ライフサイエンスコーパス: free

1 dditionally, light is non-invasive and waste-free.

2 , rendering 34 (54%) of 63 patients fragment free.

3 operations and store reagents refrigeration-free.

4 val, many patients are not rendered fragment free.

5 es.Photoacoustic microscopy allows for label-free 3D in vivo imaging by detecting the acoustic respon

6 These methods allow for the reference-free 3D reconstruction of nanomolecular structures from

7 Now a superior hydrogen-free 5/6/5 fused ring energetic material, 1,2,9,10-tetra

8 of the bound 11-cis-retinal chromophore with free 9-cis-retinal from Rho in an in vitro phospholipid/

9 s were found to be concerted involving small free activation energies and are all exoenergonic.

10 ability by this non-enzymatic, amplification-free ADNA method.

11 ter Elective Surgery study enrolled dementia-free adults >/=70 years old undergoing major scheduled n

12 to elevated [CO2] (E-[CO2]) by comparison to free-air CO2 enrichment (FACE) and chamber experiments.

13 shed that the reaction involves formation of free alkynylboronate and the two boryl substituents are

14 mounts of total cellular protein and several free amino acids.

15 y explained by periodic inhibition caused by free ammonia due to periodic transient pH upshifts.

16 strate the use of NMR to distinguish between free and bound polymer and to characterize the degree to

17 portance of individual receptors in HCV cell-free and cell-to-cell transmission.

18 ognitive tests (free and total recall of the Free and Cued Selective Reminding test, ten Mini-Mental

19 concentrates (WPC) were hydrolyzed with both free and immobilized enzyme, reaching a similar degree o

20 esis of homopropargylic alcohols under metal-free and mild condition is described.

21 nted here depicted no differences in disease-free and overall 3-year survival for open and MI esophag

22 site Z score combining four cognitive tests (free and total recall of the Free and Cued Selective Rem

23 An efficient, solvent-free, and eco-friendly domino reaction of 5/6-membered c

24 rates, short reaction time, transition metal-free, and gram-scale synthesis are the advantages of thi

25 A mild, oxidant-free, and selective Cp*Co(III) -catalyzed amidation of t

26 structure of kinesin-6 Zen4 in a nucleotide-free, apo state, with the NL initial segment (NIS) adopt

27 rent apocarotenoids were identified, 14 were free apocarotenoids and 11 were apocarotenoids fatty aci

28 Here we introduce a protecting-group-free approach for the alpha-functionalization of cyclic

29 ion mass spectrometry (ToF-SIMS) as a label-free approach to chemically map small molecules in aggre

30 ical composition of live cells using a label-free approach, confocal Raman microspectroscopy.

31 of adherent cells to move into adjacent cell-free areas, thus providing information on cell culture v

32 rest cells and pigment localized only to PNA-free areas.

33 We describe here a serum-free, artificial thymic organoid (ATO) system that suppo

34 -resolution fMRI findings suggest that model-free aspects of reward learning in humans can be explain

35 edback resistance mutations caused increased free BCAA levels in both seedlings and seeds.

36 graphy (NIR-C) provides real-time, radiation-free biliary anatomy enhancement.

37 opment of a 3D OrbiSIMS instrument for label-free biomedical imaging.

38 BR-levels and the fractions free/BR follow characteristic sigmoid plots when represe

39 were seen between breath-hold rate 3 SMS and free-breathing rate 2 SMS excitation in transmural myofi

40 that many yeast promoters are not nucleosome-free but instead occupied by easily digested, unstable,

41 omplement component iC3b and ICAM-1 in shear-free, but not shear-flow, conditions.

42 tion, herein, we discovered a mild and metal-free C-H sulfenylation/intramolecular rearrangement casc

43 iggered by a transient rise in intracellular free calcium concentration linked to a change in the str

44 this evidence of "silencing", intracellular free calcium imaging showed that the cells were still vi

45 The UV light generates free carriers in a photosensitive ZnO spacer layer, whic

46 in-bound Cbl followed by lysosomal export of free Cbl to the cytosol and further processing to these

47 data structure in our code, i.e., a lattice-free cell list, with a time and space cost linearly prop

48 Optical manipulation and label-free characterization of nanoscale structures open up ne

49 mittent drinking 20% ethanol in a two-bottle free choice protocol for 8 weeks), the basal firing rate

50 Plasma concentrations of free choline, betaine, and phosphatidylcholine were meas

51 s allocation problem and present a covariate free class allocation approach based on the distribution

52 permanent dentition compared to their caries-free contemporaries.

