ライフサイエンスコーパス: broad

1 'colour barrier', owing to the intrinsically broad (about 1,500 inverse centimetres) and featureless

2 ur analyses focused on BH3 mimetics that are broad acting (ABT263 and obatoclax) or selective (ABT199

3 sponse zinc finger transcription factor with broad actions, including in differentiation, mitogenesis

4 first-generation CDK inhibitors demonstrated broad activity upon several CDKs, which likely explains

5 dictyExpress and GenBoard enable broad adoption of next generation sequencing based inqui

6 Here, we utilized the broad anatomical coverage of iEEG recordings in 12 eye-t

7 ributions of the fluorescence fractions were broad and chromatographically unresolved, possibly repre

8 lly connected, potentially leading to both a broad and deep engagement in science.

9 Aligned with the need for new broad and easily modifiable platforms for H2S donation,

10 wn to be a dimeric peripheral protein with a broad and flat basic surface that can associate with ani

11 pidemiological assessment, GBD 2015 provides broad and frequently updated measures of scabies burden

12 ictive modeling technology, and (3) foster a broad and informed discussion involving all stakeholders

13 nflammatory demyelination polyneuropathy are broad and may include dysfunctions at the nodes of Ranvi

14 eata (AA) have evolved over the decades from broad and nonspecific therapies to those that are now mo

15 we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomod

16 mmunization resulted in rapid elicitation of broad and potent serum antibody responses in all four co

17 ification of donors with the most potent and broad anti-HIV serum neutralizing responses were crucial

18 We show here that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inh

19 few somatic hypermutations are required for broad antiviral activity, and germline-approximating var

20 tified as potent viral DNA mutators and have broad antiviral activity.

21 lights a powerful experimental strategy with broad applicability for future studies of disorders with

22 esents a promising RNA-editing platform with broad applicability for research, therapeutics, and biot

23 Here, we improve the broad applicability of cotranscriptional SHAPE-Seq by de

24 nalized, autologous anticancer vaccines with broad applicability.

25 catalyzed carbonylation reactions have found broad application in total synthesis of natural products

26 tosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatmen

27 This methodology shows great potential for broad application to studies of protein cofactor-small m

28 isting SMT analysis routines and should find broad applications in SMT analysis.

29 However, for broad applications of fatty acid-conjugation, several is

30 nd azido-cholesterol derivatives demonstrate broad applications of this method in organic synthesis,

31 Ubiquitination regulates a broad array of cellular processes, and defective ubiquit

32 rs are extensively employed for diagnosing a broad array of diseases and disorders in clinical settin

33 imate change on biodiversity must consider a broad array of ecological processes.

34 h to extract discriminant information from a broad array of features (N = 432), including: genomic da

35 e it will be of interest to researchers in a broad array of fields.

36 ut microbiome have been found to influence a broad array of pathologic conditions ranging from heart

37 Our personal preferences affect a broad array of social behaviors.

38 lop a methodical approach that would yield a broad assessment of National Toxicology Program's (NTP's

39 to unlock the potential of these data for a broad audience of scientists with various areas of exper

40 al shape of the continuum band, an unusually broad band extending from 2,300 to well below 1,700 cm(-

41 n-linear gain was typically 10-30 dB and was broad-band rather than sharply tuned.

42 Only saccular or broad-based aneurysms 2 mm or larger in greatest dimensi

43 roups of the Chinese population and warrants broad-based, global strategy, such as greater efforts in

44 ncrease all poor households' income may have broad benefits by reducing poverty, but is unlikely to b

45 mTOR folate sensing may have broad biological significance because of the critical ro

46 The flattening of leaves to form broad blades is an important adaptation that maximizes p

47 ation of patients with type 2 diabetes and a broad cardiovascular risk profile, SGLT2 inhibitor use w

48 cal frameworks were identified, addressing 5 broad categories of impact: (1) 'primary research-relate

49 ity of these mutational events fall into two broad categories: inactivation of tumor suppressor genes

50 Studies have fallen primarily into 2 broad categories: prospective cohort studies and interve

51 Broad cellular antiproliferative potency of 24 is suppor

52 Despite the broad cellular impact of SCF enzymes, important question

53 t they were often ecological in design, used broad census geographic levels, lacked individual-level

54 amples of noncovalent complexes drawn from a broad class of nucleic acids and transient protein compl

55 nt with the stationary-state statistics of a broad class of resource-limited community dynamics model

56 detecting interfacial electron transfer in a broad class of systems, including other transition metal

57 ion (HC) stratifies and classifies data from broad classes into more specific classes.

58 evaluates the relative contributions of two broad classes of carbonyl-containing compounds, ketones/

59 HA-4 directly activates mRNA expression of a broad cohort of epithelial genes, including junctional f

60 present in a mixture was demonstrated over a broad concentration range.

61 erric form, such that it is able to sample a broad conformational space.

62 tiered consent and controlled data sharing; broad consent and controlled data sharing; or broad cons

63 road consent and controlled data sharing; or broad consent and open data sharing.

64 with communities may increase acceptance of broad consent and wide data sharing in biobank research.

65 cruitment to clathrin structures, indicating broad control of CCP assembly by Ca(2+) signals.

66 Considering the broad coverage of the coating in terms of analytes extra

67 ur group to protect chimpanzees and generate broad cross-neutralizing antibodies in animals and human

68 A broad depression phenotype including both phenotypes has

69 bivorous insects, most crustaceans have very broad diets, and the increased richness of taxa that inc

70 s after liver transplantation is rare, and a broad differential diagnosis has to be considered.

71 larity, regioregular P3EHT exhibits a rather broad distribution in polymer chain conformation due to

72 . inquisitor structures are intrinsic to the broad distribution of limiting scission lengths.

73 these international initiatives and ensuring broad distribution of novel technologies and open access

74 The dwell times showed a broad distribution, but were longer than a minute for a

75 Our findings implicate TOP2A cleavage as a broad DNA damage mechanism in oncogenic translocations a

76 A low-amplitude, broad-duration (40-50 ms) central peak of EMG-EMG synchr

77 that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdys

78 formation and intrahepatic accumulation have broad effects on metabolic liver functions.

79 le prediction of effectors possessing either broad efficacy or host specificity, a combined secretome

80 those few tropical species that occur across broad elevational gradients (elevational generalists) re

81 2SubPc-TCBD-aniline gave rise to an intense, broad emission, which red shifts upon increasing the sol

82 concentrations of hydrogen, consistent with broad expanses of water ice, confirming theoretical pred

83 to the bryostatin supply problem also opens broad, facile, and efficient access to derivatives and p

84 gents in a range of preclinical models using broad field sources of various energies.

85 ral optical properties simultaneously over a broad frequency range.

86 ith ultra-short laser pulses containing very broad frequency spectra where their amplitudes and phase

87 tral and completely atom-economical, exhibit broad functional group tolerance, and occur readily at r

88 rn fallow deer putative populations across a broad geographic range using microsatellite and mitochon

89 we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte

90 Super-enhancers and broad H3K4me3 domains showed higher association with chr

91 ecific isolate, a dicot specific isolate and broad host range isolate infecting both monocot and dico

92 To enable the identification of such broad impact eQTL, we introduce CONFETI: Confounding Fac

93 anism for Ca(2+) mobilization by beta2AR has broad implications for adrenergic signaling, cross-talk

94 es in generating the acinar lineage that has broad implications for epithelial morphogenesis.

95 Our study has broad implications for human disorders associated with U

96 phenotypes without user training, which has broad implications for improved assay development in hig

97 cing cellular function and inflammation with broad implications for inflammation-associated diseases

98 rom expanded, low density protein states has broad implications for our understanding of allostery an

99 the classic GPCR ternary-complex model, with broad implications for the multiplicity inherent in sign

100 methodological and empirical insights, with broad implications for understanding the functional and

101 Despite broad improvements in clinical parameters, total bacteri

102 Transcriptomic analysis revealed broad inflammatory pathways associated with uric acid pr

103 ilable from the Gene Expression Omnibus, the Broad Institute, The Cancer Genome Atlas (TCGA), and the

104 They are of broad interest as a site for therapeutic intervention in

105 d hybrid material, is truly new and may have broad interest in combination of experimental and comput

106 New World bird species distributed across a broad latitudinal gradient and estimated a suite of metr

107 eptide levels, strengthen the evidence for a broad link between the kinin-kallikrein and complement s

108 , suggesting that they are embedded within a broad macroscale gradient.

109 The objective of this study was to use a broad method of capturing sepsis cases to estimate 2004-

110 MMP-14 by modifying the natural non-specific broad MMP inhibitor protein N-TIMP2 to interact optimall

111 esting tool to identify high-risk groups for broad monitoring of HPV-associated cancers in resource-c

112 he upper gingiva, widely spaced teeth, and a broad nasal tip.

113 d GWAS-reverse genetic strategy revealed the broad natural variation in low-water-potential-induced A

114 ave also been taken, which rely on screening broad, natural genetic diversity for metabolic diversity

115 having low, sagittally flat, and inferiorly broad neurocrania.

116 tinct antibody specificities with potent and broad neutralizing activity against all seven HCV genoty

117 This study highlights broad non-compliance of a range of popular pet foods sol

118 f carbonyl functional groups summing up to a broad, nondistinctive signal.

119 bly use broadband current sources to produce broad or narrow bandwidth pulses.

120 ggest that visual experience determines when broad orientation selectivity emerges in visual cortical

121 al mechanism contributes to the emergence of broad orientation selectivity in PV interneurons.

122 This review provides a broad overview of the importance of the host microbiome

123 However, despite their broad participation in these evolutionarily critical rol

124 ecies have so far been limited to describing broad patterns based on anonymous markers of DNA methyla

125 These methods allow us to associate broad patterns of community turnover to local, species-l

126 Heat capacity of TlInTe2 exhibits a broad peak at low-temperatures due to contribution from

127 ucts downstream analysis such as: narrow and broad peak calling, peak annotation, and motif identific

128 -280 Hz; the second, and stronger, band is a broad peak in the 400-500 Hz range (termed omega).

129 ed benefits of recyclability, stability in a broad pH range, and selectivity for toxic metals.

130 y, TUBB4A mutations are known to result in a broad phenotypic spectrum, ranging from primary dystonia

131 Candidate phyla (CP) are broad phylogenetic clusters of organisms that lack cultu

132 ized by several specific genomic features as broad ploidy variation, high chromosome numbers, presenc

133 This is the first serosurvey confirming broad population-level impact in males from female HPV v

134 This approach has broad potential to probe the binding of a variety of lig

135 t antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo

136 gimens have been used successfully to induce broad protection against influenza viruses in humans, an

137 irable for purposes of simplicity, cost, and broad protection against multiple National Institute of

138 e of new variants, it is essential to induce broad protection and restrict pneumococcal colonization.

139 act of water moving across the ice surface a broad quantification of surface meltwater and its draina

140 of actin polymerization and inhibition of a broad range of actin-dependent functions, including phag

141 utilize a simple Ni-catalyst and work with a broad range of alkenes and aryl bromides.

142 ations of this fundamental study extend to a broad range of applications, well beyond the polymeric n

143 ultra-high sensitivity thermal sensors for a broad range of applications.

144 zes heat-sensitive reagents and simplifies a broad range of assays, including isothermal nucleic acid

145 an increased antimicrobial activity toward a broad range of bacteria, relative to OV-3, with MICs as

146 successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of

147 ot only with Rpl13a snoRNAs, but also with a broad range of box C/D and box H/ACA snoRNAs.

148 s a small enveloped RNA virus that infects a broad range of cells during infection.

149 rged solid-liquid interfaces is central to a broad range of chemical and transport phenomena.

150 apparent that FGS has great potential for a broad range of clinical applications.

151 substantial experience in applying CBCT to a broad range of clinical scenarios that involve critical

152 against other flaviviruses and neutralize a broad range of dengue virus and ZIKV isolates.

153 and inspire many new opportunities across a broad range of disciplines.

154 to contrasting effects of sticklebacks on a broad range of ecosystem properties, including zooplankt

155 hemical, and chemical levels has unearthed a broad range of enzymes, sulfur shuttles, and chemical me

156 Here, we review a broad range of experimental and theoretical results sugg

157 From a broad range of experimental features, supported by theor

158 ce, was conducted to identify and describe a broad range of factors affecting implementation success,

159 Different classes of MGE show a broad range of fitness effects, from the nearly neutral

160 thereby offering the potential to generate a broad range of fluorinated small-molecule targets in liv

161 ing the maximum absorptive coupling across a broad range of frequencies in terahertz (THz) band.

162 Homologs of Xpp1 are found among a broad range of fungi, including the biocontrol agent Tri

163 A broad range of glycocalyx depth measurements (0.17-3.02

164 Neighborhood conditions may influence a broad range of health indicators, including obesity, inj

165 ularly in vulnerable brain regions, across a broad range of hemoglobin values.

166 eous and low-loss response, and supporting a broad range of high-k modes.

167 ing antibody (bnAb) that is active against a broad range of HIV-1 primary isolates in vitro and prote

168 lly linked to the onset and progression of a broad range of human diseases.

169 n any mouse model opens the possibility of a broad range of investigations of mural cells in vascular

170 l brain training programs claim to improve a broad range of mental processes; however, evidence for t

171 t yields silica-supported M(III) sites for a broad range of metals.

172 troduces a potentially new application for a broad range of micro- and nanoparticles to maximize rece

173 ydrocarbon (HC) surfactants, which display a broad range of mutual miscibilities in mixed micelles.

174 ative version of DA1 enhances leaf size in a broad range of natural accessions of this species, indic

175 A vaccine that protects against a broad range of New World arenaviruses is desirable for p

176 Under the optimized reaction conditions, a broad range of nitrogen nucleophiles and carbon electrop

177 s hydrogen peroxide, from the oxidation of a broad range of olefins.

178 agnetic resonance (primary techniques) and a broad range of other experimental approaches (secondary

179 a more deliberative process through which a broad range of outcomes is scrutinized and the balance o

180 is a controversial one, as evident from the broad range of partly incompatible comments it has elici

181 utes to host defense against infections by a broad range of pathogens.

182 d with higher hospitalization costs across a broad range of patient and hospital characteristics.

183 anomalous dispersion can be scaled within a broad range of peak powers against the principle of cons

184 ramatic degradation of beam quality within a broad range of peak powers, varying from just a few to h

185 st Africa that is home to individuals with a broad range of phenotypic values for eye and skin color

186 junction with MS and is expected to enable a broad range of previously challenging or intractable sep

187 ore present at important concentrations in a broad range of raw and fermented foods.

188 ich supports generating models stable over a broad range of reconstructed and synthetic morphologies.

189 ition and demonstrate that BoNT/DC can use a broad range of sialic acid-containing moieties as co-rec

190 he review methodology enabled inclusion of a broad range of studies and permitted common features of

191 onase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, e

192 to a theoretical framework for describing a broad range of such kinetic processes without detailed k

193 Here, we used mass cytometry including a broad range of surface markers and transcription factors

194 the capability of C. merolae to grow under a broad range of temperatures.

195 te a new high-yielding modular approach to a broad range of trimeric and hexameric S- and Se-bridged

196 uding IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses.

197 The sensitization is achieved with a broad range of visible light excitation (400-600 nm).

198 oral autocorrelation and should occur over a broad range of warming scenarios.

199 simple, straightforward, and economic with a broad range substrate scope.

200 e and abundant access to tCS may represent a broad-reaching and important advance for future mental h

201 f the CSN in regulating EGFR neddylation has broad-reaching implications for understanding how homeos

202 Despite broad recognition of the importance of the third dimensi

203 organic matter and is mainly localized on a broad region of 1000 square kilometers close to the 50

204 ng stochastic fluctuations witnessed as very broad resistance (R) histograms with widths comparable t

205 Producing compounds is often part of a more broad response of the plant to changes in the environmen

206 Since that time, it has been found to have a broad role in gene induction in diverse cellular respons

207 Functional evidence supports broad roles for the TRN in arousal, attention, and senso

208 genome and a transcriptome atlas covering a broad sample of organs and developmental stages.

209 ipsilaterally projecting neurons suggests a broad sampling from inputs on the ipsilateral side.

210 suggests that parturition is associated with broad scale histone de-acetylation.

211 Nevertheless, current broad scale representations of change in major land use

212 These broad-scale differences have been known for decades, yet

213 The influence of broad-scale gradients (e.g. temperature and precipitatio

214 A broad-scale re-examination of their interaction indicate

215 This method has a broad scope and enables both the synthesis of isolable s

216 This reaction enjoys broad scope and functional group tolerance.

217 The broad scope of this method was demonstrated.

218 Broad screening of relatives and systematic tests, inclu

219 Genetic investigations, particularly broad sequencing methods, have high diagnostic yields in

220 a class of hierarchical architectures and a broad set of biologically plausible learning rules gener

221 Here, using a broad set of in vitro and in silico techniques we addres

222 This broad set of ligand-bound poses is then used to investig

223 th of African Americans require input from a broad set of stakeholders, including clinicians and rese

224 The broad significance of this work is the demonstration of

225 t the absence of these features results in a broad specificity toward Ins(1,2,4,5,6)P5 These features

226 Here, we present how the broad-specificity protease subtilisin enables mapping of

227 arrays, and silicon photomultipliers over a broad spectral range.The performance of silicon single-p

228 , the increasing resistance of bacteria to a broad spectrum of commonly used antibiotics has become a

229 onizing STAT3 could lead to suppression of a broad spectrum of cytokines and growth factors to allow

230 ponse (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases.

231 The broad spectrum of eIF4F-resistant translatomes is incomp

232 While those previous models included a broad spectrum of experimental conditions and dealt only

233 njoys robust prediction performance across a broad spectrum of genetic architectures.

234 preferentially, the HA190 mutant bound to a broad spectrum of glycans with alpha2,6/8/9-linked siali

235 for the detection and characterization of a broad spectrum of GMOs in routine analysis of food/feed

236 A broad spectrum of human diseases called ciliopathies is

237 come IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling.

238 opt the design to diverse GPCRs that sense a broad spectrum of ligands, including synthetic compounds

239 Our patient cohort exhibited a broad spectrum of neurodevelopmental phenotypes, compris

240 n human keratinocytes that are involved in a broad spectrum of nonoverlapping functions.

241 ophy; the encoded proteins are involved in a broad spectrum of pathways.

242 tion protocol is safe and effective across a broad spectrum of patients, irrespective of the type of

243 These observations are consistent across a broad spectrum of patients, risk factors, and concomitan

244 games and musical instruments, can impart a broad spectrum of perceptual benefits.

245 hat affects various cellular events during a broad spectrum of physiological and pathological conditi

246 Hsp70 participates in a broad spectrum of protein folding processes extending fr

247 re we conduct an extensive study analysing a broad spectrum of RNA-seq workflows.

248 , but also provides a general approach for a broad spectrum of therapeutic proteins for in vivo appli

249 d by parametric down-conversion and report a broad spectrum with the angular Schmidt number 82.1.

250 ty ramp of the target, leading to an overall broad spectrum.

251 To compare the effectiveness of broad-spectrum and narrow-spectrum antibiotic treatment

252 Fluoroquinolones are broad-spectrum antibacterials that target DNA gyrase by

253 The impact of broad-spectrum antibiotics on antimicrobial resistance a

254 Broad-spectrum antibiotics vs narrow-spectrum antibiotic

255 acute sinusitis), 868 (35%) were prescribed broad-spectrum antibiotics.

256 L. reuteri bacteria convert glycerol to the broad-spectrum antimicrobial compound reuterin.

257 ttenuated viral RNA production and displayed broad-spectrum antiviral activity against other alphavir

258 LJ001 is a broad-spectrum antiviral compound that inhibits envelope

259 e findings identify ZMPSTE24 as an intrinsic broad-spectrum antiviral protein and provide insights in

260 e of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a b

261 Broad-spectrum antivirals are highly sought after and st

262 ediated inhibition, the potential utility of broad-spectrum aptamers to overcome resistance, and mole

263 ves the way for the development of selective broad-spectrum bacterial collagenase inhibitors with pot

264 Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum beta-lactamase (BlaC) that mediates resis

265 trum beta-lactamases (ESBLs), AmpCs, K1, and broad-spectrum beta-lactamases.

266 e fused Bti's Cyt1Aa to Ls's BinA yielding a broad-spectrum chimeric protein highly mosquitocidal to

267 joene could be a lead structure in search of broad-spectrum compounds transcending the Gram negative-

268 We used two broad-spectrum detection strategies to identify pathogen

269 for pediatric ALL and the first to include a broad-spectrum fluoroquinolone.

270 (PAT) genes, which convey resistance to the broad-spectrum herbicide phosphinothricin (also known as

271 Non-pseudoknot RNA aptamers exhibited broad-spectrum inhibition.

272 In the second case, the affinities of a broad-spectrum inhibitor for 22 bromodomains were calcul

273 Therefore, the risks and benefits of using broad-spectrum LRAs need to be carefully evaluated, part

274 failed clinical trials has demonstrated that broad-spectrum MMP inhibitors have limited clinical util

275 development of a safe, highly effective, and broad-spectrum RBD-based subunit vaccine to prevent MERS

276 The development of broad-spectrum therapies against members of the Marburgv

277 tructural analyses guided the discovery of a broad, splicing-modulated interaction network between MD

278 I concur with the broad strokes of the theory they set out, and also clari

279 This protocol exhibits a broad substrate scope and is compatible with symmetrical

280 A broad substrate scope is demonstrated for both quinazoli

281 The reaction showed broad substrate scope with good to excellent yields.

282 mple, mild, and highly regioselective with a broad substrate scope.

283 SbCYP82D1.1 has broad substrate specificity for flavones such as chrysin

284 e approximately 700-kDa superassembly with a broad surface suitable for membrane interaction, toward

285 echanisms observed in BeH2 and LiBeH3 over a broad temperature range.

286 related behaviors is much more divergent and broad than such constellations suggest.

287 Nevertheless, evidence is accruing for broad, threat-neutral sensory hyperactivity in post-trau

288 The broad tissue expression of MeCP2 suggests that it may be

289 aling, which translates into activation of a broad transcriptional program dominated by upregulation

290 thology and beta cell health, which may have broad translational implications for therapeutics aimed

291 with nanoridges (lacs2 and pec1 mutants); a broad translucent cuticle (cyp77a6 and dcr mutants); and

292 eening described by Glorius et al., builds a broad understanding of the impact of individual function

293 The PCDDB has found broad usage by the structural biology, bioinformatics, a

294 SLIM SUPER high resolution TWIM platform has broad utility in conjunction with MS and is expected to

295 The method that we introduce can have broad utility in membrane protein research, as it can be

296 um(II)-catalyzed oxidation reactions exhibit broad utility in organic synthesis; however, they often

297 e biophysical and evolutionary rationale for broad variation in protein family sizes, prevalence of c

298 clic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabl

299 opamine (DA) receptors that are present in a broad variety of organs and cells throughout the body.

300 -performance photodetectors operating over a broad wavelength range from ultraviolet, visible, to inf