ライフサイエンスコーパス: conformation

1 s embraced to achieve its cleavage competent conformation.

2 The channel adopts an open conformation.

3 , molecules 1 and 4 prefer to adopt the Pheq conformation.

4 , folding stem IIB into a proper Rev binding conformation.

5 d shows subtle but clear changes in tertiary conformation.

6 t monoclonal antibody specific for the pre-F conformation.

7 te is closed in a highly strained asymmetric conformation.

8 ng a catalytically competent dimeric cyclase conformation.

9 nd, capturing the receptor in an active-like conformation.

10 One state contains a compact inactive RF2 conformation.

11 bly different from those in the ligand-bound conformation.

12 l apex or rotated into a receptor-accessible conformation.

13 y stabilizing the closed E2 approximately Ub conformation.

14 ethylation or demethylation, and alter their conformation.

15 e trimer to adopt either a closed or an open conformation.

16 hexamer (site I), stabilizing it in the T3R3 conformation.

17 ransport domain toward their own alternative conformation.

18 red for the active site to assume the proper conformation.

19 es that are defined by the twisted molecular conformation.

20 C-terminal domain has a PG-binding-competent conformation.

21 izes the RNA by locking it into a particular conformation.

22 the bulk to a greater degree than is the cis conformation.

23 ually inserted into the membrane in a native conformation.

24 interaction, causing PSD-95 to adopt an open conformation.

25 n, called Pre-F-GCN4t, stabilized in a pre-F conformation.

26 in (Pdx), shows that P450cam adopts the open conformation.

27 es a robust screening system to monitor apoE conformation.

28 nformation, whereas cSH2 prefers a collapsed conformation.

29 isulfide connectivity underlying E1E2 native conformation.

30 fy signals or stabilize a particular protein conformation.

31 access to the pore even in the NBD-dimerized conformation.

32 eters depended on the technique used and BSA conformation.

33 etal coordination in an open non-DNA-binding conformation.

34 glycoproteins, likely through altering their conformation.

35 y alter the proportions of the two CD4-bound conformations.

36 structure dominated by turn and random coil conformations.

37 compaction of the two different families of conformations.

38 the sampling of many potentially productive conformations.

39 served in experiments originate from compact conformations.

40 nomeric spikes similar to one of the crystal conformations.

41 s of EPOR truly represent active or inactive conformations.

42 modynamic stabilities of different molecular conformations.

43 de inhibitors having non-helical or extended conformations.

44 r revealed three dominant classes of subunit conformations.

45 igand that can adopt two distinct rotational conformations.

46 y changing the ensemble of likely low-energy conformations.

47 tate, with the guests bound in axial/diaxial conformations.

48 and other biomacromolecules in their native conformations.

49 e dynamic entities and populate ensembles of conformations.

50 -occluded, inward-occluded, and inward GLUT1 conformations.

51 ate equilibrium between compact and extended conformations.

52 a interacts predominantly in resting channel conformations.

53 xible regions that adopt multiple structural conformations.

54 d interesting to characterize the structural conformations adopted by these intermediates, also calle

55 esions might stabilize intermediate receptor conformations along the OFF-ON energy landscape.

56 Chromatin conformation analysis revealed that these enhancers and

57 luding positional sensing, biomacromolecular conformation analysis, and real-time kinetic monitoring

58 mic equilibrium between the known, common Ub conformation and a distinct, second conformation wherein

59 Peptides undergo changes in conformation and aggregation state in the presence of me

60 Our results show an unexpected FIN219 conformation and demonstrate various differences between

61 tion to membranes and helps maintain protein conformation and function.

62 the effects of the sSNP and rescues protein conformation and function.

63 t with the concept that abnormal AAT protein conformation and intrahepatic accumulation have broad ef

64 omputational approaches for measuring genome conformation and nuclear organization, and investigate h

65 ed by binding of l-arginine in a nonoxidized conformation and of 2-oxoglutarate in an unprecedented h

66 t of distinct intramolecular motifs on xylan conformation and on the interaction with cellulose surfa

67 the presence of membranes; conversely, lipid conformation and packing can adapt to the presence of pe

68 c18c, like Munc18a, binds to both the closed conformation and the N-peptide of Syx4.

