ライフサイエンスコーパス: differentiative

1 showed similar integrative, migrational and differentiative abilities to those of transplanted wild-

2 stem cells have equivalent proliferative and differentiative abilities.

3 interaction serves to retain cells in a pre-differentiative, actively proliferative state despite th

4 the DDR1 sequences) and markedly reduced the differentiative activity of the receptor.

5 and yolk sac cells are compromised in their differentiative and growth potential.

6 this differentiation process to compare the differentiative and invasive potential of cytotrophoblas

7 ntrol of proliferation is distinguished from differentiative and maturational responses to ecdysteroi

8 y of ligands of erbB receptors, induces both differentiative and mitogenic effects on cultured human

9 gest that BMP-2 and FGF-4 possess respective differentiative and proliferative activities, the combin

10 ratinocyte Growth Factor (KGF or FGF7) has a differentiative and proliferative effect on the epitheli

11 vitro without the concomitant loss of their differentiative and proliferative potential in vivo have

12 topoietic progenitor cells compromised their differentiative and proliferative potential, and enhance

13 cally inactive SHP-2 mutant suppressed their differentiative and proliferative responses to IL-3, dem

14 (ii) retinoid X receptors mediate prominent differentiative and weak proliferative effects; (iii) th

15 ess molecules relating to anti-inflammatory, differentiative, and metabolic processes, e.g., the anti

16 ng in the Ras pathway to transmit mitogenic, differentiative, and oncogenic signals to the downstream

17 ate that GSK3 inhibition acts to prime a pro-differentiative/apoptotic transcription program in the n

18 Thus, the different morphogenetic and differentiative behavior of neural crest subsets in vivo

19 om adults have exceptional proliferative and differentiative capability in vitro yet respond minimall

20 hese adult bone marrow cells have tremendous differentiative capacity as they can also differentiate

21 Here, we examine the developmental and differentiative capacity of cerebral organoids.

22 In contrast, the increased proliferation and differentiative capacity of p27(Kip1)-deficient T cells

23 dividuals, eg, self-renewal and multilineage differentiative capacity, might be perturbed due to the

24 for the proper positional specification and differentiative cell fate of enteric neurons.

25 tem cells (MSC) display great proliferative, differentiative, chemotactic, and immune-modulatory prop

26 tigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune

27 s to respond to survival, proliferative, and differentiative cues.

28 lopoiesis directly by replacing cytokine and differentiative cues.

29 to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data i

30 tion, implicating EKLF sumoylation status in differentiative decisions emanating from the MEP.

31 tric, proliferative division, to asymmetric, differentiative division.

32 in-of-function transgenics, Neurog2 promoted differentiative divisions and extended the period of Tbr

33 cells from symmetric (growth) to asymmetric (differentiative) divisions.

34 ated by retinoic acid receptors, whereas its differentiative effect at high dose may be mediated by r

35 n studies revealed a pro-proliferative, anti-differentiative effect of PKD on keratinocyte maturation

36 e 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneou

37 chimeric transcription factors can block the differentiative effects of growth factors.

38 ntrol of its p35 subunit, which requires the differentiative effects of IFN-gamma for expression.

39 proliferation and the pro-proliferative/anti-differentiative effects of PKD co-expression on keratino

40 costatin M (OM) exerts growth-inhibitory and differentiative effects on breast cancer cells.

41 phin best characterized for its survival and differentiative effects on neurons expressing the trk B

42 We conclude that progestins exert differentiative effects on tumors characterized by trans

43 ven when leukemic cells are resistant to its differentiative effects.

44 n of PR and Stat5-mediated proliferative and differentiative events in the mammary gland.

45 , CD19, is likewise essential for key B cell differentiative events including the formation of B-1, g

46 environments that are likely to induce these differentiative events.

47 hown to function both as a proliferative and differentiative factor for megakaryocytes and as a survi

48 s on the role of activin as a target-derived differentiative factor in neural development that has ad

49 te strong responses to ubiquitous growth and differentiative factors.

50 a homogenous population with regard to their differentiative fate as SNS neurons, these results indic

51 and memory CD4 T cell subsets and follow the differentiative fate of effector cells in vivo.

52 cell-bound ligands profoundly influence the differentiative fate of lymphocytes during an immune res

53 single cells and analysis of the subsequent differentiative fate of these cells as an immune respons

54 work towards redefining the identity and the differentiative fate of these primitive cells.

55 ML pathogenesis by inhibiting the normal pro-differentiative function of ATRA, paving the way for new

56 Thus, the signals which mediate a differentiative function of the IL7R in B lymphopoiesis

57 were normal in number, in proliferative and differentiative function, and in migration and homing to

58 by these regions and that proliferative and differentiative functions can be induced by different re

59 nitors, stimulating mitogenic, survival, and differentiative growth response pathways.

