ライフサイエンスコーパス: fragile

1 ithout inhibitory feedback is functional but fragile.

2 c patient subgroups, such as the elderly and fragile.

3 s cells are dynamic, chemically diverse, and fragile.

4 pristine matter and coherence was considered fragile.

5 remain at risk and hence the gains made are fragile.

6 Fragile 3D floc samples were successfully captured and s

7 However, superhydrophobicity is remarkably fragile and can break down due to the wetting of the sur

8 tivity of bioorthogonal reagents in the most fragile and complex organs.

9 owever, multiparty entanglement is generally fragile and difficult to quantify.

10 cuticle of LmCYP4G102-knockdown locusts was fragile and easier deformable than in control animals.

11 n adopted immunity, although fundamental, is fragile and failing.

12 bers used for in vivo bioanalysis can be too fragile and flexible, which limits suitability for direc

13 population, a situation in which ongoing-but fragile and limited-health cooperation and training arra

14 Sialic acids are fragile and prone to fragmentation under electrospray io

15 used for these studies, which are large and fragile and remain laboratory instruments.

16 However, these gains are fragile, and coverage is far from optimal.

17 powerful, on average, they tend to be weak, fragile, and fleeting.

18 es in person perception were generally weak, fragile, and fleeting; (2) Social perceptions were often

19 a PET10 deletion strongly aggregate, appear fragile, and fuse in vivo when cells are cultured in ole

20 uption by noise: redundant codes can be very fragile, and synergistic codes can-in some cases-optimiz

21 ce is lost, the vessels can be malformed and fragile, and they can lose arteriovenous differentiation

22 production, resulting in the formation of a fragile biofilm in Streptococcus sanguinis.

23 nent system in S. sanguinis SK36, produced a fragile biofilm.

24 cal CT analysis--those with osteoporosis or "fragile bone strength"--agreed well against classificati

25 ion named seal was produced, associated with fragile bones and susceptibility to fractures (spine and

26 and alter chromatin structure, especially in fragile cells such as neurons.

27 sible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.

28 lance, thus preventing falls among older and fragile citizens.

29 h promotion and basic first-line services in fragile contexts with weak secondary health service infr

30 grid express interactions among modules with fragile couplings that amplify even small shocks, thus p

31 rms well-ordered crystals, whereas rA6 forms fragile crystalline-like structures, and rA5, rA8 and rA

32 HHT is characterized by development of fragile, direct connections between arteries and veins,

33 ight into why human neoplastic translocation fragile DNA sequences are more prone to enzymes or agent

34 can show stable, divergent, and metastable (fragile) dynamics.

35 nservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming.

36 sions, affecting the climate impact of these fragile ecosystems.

37 n the case of young children and the case of fragile egos.

38 Because PT-symmetry has been thought of as fragile, experimental realisations to date have been usu

39 tection to human telomeres, as well as other fragile genomic sites.

40 te its remote location, the deep sea and its fragile habitats are already being exposed to human wast

41 s-Danlos syndrome (cEDS) is characterized by fragile, hyperextensible skin and hypermobile joints.

42 ow firing rate is surprisingly difficult and fragile in a biological context.

43 ient's blood (e.g., red blood cells are more fragile in patients undergoing chemotherapy) and the car

44 However, existing bioengineered lungs are fragile, in part because of their immature vascular stru

45 The intensity of these fragile ions gradually disappeared at voltages beyond 50

46 idative damage in lipids and proteins, and a fragile juvenile plumage.

47 rd trials, as mediated by robust priming and fragile learning.