53 ifferent plaque microbiome than their caries-free counterparts, with the S-ECC group containing highe

54 We report an unprecedented transition metal-free coupling of indoles with aryl halides.

55 regimen and reduce treatment time to relapse-free cure by 75%.

56 included organ-specific symptoms, medication-free days, rhinitis severity and asthma control.

57 re, we investigated model-based versus model-free decision making and its neural correlates as well a

58 oteasome-dependent turnover of ACD11 in cell-free degradation assays.

59 cular bonds and is therefore ideal for label-free detection of chemical species.

60 cromx7micromx5microm, which allows for label-free detection of explosive molecules such as trinitroto

61 While typically managed by gluten-free diet and dapsone, treatment of DH refractory to sta

62 Mice maintained on a vitamin A-free diet lose HSCs and show a disrupted re-entry into d

63 f 59 individuals on a self-instituted gluten-free diet, for whom celiac disease had been excluded.

64 sease-related outcomes and 5-year recurrence-free, disease-specific, and overall survival.

65 Quantification of cell-free DNA (cfDNA) in circulating blood derived from a tra

66 e sensor stability and sensitivity for label free DNA and protein sensing for the first time.

67 ch exploits the diagnostic potential of cell-free DNA by determining not only the presence but also t

68 The presence of longer nucleosome-free DNA regions can positively or negatively affect the

69 proportion of tumor-derived DNA in the cell-free DNA scenarios.

70 ive, orthotopic 4T1 tumor model in vivo than free DOX and GEM and the single drug HA conjugates.

71 The systemic exposure of the free drug was much lower than that achieved with the lip

72 resolution in vivo more efficiently than the free drug.

73 To characterize plasma cell-free eccDNAs, we performed sequencing analysis in 26 lib

74 erview of the defects in carbon-based, metal-free electrocatalysts for ORR and various defects in met

75 Metal-free electrocatalysts have been extensively developed to

76 ecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchro

77 Free-electron lasers providing ultra-short high-brightne

78 eate at these landmarks and grow while their free ends diffuse.

79 Free energies of activation for all elementary reactions

80 endent manner given reasonable values of the free energies of specific and non-specific DNA binding a

81 ology to measure resting affinities (binding free energies) of these and other agonists in adult-type

82 We find that the differences in free energy between the individual complexes in bulk wat

83 According to our simulations and free energy calculations, the Gly1629Glu mutation causes

84 concentrations and do not take into account free energy costs that may be associated with structural

85 4 isoform, reflecting how S672R remodels the free energy landscape for the modulation of HCN4 by cAMP

86 This process is driven by the interfacial free energy minimization, which gives rise to a breakup

87 lar dynamics method to calculate the binding free energy of a series of alpha-ketoamide analogues rel

88 vel recognition mechanisms and calculate the free energy of binding the hypothesized ligands to YKL-4

89 n ionic potential and the enthalpy and Gibbs free energy of formation for previously measured oxyanio

90 d domain organization due to favorable Gibbs free energy of phospholipid mixing.

91 To prove the concept, we employed free energy perturbation (FEP) coupled with lambda-excha

92 using molecular dynamics simulations and the free energy perturbation method (MD/FEP) in fragment opt

93 concentration, although the grand canonical free energy profiles are uphill for HTT exon 1 fragments

94 organic conversions but has to overcome high free-energy barriers in water.