69 ial segment (NIS) adopting a backward-docked conformation and the preceding alpha6 helix partially me

70 the characteristic caliper-like DNA-binding conformation and the second monomer exhibiting disrupted

71 sensing, which range from changes in protein conformation and transcription factor localization to ch

72 Although understanding the conformations and arrangements of conjugated materials a

73 ction and analysis, and probing nucleic acid conformations and binding interactions.

74 uce kinase activity over a range of receptor conformations and dynamic motions.

75 is accompanied by large changes in local tau conformations and irreversible aggregation.

76 e CDR loops, CDR H3 does not adopt canonical conformations and must be modeled de novo.

77 ctural determinants that distinguish the two conformations and possible rearrangements of TMHs within

78 ank (PDB), only 22% of them have alternative conformations and the remaining proteins have different

79 noporphyrin molecular dyads having different conformations and therefore different interchromophore e

80 nv has been identified as one such preferred conformation, and a current leading vaccine candidate is

81 loaders bind and stabilize clamps in an open conformation, and in the second stage, clamp loaders pla

82 ure, the voltage sensors adopt a depolarized conformation, and the pore is open.

83 he Arp2/3 complex, induced the standard open conformation, and two new masses appeared at positions n

84 tern and more precisely tractable chromosome conformations, and the large-scale genomic organization

85 roteins can attain both compact and expanded conformations, and the level of expansion may be regulat

86 ry proteins adopt distinct bound and unbound conformations, and use this structural flexibility to bi

87 These compact conformations are amenable to cooperative, high-affinity

88 uctural and dynamical aspects of the helical conformations are explored, with a focus on contrasting

89 The more axial-rich donors in skew and boat conformations are thus preorganized closer to the assume

90 taG, of 6 kcal.mol(-1) between the two local conformations around a single bond.

91 150-loop of the H15 HA retains the conserved conformation as in H7 and H10 HAs.

92 ignaling potency, suggesting an altered GPCR conformation as the underlying basis for GPCR priming.

93 icate that the macrocycle adopts a boat-like conformation at the final station, which contrasts with

94 station, which contrasts with the chair-like conformation at the initial station.

95 aracterized by different aromatic side-chain conformations at the RNA-binding surface allow for high-

96 tructures, template 1-MeA rotates to the syn conformation but pairs differently with dTTP versus dCTP

97 o a simple binary switch between two defined conformations, but the activated receptor is in equilibr

98 Stabilization of the bent conformation by integrin transmembrane and cytoplasmic d

99 aled molecular-level perturbations of fibril conformation by the PD-related mutations that are not ap

100 The increased sampling of an open Skp1 conformation can explain how glycosylation enhances inte

101 e inhibitor and IRAP that are unique to this conformation can explain the strong selectivity compared

102 NA positioning on the nucleosome and the DNA conformation can provide key regulatory signals.

103 phosphorylation sites is required for a GC-A conformation capable of transmitting the hormone binding

104 Chromosome conformation capture (3C) methods are central to underst

105 serve chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human

106 Here we use chromosome conformation capture (Hi-C) to study mitotic chromosome

107 act with the 7p14.3 locus by Hi-C chromosome conformation capture data.

108 expression, DNA methylation, and chromosome conformation capture experiments into network models tha

109 ian genomes using data from a new chromosome conformation capture procedure that allows us to first i

110 With the development of chromosomal conformation capturing techniques, particularly, the Hi-

111 inhibit GTP binding/signalling by driving a conformation change that disorganizes the TG2 GTP bindin

112 We find how the rates of conformation changes depend on the substrate stiffness a

113 ce of 2,3-BPG-deoxyHbA and causes additional conformation changes to the T-state Hb.