48 that water is a mixture of a high density, "fragile" liquid, and a low density, "strong" liquid, the

49 The change is much greater in fragile liquids, with the activation energy becoming ver

50 n excitations are quite similar indicating a fragile low temperature ground state with respect to the

51 ly significant dichotomous results are often fragile, meaning that a difference of only a couple of e

52 usion-promoting proteins, and deliver large, fragile membrane protein complexes into the target bilay

53 s rarely been analyzed, foremost because the fragile membranous structures in the inner ear are hard

54 For fragile models, fluctuations of the single-neuron dynami

55 he experimentally used treatment protocol is fragile (nonrobust) and (ii) discovered an alternative r

56 Its glassy state is neither fragile nor strong.

57 -encoded nucleosome fragility, we also found fragile nucleosomes at locations where we expected to fi

58 Genes with fragile nucleosomes in their promoters tended to be lowl

59 that for nearly all mouse genes, a class of fragile nucleosomes occupies previously designated nucle

60 Fragile nucleosomes were defined by nucleosomal DNA frag

61 protein complexes, with little evidence for fragile nucleosomes.

62 tead occupied by easily digested, unstable, "fragile" nucleosomes.

63 In regions with scarce resources, fragile or fragmented health systems, cancer contributes

64 , although severe complications can occur in fragile patients.

65 an evolutionary history of hybridization and fragile prezygotic isolating mechanisms.

66 ructural barriers that impede replication at fragile regions in the genome.

67 primary cells steadily accrue macroH2A1.2 at fragile regions, whereas macroH2A1.2 loss in these cells

68 rmation of the apical hook that protects the fragile shoot apical meristem when it breaks through the

69 y reductive amination; (ii) stabilization of fragile sialic acids by carbodiimide coupling; (iii) rel

70 pecific enrichment results as well as highly fragile significances.

71 The magnetic structure in GdPd3 is highly fragile since applied magnetic fields of moderate streng

72 In this study, loss of expression of the fragile site-encoded Wwox protein was found to contribut

73 -to-replicate genomic regions, namely common fragile sites (CFS).

74 Common fragile sites (CFSs) are genomic regions that are unstab

75 ves late replication intermediates at common fragile sites (CFSs) during early mitosis to trigger DNA

76 RC sites are strongly associated with common fragile sites and recurrent deletions in cancers.

77 ad of the fork, including stable protein-DNA fragile sites and termination.

78 addition, important genomic elements such as fragile sites and tRNA genes are found to be clustered s

79 construct a statistical model that separates fragile sites from regions showing signatures of positiv

80 Thus, loop anchors serve as fragile sites that generate DSBs and chromosomal rearran

81 occur either over tumour suppressors or over fragile sites, regions of increased genomic instability.

82 ffected genes overlap with early replicating fragile sites, show elevated levels of gammaH2AX, and su

83 mic loci/regions include centromeres, common fragile sites, subtelomeres, and telomeres.

84 collapse, late origin firing and stabilizes fragile sites.

85 ution view of replication-associated genomic fragile sites.

86 omotes replication of DNA lesions and common fragile sites.

87 lose their biological activity due to their fragile structural conformation during formulation, stor

88 s, phenols, and malonates to be present, and fragile structures are also tolerated.

89 y treated flours suggested the production of fragile structures that broke easily.

90 This presents a difficult situation whereby fragile substrates such as lactone will be hydrolyzed by

91 , however, are anticipated to be exceedingly fragile, suppressed by very small Zeeman energies.

92 Members of the Cryptochiridae are small, fragile, symbiotic crabs that live in domiciles in moder

93 We observe frequent fragile telomeres in ALT cells, suggesting that telomere

94 ll lines, we show that ALT cells harbor more fragile telomeres representing telomere replication prob

95 ective POT1-TPP1 complex leads to longer and fragile telomeres, which in turn promotes genomic instab

96 ith increased frequencies of deprotected and fragile telomeres.

97 -8) Pa, G(T) and D(T) have super-Arrhenius ("fragile") temperature dependences, but both cross over t

98 es of the brain, and provide rigidity to the fragile tissue while eliminating background interference

99 we find that although human life is somewhat fragile to nearby events, the resilience of Ecdysozoa su

100 Therefore, the CphA active - site is fragile to substitutions, suggesting active-site residue

101 oportion of which explains the anomalies and fragile-to-strong crossover in water.