95 From these free-energy calculations, we determined the kinetics and

96 r dynamics simulations that characterize the free-energy profiles of explicit proton transport throug

97 Free-energy simulations elucidate the active site confor

98 d 6 months of treatment and remained seizure-free entered a 6-month maintenance period on the same do

99 rovements in patient safety, and create harm free environments for patients, it is crucial that nursi

100 We demonstrate that, while free enzymes display weak activities for only a short du

101 In this work, free, esterified and insoluble-bound phenolics were extr

102 Each droplet contains a cell-free expression system and is connected to its neighbor

103 scherichia coli protein solubility in a cell-free expression system, 35 sequence-based properties are

104 es of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients an

105 Plateau-Rayleigh (PR) instabilities of a free-falling jet of an aqueous medium containing the CNC

106 nied by dyslipidemia with elevated levels of free fatty acids (FFAs).

107 nalyses indicate that TAG lipolysis releases free fatty acids at a time that correlates well with mei

108 ssiveness were identified, including various free fatty acids, metabolites, and complex lipids such a

109 upied WH2 domains transiently associate with free filament ends, preventing their growth and dynamica

110 The mean cost for autologous free flap breast reconstruction was $22677 (interquartil

111 In this study, label-free fluorescence spectroscopy was used for the first ti

112 n the lignan macromolecule and slightly in a free form.

113 analysis including 21870 participants (20163 free from CVD at baseline) from 3 studies: Cardiovascula

114 urrence were recorded, and all patients were free from distant metastasis.

115 generate digitized filling flow, completely free from errors due to changes in viscosity.

116 Notably, ARv5es was free from HSP90, exclusively nuclear, and constitutively

117 005 and 2009 who were >40 years of age, were free from previous cancer, and had >/=80% adherence duri

118 hat are related to future goals, or at least free from the constraints of immediate environmental inp

119 eloping rechargeable iodine-carbon batteries free from the unsafe lithium/sodium metals, and hence el

120 usion in Saccharomyces cerevisiae Using cell-free fusion assays and light microscopy, we find that GT

121 al proteins inside the vacuole and decreased free GFP, consistent with decreased mitophagy.

122 roup and none of the patients in the alcohol-free group.

123 e mosquitoes than children who were parasite free, harbored asexual stages, or had gametocytes at sub

124 ne waste and its use demonstrated in a metal-free heterogeneous selective oxidation of 5-hydroxymethy

125 oximations, discerning between innate, model-free, heuristic, and model-based controllers.

126 Here, we adopt a label-free, high-throughput, and continuous technique utilizin

127 ber of infection events per cell during cell-free HIV-1 infection follows a negative-binomial distrib

128 trate that freshly thawed cryopreserved xeno-free human umbilical cord-mesenchymal stem/stromal cells

129 gosaccharides, deoxysugars, saccharides with free hydroxyl groups, pyranose, and furanose substrates.

130 Omalizumab binds to free IgE, which lowers free IgE levels and causes FcepsilonRI receptors on baso

131 Omalizumab binds to free IgE, which lowers free IgE levels and causes Fcepsi

132 ming the basis of this cost-efficient, label-free immunoassay, CuONRs, synthesized using a simple hyd

133 e across clinically relevant levels by label free impedance derived redox capacitance.

134 The conjugate shows weak luminescence when free in solution or with well matched DNA but exhibits a

135 llular signal-regulated kinase 1/2 and label free, in a parallel manner without affecting the maximum

136 ght not be horizontally symmetric as in pain-free individuals, but instead larger around the affected

137 Therefore a simple, rapid, label free, inexpensive, excellent, sensitive and selective el

138 approaches for the speedy, stable and marker-free introduction of transgenes encoding the DiCre recom

139 ign and application of single-chain cofactor-free kinases with photoswitchable activity.

140 rolyze lactose in milk more efficiently than free lactase.

141 the central phase and is encompassed by two free liquid membranes (FLMs) and two extraction solution

142 mber 2013 through May 2017, along with tumor-free liver tissues (control tissues) and peripheral bloo

143 gens (protists & fungi), along with relevant free-living and non-pathogenic species, and select patho

144 s suggest that these particle-associated and free-living bacterial assemblages are functionally diffe

145 ighest levels of the Ss-riok-2 transcript in free-living females and parasitic females.

