ライフサイエンスコーパス: catastrophic

1 neutrophils, and vision loss is potentially catastrophic.

2 uberculosis through costs to patients can be catastrophic.

3 ompression following TPV implantation can be catastrophic.

4 regation of homologs before pairing would be catastrophic.

5 Different attack rate scenarios for catastrophic (30.15%), strong (21.96%), and moderate (11

6 system disturbance and recovery, sustained a catastrophic 50-foot free-fall from the top of the rainf

7 a global public health problem resulting in catastrophic accidents, increased mortality, and hundred

8 this study was to identify risk factors for catastrophic adverse outcomes in children with PH underg

9 s affecting binary cell-ECM interactions are catastrophic and could contribute to loss of tissue arch

10 as, or supervolcanoes, are sites of the most catastrophic and hazardous events on Earth, yet the temp

11 ountries, out-of-pocket spending can be both catastrophic and impoverishing at all income levels, but

12 tive inhibition of N-myristoylation leads to catastrophic and irreversible failure to assemble the in

13 >1.5 degrees C as dangerous; >3 degrees C as catastrophic; and >5 degrees C as unknown, implying beyo

14 h this extreme clinical phenotype, including catastrophic antiphospholipid syndrome (APS), atypical p

15 Catastrophic antiphospholipid syndrome (CAPS) is a poten

16 sels of autopsy specimens from patients with catastrophic antiphospholipid syndrome.

17 uated autopsy specimens from persons who had catastrophic antiphospholipid syndrome.

18 Patients with catastrophic APS also benefit from immunosuppressive the

19 Dam1 is not phosphorylated are not nearly as catastrophic as when Mps1 is inactivated.

20 s on Rusinga Island, Kenya, have uncovered a catastrophic assemblage of the wildebeest-like bovid Rus

21 gy between familiar phenomena of raining and catastrophic asteroid strikes.

22 he accumulation of misfolded proteins can be catastrophic at both the cellular and organismal level.

23 chaotic plastic flows consisting of several catastrophic avalanches under the applied loading.

24 fficient angiogenesis in corpus callosum and catastrophic axon loss.

25 0% of household annual income was defined as catastrophic because this threshold was most strongly as

26 DR TB-related costs were catastrophic before and after TB-specific or TB-sensitiv

27 In an era of catastrophic biodiversity loss, robust indicators produc

28 existing predictions of either stability or catastrophic biomass loss, the Amazon forest's response

29 events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganiz

30 ranging from controlled state switching to a catastrophic break-down; signals that predict critical t

31 erialis has not arisen as a consequence of a catastrophic breakdown in the regulation of repeat ampli

32 o objects near the Sun arises from the super-catastrophic breakup (that is, almost complete disintegr

33 xtreme TB-associated costs have been termed "catastrophic" but are poorly defined.

34 hree decades, with the LPHI warming becoming catastrophic by 2050.

35 This cytoskeletal compromise induces catastrophic Ca(2+) influx mediated by the mechanosensit

36 dwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not dec

37 model is an efficient method for predicting catastrophic cascading events with potential application

38 motaxis but contribute to a distinct form of catastrophic cell death we term cytothripsis.

39 II binding, which causes septal defects and catastrophic cell envelope damage.

40 Chromothripsis is a catastrophic cellular event recently described in cancer

41 t survival mechanism functions downstream of catastrophic cellular stress and p53 to eliminate neurob

42 Neuroblasts experiencing catastrophic cellular stress, or overexpressing p53, los

43 This work reports a controllable catastrophic change of poly-Si NWs by thermally-assisted

44 he direct and real time observation of these catastrophic changes of poly-Si nanowires for the first

45 Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizure

46 this synergistic toxicity is associated with catastrophic chromosomal fragmentation.

47 We also identify multiple cases of catastrophic chromosomal rearrangements known as chromoa

48 release and reattachment cycle could prevent catastrophic chromosome segregation errors in meiosis.

49 ng global warming below 2 degrees C to avoid catastrophic climate change will require atmospheric car

50 For catastrophic coastal flooding, when wind-driven storm su

51 the generation of activation waves and their catastrophic collapse can be observed.

52 act with warming oceans may be vulnerable to catastrophic collapse even with little atmospheric warmi

53 This catastrophic collapse occurs because of the positive fee

54 The massive star ends its life with a catastrophic collapse to leave a black hole-a promising

55 ucer-freeloader ecosystem as it approaches a catastrophic collapse.

56 veral recommendations to avoid this rare but catastrophic complication in the future.

57 body-positive patients could ameliorate this catastrophic complication.

58 mbrane oxygenation interaction to avoid such catastrophic complications.

59 repeatedly crossing the species barrier with catastrophic consequences at the level of host communiti

60 the other hand, genomic instability can have catastrophic consequences for age-related diseases such

61 of the developed coast increases the risk of catastrophic consequences in the case of defense failure

62 e BMPR2-mediated signaling pathways can have catastrophic consequences in women for the maintenance o

63 ess the threat of antibiotic resistance, the catastrophic consequences of inaction, and the need for

64 ics, to name a few, where regime shifts have catastrophic consequences that are mostly irreversible (

65 T, the occlusion of the portal vein can have catastrophic consequences to the graft including acute l

66 in their premature arousal from stupor with catastrophic consequences.

67 ic aortic wall can degenerate over time with catastrophic consequences.

68 ox or a related virus, monkeypox, would have catastrophic consequences.

69 networked dynamical systems, often can have catastrophic consequences.

70 Widespread temperature stress has caused catastrophic coral bleaching events that have been devas

71 ete genome duplication or result in possibly catastrophic corruption of the genetic code.

72 ciated with a higher likelihood of incurring catastrophic costs (54% [95% CI = 43%-61%] versus 38% [9

73 = 1.01 [95% CI = 1.00-1.01], p = 0.02), and catastrophic costs (OR = 1.7 [95% CI = 1.1-2.6], p = 0.0

74 ulation attributable fraction indicated that catastrophic costs and MDR TB were associated with simil

75 hanges in the number of households incurring catastrophic costs and were assessed by quintiles of hou

76 as effective or affordable for preventing TB catastrophic costs as a TB-specific cash transfer approa

77 We defined tuberculosis-related catastrophic costs as the sum of direct medical, direct

78 ould decrease household tuberculosis-related catastrophic costs by 5-20%, but gains would be seen lar

79 of households incurring tuberculosis-related catastrophic costs by 6-19%.

80 they would be insufficient to prevent DS TB catastrophic costs in 4 out of 6 countries, and when inc

81 uld be insufficient to prevent DS TB-related catastrophic costs in any of the 6 countries, and when i

82 stics, and treatment services while avoiding catastrophic costs incurred by patients.

83 sitivity analyses demonstrated that existing catastrophic costs thresholds (>/=10% or >/=15% of house

84 le fraction of adverse outcomes explained by catastrophic costs was 18% (95% CI = 6.9%-28%), similar

85 Catastrophic costs were incurred by 345 households (39%)

86 Preventing DR TB-related catastrophic costs will require considerable additional

87 imated the reduction in tuberculosis-related catastrophic costs with an aggressive expansion of tuber

88 , and when increased enough to prevent DS TB catastrophic costs would require a budget between $298 m

89 , and when increased enough to prevent DS TB catastrophic costs would require a budget between $3.8 m

90 o create a clinically relevant definition of catastrophic costs.

91 these 2 cash transfer approaches to prevent catastrophic costs.

92 cash transfers, are endorsed to help prevent catastrophic costs.

93 nstead of 20% as the threshold for measuring catastrophic costs.

94 ansion of tuberculosis services might reduce catastrophic costs.

95 In mice, loss of TASP1 function led to catastrophic craniofacial malformations that were associ

96 mo-Triassic Mass Extinction (PTME), the most catastrophic crisis in Phanerozoic history.

97 n combination, high EC and VPD generate near catastrophic crop loss as predicted yield approaches zer

98 ive disease management strategies to prevent catastrophic crop losses require rapid, sensitive, and m

99 -induced damage and subsequent repair caused catastrophic crypt loss and deterioration of crypt-villu

100 al T -cell response leading to a potentially catastrophic "cytokine storm".

101 rated, the regrowth of material lost through catastrophic damage requires a regenerative-like approac

102 ses to infection that range from recovery to catastrophic decline and extirpation.

103 Remarkably, deletion of SKa leads to catastrophic defects in both the insect stage and mammal

104 ortality events (MMEs) are rapidly occurring catastrophic demographic events that punctuate backgroun

105 from growing in a distinctly polar manner to catastrophic depolymerization (dynamic instability) both

106 d contact with indigenous populations led to catastrophic depopulation primarily through the introduc

107 mbranes, may participate in the regulated or catastrophic dismantling of organelles.

108 ngoing, eastern US forests formed during the catastrophic disturbance era followed by fire suppressio

109 systems commonly experience and recover from catastrophic disturbances (e.g., forest fires, traffic j

110 nly illustrates mechanisms that give rise to catastrophic divergence and confirms intuitive accounts

111 We find that catastrophic DNA damage occurs during S-phase of the cel

112 ATM inhibition caused catastrophic DNA damage, mitotic cell cycle arrest, and

113 Nde1 mutant neural progenitors showed catastrophic DNA double strand breaks concurrent with th

114 with global perturbations resulting from the catastrophic drainage of proglacial Lake Agassiz at ca.

115 These data are consistent with a catastrophic driver for the extinction, such as bolide i

116 disconnects, indicating that there is not a catastrophic effect of isolated cell failures.

117 ic methods that can mitigate the potentially catastrophic effects of infectious outbreaks in farmed a

118 the absence of these mechanisms can lead to catastrophic effects on genome stability and cell viabil

119 ty-dependent neuropeptide corelease can have catastrophic effects on neocortical dynamics.

120 s a period of ecological flux spurred by the catastrophic end-Permian mass extinction and terminating

121 are extremely low and cannot account for the catastrophic epidemics of Gambian HAT (gHAT) seen over t

122 as the product of gigantic floods due to the catastrophic eruption of groundwater that may also have

123 storically derived demographic data from the catastrophic European Black Death/bubonic plague (Yersin

124 hromosome shattering involving a single-step catastrophic event (chromothripsis) was recently propose

125 are minor overall in view of the potentially catastrophic event that is being treated.

126 At the time, this catastrophic event was considered unprecedented and spar

127 cancer genome may instead undergo a one-time catastrophic event, such as chromothripsis, where a larg

128 wed that in 2% to 3% of all cancers a single catastrophic event, termed chromothripsis, can lead to m

129 ents that appear to be derived from a single catastrophic event.

130 enon of chromosome fragmentation in a single catastrophic event.

131 espond quickly to and recover from the final catastrophic event.

132 underestimate the probability and impact of catastrophic events (e.g., economic crises, natural disa

133 Acute catastrophic events can cause significant damage to mari

134 mpening possible perturbations might lead to catastrophic events when those perturbations exceed cert

135 While regular earthquakes are catastrophic events with rupture velocities governed by

136 the acceleration toward failure exhibited by catastrophic events.

137 ban planning to mitigation of the effects of catastrophic events.

138 stimates were sensitive to the definition of catastrophic expenditure and the costs of care.

139 To estimate the global incidence of catastrophic expenditure due to surgery, we built a stoc

140 ately 150 million individuals worldwide face catastrophic expenditure each year from medical costs al

141 rior credible interval 3.2-4.2 billion) risk catastrophic expenditure if they need surgery.

142 The burden of catastrophic expenditure is highest in countries of low

143 ditions cause 81 million individuals to face catastrophic expenditure, of which less than half is att

144 This will protect households from catastrophic expenditures and increase the development c

145 er diagnosis is increasingly responsible for catastrophic expenditures that negatively affect not onl

146 The specifics of these catastrophic explosions remain uncertain, due partly to

147 ra, El Salvador, which has a long history of catastrophic explosive eruptions.

148 Identifying the early warning signals of catastrophic extinctions has recently become a central f

149 ional stick-slip instabilities, resulting in catastrophic failure and seismic rupture.

150 rease non-linearly, ending in a system-sized catastrophic failure event.

151 lastic strain on each shear band so that the catastrophic failure is prevented or delayed, and promot

152 an evolve to a critical dynamics, making the catastrophic failure more predictable than the ones with

153 Catastrophic failure occurs only when the slip surface i

154 that loss of Merlin in these cells causes a catastrophic failure of axonal regeneration and remyelin

155 The catastrophic failure of human metabolism observed in aut

156 standing millions of cycles of loads without catastrophic failure, while also protecting the dental p

157 es to transition via runaway acceleration to catastrophic failure.

158 less slide slowly for months or years before catastrophic failure.

159 ling often lead to severe safety hazards and catastrophic failure.

160 predict the time at which these potentially catastrophic failures occur.

161 sis shows that in the specimens with delayed catastrophic failures, the plastic flow can evolve to a

162 an occur either smoothly or in an abrupt and catastrophic fashion.

163 ding to a definable set of lineage-dependent catastrophic fates.

164 and therefore eutrophication could initiate catastrophic feedback to global warming via dramatically

165 For this model, catastrophic filter divergence is not an artifact of num

166 l forecast model that transparently exhibits catastrophic filter divergence under all ensemble method

167 steries is the numerical phenomenon known as catastrophic filter divergence, whereby ensemble-state e

168 ca could lessen, although not eliminate, the catastrophic financial burden on affected households.

169 ate threshold conditions for high-intensity, catastrophic fires during nondrought years.

170 and impacts of wildfires was reduced as only catastrophic fires were allowed to escape.

171 as that will eventually experience increased catastrophic flooding and land loss.

172 is characterized by features associated with catastrophic flooding indicates final breaching of the S

173 4 billion years ago an ocean fed by enormous catastrophic floods covered most of the Martian northern

174 Catastrophic floods generated ~3.2 Ga by rapid groundwat

175 ribed as historically recent and potentially catastrophic for both humanity and the biosphere.

176 care, as health expenditures are financially catastrophic for families worldwide.

177 This extreme event is accompanied by a catastrophic force drop as observed in the experimental

178 We term this catastrophic force-triggered increase in off-rate a trip

179 via carbon starvation, causing more frequent catastrophic forest die-offs than the present projection

180 In this paper, we test whether catastrophic forgetting can be reduced by evolving modul

181 plasticity in SmNiO3 perovskites to address catastrophic forgetting in a dynamic learning environmen

182 of this and it has been widely thought that catastrophic forgetting is an inevitable feature of conn

183 animals might be to alleviate the problem of catastrophic forgetting.

184 previously acquired skills, a problem called catastrophic forgetting.

185 the helicases BLM and FBH1, suppresses both catastrophic fork processing and the accumulation of chr

186 Volatile depletion is consistent with catastrophic formation, such as a giant impact, whereas

187 nal research findings on several of the most catastrophic forms of pediatric epilepsy.

188 d chemo-mechanical stresses can also lead to catastrophic fracture of electrolyte membranes.

189 trophes.' Landscape-scale severe burning was catastrophic from a tree overstory perspective, but from

190 equent rounds of replication and lead to the catastrophic generation of a double-strand break at the

191 Whole-genome sequencing uncovered a catastrophic genome rearrangement in TB that caused the

192 Our findings show that catastrophic genome rearrangements arise spontaneously a

193 ng of replication-associated breaks leads to catastrophic genome rearrangements, revealing an importa

194 ypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'sha

195 o survive, proliferate, repair the otherwise catastrophic genomic events and evolve.

196 In response to catastrophic genotoxic stress, apoptosis prevents the pe

197 by sill complexes are more likely to trigger catastrophic global environmental change than their floo

198 eal that decreased fitness can result from a catastrophic growth arrest caused by unexpected darkness

199 te summer 2010/11, A. antarctica experienced catastrophic (>90%) dieback in several regions of Shark

200 GF was due to catastrophic gut loss (Type-I, 42%), technical complicat

201 k for increases in zoster following death or catastrophic health event occurring in a previously heal

202 ownership, household economic hardship, and catastrophic health expenditure).

203 %, P < 0.0001; and change in proportion with catastrophic health expenditure: -7%, P = 0.02).

204 es such as public finance can insure against catastrophic health expenditures.

205 ween 2000 and 2010, and associations between catastrophic health spending and macroeconomic and healt

206 We aimed to estimate the global incidence of catastrophic health spending, trends between 2000 and 20

207 lobally, 808 million people in 2010 incurred catastrophic health spending.

208 k water absorbs strongly, often resulting in catastrophic heating.

209 rom destruction of these cells and resulting catastrophic hemorrhage.

210 dent parallel adaptive change in response to catastrophic human disturbance.

211 out natural interglacial precedents, such as catastrophic ice-sheet collapse, or activation of major

212 ricted to centennial-scale excursions during catastrophic iceberg discharges of the Heinrich stadials

213 Subacute potentially catastrophic illnesses in three diverse ICU populations

214 ICUs are susceptible to subacute potentially catastrophic illnesses such as respiratory failure, seps

215 virus-1 (HIV-1) infection eventually induces catastrophic immune destruction have been elucidated, th

216 weeks, which offers hope in mitigating their catastrophic impact on life, agriculture and property.Ag

217 se epidemics, slavery, and violence that had catastrophic impacts on indigenous cultures.

218 the combined exposures simulated had mild to catastrophic impacts on ovulation.

219 d microembolization is underrecognized until catastrophic impairment or death.

220 ore cash transfers, DS TB-related costs were catastrophic in 6 out of 7 countries.

221 and >5 degrees C as unknown, implying beyond catastrophic, including existential threats.

222 er-associated variant, POLD1-R689W, causes a catastrophic increase in spontaneous mutagenesis.

223 or vertically, effects range from cryptic to catastrophic; individual level effects being extrapolate

224 activation in M. arenaria is an example of a catastrophic induction of genetic instability that may i

225 ely induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge

226 Preparation for a potentially catastrophic influenza pandemic requires novel influenza

227 the high-risk 65+ years subpopulation in the catastrophic influenza pandemic, and highest among the h

228 onsequently, prevention of these potentially catastrophic injuries is vital, and practitioners need t

229 3/1994 through 2011/2012 academic years, and catastrophic insurance records were used to find cardiac

230 eme flood events have the potential to cause catastrophic landscape change in short periods of time (

231 Catastrophic landslides cause billions of dollars in dam

232 Catastrophic landslides involve the acceleration and dec

233 w the dangerous level and the LPHI below the catastrophic level, both in the near term (<2050) and in

234 atially-dependent feedbacks, and can undergo catastrophic loss in response to changing landscape driv

235 cting specificity residues to mutate without catastrophic loss of DNA binding.

236 development of hyperglycemia related to the catastrophic loss of insulin, hep-tg mice continued to h

237 degeneration of motor neurons resulting in a catastrophic loss of motor function.

238 lomere dysfunction-induced foci, followed by catastrophic loss of telomeres.

239 mutant, grown in abundant glucose, undergoes catastrophic loss of viability when parasites deplete gl

240 l predicts that antibody levels and avidity, catastrophic loss rates, and population carrying capacit

241 Even a catastrophic mass mortality event of 2 billion deaths ov

242 ons in the conserved kinase, Mps1, result in catastrophic meiotic segregation errors but mild mitotic

243 ich was carved during the Pleistocene by the catastrophic Missoula floods in eastern Washington, USA.

244 1E (HP1E) sire inviable embryos that undergo catastrophic mitosis.

245 misalignment in metaphase, often leading to catastrophic mitotic failure.

246 has long been thought to be the result of a catastrophic Moon-forming giant impact event.