114 The spatial distributions of each conformation class differed among oligomers, and most ol

115 ntained 10-12 subunits of the three dominant conformation classes.

116 twofold noncrystallographic symmetry axis, a conformation clearly distinct from that of actin subunit

117 esults in the spontaneous sampling of an Env conformation closer to the CD4-bound state.

118 The flexible Ser65 loop in the Ub-CR conformation contacts the activation segment, facilitati

119 namics simulations to determine ensembles of conformations corresponding to the denatured, transition

120 ies form Watson-Crick-like base pairs, their conformation could not be directly deduced from the expe

121 uantitative trait loci (eQTL) or Hi-C genome conformation data and reports the most likely candidate

122 stabilizing either the folded or unfolded TL conformation decreased termination rate.

123 ed for the first time that MK-2 has a folded conformation defined by the isoprenyl side-chain folding

124 Mcc(ia) prion-like activity is conformation-dependent and could be reduced by immunodep

125 amyloid structures distinguished by amyloid conformation-dependent monoclonal antibodies have simila

126 to understand how a protein's 3-dimensional conformation determines its capacity to interact with po

127 We show that NEMO adopts a more compact conformation (Dmax=320A) than predicted for a fully exte

128 a rather broad distribution in polymer chain conformation due to the strong steric hindrance of bulky

129 cal activity due to their fragile structural conformation during formulation, storage, and delivery.

130 is associated with two distinct sets of loop conformations, each essential for one function.

131 -chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP, with

132 activity resulting from the complex form, a conformation for domain switching, allows FIN219 to swit

133 these structures also revealed well-ordered conformations for the EF loop of VP2, the GH loop of VP3

134 We used molecular mechanics to illustrate conformations found by the NMR experiments.

135 quantitative trait loci (meQTLs), chromatin conformation from publicly available datasets (Hi-C and

136 C)) to selectively propagate optimized prion conformations from larger ensembles generated in the spe

137 uctures to compute the Global Minimum Energy Conformation (GMEC).

138 Moreover, the ground state conformation has been identified and it is shown that it

139 s, structural determinants for the different conformations have remained largely obscure.

140 f these functions is their ability to change conformation in response to mechanical stimuli.

141 main keep the EHD2 dimer in an autoinhibited conformation in solution.

142 bles the determination of the correct ligand conformation in the bound state.

143 is due to an alternative nucleotide binding conformation in the precatalytic ternary structures (hPo

144 of calcium, are compacted but adopt an open conformation in the presence of calcium, enabling actin

145 CaM adopts a highly compact conformation in which its open Ca(2+)-activated C-lobe a

146 energy simulations elucidate the active site conformations in the AppA (activation of photopigment an

147 inus, which was suggested to adopt different conformations in the inward facing, outward facing and a

148 firin was dissolved in GAA its alpha-helical conformation increased substantially.

149 termed the stalk, which adopts a beta-strand conformation, instead of forming an alpha-helix as obser

150 its postfusion (post-F) or prefusion (pre-F) conformation is a target for neutralizing antibodies and

151 The polymerase conformation is affected by the methyltransferase, which

152 the rotating lever arm toward the poststroke conformation is almost flat, implying that the lever arm

153 We find that the helical TM5i conformation is associated with a higher propensity for

154 The right-handed helical conformation is engineered into the polymers by preinsta

155 ther, these data suggest that Arp2/3 complex conformation is highly polymorphic and that its activiti

156 sion state and triggering to the post-fusion conformation is important for understanding F protein fu

157 the link between secondary structure and RNA conformation is only beginning to be understood.

158 und to be catalyzed; additionally, the trans conformation is selectively solvated within the bulk to

159 Its overall conformation is similar to SOSIP.664 and native Env trim

160 The resulting conformation is similar to the conformation of the inhib

161 This secondary conformation is stable over a wide range of different co

162 ike state of BAK1 and stabilizes an inactive conformation known to recur in protein kinases.