102 Fragile transition metal complex ions such as [Cr(H2O)4C

103 ding and/or the beta-annulus, making it more fragile under neutral/basic pH conditions.

104 materials, which originates from relatively fragile/weak bonds between inorganic and organic constit

105 , optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances

106 systems are typically costly, toxic, and/or fragile, with limited chemical versatility.

107 The population is fragile, with no growth projected under current conditio

108 hildren with a disability as a result of the Fragile X (FX) premutation, a genetic abnormality in FMR

109 athophysiology of FXS.SIGNIFICANCE STATEMENT Fragile X (FXS) individuals have a range of sensory rela

110 ngs identify RSK as a therapeutic target for fragile X and suggest the therapeutic potential of drugs

111 enic syndromes highly comorbid with autism - fragile X and tuberous sclerosis types 1 and 2 syndromes

112 related protein 1 (FXR1P) is a member of the fragile X family of RNA-binding proteins, which includes

113 e a long-standing unanswered question in the fragile X field, which is also relevant to autism pathog

114 lb circuits exhibited axonal localization of Fragile X granules (FXGs), structures that comprise ribo

115 l translational machinery is associated with Fragile X granules (FXGs), which are restricted to axons

116 FXGs (Fragile X granules) are axonal RNPs present in a stereot

117 cortex and hippocampus in wild-type (WT) and fragile X knockout (FMR1-KO) mice during the first 5 wee

118 Silencing of fragile X mental retardation 1 (FMR1) gene and loss of f

119 00 CGG repeat expansion in the 5'-UTR of the fragile X mental retardation 1 (FMR1) gene is known as a

120 e sensory abilities disrupted by loss of the Fragile X Mental Retardation 1 (Fmr1) gene.

121 to rescue the dendritic spine defects of the Fragile X Mental Retardation 1 gene KO neurons.

122 Finally, upregulating fragile X mental retardation 1 protein (Fmr1, also calle

123 rative molecular analysis converged on FMR1 (Fragile X Mental Retardation 1), an important negative r

124 The expression levels of FXR1 (fragile X mental retardation autosomal homolog 1), an RN

125 e biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulate

126 Pum2 display RNA-dependent interaction with fragile X mental retardation protein (FMRP) and bind to

127 pathophysiology associated with the loss of fragile X mental retardation protein (FMRP) and haploins

128 nnel open probability was reduced by loss of fragile X mental retardation protein (FMRP) and that FMR

129 es, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the rela

130 mental retardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragil

131 Loss of fragile X mental retardation protein (FMRP) causes fragi

132 es to understand how the loss of function of fragile X mental retardation protein (FMRP) causes fragi

133 brain.SIGNIFICANCE STATEMENT The absence of Fragile X Mental Retardation Protein (FMRP) from birth r

134 How the loss of fragile X mental retardation protein (FMRP) in different

135 ndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons.

136 Fragile X mental retardation protein (FMRP) is a multifu

137 Fragile X mental retardation protein (FMRP) is thought t

138 tic protein synthesis resulting from loss of fragile X mental retardation protein (FMRP) is thought t

139 In fragile X syndrome, the absence of fragile X mental retardation protein (FMRP) leads to def

140 Fragile X mental retardation protein (FMRP) loss causes

141 Here we show that the effect of loss of fragile X mental retardation protein (FMRP) on these pat

142 expected, P = .0062) and for targets of the fragile X mental retardation protein (FMRP) pathway (10

143 opic glutamate receptor signaling though the fragile X mental retardation protein (FMRP) pathway may

144 The fragile X mental retardation protein (FMRP) plays an imp

145 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is c

146 Fragile X mental retardation protein (FMRP) sculpts syna

147 More recently, fragile X mental retardation protein (FMRP), an RNA-bind

148 ires protein translation and is dependent on fragile X mental retardation protein (FMRP), the protein

149 Fragile X mental retardation protein (FMRP), the protein

150 FXS results from the loss of function of fragile X mental retardation protein (FMRP), which repre

151 rum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP).