247 nfested watersheds to retain nitrate despite catastrophic mortality of the dominant canopy tree speci

248 ve diseases share common features, including catastrophic neuronal loss that leads to cognitive or mo

249 sary of the Chernobyl disaster, the two most catastrophic nuclear accidents in history, both occurred

250 asked: What is the likelihood that a similar catastrophic oil spill (with a volume over 1 million bar

251 The return period of a catastrophic oil spill in OCS areas is estimated to be 1

252 Catastrophic oil spills and oil from waste waters such a

253 Catastrophic oil spills stimulate these organisms to "bl

254 s provide a reliable large-scale response to catastrophic oil spills that can be used when the prefer

255 chanisms, including: the origination of bulk catastrophic optical damage (COD) due to locally high en

256 s limited by insufficient infrastructure and catastrophic out-of-pocket costs.

257 y preventive services, and nearly eliminated catastrophic out-of-pocket medical expenditures.

258 in large bedrock canyons that were carved by catastrophic outburst floods.

259 ve patients were more likely to experience a catastrophic outcome (adjusted odds ratio [AOR], 9.03 [9

260 loss (EGL) after kidney transplantation is a catastrophic outcome that is assumed to be more likely a

261 nts with EF <45% have severe LV dysfunction, catastrophic outcome under medical management, and shoul

262 n variable effectiveness in preventing rare, catastrophic outcomes such as cardiac arrest and death.

263 critical deterioration in addition to rare, catastrophic outcomes.

264 phic payment incidence was positive whatever catastrophic payment incidence measure was used.

265 ion-weighted median annual rate of change of catastrophic payment incidence was positive whatever cat

266 spent on health is not sufficient to reduce catastrophic payment incidence; rather, what is required

267 Incidence of catastrophic payments was correlated positively with GDP

268 Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual

269 complex formation, which in turn results in catastrophic physiological consequences.

270 high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and o

271 e mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality

272 ed with control animals, Trib1-/- mice had a catastrophic prognosis, with frequent cardiac rupture, a

273 ei that predispose chromosomes to subsequent catastrophic pulverization thereby independently amplify

274 esistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality.

275 ity loss and, in the more dramatic cases, to catastrophic regime change.

276 for his disease and critical to prevent the catastrophic sequela of HLH.

277 s presented here can help further understand catastrophic shifts and contribute to the discussion abo

278 ese ingredients can alter the possibility of catastrophic shifts by giving rise to much smoother and

279 ons and C. difficile inoculation can produce catastrophic shifts that persist even after removal of t

280 e pattern may provide early warning for such catastrophic shifts.

281 rse treatment outcomes and have been termed "catastrophic." Social protection initiatives, including

282 he relation between a country's incidence of catastrophic spending and gross domestic product (GDP) p

283 The global incidence of catastrophic spending at the 10% threshold was estimated

284 he high-risk 0-19 years subpopulation in the catastrophic, strong and moderate influenza pandemics.

285 e high-risk 20-64 years subpopulation in the catastrophic, strong and moderate influenza pandemics.

286 her than among the adults and seniors in the catastrophic, strong, and moderate influenza pandemic sc

287 y of the polymeric calsequestrin network and catastrophic structural changes in the SR.

288 integration host factor (IHF), which induce catastrophic structural collapse of biofilms formed by n

289 res in S phase, which is required to prevent catastrophic t-loop processing by structure-specific nuc

290 omote rapid telomere resection, resulting in catastrophic telomere loss and the generation of telomer

291 Catastrophic thrombotic syndromes are characterized by r

292 udden fluctuations in the environment can be catastrophic to a population if it relies solely on sens

293 for controlling the outbreak and averting a catastrophic toll of EVD cases and deaths.

294 ventually lead to impaired organ function or catastrophic transformation such as cancer.

295 In 1965, a catastrophic underground blowout occurred during the dri

296 glioblastoma cells and induces cell death by catastrophic vacuolization.

297 ation, including elevated blood ammonia, and catastrophic weight loss, which, in Mut(ki/ki) mice, is

298 We defined health spending as catastrophic when it exceeded 10% or 25% of household co

299 specification pathways makes it particularly catastrophic when they malfunction, both during developm

300 th free-living stages, such as fungi causing catastrophic wildlife declines on a global scale, must c