ライフサイエンスコーパス: concert

1 fferent reaction pathways (i.e., stepwise vs concerted).

2 endothelial cells, and podocytes, working in concert.

3 eps: C-H bond activation; C-C coupling via a concerted 1,2-aryl transfer; proto-demetalation; nucleop

4 isomer, perhaps hinting at the potential for concerted 2 e(-) /2 H(+) transfers.

5 ent with an iron(III)-mediated asynchronous, concerted [2+2]-cycloaddition to form an intermediate ox

6 embered macrolactone, which may proceed as a concerted [4+2] Diels-Alder reaction or a stepwise [6+4]

7 n response to abiotic stress, which requires concerted action of both cis- and trans-regulatory featu

8 Taken together, we propose that the concerted action of DDK, Polo-like kinase, and CDK1 prom

9 yotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivit

10 g embryonic morphogenesis is mediated by the concerted action of four proteins that delay the formati

11 ial developmental response that involves the concerted action of many different cell types, is highly

12 iated fear-memory enhancement results from a concerted action of mechanisms that strengthen memory th

13 proteins across cellular membranes with the concerted action of mostly three membrane proteins: TatA

14 This can be achieved by a concerted action of peptidoglycan (PG) hydrolases and PG

15 Concerted action of priming and activating amino acids i

16 ating is a cooperative process involving the concerted action of residues from more than a single pro

17 associated siRNAs involves the noncanonical, concerted action of RNA POLYMERASE IV, RNA-DEPENDENT RNA

18 holesterol homeostasis is maintained through concerted action of the SREBPs and LXRs.

19 ensity of docked vesicles, suggesting that a concerted action of these mechanisms underlies the funct

20 Here we show that the concerted action of two enzymes commonly involved in nat

21 rrelations can be explained as a result of a concerted action of two mutation mechanisms, which we na

22 Fusion is orchestrated via the concerted action of two surface glycoproteins: an attach

23 d a complex polyferredoxin, each require the concerted action of two translocases for their assembly.

24 Thus, our data show how the concerted actions of FGF13 and FGF14 regulate the polari

25 ular inflammation and thrombosis require the concerted actions of several different agonists, many of

26 alternative polyadenylation, and it is their concerted actions that define a gene's expression outcom

27 Infection is restrained by the concerted activation of tissue-resident and circulating

28 helial sheet, but which we now show involves concerted active cell movement.

29 drug-induced cross-link repair requires the concerted activities of translesion synthesis (TLS), Fan

30 which likely discharge in response to either concerted activity among a large proportion of inputs or

31 ddition-elimination (TEWT) to a lower energy concerted acyl substitution (TES148C), accounting for th

32 ons indicate that the cycloaddition involves concerted addition of the diene onto the oxidopyridinium

33 ments containing Asn/Gln residues may act in concert along a replicative interface to promote prion c

34 clusion with bound ATP and calcium is highly concerted and cooperative, the phosphorylation of Asp351

35 a mood-related circuit believed to provide a concerted and distributed regulation of the excitability

36 on is re-established after DSB repair by the concerted and interdependent action of replication-indep

37 calculations for two reaction pathways, one concerted and one stepwise, for the production of each e

38 oss-tissues variability that is functionally concerted and reproducible across different datasets, su

39 Both concerted and stepwise cycloadditions are predicted, dep

40 he reactivity of C horizontal lineC bonds, a concerted anti-addition pathway was favored due to the t

41 hus appears that platelets not only serve in concert as building blocks of the hemostatic plug but al

42 utational and experimental results support a concerted asynchronous [3 + 2] cycloaddition involving a

43 ed-state triple proton transfer (ESTPT) in a concerted, asynchronous manner.

44 may not be a single state, which implies non-concerted atomic motions on a multidimensional energy la

45 could be associated with a different mode of concerted bond cleavage rather than two different reacti

46 only involved multiple techniques working in concert but also illustrated a unique way in which hits

47 ion, intramolecular 1,6 proton transfer, and concerted but asynchronous bicyclization events.