152 mutation that disrupts the transcription of Fragile X Mental Retardation Protein (FMRP).

153 of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).

154 sulting from the partial or complete loss of fragile X mental retardation protein (FMRP).

155 The process is antagonized by fragile X mental retardation protein (FMRP).

156 ts (SNVs; P=5.4 x 10(-4)) and targets of the Fragile X mental retardation protein (P=0.0018).

157 The resulting absence of fragile X mental retardation protein 1 (FMRP) leads to b

158 crucially on protein synthesis controlled by fragile X mental retardation protein and on Arc signalin

159 Loss of the Fragile X mental retardation protein leads to excessive

160 trated that hYVH1 co-localizes with YB-1 and fragile X mental retardation protein on stress granules

161 anslational regulatory complex that includes fragile X mental retardation protein, DEAD box helicase

162 including Y box-binding protein 1 (YB-1) and fragile X mental retardation protein, proteins that func

163 analyzed 15 synaptic proteins in normal and Fragile X mental retardation syndrome (FXS) model mouse

164 Here, we show that the fragile X mental retardation-related protein 2 (FXR2P) c

165 ing networks are altered in the neocortex of fragile X mice such that S6 phosphorylation receives abe

166 We show that in fragile X mice, S6 is regulated by ERK via the "alternat

167 R) signaling is elevated in the neocortex of fragile X mice.

168 ces susceptibility to audiogenic seizures in fragile X mice.

169 itive phenotypes displayed by the Drosophila fragile X model, and thus reveal a metabolic pathway tha

170 cal, and behavioral symptoms observed in the fragile X mouse.

171 G repeat RAN translation in the 5' leader of fragile X mRNA, FMR1.

172 ior and to rescue the memory deficits in the fragile X mutant fly.

173 d by new and already approved drugs to treat fragile X patients.

174 Improvements in fragile X phenotypes have been observed following chroni

175 ) complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as bindin

176 intact brain that contain one or more of the Fragile X related (FXR) proteins (FMRP, FXR2P, and FXR1P

177 Fragile X related protein 1 (FXR1P) is a member of the f

178 and its inhibition by overexpression of the fragile X retardation protein Fmr1.

179 here that in mouse models PFC dysfunction in Fragile X Syndrome (FX) can be attributed to the continu

180 Fragile X Syndrome (FX) is generally considered a develo

181 ptors (mGlu1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially tra

182 Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are developmental disorders.

183 e behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result f

184 e X mental retardation protein (FMRP) causes fragile X syndrome (FXS) have largely focused on neurons

185 Fragile X syndrome (FXS) is a leading genetic cause of i

186 Fragile X syndrome (FXS) is a neurodevelopmental disease

187 Fragile X syndrome (FXS) is a neurodevelopmental disorde

188 Fragile X syndrome (FXS) is an undertreated neurodevelop

189 Fragile X syndrome (FXS) is caused by the absence of the

190 Fragile X syndrome (FXS) is characterized by sensory hyp

191 Fragile X syndrome (FXS) is the leading monogenic cause

192 Fragile X syndrome (FXS) is the most common form of inhe

193 Fragile X syndrome (FXS) is the most common form of inhe

194 Fragile X syndrome (FXS) is the most common heritable ca

195 ssing deficits in FXS.SIGNIFICANCE STATEMENT Fragile X Syndrome (FXS) is the most common inheritable

196 specially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just begun to be

197 Fragile X syndrome (FXS) results from a repeat expansion

198 le X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder characteriz

199 Fragile X syndrome (FXS), a heritable intellectual and a

200 ental retardation protein (FMRP) loss causes Fragile X syndrome (FXS), a major disorder characterized

201 autism spectrum disorders (ASDs), including fragile X syndrome (FXS), and frequently leads to tactil

202 Fragile X syndrome (FXS), caused by the loss of function

203 Fragile X syndrome (FXS), due to mutations of the FMR1 g

204 ty (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-

205 trum disorder (ASD), including in those with fragile X syndrome (FXS), one of the most common genetic

206 Fragile X syndrome (FXS), the most common form of inheri

207 get for diseases affecting synapses, such as fragile X syndrome (FXS), the most common heritable auti

208 FMR1 gene silencing results in fragile X syndrome (FXS), the most common heritable caus

209 One such condition is fragile X syndrome (FXS), which is considered to be caus

210 e X mental retardation protein (FMRP) causes fragile X syndrome (FXS), yet the mechanisms underlying

211 rited form of mental retardation and autism, fragile X syndrome (FXS).

212 on heritable autism spectrum disorder (ASD), fragile X syndrome (FXS).

213 ing causes of abnormal sensory processing in Fragile X syndrome (FXS).

214 tual deficits and sensory dysfunction in the fragile X syndrome (FXS).

215 dult Fmr1 knock-out mice, the mouse model of fragile X syndrome (FXS).

216 receptor might hold therapeutic benefits in Fragile X syndrome (FXS).

217 f the prevalent symptoms in individuals with Fragile X syndrome (FXS).

218 man's syndrome (34%), CHARGE syndrome (30%), fragile X syndrome (male individuals only 30%; mixed sex

219 f several neurological conditions, including Fragile X syndrome and Alzheimer's disease.

220 everal individuals clinically diagnosed with fragile X syndrome and autism spectrum disorder.

221 t of the neocortex, an area affected in both fragile X syndrome and autism spectrum disorder.

222 lem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable un

223 Recent evidence suggests that Fragile X syndrome and other types of autism are associa

224 hysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of o

225 pression) relevant to the pathophysiology of fragile X syndrome as well as neural correlates of cogni

226 tion patterns at specific genomic regions in fragile X syndrome cells, and identified dysregulated ge

227 Studies performed on animal models of fragile X syndrome have revealed links between modificat

228 entiated to dorsal forebrain cell fates, our fragile X syndrome human pluripotent stem cell lines exh

229 analysed the early stages of neurogenesis in fragile X syndrome human pluripotent stem cells.

230 ABSTRACT: Fragile X syndrome is the most common form of inherited

231 This finding is of high relevance because Fragile X syndrome is the most common monogenetic cause

232 tism spectrum disorder patients, among which fragile X syndrome is the primary monogenic cause.

233 The Drosophila Fragile X Syndrome model has long generated insights int

234 tion has been most well characterized in the fragile X syndrome mouse model, the Fmr1 knock-out (KO)

235 Fragile X syndrome results from loss of FMR1 expression.

236 ulated gene- and network-level correlates of fragile X syndrome that are associated with developmenta

237 We then describe what we have learned from fragile X syndrome that may be applicable to other psych

238 Specifically, Fmr1 (fragile X syndrome) and Ube3a (Angelman syndrome) are tr

239 e expansion disorders (Friedreich ataxia and fragile X syndrome), and cancer.

240 This form of plasticity is deregulated in Fragile X Syndrome, a monogenic form of autism in humans

241 comprehensive manner, we begin by selecting fragile X syndrome, a neurogenetic disease with cognitiv

242 or fly models of Alzheimer's disease and the Fragile X syndrome, allowing applications such as geneti

243 evelopmental disorders, Rett syndrome (RTT), fragile X syndrome, and CDKL5 syndrome, also affects fem

244 in myotonic dystrophy, and (CGG)n repeats in fragile X syndrome, are also subject to double-strand br

245 otein (FMRP), the protein that is lacking in fragile X syndrome, binds neuroligin-1 and -3 mRNA.

246 cess that is deficient in the mouse model of Fragile X Syndrome, Fmr1 KO.