146 ktonic MGII associated with particles and in free-living forms in the Pearl River Estuary (PRE) over

147 We compiled data from studies measuring free-living N fixation in response to N, P and Mo fertil

148 Prenol was attractive to dauers of some free-living nematodes and insect larvae.

149 tems are gene modules that are ubiquitous in free-living prokaryotes.

150 y the relative lack of information about key free-living species.

151 The activity of the "drug-free macromolecular therapeutics" is based on the biorec

152 ific methods to measure utility in a context-free manner and have important implications for theories

153 hase kinase-3 (GSK3) inhibitor, and in serum-free media.

154 tible 3F7.A10 hybridoma cells grown in serum-free medium mounted strong anti-Id responses.

155 8del-CFTR more rapidly lost function in cell-free membrane patches and showed altered channel gating

156 (fusion) sintering that requires both oxide-free metal surfaces and high temperature conditions.

157 the result of reversible equilibria between free, metal-complexed and oxidized forms of VSCs.

158 A versatile, efficient, and metal-free method for construction of discrete oligomers with

159 a, which would affect amplicon based and PCR free methods alike.

160 a We observed that the crystal structures of free, Mg(2+)-bound, and beryllofluoridated CKI1RD (a sta

161 pecific CD8 T cells transferred into antigen-free mice revealed that differentiation to memory cells

162 By colonizing adult germ-free mice with the cecal contents of neonatal and adult

163 cterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mice is

164 colonization in antibiotic-treated and germ-free mice, using cultured commensals from the Actinobact

165 We report a label-free microfluidic technique to separate live and dead ce

166 y was validated by spiking OTC to antibiotic free milk samples and results could be accomplished with

167 For this purpose, pesticide-free milled toasted maize and wheat samples were spiked

168 Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant e

169 mid-IR waveguide successfully perform label-free monitoring of various organic solvents.

170 This is coupled with an increased pool of free NADH, increased mitochondrial biogenesis, triggerin

171 hic or hydrophobic substrates in a detergent-free native or artificial membrane environment.

172 e likely than age to provide higher category-free net reclassification improvement among participants

173 Compared with the paper-free non-hybrid microfluidic biochip over a period of th

174 th markers spaced by every 10 cM and a model-free nonparametric linkage (NPL-all) analysis was carrie

175 nals Follow-Up Study (1986 to 2012) who were free of cancer, heart disease, and stroke at baseline.

176 had complete risk factor profiles, and were free of clinical CVD, were included in this study.

177 ; 15 of the 17 patients (88%) were alive and free of major functional disability, with minimal clinic

178 1) of best-selling moisturizer products were free of NACDG allergens.

179 implies the practicability to construct gain-free omnidirectionally non-reflecting absorbers.Reflecti

180 ere, Barzanjeh et al. demonstrate a magnetic-free on-chip microwave circulator that utilizes the inte

181 cer patients who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the antitumo

182 Fullerene-free organic solar cells show over 11% power conversion

183 dmits tunable trophic coherence via a single free parameter.

184 oss stimuli, is well-fit by a model with one free parameter: pleasure amplitude.

185 were compared in CAV-positive (n=52) and CAV-free patients (n=51).

186 A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Ca

187 genomic profiling of 138 IMs from 148 cancer-free patients, recruited through a 10-year prospective s

188 Herein, we report a silver-free Pd(II)-catalyzed C(sp(3))-H arylation of saturated

189 sitive, high-capacity method for quantifying free PEG and PEGylated molecules.

190 the binding capacity and detection limit for free PEG and PEGylated molecules.

191 d by electrospray ionization) to the solvent-free peptide ion.

192 During the treatment-free phase, no progression toward advanced phase CML occ

193 e ability of NKA to transform ATP to ADP and free phosphate, the latter reacting with ammonium molybd

194 A metal-free photoanode nanojunction architecture, composed of B

195 myelin at subdiffraction scales, using label-free polarization-resolved coherent anti-Stokes Raman, w

196 y 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates.

197 method is a time and cost-saving extraction-free procedure measuring in vitro antioxidant capacity w

198 rn as ingredients for whole grain and gluten-free products.

199 Here, we present an approach of cell-free protein synthesis (CFPS) that provides proteins wit

200 ble polystyrene cores crosslinked with metal-free purely organic phosphors.

