ライフサイエンスコーパス: blood

1 rces of the ancient resin known as "dragon's blood".

2 ns such as in platelet-rich plasma and whole blood.

3 tularensis was spiked into human or macaque blood.

4 PCR mixtures and B. anthracis CFU into human blood.

5 bility to escape the innate immune system in blood.

6 e upregulated on HSV-specific CD8 T cells in blood.

7 expression quantitative trait loci in whole blood.

8 or another compartment and reemerged in the blood 24 weeks after treatment.

9 Peripheral blood ADAM17 activity and soluble CD163 levels were elev

10 NfL concentrations in blood and CSF were recently shown to have prognostic val

11 HSA is the most abundant protein in the blood and has a long circulation half-life (19 days).

12 rrow (BM)-transplanted OS mice in peripheral blood and hematopoietic organs, such as the BM, thymus,

13 Here we report that IGF-1 level in blood and IGF-1 signaling demonstrates circadian rhythms

14 CSF-producing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and

15 ication of excessive IFN-gamma production by blood and lymph node-derived T cells of patients with CV

16 valves, which maintain the separation of the blood and lymphatic vascular systems, and the lymphatic

17 ion-arteriovenous malformation (CM-AVM) is a blood and lymphatic vessel (LV) disorder that is caused

18 depleted CD20(+) B lymphocytes in peripheral blood and lymphoid tissues confirming that SGN-CD19B is

19 ses reported to the Center for International Blood and Marrow Transplant Research or Eurocord and Eur

20 Research or Eurocord and European Group for Blood and Marrow Transplant.

21 helium, with very low silver levels found in blood and no detectable silver measured in the olfactory

22 In 641 newborns, cord blood and placental telomere length were significantly a

23 repressor (AHRR) locus, which is observed in blood and squamous epithelial cells of smokers, but not

24 with daily clinical review and collection of blood and stool cultures.

25 re during midgestation (weeks 12-25 for cord blood and weeks 15-27 for placenta).

26 d lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/Fg

27 lls that lie in direct contact with maternal blood, and show that these cells recapitulate the antivi

28 at least 20% of the small molecules in human blood are products of the microbiota.

29 6 shows good potency in an IDO-1 human whole blood assay and also shows a very favorable ADME profile

30 ncy have been described in placenta and cord blood at delivery, in fetal lung, and in buccal epitheli

31 Flow cytometric analysis of peripheral blood B cells of 30 MC-negative HCV-infected patients an

32 f CD in the United States to date outside of blood banks, we found a CD prevalence of 1.24%.

33 muscle wasting and the discovery of reliable blood-based biomarkers could be useful for the disease p

34 blood for transfusion, cellular therapy and blood-based diagnostics, and could significantly improve

35 l potential biomarkers that can be used in a blood-based panel to allow earlier identification of ind

36 e presence of maternal T cells in peripheral blood before transplantation, is detectable in a signifi

37 In animal studies, central and blood borne inflammatory cytokines that can be elevated

38 s (HCV) infection is the most common chronic blood-borne infection in the United States and a leading

39 The blood brain barrier separates the circulating blood from

40 rated that [(11)C]-(R)-3 readily crosses the blood-brain barrier (BBB) in rodents and selectively bin

41 Culture-based blood-brain barrier (BBB) models are crucial tools to en

42 central nervous system (CNS) compromise the blood-brain barrier (BBB) via increased vascular permeab

43 CED) provides a powerful means to bypass the blood-brain barrier and drive widespread distribution of

44 Blood-brain barrier disruption (BBB) and release of toxi

45 ly accounted for by age- or disease-specific blood-brain barrier disruption is unclear, and this is a

46 it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological states

47 ce in an all-human, in vitro, 3-dimensional, blood-brain barrier model exemplifies tight-junction int

48 We prevent blood-brain barrier passage of DT through PEGylation, wh

49 l drugs with optimal penetration through the blood-brain barrier should be considered even for patien

50 at trimethylamine-N-oxide (TMAO) crosses the blood-brain barrier.

51 Blood, bronchoalveolar lavage, large proximal, and small

52 The most common adverse effect was decreased blood calcium (68.9% vs 59.8%).

53 Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptom

54 In blood cancers, the synergism between HIF overexpression

55 nal bleeding is a leading indication for red blood cell (RBC) transfusion worldwide, although optimal

56 flammation, fluid, appendicoliths, and white blood cell count (WBC) were significantly correlated wit

57 o experiment-simulating an entire mammal red blood cell lipid bilayer and cytoskeleton as modeled by

58 A patient with asplenia and multiple red blood cell transfusions acquired babesiosis infection wi

59 Among patients who received red blood cell transfusions, receipt of a transfusion from a

60 e in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation aft

61 en supply, typically delivered by packed red blood cells (RBC).

62 sed the inflammatory potential of peripheral blood cells after lunch.Compared with 3 meals/d, meal sk

63 microm-50 microm) used to first deplete red blood cells and platelets.

64 Mice transfused with these red blood cells are resistant to highly lethal doses of BoNT

65 Mice whose red blood cells carry the chimeric proteins exhibit resistan

66 e mutations have recently been identified in blood cells from normal, healthy elderly individuals wit

67 D50) of BoNT/A, and transfusion of these red blood cells into naive mice affords protection for up to

68 ises when a substantial proportion of mature blood cells is derived from a single dominant hematopoie

69 d CD34+ culture system to engineer human red blood cells that express these chimeric proteins.

70 Tenofovir-diphosphate (TFV-DP) in red blood cells was used to categorize participants into hig

71 disseminated cells with platelets and white blood cells.

72 Xenogeneic peripheral blood chimerism was assessed after each infusion.

73 Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of

74 nsform a ubiquitous but normally nonadhesive blood constituent to increase the efficiency, strength,

75 eline period with the EOS calculator period, blood culture use decreased from 14.5% to 4.9% (adjusted

76 tics were associated with a 45% reduction in blood culture yield and approximately 20% reduction in y

77 n active antibiotic for at least 2 days when blood cultures were taken, and subsequent episodes in th

78 dorsal spinal neurons, blockade of Kv3.4 by blood depressing substance II suppresses axon growth via

79 d by independent validation of selected cord blood differentially methylated regions, using bisulfite

80 processes, including cancers, infection, and blood diseases.

81 e aimed at investigating how smoking affects blood DNA methylation in MS patients, by assaying genome

82 examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the develo

83 quencing analysis in 26 libraries from three blood donors and negative controls.

84 ucing the antibody negative window period in blood donors in resource limited settings where nucleic

85 ising 6 study periods, during which they had blood draws before and after medication administration.

86 in fetal lung, and in buccal epithelium and blood during childhood.

87 fold greater heart mass, 60-90% reduction in blood ejection fraction relative to control mice, and ev

88 of this study were to determine whether the blood eosinophil molecular pattern of children with EoE

89 attenuated bacterial survival in human whole blood ex vivo, which was associated with increased killi

90 Leukocytes in CSWB-treated blood exhibited significantly higher viability and CD45

91 ctorial capacity, as it is only females that blood feed and thus transmit human malaria.

92 Cessation of cerebral blood flow (CBF) leads to cell death in the infarct core

93 r survivors had significantly lower cerebral blood flow and metabolic activity in key brain areas com

94 ilities to measure maximal absolute coronary blood flow and minimal microcirculatory resistance.

95 smitters, and releasing factors to influence blood flow and neuronal activity.

96 neous coronary intervention (PCI) to restore blood flow in an infarct-related coronary artery improve

97 Continuous renal replacement therapy using blood flow rate set at 250 mL/min was not more likely to

98 G patients had significantly higher cerebral blood flow than did Fontan patients.

99 'inside-out' electrical signaling to direct blood flow to active brain regions.

100 After 10 h in hypoxia, decreased blood flow to the major nodes of the default mode networ

101 motion phases, contrast-agent dynamics, and blood flow velocity fields.

102 Blood flow was determined by transcranial Doppler ultras

103 by transcranial Doppler ultrasound (cerebral blood flow) and constant infusion thermodilution (femora

104 nd constant infusion thermodilution (femoral blood flow) with net exchange calculated via the Fick pr

105 the role of blood vessel tone in regulating blood flow.

106 es: the coupling between neural activity and blood flow.

107 cRNAs complement of Schistosoma mansoni, the blood fluke that causes schistosomiasis, ranked among th

108 nts a feasible alternative for fractionating blood for transfusion, cellular therapy and blood-based

109 idences reported glycosyltransferases in the blood, freely circulating or wrapped within vesicles.

110 lood brain barrier separates the circulating blood from the extracellular fluid in the central nervou

111 The measured values of whole blood from the micro-channel (4.17cP) and the vacuum met

112 We used microarray data on whole blood from two independent case-control studies of MDD:

113 ositively with mycobacterial growth in whole blood from UK/Asian adults and, to a lesser extent, in P

114 mic (4x basal) hyperglycemic clamp (arterial blood glucose 146 +/- 2 mg/dL) with portal GLC infusion.

115 control (random blood glucose [RBG], fasting blood glucose [FBG], and glycated hemoglobin [HbA1c]) an

116 elationship between glycemic control (random blood glucose [RBG], fasting blood glucose [FBG], and gl

117 mptying (3-dimensional ultrasonography), and blood glucose and plasma gut-hormone concentrations [ins

118 ptide 1), a critical incretin that regulates blood glucose homeostasis.

119 also lowered insulin levels while increasing blood glucose in vivo.

120 The rate of documented hypoglycemia with a blood glucose level of 55 mg per deciliter (3.1 mmol per

121 Only 8% monitored their blood glucose levels daily, 15% monitored weekly, and 10

122 manufacturers to evaluate the performance of blood glucose meters in critically ill patient settings.

123 me's potential for the use as the enzyme for blood glucose monitor enzyme sensor strips was evaluated

124 idence interval [CI], 1.04-1.16), low CSF to blood glucose ratio (HR, 1.16 per 0.10 decrease; 95% CI,

125 Regulation of blood glucose requires precise coordination between diff

126 otal cholesterol, triglycerides, and fasting blood glucose) and identified several cis-eGenes (ALDH2

127 a750-labeled antibody formats showed shorter blood half-times and higher liver uptake than the radiol

128 mpatible marker of UM171-expanded human cord blood HSCs.

129 l major time-dependent phenotypic changes in blood immune cell subsets that occur following trauma, i

130 sis, risk factors for death were presence of blood in stool and severe dehydration.

131 reased presence of MDSCs in their peripheral blood, in comparison with normal controls.

132 TM) accumulation was considered to be due to blood infiltration or local proliferation, although the

133 ts enrolled in the National Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic A

134 Although the National Heart, Lung, and Blood Institute increased funding of career development

135 or IDCM using the National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry

136 nfirmed that the spatial acceleration of the blood jet through the valve is most significant (account

137 The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the

138 n-lineage ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression

139 The recruitment of blood leukocytes across the endothelium to sites of tiss

140 stosterone levels may not accurately reflect blood levels during mini-puberty.

141 vice that isolates and enumerates peripheral blood lymphoblasts using affinity separations.

142 ting mosquitoes after oral feeding of spiked-blood meals, representing an additional safety feature.

143 hours over the course of their up to 96 hour blood meals.

144 d demographics, anthropometrics, cardiac and blood measures, diet and exercise, physical and mental h

145 Blood metabolite analysis 60 min after injection of the

146 arrier disruption (BBB) and release of toxic blood molecules into the brain contributes to neuronal i

147 Two subsets of blood monocytes are commonly described in mice and human

148 Peripheral blood monocytes play a role in sarcoidosis inflammation.

149 on by natural killer cells, and expansion of blood monocytes with less proinflammatory cytokine respo

150 remained off ERT with normalized peripheral blood mononuclear cell (PBMC) ADA activity, improved lym

151 Suppression of parasite-specific peripheral blood mononuclear cell (PBMC) proliferation was evident,

152 Mycobacterial growth in peripheral blood mononuclear cells (PBMC) from both humans and maca

153 ve T cells were sorted from human peripheral blood mononuclear cells (PBMCs) by intracellular stainin

154 1 or primary AML cells with donor peripheral blood mononuclear cells elicited a cell contact-dependen

155 Peripheral blood mononuclear cells from healthy controls and viremi

156 FN-gamma and IL-17A production in peripheral blood mononuclear cells from HIV-infected ART-treated in

157 and Leishmania antigen-stimulated peripheral blood mononuclear cells from patients infected with L. b

158 Applying CARD-SGS to blood mononuclear cells in six samples from four HIV-inf

159 nist, GS-9620, activated HIV from peripheral blood mononuclear cells isolated from HIV-infected indiv

160 Knockdown of LY6E in human peripheral blood mononuclear, SupT1, and THP-1 cells diminishes HIV

161 ly in lesional but also nonlesional skin and blood, more complex biomarker models of AD are needed.

162 ositivity (HR, 1.37; 95% CI, 1.02-1.84), and blood neutrophilia (HR, 1.06 per 109 neutrophils/L incre

163 transporters, SLC and ABC, in resting human blood neutrophils.

164 enome-wide DNA methylation in umbilical cord blood nucleated cells in Project Viva, a prospective U.S

165 6(+) and CXCR3(+) Th cells accumulate in the blood of aviremic HIV-1-infected patients on long-term a

166 as IL-10 levels were increased in peripheral blood of clinical responders after 12 wk of treatment wi

167 on of an exosome-associated biomarker in the blood of patients provides novel, and less invasive, opp

168 conditionally essential for GBS survival in blood, of which 75% were members of the capsular polysac

169 detection of multiple viruses included cord blood or HLA-mismatched HCT, myeloablative conditioning,

170 Elevated TGs level in blood over 500mg/dL is a biomarker for cardiovascular di

171 as reward accumulated within a context, and blood oxygen level dependent (BOLD) signals in the ventr

172 In photosensitive epilepsy, alpha-related blood oxygen level-dependent signal changes demonstrated

173 ead measures of human brain activity are the blood-oxygen-level dependent (BOLD) signal and surface f

174 s, trigger sounds elicit greatly exaggerated blood-oxygen-level-dependent (BOLD) responses in the ant

175 ight loss, changes in nutritional as well as blood parameters, leukocyte depletion, and bone marrow h

176 sity, density, and coagulation rate of human blood plasma were measured along with the standard coagu

177 tive capture of MC-LR from aqueous media and blood plasma.

178 w abundance proteins (e.g., </= 100 pg/mL in blood plasma/serum) using targeted proteomics approaches

179 Activity was determined in whole blood, plasma, and urine.

180 r (18)F-4FMFES, notably a 4-fold decrease in blood-pool activity as compared with (18)F-FES.

181 t 72 and 144 h after injection, but tumor-to-blood-pool SUV ratios increased with time after injectio

182 l CVRFs (n = 740) was also defined as having blood pressure <120/80 mm Hg, fasting glucose <100 mg/dl

183 The correlation was low for systolic blood pressure (0.39; P<0.0001).

184 actorial design to target levels of systolic blood pressure (130-149mmHg vs <130mmHg; open label) and

185 It is unclear whether intensive lowering of blood pressure (BP) at the acute phase of intracerebral

186 It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended wou

187 ransport by the renal tubule is critical for blood pressure (BP), acid-base, and potassium homeostasi

188 In adults, high blood pressure (BP), adverse serum lipids, and smoking a

189 Detection, Evaluation, and Treatment of High Blood Pressure (JNC7).

190 6 to -4.2; 6 studies; I2 = 51%) for systolic blood pressure and -4.0 mm Hg (95% CI, -5.6 to -2.5; 6 s

191 As an add-on to losartan, Ly normalized blood pressure and albuminuria, and prevented CKD progre

192 All approaches achieved target blood pressure by 60 minutes.

193 rations in microbial communities relevant in blood pressure control.

194 y (1.53, 1.13-2.07; p=0.054), and have their blood pressure controlled (2.06, 1.69-2.50; p<0.0001) th

195 ored weekly, and 10% reported checking their blood pressure daily and 43% took their medications as p

196 soconstriction and prolonged the increase in blood pressure in anaesthetised rats.

197 affecting the ventricular refractoriness or blood pressure in pigs subjected to 7 days atrial tachyp

198 ning for preeclampsia in pregnant women with blood pressure measurements throughout pregnancy.

199 above 150 mm Hg to achieve a target systolic blood pressure of less than 150 mm Hg to reduce the risk

200 adults aged 60 years or older with systolic blood pressure persistently at or above 150 mm Hg to ach

201 ndings highlight new biological pathways for blood pressure regulation enriched for genes expressed i

202 ussion of the benefits and harms of specific blood pressure targets with the patient.

203 rs of contact showed greater improvements in blood pressure than control groups: -6.4 mm Hg (95% CI,

204 hborhoods was associated with lower systolic blood pressure than was consistent residence in low-inco

205 revealed no abnormalities in heart rate and blood pressure variability however the sympathetic skin

206 At initial clinic visit, her blood pressure was 138/84 with an unremarkable cardiovas

207 Blood pressure was assessed on 6 occasions between the a

208 Changes-over-time temperature, blood pressure, and heart rate outcomes were also signif

209 etabolic traits (BMI, systolic and diastolic blood pressure, LDL cholesterol, HDL cholesterol, total

210 cis-eGenes (ALDH2 for systolic and diastolic blood pressure, MCM6 and DARS for total cholesterol, and

211 an independent association between post-TAVR blood pressure, systemic arterial load, and mortality.