48 Duplication is concerted by replisomes.

49 xample of a one-electron redox event causing concerted change in multiple iron centers.

50 Transitions between modes are said to spark concerted changes in the morphology, physiology, behavio

51 (CW) and kinase-off (CCW A) states differ by concerted changes in the positions of spin-label sites a

52 sole carbon source requires more robust and concerted chitinase activity.

53 ytic domains (HNH and RuvC), responsible for concerted cleavage of the two DNA strands.

54 This can only be achieved through a concerted collaborative approach from physicians, indust

55 ses on the four domains of Scap that undergo concerted conformational changes in response to choleste

56 site, which confers substrate specificity by concerted conformational changes of the central beta hai

57 molecular simulations to accurately describe concerted conformational transitions identifying the ove

58 ng different metal catalysts orchestrated in concert constitute an attractive alternative to multi-st

59 evidence that internal friction arises from concerted, crankshaft-like dihedral rearrangements.

60 cyclization and supporting rate-determining concerted cyclization.

61 OH oxidation does not necessarily induce its concerted deprotonation.

62 a free energy barrier of 22 kcal/mol for the concerted Diels-Alder process and provide no evidence of

63 Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p.

64 onent hydrocarbon systems to investigate how concerted-distinct conformational changes of hydrocarbon

65 This type of concerted divergence is a previously unreported fate of

66 Here, we provide an example of concerted divergence of simultaneously duplicated genes

67 leavage site in a conformation essential for concerted DNA cutting.

68 uced in an intricate process that includes a concerted down-regulation of genes encoding rRNA and rib

69 nd next-generation zirconias, representing a concerted drive toward greater translucency while preser

70 repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a

71 to take place via two competing pathways, a concerted E2 elimination and a SN2 nucleophilic substitu

72 d very large depolarization depending on the concerted effects of extreme lifetime enhancement and re

73 argue that the future use of MRTs requires a concerted effort among the global research and clinical

74 he final step, called maturation, involves a concerted effort between Csm3, a ruler protein in Cas10-

75 and implementation science), we can drive a concerted effort focused on cancer vaccines to reprogram

76 In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), inte

77 iders delivering HCV care, contributing to a concerted effort to reduce the overall burden of HCV inf

78 s in health systems should be accompanied by concerted efforts to improve quality of care in faciliti

79 1 S-palmitoylation, which acting alone or in concert, enables the normal occurrence of the fission-fu

80 Direct observation of concerted equilibrium fluctuations would therefore be an

81 two subgenera, suggesting different rates of concerted evolution in two subgenera which could be attr

82 GC plays in various genetic diseases and the concerted evolution of gene families, the parameters tha

83 h recombination and breakpoint repair, while concerted evolution of IR1 is driven by gene conversion

84 Still, support for this idea of concerted evolution of the morphology of the lizard sens

85 sovers lead to repeat homogenization through concerted evolution, although the degree of unequal cros

86 ual conditions for both processes to work in concert existed is uncertain.

87 Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are

88 g inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses.

89 the oxygen abstracts the leaving H-atom in a concerted, four-center (H3C...*...H...O*)() transition s

90 monas palustris BisB18 and demonstrate their concerted function in vitro.

91 Despite concerted functional genomic efforts to understand the c

92 d elucidate their mechanisms of action using concerted genetics, protein interaction analyses, and ce

93 uence of proton and electron transfer steps, concerted H atom transfer steps, or some combination the

94 to project their sound more effectively in a concert hall-despite seeming relatively quiet under the

95 These isotope effects support concerted hydride and proton transfer for both light and

96 d carboxy-terminal domains essential for the concerted integration reaction.

97 he stiffness and its gradients emerge from a concerted interaction across multiple length-scales: pac

98 pening of its periplasmic aperture through a concerted interaction with MexA.

99 The assembly of coronavirus virions entails concerted interactions among the viral structural protei

100 ull potential as monomers but rather undergo concerted interactions as either homo-oligomers or with

101 Concerted internal combustion engine improvements result

102 missions by less (42 +/- 10% reduction) than concerted internal combustion engines improvements.