201 tin was at least 3 times better than that of free quercetin.

202 Results were consistent with a free radical chain scission mechanism, supported by meas

203 the stronger oxidant AgBF4 formed the metal-free radical dication L(.2+) .

204 reversion of the quadricyclanes occurs via a free radical mechanism with very little contribution fro

205 to whether our data may form the basis for a free radical substituent constant, sigmaQ*, analogous to

206 This peptidomimetic/free radical system is a potentially excellent template

207 greatly increases the local concentration of free radicals, thereby strongly influencing particle gro

208 may also participate in the inactivation of free radicals.

209 umor tissue prevents the formation of oxygen free radicals.

210 dimethyl sulfoxide as an oxidant under metal-free reaction conditions.

211 The transition-metal-free reaction proceeds in a regio- and stereoselective f

212 om 215 epilepsy patients as they performed a free recall task.

213 Using cell-free reconstitution with purified Vps13p, we show that V

214 ideal duration of treatment with interferon-free regimens, particularly in HIV-coinfected individual

215 ACH-focused intervention in a previously CRE-free region, including active surveillance for CRE carri

216 The threat of free-riding makes the marshalling of cooperation from gr

217 lations to determine the both complexes have free rotation around the CPh-B1 bond.

218 model of GenK catalysis is proposed wherein free rotation of the radical-bearing carbon is prevented

219 We solve for the halo-free sample transmission function by using a physical mo

220 Both self-designated peanut-free schools and schools banning peanuts from being serv

221 of ZnO QDs and is applied towards substrate-free Schottky photodetector applications.

222 Such an approach may find use in label-free selection of cells for a highly expressed molecular

223 A new enzyme-free sensor based on iron oxide (Fe3O4) nanodots fabrica

224 Alignment-free sequence comparison approaches have been garnering

225 e that linear-field particle acceleration in free space is very doubtful given that first-order elect

226 lectron-photon interactions are forbidden in free space.

227 mising new route for polarization control of free-space terahertz beams.

228 he iron complex is in equilibrium with an N2-free species.

229 to explore these issues using three chemical-free specimen preparations: lyophilization, cryofixation

230 crowire closely resemble that of an isolated free-standing cylinder (current proportional, variant el

231 m was underestimating the probability of BCR-free status in the ePLND+SNB group, whereas the ePLND gr

232 A metal and solvent free strategy to functionalize aryl methyl ethers throug

233 e and energy exchange enhanced the effect of free sugars on total and LDL cholesterol and triacylglyc

234 ithin its clinical range with Raman, a label-free surface-enhanced Raman spectroscopy (SERS) approach

235 To evaluate conditional disease-free survival (CDFS) for patients who underwent curative

236 ongest predictor of overall (OS) and disease free survival (DFS) (p = 0.00001; p = 0.01, respectively

237 The primary objective of the trial was event-free survival (EFS) from randomization.

238 /- 3% vs 90% +/- 4%; Plog-rank = .64), event-free survival (EFS; 87% +/- 3% vs 89% +/- 4%; Plog-rank

239 utations, correlated with reduced recurrence-free survival (P = 0.001).

240 low survival (P < 0.0001) and low recurrence-free survival (P = 0.007).

241 e response rate of 12.5%, median progression-free survival (PFS) of 14 months, and 2-year PFS of 20.4

242 studies reported MRD status and progression-free survival (PFS) or overall survival (OS) in 20 or mo

243 ted a significant improvement in progression-free survival (PFS) with ixazomib-lenalidomide-dexametha

244 stic factors (10-year biochemical recurrence-free survival [bRFS], 29%; distant metastasis-free survi

245 ree survival [bRFS], 29%; distant metastasis-free survival [DMFS], 53%; prostate cancer-specific surv

246 ion of patients who achieved pCR and disease-free survival after neoadjuvant treatment according to B

247 ere 72% (95% CI, 56% to 84%) for progression-free survival and 79% (95% CI, 63% to 89%) for overall s

248 (SLC22A4; ETT) strongly predicts poor event-free survival and overall survival in multiple cohorts o

249 Progression-free survival and overall survival were secondary end po

250 Recurrence-free survival and recurrence rates.

251 Secondary end points included disease-free survival and the cumulative rate of nonsentinel-nod

252 e were significant predictors of ventilation-free survival and Tw Pdi and maximal static expiratory m

253 on with incomplete recovery), inferior event-free survival as well as overall survival in both trials

254 to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX.