60 progesterone can be either proliferative or differentiative in different target cells.

61 e doubt on the hypothesis of hierarchical or differentiative loss of tumorigenicity.

62 5, a proliferative marker, and involucrin, a differentiative marker, respectively.

63 to expect that special developmental and/or differentiative mechanisms operate in response to inflam

64 cells (RGCs) to switch from proliferative to differentiative neuron-generating divisions, but the mol

65 pe, suggesting the existence of an Ag-driven differentiative pathway from B-2 to B-1.

66 (SHH), but the precise role of Nurr1 in this differentiative pathway has not been established.

67 suggesting that these subsets constituted a differentiative pathway with progressive telomere shorte

68 -2 and B-1, further evidence of a B-2 to B-1 differentiative pathway.

69 Thus, the growth inhibitory and differentiative pathways activated by TGF-beta and activ

70 activation process and to further define the differentiative pathways and functional characteristics

71 These results are key to understanding how differentiative pathways are controlled and cellular phe

72 shaft and sheath cells in the post-mitotic (differentiative) phase.

73 we performed a comprehensive analysis of DC differentiative potential among lymphoid and B lymphoid

74 Rat PDL DPCs also exhibited differentiative potential characteristic of stem cells.

75 vity, proliferative capacity, karyotype, and differentiative potential in routine culture and under c

76 This approach uses the differentiative potential of MSCs induced by the tumor m

77 Whether memory B cells possess altered differentiative potentials and respond in a qualitativel

78 To better understand the differentiative processes occurring within murine GCs, w

79 supporting somatic cells guides many of the differentiative processes of gametogenesis.

80 cated in a wide variety of proliferative and differentiative processes.

81 y and anchorage-dependent growth by inducing differentiative programs and cell cycle progression, (ii

82 uired for the execution of developmental and differentiative programs in a variety of cell and tissue

83 ective target for a HOX protein and link the differentiative properties of a transcription factor and

84 es most colon cancer cell lines to undergo a differentiative response and reverse their malignant phe

85 tially regulated two-stage mechanism for the differentiative response of PC12 cells to NGF.

86 gulated kinase, an event associated with the differentiative response of these cells.

87 ases that activate mitogenic, motogenic, and differentiative responses in different tissues.

88 -dependent signaling pathway participates in differentiative responses of cells in the developing CNS

89 echanisms that relay information to initiate differentiative responses of neural precursor cells are

90 required for IL-4-induced proliferative and differentiative responses, both signaling proteins are d

91 the Ras-MAP kinase pathway that mediates the differentiative responses, the signal transduction pathw

92 bringing about Ag-specific proliferative and differentiative responses.

93 rrent work supports a dual proliferative and differentiative role for the LF receptor, but only a dif

94 tiative role for the LF receptor, but only a differentiative role for the SF1a receptor.

95 us, our results indicate that AQP3 has a pro-differentiative role in epidermal keratinocytes and that

96 n factor will be present when needed for its differentiative role.

97 functions as a pro-proliferative and/or anti-differentiative signal in keratinocytes and hypothesized

98 " this primary alcohol to PLD2 to form a pro-differentiative signal, such that the action of AQP3 to

99 to catenin, regulation of beta-catenin as a differentiative signaling molecule, and promotion of mic

100 that initially integrates proliferative and differentiative signals and subsequently maintains stabi

101 of partial receptor complexes that transduce differentiative signals during thymic development.

102 t cytokine receptors can provide the trophic/differentiative signals for subsequent CD8(+) thymocyte

103 ng-bone growth in chrondrocytes, it produces differentiative signals similar to those of FGFR1, to wh

104 receptors provide both survival and trophic/differentiative signals with varying degrees of redundan

105 onal, inflammatory, mitogenic, apoptotic and differentiative signals.

106 mal proliferative signals and contributes to differentiative signals.

107 nds upon a wide variety of proliferative and differentiative signals.

108 lasmic domain in mediating proliferative and differentiative signals; and (4) the regulation of proli

109 involvement of coreceptors in signaling and differentiative stage of the responding cell.

110 Knowing at what differentiative stage(s) developing B cells undergo rece

111 candidate for a gene that might regulate the differentiative state of VSMCs.

112 ssion of satellite cells into the myogenin+, differentiative state.

113 Cornification is the final differentiative step for epidermal keratinocytes and inv

114 The precise mechanisms of these differentiative steps remain elusive.

115 scues GZ exit, suggesting a model for future differentiative therapies.

116 as well as in both the proliferative and the differentiative zones of the brain and neural tube.