103 production is tightly regulated through the concerted interplay of sequential Lgl1-dependent global

104 the studied cycloadditions were found to be concerted involving small free activation energies and a

105 lucidate that the low energy barriers of the concerted ionic diffusion are a result of unique mobile

106 r heterolysis of the boronate competing with concerted ipso protonation/C-B cleavage.

107 o- and antiferro-elastic interactions) drive concerted lattice distortions.

108 acellular volume control and is regulated by concerted liver, muscle, and renal actions.

109 per into membranes when FP1 and FP2 act in a concerted manner, suggesting that they form an extended

110 euron character proposing the existence of a concerted maturation process, which seems to endow this

111 carbation process does not proceed through a concerted mechanism as in alkyne syn-hydroboration, or t

112 eriments and computational studies support a concerted mechanism for the migratory insertion of the a

113 Furthermore, our data support the idea of a concerted mechanism involving TFIIIB and RNA polymerase

114 een these three regions, which may suggest a concerted mechanism of toxicity.

115 These results imply a synchronous concerted mechanism, in which the proton and electron tr

116 sylation is shown to occur by an effectively concerted mechanism.

117 iphilic metal-ligand assistance" (AMLA) and "concerted metalation deprotonation" (CMD) concepts.

118 While the C-H cleavage occurs via the concerted metalation-deprotonation (CMD) mechanism in al

119 arylsilver(I) species, presumably through a concerted metalation-deprotonation pathway.

120 by means of an external carboxylate-assisted concerted metalation/deprotonation mechanism.

121 ical in solids, but instead proceeds through concerted migrations of multiple ions with low energy ba

122 tions between crystal structures involve the concerted motion of a few atoms, without diffusion.

123 Here we analyse the concerted motion of G-protein-coupled receptors and G pr

124 duced by ATP hydrolysis is harnessed via the concerted motion of the protein-protein interfaces in th

125 ion conserves functional dynamics, i.e., the concerted motion or displacement of large protein region

126 pecifically, low-frequency motions involving concerted motions of the crown scaffold and the H3O(+) i

127 This could be explained by assuming that the concerted motions of two preceding or following coils re

128 We propose that a concerted movement involving the NTD, C-terminal NADH, a

129 closing of the MacB periplasmic domains via concerted movements of the second transmembrane segment

130 up was formed to facilitate the first large, concerted, multiancestry study to systematically evaluat

131 naccurate label of PenA as well as propose a concerted multidisciplinary approach to address this imp

132 Success in this research will require a concerted, multidisciplinary effort on the part of tuber

133 nvironment, promoting ecological changes and concerted multispecies efforts that are conducive to aci

134 at binds very tightly to chromatin through a concerted multivalent binding mode.

135 dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism.

136 oung singers was carried out during a public concert of Bach's Christmas Oratorio.

137 n by environmental perturbations can work in concert or antagonistically to influence ecosystem funct

138 ws that varying sulfidation protocols (e.g., concerted or sequential) and key operational variables (

139 er, whether their catalytic cycles involve a concerted or stepwise cyclization mechanism has not been

140 which also show that the reaction follows a concerted pathway without formation of an intermediate.

141 A computational search has revealed concerted pathways for [2 + 2] cycloaddition of ethylene

142 Four different concerted pathways have been found, three of them pseudo

143 steps, the resulting photoproduct decays via concerted PCET (tau = 4.7 mus) with an H/D kinetic isoto

144 This method allowed us to dissect the concerted process of E1-E2-catalyzed Ub conjugation in o

145 nate immune response to infection requires a concerted process of gene expression that is regulated a

146 igh resolution structural description of the concerted process of synthesis and ligand-induced restru

147 Inflammation is an extensively concerted process that confers protection to the host en

148 ncoupling these two processes and converting concerted processes into their "interrupted" versions by

149 The concerted production of neurons and glia by neural stem

150 onses against invading pathogens require the concerted production of three key cytokines: TNF-alpha,

151 her vibronic transitions, that contribute to concerted proton coupled electron transfer must also be

152 Mechanistic experiments implicate a concerted proton-coupled electron transfer (PCET) pathwa

153 The distance dependence of concerted proton-coupled electron transfer (PCET) reacti

154 Moreover, this study demonstrates that concerted proton-coupled electron transfer can enable ho

155 ge-recombination reaction seems to involve a concerted proton-coupled two-electron oxidation of AQH2.

156 Multiple-site concerted proton-electron transfer (MS-CPET) reactions w

157 basic with a pKa of 24.3.2 is competent for concerted proton-electron transfer from TEMPOH, but is a

158 inetic and thermodynamic analyses evidence a concerted proton-electron transfer pathway for these pro

159 OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion ce

160 gger lattice-oxygen oxidation and enable non-concerted proton-electron transfers during OER.

161 ble hydrogen electrode scale, indicating non-concerted proton-electron transfers in the OER mechanism

162 e residue interaction networks revealed that concerted rearrangements of local interacting modules at

163 An unprecedented concerted reductive elimination mechanism for benzoxazol

164 ave had little effect on disease burden, and concerted regulatory and fiscal action by the UK Governm

165 complex biological mechanisms occur through concerted relationships of multiple genes working in net

166 posttranscriptional regulator RsmA imposes a concerted repression on all three T6SS clusters.

167 g, suggesting that this system can mediate a concerted response to most of the established host-relat

168 indicate that FIS2 and MEA have diverged in concert, resulting in functional divergence of the PRC2

169 irs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymph

170 stems can control the reactivity and how the concerted scission of the central sigma bond is prevente

171 In concert, shortly upon induction of DA1 and BB expression

172 nerve repair through integration of multiple concerted signals.

173 plex by restricting coupled fast motions and concerted slower motions.

174 the reaction mechanism reveal an unexpected, concerted SNAr mechanism, with the organocatalyst playin

175 those of transition-state calculations for a concerted SNAr reaction with a bromine nucleofug, gives

176 limitations have revealed a clear need for a concerted software engineering effort to support emergin

177 yl CoAs and diacylglycerols, and may work in concert spatially and temporally to synthesize diverse T

178 Normally the AIS performs two tasks in concert, stabilizing neural polarity and generating acti

179 In other words, channel opening is a highly concerted, switch-like process.

180 Concerted tandem and traveling wave ion mobility mass sp

181 d environmental chemicals produce effects in concert that lead to carcinogenesis?

182 In concert, these findings suggest that molecular alteratio

183 Considered in concert, these results are relevant to both the genetic

184 In concert, they determine the structural, electrical and m

185 Thus, PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene ex

186 These domains act in concert to condense Gag into a membrane-bounded protein

187 reveal how unique postsynaptic CAMs work in concert to control synaptogenesis and establish a genera

188 LIPA2, suggesting that these two SPHs act in concert to control the melanization response.

189 A-binding transcription factors that work in concert to control the timing and magnitude of gene expr

190 se activity and RNase H activity that act in concert to convert single-stranded RNA of the viral geno

191 that multiple neuropeptides need to work in concert to coordinate certain behaviors.

192 eton asymmetrical contraction participate in concert to drive apical centrosome migration.

193 ry inversely, so that the two factors act in concert to either enhance or inhibit basin-wide hurrican

194 SOX and the host exoribonuclease Xrn1 act in concert to elicit the rapid degradation of mRNA substrat

195 an amine HCl salt and a bisthiourea, work in concert to enable the generation of oxocarbenium ions un

196 new insights into how the DRN and SC work in concert to extract and translate visual threats into def

197 iological, and immunological features act in concert to foster a particularly tolerant microenvironme

198 dases, artificial and biomachines working in concert to generate a product that cannot be made by eit

199 PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesic

200 factor kappa B-mediated inflammation act in concert to mediate AEG-1-induced NASH.

201 roups of extraocular motoneurons that act in concert to mediate the large dynamic range of extraocula

202 se NVU components as well as how they act in concert to modify cerebrovascular function and permeabil

203 e insight into how tumor cell signals act in concert to modulate cytoskeletal contractility and adher

204 asion and subversion mechanisms that work in concert to overcome immune recognition and effector func

205 inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response.

206 ctions, BF and orexin neurons likely work in concert to promote arousal, motivation, and other behavi

207 In turn, both LOX and IL6 were acting in concert to promote RANKL-dependent osteoclast differenti

208 tion, and local chemokine production work in concert to recruit Tregs into neonatal skin, thereby est

209 ding RNA (lncRNA) regulatory networks act in concert to regulate key aspects of thermogenic adipocyte

210 Nonetheless, how individual TFs act in concert to regulate mRNA gene expression in a single cel

211 S574 phosphorylation act independently or in concert to regulate the apoptotic function of FOXO3.

212 As DA and GABA work in concert to shape and synchronize neuronal ensembles in t

213 e product of thousands of proteins acting in concert to shape the cellular response.

214 ains, the alpha1- and alpha7-helixes work in concert to shift the metal-ion-dependent adhesion site b

215 ste nerves and local taste epithelium act in concert to support continued taste bud differentiation.

216 US18 and US20 work in concert to suppress cell surface expression of the criti

217 ypervalent bonding, and the way they work in concert to yield this unusual case of multiple hypervale

218 isplay their influence, and how they work in concert, to provide signals essential for integration an

219 ether, our study reveals novel principles of concerted transcriptional regulation by multiple TRs at

220 The concerted transition model for multimeric proteins is a

221 ar isoboles of additivity are predicted by a concerted transition model where the binding of each GAB

222 and basal activity was well described by the concerted transition model.

223 arbon-fluorine bond formation proceeds via a concerted transition state rather than a discrete Meisen

224 Our results show the delicate nature of the concerted versus stepwise mechanism of inverse electron-

225 th high plant diversity and warming, and, in concert, warming ( approximately 1.5 degrees C average a

226 criptomic changes caused by cAMP occurred in concert with 5hmC elevation in differentially transcribe

227 Such an achievement, in concert with a mitochondria-adapted CRISPR/Cas9 platform

228 compared to REFs, p = 0.003) was observed in concert with a significant enhancement in soil water con

229 rigenesis requires oncogenic KRAS or BRAF in concert with aberrant STAT3 activation in epithelial pre

230 t SC activity can be modified dynamically in concert with adaptive behaviors and suggests that an int

231 ploying a multi-cation binary electrolyte in concert with an alloyed negative electrode, calcium solu

232 t BRC1 regulates bud activation potential in concert with an auxin transport-based mechanism underpin

233 resolving role on macrophages when acting in concert with apoptotic PMN-expressed D6.

234 re cerebellum and cortex, working closely in concert with basal ganglia, are also involved in tic pro

235 In concert with BMI1-induced repression of the p16(INK4a) t

236 c axon growth capacity during development in concert with changes in Kruppel-like transcription facto

237 s of an impending cardiac event when used in concert with clinical history and other diagnostics wher

238 It is now clear that alloantibody can, in concert with colony-stimulating factor 1 (CSF-1)-depende

239 e sky-LOSA optical measurement technique, in concert with comprehensive Monte Carlo-based uncertainty

240 the preservation of neurogenic potential in concert with dopamine.

241 ansient, dose-dependent viraemia occurred in concert with early reactogenicity.

242 n contact strength during differentiation in concert with enhancer acquisition of the H3K27ac activat

243 llectively, our ice core data on bacteria in concert with environmental and anthropogenic proxies ind

244 hemistries for other protein systems and, in concert with experiments, provide full analytical soluti

245 ron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperon

246 In concert with findings from deletion of the ARP2/3 comple

247 loral antagonist that promotes SAM growth in concert with floral transition protects it from such ter

248 ctrometry-based phosphoproteomics dataset in concert with gene expression analysis, we selected over

249 evelopment of isoform-independent assays, in concert with genetic, epidemiological, translational, an

250 s of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poorly

251 DLG-1 protein is delayed by ZEN-4, acting in concert with its binding partner CYK-4/MgcRacGAP.

252 tween the tiny polyps of the coral animal in concert with its unicellular symbiotic algae and a wide

253 atalytic responsiveness of these proteins in concert with key intracellular events.