247 expansions, including those associated with fragile X syndrome, Friedreich's ataxia, and Huntington'

248 gh incidence of autistic behaviours, such as fragile X syndrome, has the potential to identify genes

249 expansions in diseases such as hemophilia A, fragile X syndrome, Hunter syndrome, and Friedreich's at

250 ause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-

251 of disorders where it is disrupted, such as Fragile X syndrome, Rett syndrome, epilepsy, major depre

252 In fragile X syndrome, the absence of fragile X mental reta

253 Among these disorders is fragile X syndrome, the most common cause of inherited i

254 Fragile X syndrome, the most common known monogenic caus

255 he impairment in spinogenesis, a hallmark in Fragile X syndrome, thereby linking the regulation of ac

256 onic dystrophy, spinal muscular atrophy, and fragile X syndrome, with broader implications for other

257 These fragile X syndrome-aberrant networks are significantly e

258 omised in a severe monogenic form of autism, Fragile X Syndrome.

259 lated in autism spectrum disorder as well as fragile X syndrome.

260 nal regulation of a distinct set of genes in fragile X syndrome.

261 iology in 16p11.2 microdeletion syndrome and fragile X syndrome.

262 ysfunctional prefrontal cortex processing in fragile X syndrome.

263 l of the developmental neurological disorder Fragile X syndrome.

264 s primary contributors to the development of fragile X syndrome.

265 tions, including nociception, addiction, and fragile X syndrome.

266 of intellectual disability and autism called fragile X syndrome.

267 ated in autism spectrum disorders, including Fragile X syndrome.

268 brain disorders including schizophrenia and fragile X syndrome.

269 e and behavioural phenotypes associated with fragile X syndrome.

270 al and neuropsychiatric disorders, including fragile X syndrome.

271 There is currently no cure for fragile X, although medications targeting specific FXS s

272 othesis of shared pathophysiology of RTT and fragile X, another monogenic cause of autism and intelle

273 omised in a Drosophila melanogaster model of Fragile X, highlighting intriguing new mechanistic conne

274 In brains of a mouse model of fragile X, mGlu5 is less associated with its binding par

275 In fragile X, the loss of the mRNA translational repressor

276 Fragile X-associated disorders are a family of genetic c

277 to the phenotypes observed in patients with fragile X-associated disorders.

278 Fragile X-associated tremor/ataxia syndrome (FXTAS) is a

279 Fragile X-associated tremor/ataxia syndrome (FXTAS) is a

280 Fragile X-associated tremor/ataxia syndrome (FXTAS) is o

281 are associated with FMR1 overexpression and Fragile X-associated tremor/ataxia syndrome (FXTAS), a l

282 e affected by the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS), pri

283 gnitive deficits are common in patients with fragile X-associated tremor/ataxia syndrome (FXTAS), wit

284 sent in a 5' untranslated region that causes fragile X-associated tremor/ataxia syndrome (FXTAS).

285 that translation of expanded CGG repeats in fragile X-associated tremor/ataxia syndrome is initiated

286 AN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing s

287 The review includes fragile X-associated tremor/ataxia syndrome, spinocerebe

288 mentia (C9RAN) and at CGG repeats that cause fragile X-associated tremor/ataxia syndrome.

289 neurodegenerative disorders such as ALS and fragile X-associated tremor/ataxia syndrome.

290 e locus involvement may resolve up to 58% of Fragile X-negative cases.

291 nown to contribute to hippocampal defects in fragile X.

292 in response to ethanol treatment, requiring fragile-X mental retardation protein (FMRP).

293 m disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene.

294 Thus, two consequences of the Fragile-X mutation converge on plasticity at one site in

295 Fragile-X syndrome (FXS) patients display intellectual d

296 BPN14770 may be useful for the treatment of fragile-X syndrome and other disorders with decreased cA

297 rtex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory.

298 in the remaining 43% (1% were found to have Fragile-X).

299 Here, we have transferred human fragile zones into S. cerevisiae in the context of a gen

300 double-strand breaks (DSBs) occurring within fragile zones of less than 200 base pairs account for th