 ositively charged residues in the C-terminal helix to engage in DNA binding, triggering a major repro

266 helix-turn-helix (wHTH) motifs use an alpha helix to read the base sequence in the major groove whil

267 ain (LBD) of hPXR, interacting with the AF-2 helix to stabilize the LBD for coactivator binding.

268 target RNA and extends a newly-formed alpha helix to the distal loop where it forms protein interact

269 identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IRE1alpha RNase tar

270 r of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an important role

271 6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the expression

272 Homeodomain and basic helix-loop-helix transcription factors are required for retinogenes

273 The functionally relevant random-coil-alpha-helix transition associated with Ca(2+) uptake that invo

274 duced Circulating LncRNA) partakes in triple helix (triplex) formation, is transiently elevated follo

275 r emission, while the closure of the labeled helix turn reduces this emission.

276 The helix, turn, and beta-strand motifs of biopolymer folded

277 onsists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain.

278 TFs with winged helix-turn-helix (wHTH) motifs use an alpha helix to rea

279 n synthesized and shown to form well-defined helix-turn-helix architectures in which helical and shee

280 pin domain, a helical hairpin, and bipartite helix-turn-helix motif.

281 kDa T7 protein, Gp5.7, which adopts a winged helix-turn-helix-like structure and specifically repress

282 s suggest that a likely mechanism for triple helix unfolding is intermolecular shearing of collagen a

283 analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central

284 A serine residue on the DIV S2 helix was found to be sufficient to explain Pre1a's pote

285 Although the Bik BH3 helix was sufficient to enrich for ER-Bak and elicit ER

286 In the canonical DNA double helix, Watson-Crick (WC) base pairs (bps) exist in dynam

287 exposed conformation stacked within the DNA helix, where it effectively blocks nucleotide incorporat

288 sing site is located on the face of the beta-helix whereas the C-terminal domain is likely involved i

289 to GPP, until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity

290 ructurally blocked by the HECT domain alpha1-helix, which further undergoes ubiquitylation on a conse

291 sis suggests that it can form an amphipathic helix, which is ideal for lipid membrane interaction.

292 des extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight

293 ith an antiparallel motion of the C-terminal helix, which may alter the native-state structural ensem

294 Four Vps4 subunits form a helix whose interfaces are consistent with ATP binding,

295 TFs with winged helix-turn-helix (wHTH) motifs use an alpha helix to read the base

296 es possess an unstructured beta-domain and C-helix with the rest of the alpha-domain remaining native

297 d circular dichroism revealed an amphipathic helix within this 12-residue region.

298 Furthermore, the incipient alpha-helix (within the purified soluble C terminus) partition

299 1, can spontaneously assemble into a double helix without the need for a covalently connected linear

300 nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypi