ライフサイエンスコーパス: burden

1 utility caused by daily medication use (pill burden).

2 Further, trazodone reduced p-tau burden.

3 sk factors, but high infectious inflammatory burden.

4 accurate volumetric quantification of plaque burden.

5 d comparable immune-reconstitution and viral burden.

6 ancer risk, and an unnecessary psychological burden.

7 cation did not seem to match epidemiological burden.

8 STAT4-dependent manner to limit early viral burden.

9 RG1(+) ILC-2 cell number and reduced disease burden.

10 rgeting private events in reducing the tumor burden.

11 fy treatment algorithms and reduce treatment burden.

12 istosomiasis in patients with a low parasite burden.

13 stically significant improvements in symptom burden.

14 d not require a high intracellular bacterial burden.

15 nce between T-cell reinvigoration and tumour burden.

16 ere, by reducing etiology-specific diarrheal burden.

17 ation cost concerns, and perceived financial burden.

18 s the second largest cause of global disease burden.

19 isability, with a considerable socioeconomic burden.

20 its expression can be accommodated with less burden.

21 strongylus brasiliensis, increasing parasite burden.

22 al knowledge to help to counter some of this burden.

23 d by both polygenic and clinical risk factor burden.

24 nical trials to reduce disparities in cancer burden.

25 preserves IgM levels, and reduces bacterial burden.

26 crease the global atmospheric greenhouse gas burden.

27 estimates might have underestimated disease burden.

28 eters for quantification of whole-body tumor burden.

29 n America and is becoming a worldwide health burden.

30 n reversing the continuing increases in this burden.

31 reads- that cause significant computational burden.

32 lmonids, constituting a significant economic burden.

33 ribute substantially to Lesch-Nyhan syndrome burden.

34 ed to increased pathological alpha-synuclein burden.

35 de vaccine status, to predict future disease burden.

36 cular risk, represents a major public health burden.

37 d is a leading contributor to global disease burden.

38 contributors to the excess total cumulative burden.

39 assification accuracy and high-computational burden.

40 isk of perceiving donation-related financial burden.

41 a mechanism for altering tissue-specific Se burdens.

42 n, which correlated with increased bacterial burdens.

43 soriasis had increased total coronary plaque burden (1.22+/-0.31 versus 1.04+/-0.22, P=0.001), NCB (1

44 hest death rate (>35%) and per-case economic burden ($3.3 million) of any foodborne pathogen in the U

45 etastatic protein expression) and metastatic burden, accompanied with TAM polarization away from the

46 enormous morbidity, mortality, and economic burdens across the globe.

47 Expanding our understanding of the burden AKI has on the clinical course of burn patients w

48 RV decompression have a high reintervention burden although most achieve 2-ventricle circulation.

49 ers, one of the leading causes of the global burden among men worldwide.

50 DR to mitigate the vision-related functional burden among US adults with diabetes.

51 Tau burden, amyloid burden, and cortical thickness.

52 Burden analyses of rare and singleton variants predicted

53 ately 40% in countries with a high infection burden and 12% and 7% in countries with moderate and low

54 use (IDU) is a substantial cause of disease burden and a contributor to blood-borne virus transmissi

55 ting facilities, may reduce the private cost burden and achieve high emission reductions, especially

56 Symptom burden and anxiety during HCT hospitalization partially

57 a significant reduction of cerebral amyloid burden and BACE1 accumulation in dystrophic neurites in

58 points; higher scores indicate less symptom burden and better quality of life).

59 er uptake was compared with calcified plaque burden and cardiovascular risk factors.

60 s, how the immune response controls parasite burden and contributes to tissue damage, and what mechan

61 are at higher risk for greater organ failure burden and death.

62 Increased mutation burden and defective DNA repair are associated with resp

63 The burden and determinants of complications and comorbiditi

64 Our data show a high burden and discordant pattern of HBV infection in rural

65 loss in vivo, significantly reducing lesion burden and extending longevity.

66 re generally characterized by low mutational burden and few recurrently mutated genes.

67 h resulted in prolonged elevations in fungal burden and histopathologic evidence of chronic lung infl

68 cted neutropenic lung correlated with fungal burden and hyphal length but not induction of GT biosynt

69 ught to evaluate the prevalence of financial burden and identify associations between a higher percen

70 The cumulative burden and importance of cardiovascular risk factors hav

71 erapies for CTCL may variably decrease tumor burden and improve quality of life, but offer limited ef

72 g of il1beta, results in increased bacterial burden and less infiltration of macrophages to sites of

73 cal management of HF that can reduce disease burden and may help improve clinical outcomes in this vu

74 MLL-AF9-driven leukemogenesis reduced tumor burden and prolonged host survival.

75 AML patient-derived xenografts reduced tumor burden and prolonged overall survival without affecting

76 Bacterial burden and pulmonary immunopathology of chimeric mice la

77 fected IL-21R KO mice had enhanced bacterial burden and reduced infiltration of Ag-specific T cells i

78 llows for a better understanding of the true burden and seasonality of disease that is essential to p

79 a reduction of PID frequency and overall PID burden and showed increased neuronal survival after stro

80 ) encapsulated SC-ENb-TRAIL alleviates tumor burden and significantly increases survival.

81 e of the method used to determine metastatic burden and statistical analysis of the results, as well

82 negatively and cause emotional reactions of burden and stress.

83 Associations between indel burden and treatment response were assessed across four

84 rformance, increased CDR-SOB, higher amyloid burden and worse clinical progression (6.2 times higher

85 fficient to significantly increase bacterial burdens and kidney pathology in mice infected with MRSA.

86 applied GBD methods to generate estimates of burden, and attributable burden due to known risk factor

87 Here, we measured 2-HG, mIDH2 allele burden, and co-occurring somatic mutations in sequential

88 Tau burden, amyloid burden, and cortical thickness.

89 xolitinib showed reduction of mutated allele burden, and ruxolitinib might extend survival of patient

90 asm 15-year cumulative incidence, cumulative burden, and standardized incidence ratios for subsequent

91 ted symptom onset, higher global Abeta brain burden, and with lower delayed total recall scores in th

92 whereas their depletion led to higher tissue burdens, and CD8(-/-) mice displayed higher mortality wi

93 Overall, 26% scored their financial burden as 5 or higher; 8% scored it as 8 or higher.

94 of childhood cancer may experience financial burden as a result of health care costs, particularly be

95 irus, represent a considerable global health burden, as recognised by WHO's Battle against Respirator

96 the potential for addiction is a significant burden associated with pain management, yet its precise

97 lls in the blood and enhanced the metastatic burden at the lung.

98 use concentrations in food to determine body burdens based on individual or population characteristic

99 40; P = .005), but not inferior temporal tau burden (beta = 0.10; 95% CI, -0.08 to 0.28; P = .27).

100 0.35; 95% CI, 0.19-.52; P < .001) and Abeta burden (beta = 0.24; 95% CI, 0.08-.40; P = .005), but no

101 ated with increasing entorhinal cortical tau burden (beta = 0.35; 95% CI, 0.19-.52; P < .001) and Abe

102 ification (CARDIA) and carotid artery plaque burden (BioImage).

103 ients with an ID consult had a higher fungal burden but a lower 90-day mortality compared to patients

104 relationships are weakly related to amyloid burden, but are in part mediated by grey matter volumes.

105 Infections contribute to this burden, but etiological data are limited.

106 1-mIL-6 + dox treatment lowered total plaque burden by >60% versus untreated controls.

107 The development of LRAs is burdened by many uncertainties that make drug discovery

108 ith the recombinant protein reduced parasite burdens by 76% to >99% in comparison to a variety of dif

109 U.S. states that bear half the country's TB burden: California, Florida, New York, and Texas.

110 tau pathology, suggesting that increased tau burden cannot fully account for the effects of LC degene

111 n models were constructed for each infection-burden category to identify independent determinants of

112 but it is unclear at what levels liver fluke burdens cause production losses.

113 Gene expression burdens cells by consuming resources and energy.

114 (Min/+) mice, had increased intestinal tumor burden compared with littermate Apc (Min/+) mice.

115 , benefits) and undesirable (i.e., harms and burdens) consequences, patient values and preferences, c

116 Amyloid burden correlated strongly with reductions in IENFD, SGN

117 etermined in relation to pretreatment tumour burden correlated with clinical response.

118 MDSC burden correlates with poorer clinical outcomes, credite

119 ries affected, and to quantify global plaque burden defined as the sum of all plaque volumes.

120 Interventions could be rolled out as disease burden demands and budgets allow.

121 Thus, their tissue burden differentiates these two compounds while other ma

122 nerate estimates of burden, and attributable burden due to known risk factors.

123 lightly older hearts, perhaps reflecting the burden due to this disease.

124 life, and relieve the economic and societal burden due to variable drug responsiveness.

125 -718 expression is associated with bacterial burden during Neisseria gonorrhoeae infection and alters

126 reduction of the KIT D816V expressed allele burden (EAB) at month 6, patients were classified as KIT

127 We developed a novel methodology for burden estimation and present first WHO global and regio

128 estigate whether whole-liver enhancing tumor burden [ETB] can serve as an imaging biomarker and help

129 Reductions in otitis media (OM) burden following rollout of pneumococcal conjugate vacci

130 Residual tumor burden following treatment of ALK or ROS1(+) lung cancer

131 Falls result in substantial burden for patients and health care systems, and given t

132 sents a substantial health care and economic burden for which there are no approved therapies.

133 indicate a potentially serious human health burden from air pollution in the Kathmandu Valley.

134 explore ecological determinants of clinical burdens from C difficile infections and ribotype distrib

135 ry diseases, leading to a significant health burden globally.

136 ial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global rese

137 igh prevalence of anemia and related disease burden have been documented in China, limited evidence i

138 Differing estimates of disease burden have been reported from high-income countries com

139 mice resulted in reduced morbidity and viral burden, improved lung compliance, and increased CD8(+) T

140 s of the within-host dynamics of plasma ZIKV burden in a nonhuman primate model, allowing for charact

141 of cases of disease and significant economic burden in affected areas, no licensed vaccines or antivi

142 rites in gray and white matter with heaviest burden in basal ganglia.

143 everity of hippocampal sclerosis and seizure burden in chronic epilepsy.

144 are positively associated with cerebral tau burden in FTLD.

145 However, details of the injury burden in LMICs are less clear because of the scarcity o

146 h was accompanied by a reduced mycobacterial burden in lung and spleen and a prolonged overall surviv

147 more severe immunopathology, enhanced viral burden in multiple organs, and suppression of MCMV-speci

148 raumatic stress among patients and levels of burden in patients' carers.

149 ximately 78% of the reduction in the malaria burden in sub-Saharan Africa since 2000.

150 to modulate lung inflammation and bacterial burden in TB.

151 d and frequently updated measures of scabies burden in terms of skin effects.

152 reated mice, we further reduce the bacterial burden in the brain.

153 prior work documenting increased L1 genetic burden in the brains of PDS and also identify unique gen

154 tically reduced the skin lesion size and GAS burden in the liver and spleen.

155 Better estimates of pediatric MDR-TB burden in the United States are needed and should includ

156 s that constitute the greatest public health burden in the United States, including obesity, hyperten

157 ntries is needed, and the infectious disease burden in these countries is another reason to step up g

158 pare themselves to prevent additional health burdens in the context of a changing climate and socioec

159 bit increased survival and reduced bacterial burdens in the liver and spleen.

160 se data indicate that the enhanced bacterial burdens in Tpl2(-/-) mice are not caused primarily by im

161 gly associated with coronary atherosclerotic burden (increase [95% confidence interval] in rank of pl

162 In our adjusted models, BCC burden increased by 4% per year of age and by 6% per num

163 Lipid burden was assessed as the lipid core burden index (LCBI), and large LRP were defined as a max

164 who also have intellectual disability, this burden is concentrated in risk genes associated with neu

165 The true population burden is even larger then reported, because many of the

166 Ds and epigenetic marks, as tumor mutational burden is known to be coupled to chromatin structure, we

167 viral infection, overnutrition, or oncologic burden) is a global health problem.

168 nual income) and issues related to financial burden (jeopardizing care or changing lifestyle) among s

169 ust incorporation of numerical metastatic LN burden may augment staging and better inform adjuvant tr

170 ge in Botswana, there is still a substantial burden of advanced HIV, with 2013-2014 incidence of CM c

171 With wide ART availability, the burden of advanced human immunodeficiency virus (HIV) an

172 urveillance data are essential to reduce the burden of antimicrobial resistance.

173 The burden of atherosclerosis manifested as an increasing nu

174 To assess the patient-level and societal burden of atopic dermatitis, we comprehensively reviewed

175 here has been increasing focus on the rising burden of atrial fibrillation (AF) since the turn of the

176 To describe the burden of BCCs in patients with BCNS in the United State

177 Patients with BCNS have a high burden of BCCs.

178 on-based epidemiological study to assess the burden of behavioural and emotional problems in preschoo

179 come measures, clear evidence shows that the burden of behavioural risk factors is affected by socioe

180 equity, and women's cancers, we describe the burden of breast and cervical cancer, with an emphasis o

181 TNBCs and stem cells as they pertain to the burden of breast cancer among African-ancestry populatio

182 y disease (CAD) may help reduce the societal burden of CAD.

183 iovascular disease event types to the excess burden of cardiovascular disease is important for develo

184 Although reduced cardiac output and high burden of cardiovascular risk factors are the prevailing

185 We found a high burden of community-onset antimicrobial-resistant infect

186 omplication of an infection, has the highest burden of death and medical expenses in hospitals worldw

187 reasing incidence will contribute to reduced burden of dementia given the aging of the population is

188 The global burden of dengue and its geographic distribution have in

189 ensive framework for estimating the economic burden of dengue in any region, differentiated by four v

190 -level measurements developed for the Global Burden of Disease (GBD) 2013 study.

191 burden of scabies using data from the Global Burden of Disease (GBD) Study 2015.

192 18th leading cause of global DALYs in Global Burden of Disease 2013.

193 Data on the burden of disease have long served as a cornerstone to h

194 ing in Vietnam, which has experienced a high burden of disease in recent years.

195 There are limited data on the burden of disease posed by influenza in low- and middle-

196 udy data and methods, we also quantified the burden of disease related to high body-mass index (BMI),

197 The Global Burden of Disease Study 2013 includes estimates of globa

198 Using the Global Burden of Disease study data and methods, we also quanti

199 ins a global health problem with an enormous burden of disease, estimated at 10.4 million new cases i

200 jury incidence and prevalence to measure the burden of diseases and injuries in Japan and in the 47 J

201 rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued

202 nding can help improve interpretation of the burden of febrile illness and shape policy on fever case

203 In doing so, the burden of fragmentation model definition shifts from pro

204 x and this taxon accounted for the increased burden of fungus in the high-level samples.

205 is is the 10th of 11 articles estimating the burden of GBS disease.

206 The cumulative burden of grade 1-5 CHCs at age 50 years was highest in

207 ide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasiv

208 In this Review, we describe the burden of hearing loss and offer our and others' recomme

209 The burden of HIV in transgender women (transwomen) in Brazi

210 t life expectancy and trends in the residual burden of HIV mortality after the roll-out of a public s

211 ctive and cost-effective way of reducing the burden of HPV-related disease in MSM.

212 The net burden of HRAE was also assessed by using a previously d

213 I) is an important contributor to the global burden of ill-health and health inequality.

214 nervation (CSD) has been shown to reduce the burden of implantable cardioverter-defibrillator (ICD) s

215 Latin America has a substantial burden of influenza and rising Internet access and could

216 improvements is needed to further reduce the burden of injury in Canada.

217 ntation waitlists to evaluate changes in the burden of liver disease in the United States.

218 SynEM removes the burden of manual synapse annotation for large densely ma

219 have led to dramatic declines in the global burden of measles, but the virus remains persistent in m

220 40-65 years in Taiwan, we associated a high burden of metabolic risk factors with increased risk of

221 The high burden of morbidity, coupled with a long latency between

222 between socioeconomic status and increasing burden of mortality from non-communicable diseases is li

223 s are ongoing efforts designed to reduce the burden of neonatal sepsis.

224 ribbean was associated with an unprecedented burden of neurological disease among adults.

225 The burden of ocular trauma resulting from the recent earthq

226 Thus, the energetic burden of pH regulation is offloaded from hypoxic cells

227 ivariate collapsing [p = 1.48 x 10(-6)], and burden of rare variants [p = 1.48 x 10(-6)]).

228 tions of the South Pacific experience a high burden of rheumatic heart disease (RHD).

229 bias: sex-specific heterogeneity and higher burden of risk in female cases.

230 ivariate regression analysis to estimate the burden of RSV in children younger than 5 years in Englan

231 We provide an estimate of the global burden of scabies using data from the Global Burden of D

232 across all traits (FWERacross), an increased burden of singleton disruptive variants in the Regulome

233 ploid fetuses is affected by the genome-wide burden of slightly deleterious variants.

234 and middle-income contexts where the highest burden of stillbirths occurs.

235 ere highest in foliage, while the total tree burden of summation operator26PFASs per tree was up to 1

236 orations are essential to address the global burden of surgical disease.

237 dress potential overtreatment can reduce the burden of surgical management in patients with cancer.

238 The burden of T2D is increasing: by 2050, approximately 1 in

239 y reflected the disproportionate demographic burden of TB among the population of adult males as a wh

240 otential to greatly reduce the public health burden of the disease.

241 oved by considering the underlying infection burden of the population and by assessing the overlap of

242 ndemic has an evident impact on the relative burden of the two influenza types.

243 be continually monitored and thus carry the burden of this chronic disease.

244 ark the first attempt to quantify the global burden of this rare but serious condition.

245 ing these findings, they illustrate that the burden of work for physicians and nurses in general prac

246 h-care inequalities and reduce the financial burdens of medical care borne by non-wealthy Americans.

247 he quantitative assessment of skeletal tumor burden on bone scintigraphy (Bone Scan Index [BSI]) in p

248 higher scores representing greater migraine burden on functioning).

249 n young children, resulting in a substantial burden on health-care services.

250 ients, this condition creates a considerable burden on healthcare providers.

251 ericas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic eff

252 nic and impose significant, multidimensional burdens on patients and health care systems.

253 bottleneck more evident, placing substantial burdens on the research community to keep pace.

254 cy in endothelial autophagy increased plaque burden only in the atheroresistant areas exposed to high

255 tatistically significant difference in tumor burden or survival distributions compared to treatment w

256 Findings suggest that sea-ice OCP burdens originate from both snow and seawater.

257 ng and robust measurements of changes in tau burden over time for the evaluation of putative therapie

258 uppression of IDO activity reduced bacterial burden, pathology, and clinical signs of TB disease, lea

259 Despite an increased travel burden, patients treated at high-volume centers had impr

260 mor, age at radioembolization, hepatic tumor burden, presence of extrahepatic disease, and sex.

261 ource of the sample, with greater depression burden prevalent in clinic-based samples.

262 treatment increased lesion size and parasite burden, quantitatively reproducing the LRV1-bearing (Lgy

263 a genetic threshold may exist where mutation burden relates to visual phenotype and the presence of h

264 cidence is stabilising in western countries, burden remains high as prevalence surpasses 0.3%.

265 93% clearance of splenic and liver parasitic burden, respectively.

266 in countries with moderate and low infection burdens, respectively.

267 luciclovine avidity reflect changes in tumor burden resulting from treatment has not been shown.

268 the past 2 years and over lifetime (disease burden), risk factors for BCCs.

269 when using specificity data only from lower-burden settings.

270 ty risk, nutrient availability, and pathogen burden shape energy allocation strategies throughout the

271 mation of pediatric MDR-TB, we surveyed high-burden states for clinically diagnosed cases treated for

272 Results Functional burden (SUVtotal) assessed midtreatment was the stronges

273 phism (SNP)-set kernel association tests and burden tests.

274 life, knowledge and satisfaction, caregiver burden, time tradeoffs, and out-of-pocket costs.

275 and compare investment with national disease burden to identify areas of funding strength and potenti

276 hnic and regional differences, high exposure burden to multiple allergens was most consistently assoc

277 ention, visual impairment may become a great burden to our healthcare system.

278 more likely than donors who did not perceive burden to rent their home (57% vs. 16%, P = .03), have a

279 gies generated frequent alarms that placed a burden upon staff, but staff were able to use their cont

280 These findings were translated into health burdens using a dose-response curve generated from a sys

281 ion and perturbs central metabolism and this burden varies with the protein being overexpressed.

282 Precise estimates of neonatal sepsis burden vary by setting.

283 Lipid burden was assessed as the lipid core burden index (LCBI

284 A significant decrease in tumor burden was evident in the CTNNB1-LNP group versus all co

285 Conversely, worm burden was higher in Nmur1(-/-) mice than in control mic

286 The greatest allelic burden was in patients with increased reticulin depositi

287 Furthermore, Abeta burden was reduced by 84% overall (61% in males and 97%

288 Moreover, vision-related functional burden was significantly greater among those with severe

289 opulation calibrated to pretreatment disease burden, we identify a clinically accessible potential on

290 ors who perceived donation-related financial burden were less likely to have an income above their ZI

291 icant changes in s-tryptase/KIT D816V allele burden were observed.

292 e evident as a small subset of overall tumor burden, were not affected by beta-catenin suppression.

293 of ZIKV-immune CD8(+) T cells reduced viral burdens, whereas their depletion led to higher tissue bu

294 hain PFAAs substantially increase human body burdens, which remain elevated for many years after expo

295 pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-

296 To evaluate the association of safety-net burden with the outcomes of appendectomy.

297 an infection model that exhibits high viral burden within the central nervous system.

298 logs of strength without detectable fitness burden within the gut over 14 days.

299 hermore, most estimates of influenza disease burden worldwide rely on passive sentinel surveillance a

300 terial pneumonia is a significant healthcare burden worldwide.