163 tion of the -1 subsite mannoside to an (O)S2 conformation, matching that predicted by theory and supp

164 However, dynamic sampling of alternative conformations (microstates) in allosteric molecules comp

165 pport the concept that modulating mutant HTT conformation might provide novel therapeutic and diagnos

166 m" of heterologous interactions, enforcing a conformation more similar to that of homologous (i.e., n

167 ly at position 83, with corresponding domain conformations observed for G6.31.

168 GaMD also reveals the conformation of a catalytically competent Cas9, which is

169 the Hi-C technique, the study of the spatial conformation of a genome is becoming an important topic

170 ombination of structural features within the conformation of a protein; not only its percentage secon

171 , not essential for maintaining the inactive conformation of ADAMTS13.

172 A transient conformation of decoding-centre nucleotide G530 stabiliz

173 t the D145E mutation destabilises the native conformation of EF-hand IV, leading to a transient unfol

174 antly affect bond strength and influence the conformation of Fn upon binding.

175 Detection of the physiological conformation of G4s and their complexes opens up the pos

176 , consistent with CD4-induced changes in the conformation of gp120 and the antibody binding site.

177 The prefusion-closed conformation of HIV-1 Env has been identified as one suc

178 physiology, the in vivo oligomeric state and conformation of insulin in its storage granules in the p

179 binding pocket and, more importantly, to the conformation of its beta-rings.

180 The conformation of our LliK structure may represent a funct

181 ment of therapeutics aimed at correcting the conformation of polyglutamine-expanded proteins as well

182 ults showcase the ability to direct solution conformation of polymers through monomer design.

183 h a recent proposal that eIF4A modulates the conformation of the 40S ribosomal subunit to promote mRN

184 ich states that collagen binding changes the conformation of the A1 domain to a high-affinity GPIbalp

185 The conformation of the activation loop (T-loop) of protein

186 to mimic the suggested bioactive gamma-turn conformation of the Bip-Lys-Tyr tripeptide in Urocontrin

187 ests that pAg binding disrupts a preexisting conformation of the BTN3A1 intracellular domain.

188 lical hairpin in the NTD of DnaB altered the conformation of the helical hairpin and/or compromised i

189 accine designers have sought to restrict the conformation of the HIV-1 Env trimer to its prefusion-cl

190 The resulting conformation is similar to the conformation of the inhibitor in the active site of BACE

191 The conformation of the interacting part of the IDR was dete

192 d pharmacology, consistent with an impact on conformation of the KCNQ pore.

193 clear compartments depends on NCoA-2 and the conformation of the receptor as assessed with synthetic

194 tivated state corresponds to a "constricted" conformation of the selectivity filter.

195 We propose that a specific conformation of the Smc3p hinge and Pds5p cooperate to p

196 fect of chaperone activity on the functional conformation of the temperature-sensitive mutant cystic

197 the impact of ATP, MalE, and maltose on the conformation of the transporter during the transport cyc

198 previously unreported, predeoligomerization conformation of the trimer that has been shown to be sam

199 There, the conformation of transmembrane helices constituting a mem

200 xhibits preferential binding toward the open conformation of vinculin, suggesting that the MAPK1-vinc

201 ORE spectroscopy validate that the perturbed conformation of Y731 in R411A-alpha2 is dynamic, reformi

202 lpha) disrupts the H-bonding environment and conformation of Y731, ostensibly breaking the RT pathway

203 GMF induced two distinct open conformations of Arp2/3 complex, which correlated with t

204 e process initiated in RPc and that the RNAP conformations of intermediates are significantly differe

205 Our results also suggest multiple conformations of P450 17A1, as previously proposed on th

206 Furthermore, different conformations of phage tail fibers correlated with the a

207 rticularly by stabilizing clinically favored conformations of target proteins, with orally available,

208 The self-propagation of misfolded conformations of tau underlies neurodegenerative disease

209 dynamics studies to determine the preferred conformations of the A-A noncanonical pairs in (CAG)n an

210 Previous reports show that fH binds various conformations of the cellular prion protein, leading us

211 e the dynamics of what had been inaccessible conformations of the DNA-protein complex.