255 patient with metastatic RCC with progression-free survival of > 3.9 years.

256 NA level was associated with shorter disease-free survival of patients with TNBC.

257 Ten-year ESRD-free survival rates were 43%, 94%, and 72% in children w

258 The estimated 10-year progression-free survival rates were 9.5% and 9.2% for the 400- and

259 to lower rates of 5-year survival and event-free survival than on-pump CABG.

260 Median progression-free survival was 2.8 months (95% CI 2.8-3.6) in the bin

261 Median ITT progression-free survival was 5.2 months (95% CI, 3.2 to 7.1 months)

262 Median progression-free survival was 6.0 (95% CI, 5.0 to 7.3) months, and m

263 tivated patients (n=372), median progression-free survival was 6.8 months (95% CI 4.9-7.1) in the bup

264 Progression-free survival was prolonged significantly in patients al

265 Median progression-free survival was significantly improved in the VRd grou

266 Median progression-free survival was significantly longer in the group that

267 Major cardiovascular adverse events-free survival was worse in patients with MVO (P=0.014),

268 e 18-month Kaplan-Meier estimates of disease-free survival were significantly worse for the OAC alone

269 , disease-specific survival, and progression-free survival were the primary end points.

270 ncluded overall survival, distant metastasis-free survival, freedom from relapse, and safety.

271 lues of median overall survival, progression-free survival, response rate, and toxic effects.

272 Despite somewhat prolonged progression-free survival, treatment with lomustine plus bevacizumab

273 4 and CDK6 substantially improve progression-free survival.

274 ment did not result in prolonged progression-free-survival, fewer toxic effects, or improved quality

275 ility on par with other flavonoids in a cell-free system, Proxison is orders of magnitude more potent

276 be recapitulated in vitro with a yeast cell-free system.

277 Pesticide-free tea powder spiked at 50 and 100mugL(-1).

278 ellular nanostructure and devise a new label-free technique based on a spectroscopic analysis of refl

279 DNA synthesis and subsequent bypass by error-free template switching.

280 apping with those thought to carry out model-free temporal difference (TD) learning.

281 agnosis circulating androgens [testosterone, free testosterone, androstenedione, dehydroepiandrostero

282 cirrhosis and CSPH who had SVR to interferon-free therapy at 6 Liver Units in Spain.

283 e scale formation decreased after a chemical-free, thermal precipitation pretreatment.

284 Using label-free ToF-SIMS imaging mass spectrometry, we generated a

285 aptamer to create a novel, simple and label-free tool to detect abnormalities at an early stage of p

286 Our work constitutes a photoresist-free, top-down method to create large-area quantum dot a

287 lenediammonium/formamidinium with the dopant-free TPE HTL achieve a power conversion efficiency as hi

288 The attractive advantages of Joule-heat-free transmission of information, utilization of the pha

289 uded an eye examination as part of complete, free treatment.

290 rom the far-red to deep-blue region in metal-free triplet-triplet annihilation upconversion (TTA-UC)

291 at the triplet pair is bound with respect to free triplets with an energy that is largely material in

292 Free virions and infected cells were not readily detecta

293 HIV-1-infected cells surrounded by pools of free virions were present in 10% of intestinal crypts b

294 NAbs potently antagonize infection with cell-free virus, inhibition of HIV-1 transmission from infect

295 The incremental values of RV free wall longitudinal strain and RVESRI to risk scores

296 ollectively, these findings demonstrate that free water in the posterior substantia nigra is a valid,

297 Prior work demonstrated that free water in the posterior substantia nigra was elevate

298 g the estimation of the fractional volume of free water within a voxel, which is expected to increase

299 nopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and loca

300 ces in the number of secretory cells in germ-free zebrafish and their conventional counterparts, the