254 When used in concert with linkage analysis, haplotyping can help deli

255 In concert with local increased H3K27Ac, the strong H3K27Ac

256 eorganizing and repositioning nucleosomes in concert with many basic cellular processes.

257 ay therefore have a role in tumorigenesis in concert with mortalin, which affects MEK/ERK activity in

258 key role in modulating TB susceptibility in concert with NFkappaB1 and TNFalpha genes.

259 r/(86)Sr of vent fluids varies cyclically in concert with ocean chemistry, with some values much high

260 ets, few have evaluated their performance in concert with one another.

261 In concert with other anagenetic lineages of dinosaurs from

262 tions of the associated complexes, which, in concert with other biochemical/medical considerations, s

263 We propose that, in concert with other drivers, an overpressured sub-slab ma

264 n bronchial epithelial cells directly and in concert with other environmental stimuli to induce the p

265 microtubule bundling capacity of MAP65-1 in concert with other mitotic kinases.

266 ork, we show how water flow in the colon, in concert with other physiological factors, determine the

267 e erythroid transcriptional program works in concert with post-translational mechanisms to regulate h

268 These pairing probabilities, used in concert with prior knowledge of the canonical secondary

269 rgets for cancer drug discovery that work in concert with protein tyrosine kinases (PTK) in controlli

270 Feedforward inhibition, in concert with recurrent intracortical circuitry, produces

271 How the TCR repertoire, in concert with risk-associated MHC, imposes susceptibility

272 cts the ubiquitination of polySUMO chains in concert with several different E2 enzymes.

273 Live cell imaging in concert with shRNA tau knockdown revealed that reducing

274 se populations of splenic neutrophils act in concert with specialized macrophage and B cell populatio

275 of dehydrating grapevine (Vitis vinifera) in concert with stomatal conductance and stem and petiole h

276 magnitude to drive phloem transport only in concert with structural changes in the phloem that reduc

277 gest that synaptic kinetics are regulated in concert with synaptic sizes and reflect the functional r

278 In contrast, ATG-7 functions in concert with the DAF-7/TGF-beta pathway to promote germl

279 In concert with the decline in disparity selectivity, we ob

280 le to entrap virions, activated NF-kappaB in concert with the Ebola virus proteins at least as effect

281 Lapsyn works in concert with the fibroblast growth factor (FGF) pathway

282 ive Glt1, indicating that the glycan acts in concert with the first enzyme in the pathway, PhyA, in c

283 h cytokinin inhibits root cell elongation in concert with the hormones auxin and ethylene.

284 sporter candidate FtsW is thought to work in concert with the PG synthases penicillin-binding protein

285 valence bands that appear instantaneously in concert with the pump pulse.

286 mall dynamic exchange interaction, acting in concert with the static interaction to induce coupled pr

287 n regulate the expression of target genes in concert with the transcriptional regulators Swi4 and Swi

288 osons that occurred 38 million years ago in concert with the uplift of the plateau.

289 play disparate roles and have diversified in concert with their hosts.

290 Our study in concert with these findings provides strong support for

291 In concert with these results, targeting MUC1-C downregulat

292 In concert with these results, targeting MUC1-C in NSCLC tu

293 e coupled to promote SCC tumor initiation in concert with transforming growth factor (TGF)-beta prese

294 r breast cancer treatment, these findings in concert with trial data suggest that women should be enc

295 In concert with U-Th dates recording decreased recurrence i

296 dissociative OS-SET (SET to a sigma* orbital concerted with C-Cl breakage) in alkanes compared to ste

297 erein alkyne activation by neutral ClBcat is concerted with cyclative attack by nucleophilic sulfur.

298 innate and adaptive immune cells working in concert, with many feed-forward and regulatory interacti

299 effective and sustainable if implemented in concert within and across countries.

300 ensitive signaling pathways often operate in concert within the same cell, increasing the complexity