212 nd epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.

213 t occur between the prefusion and postfusion conformations of the fusion protein.IMPORTANCE Due to la

214 c exchange between partially closed and open conformations of the SAM-II riboswitch in the absence of

215 tain more accurate descriptions of alternate conformations of the two proteins, we first performed co

216 delta1 may up-regulate currents by promoting conformations of the voltage sensor that are associated

217 radical generation reveal that Y731 changes conformation on the ns-mus time scale, significantly fas

218 his gp140 trimer, which adopts two principal conformations, one closed and the other slightly open.

219 the four-way junction exists as a mixture of conformations, one of which is most likely the open-X st

220 ing DFT/B3LYP/pcJ-1 approximation applied to conformations optimized at DFT/B3LYP/6-311++G** level su

221 o tau aggregates forming distinct structural conformations, or strains.

222 apillary electrophoresis-based single-strand conformation polymorphism (CE-SSCP).

223 alysis demonstrated that EYA1 has a striking conformation preference for phospho-T58 of Myc.

224 suggested that outward and outward-occluded conformations present multiple beta-d-glucose and maltos

225 on sites, whereas inward-occluded and inward conformations present only a single beta-d-glucose inter

226 icates that FP E244K is trapped in a compact conformation preventing its oligomerization.

227 N582, suggesting that rapid folding of local conformation prevents glycosylation of this site in wild

228 phetamine, that is thought to disrupt DAT OF conformation, reduced the concentration of wild-type DAT

229 BAX expression levels and cytosolic conformation regulate sensitivity to BTSA1.

230 ructure, allowing RNA molecules to adopt the conformations required for interaction with their target

231 either the gauche-gauche or the gauche-trans conformation (respectively, axial or equatorial to the b

232 a C(11)=C(12) double bond locked in its cis conformation (Rh6mr), employs an atypical isomerization

233 sts that UBP684 binding may induce switch in conformation similar to glutamate LBD locked state.

234 brils could be used as immunogens to prepare conformation-specific antibodies and as novel tools to d

235 We show that a conformation-specific Fab can reactivate an IDH1 mutant

236 the B[a]P moiety is in a non-solvent exposed conformation stacked within the DNA helix, where it effe

237 are known to adopt higher and lower activity conformations, structural determinants for the different

238 lly complex disorders followed by chromosome conformation studies in relevant tissues can be successf

239 DFNKF sequence is not stable in antiparallel conformation, suggesting that the residue flanking the a

240 -acid-binding cleft of RNAP samples distinct conformations, suggesting different functional states du

241 ome ferritin-MOFs can adopt multiple lattice conformations, suggesting dynamic behavior.

242 sification of protein kinase active/inactive conformations, taking into account more structures and m

243 Thus, the more populated extended pCaM conformation targets nSH2 to release its autoinhibition

244 ar size, and likely with a different overall conformation than those formed along the on-pathway, sug

245 ion of alternative, presumably higher energy conformations than native peptide-MHC complexes.

246 trikingly, the AAUAAA PAS assumes an unusual conformation that allows this short motif to be bound di

247 free energy to shift PhyR to an open, active conformation that binds and inhibits NepR.

248 zation requires the protein to adopt an open conformation that exposes the surfaces engaging in inter

249 oxoglutarate in an unprecedented high-energy conformation that favors ethylene, relative to succinate

250 We observe a single well-defined conformation that is folded toward the surface in such a

251 yme adenylate kinase in a closed high-energy conformation that is on-pathway for catalysis.

252 cells cholesterol keeps TCRs in the resting conformation that otherwise would become spontaneously a

253 First, the RNA conformation that presents an accessible rut site promot

254 olded state towards a compact, pre-organized conformation that resembles the ligand-bound state.

255 e-to-proline mutation, locking the loop in a conformation that sterically blocks binding and neutrali

256 igh-mannose glycoform preferentially samples conformations that are more competent to FcgammaRIIIa bi

257 ng, indicating a shift toward outward-facing conformations that can be interpreted using conventional

258 a corA gene can adopt two mutually exclusive conformations that dictate accessibility of a rut site t

259 In this previously unobserved conformation, the extracellular-half of the pore-lining

260 For the Trpin/Metout conformation, the hydrogen-bonding pattern conducive to

261 In the resting conformation, the TCR is not phosphorylated and is inact

262 transport by confirming at least four GLUT1 conformations, the so-called outward, outward-occluded,

263 ible N-terminal loop for adopting its active conformation, thereby effecting substrate specificity.

264 he propensity of Env to sample the CD4-bound conformation, thereby increasing susceptibility to ADCC.

265 s helical transitions leading to post-fusion conformations, thereby favoring the pre-fusion state.

266 echanically switched from an open "W"-shaped conformation to a closed "U"-shaped form.

267 ytoplasmic domain of subunit a (aNT) changes conformation to bind rotor subunit d However, insufficie

268 anisms through which PGC1alpha changes LRH-1 conformation to drive transcription are unknown.

269 as protein kinases adopt a diverse array of conformations to respond to regulatory signals in signal

270 ly to peer algorithms, and can approach goal conformations to within a low all-atom RMSD by directing

271 -RD captured a low populated protein-folding conformation triggered by the Glu-145 replacement of Asp

272 ituted MalFGK2 in nanodiscs and analyzed its conformations under 10 different biochemical conditions

273 important for the stabilization of distinct conformations underlying functional selectivity.

274 creased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how small,

275 whether this difference is due to an altered conformation upon RNAP binding or to differences in intr

276 y stabilize the dimer-prone or monomer-prone conformations, validated in-solution, and introduced to

277 sults suggest that TMAO stabilizes collapsed conformations via a mechanism that is distinct from glyc

278 82 contributed to sugar binding in all GLUT1 conformations via hydrogen bonding.

279 d aPRP a significant change to less extended conformations was observed, while P-B peptide did not di

280 Abeta10-40 conformations were analyzed by computing secondary struc

281 n-conformation; without the ligand, only off-conformations were visualized.

282 c rings and these adopt a twisted "S"-shaped conformation when bound to A. thaliana AHAS (AtAHAS) wit

283 fts the equilibrium towards an active T-loop conformation whereas addition of the inhibitors MLN8054

284 homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphorylatable S561A mutat

285 we observe that nSH2 prefers an extended CaM conformation, whereas cSH2 prefers a collapsed conformat

286 ommon Ub conformation and a distinct, second conformation wherein the last beta-strand is retracted t

287 tionic AMPs typically exhibit an amphipathic conformation, which allows increased interaction with ne

288 adduct is able to move to a solvent-exposed conformation, which enables error-prone DNA replication

289 to such sites induces changes in the filter conformation, which play a key role in defining both sel

290 PKC-phosphorylated AT1R in a distinct active conformation, which triggers MAPK recruitment and recept

291 M2 is splayed open, reminiscent of the open conformation, while the intracellular-half is constricte

292 exists in dynamic equilibrium with holo-like conformations, while Ca(2+) uptake reduces conformationa

293 on, whereas GTP promotes a compact, inactive conformation whose ability to polymerize is unknown.

294 ob-into-hole assembly, proved to be a stable conformation with homogeneous distribution, confirming i

295 ctivated receptor in DDM is dominated by one conformation with weak pH dependence.

296 pendent of size and charge but did depend on conformation, with regular, spherical particles being de

297 ptides bind in a bidirectional yet conserved conformation within the substrate-binding cleft of OGA.

298 rst, the motor domain attains the poststroke conformation without directing the lever arm forward; an

299 irected sampling correctly identified the on-conformation; without the ligand, only off-conformations

300 for xyloglucans in both extended and coiled conformations, yet xyloglucan chains were not directly v