212 activity and pharmacological manipulation of blood pressure, we show that veterans with PTSD have aug

213 ailable were more likely to use at least one blood pressure-lowering medicine (adjusted odds ratio [O

214 0.0001) than were those in communities where blood pressure-lowering medicines were not available.

215 long with clinically important reductions in blood pressure.

216 ist did not completely block the increase in blood pressure.

217 on between variation at the SLC4A7 locus and blood pressure.

218 to -2.5; 6 studies; I2 = 17%) for diastolic blood pressure.

219 (WNK4) regulates electrolyte homeostasis and blood pressure.

220 potassium intake are associated with higher blood pressure.

221 , HDL-c, glucose, and systolic and diastolic blood pressure.

222 nd diastolic (2.25 mm Hg; 95% CI, 0.83-3.67) blood pressures.

223 Maintaining a robust blood product supply is an essential requirement to guar

224 ly represent venous engorgement and/or acute blood products within the spinal cord.

225 Characterizing blood profile of alopecia areata (AA) is important not o

226 nervous system with a very favourable brain/blood ratio.

227 tor 2-dependent manner, and the nonclassical blood resident monocyte subset that patrols the intralum

228 In the retina, endothelial cells form a blood-retina barrier by virtue of tight junctions and lo

229 The outer blood-retina barrier is established through the coordina

230 istochemical analyses of hagfish tissues and blood revealed Vwf expression in endothelial cells and t

231 highly sensitive p24 assay can help improve blood safety by reducing the antibody negative window pe

232 neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were

233 , 92% tested D816V-positive in the screening blood sample.

234 can perform these measurements from a minute blood sample.

235 en), with a mean age of 73 years, provided a blood sample; 2137 had no signs of AMD, 2209 had early A

236 (linoleic acid and arachidonic acid [AA]) in blood samples at age 8 years were measured for 940 child

237 nd serum PFOA concentration were measured in blood samples collected during 2005-2006.

238 Superoxide dismutase (SOD) level in the blood samples expressed significant positive correlation

239 Blood samples from 125 healthy Kenyan children were anal

240 sessed global RNA expression levels in whole blood samples from 150 participants, representing patien

241 n validation by collecting fingerprick whole blood samples from 20 participants to assess iron status

242 We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate

243 expression was transiently reduced in whole blood samples from both omalizumab- and placebo-treated

244 performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or unco

245 andard, a test for NK cell activity in whole blood samples identified patients with CRC with 87.0% se

246 Blood samples of 3 patients with severe G6PD deficiency

247 The clinical implication was studied in blood samples of patients with inflammatory bowel diseas

248 One-milliliter blood samples were added to the filter-based detection c

249 METHODS AND Endomyocardial biopsies and blood samples were obtained from patients with newly dia

250 s performed with a subset of placentas, cord blood samples, and buccal samples collected during the N

251 ver tissues (control tissues) and peripheral blood samples.

252 Patients and controls provided venous blood samples.

253 d results should be confirmed via testing of blood samples.

254 bolus injection of (18)F-T807 with arterial blood sampling.

255 he analysis of a reference material of human blood serum, by the spike and recovery trials with seawa

256 ue to the low sensitivity and specificity of blood smears.

257 es, bed bugs rely heavily on human or animal blood sources for survival, mating and reproduction.

258 is of a single infecting genome in a sterile blood specimen are available and have recently been comm

259 T cells subsets in blood, spleen and lymph nodes were detected dynamically

260 entrations of tenofovir diphosphate in dried blood spots.

261 ion cycle in the clinically relevant asexual blood stage of infection(1).

262 targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blo

263 reduce host cell toxicity while maintaining blood-stage and gametocytocidal antimalarial activity an

264 Exposure to blood-stage malaria infection is often persistent, leadi

265 variants of the major surface antigen of the blood stages known as Pf EMP1 encoded by up to 60 var ge

266 find are nearly identical between thymus and blood, suggesting that our analysis mainly detects selec

267 ovided the greatest compatibility with human blood, suggesting that pre-transplant perfusion of genet

268 the long-term functionality of HSCs and the blood system as a whole.

269 accurately classified patients with a single blood test into rule-out or rule-in categories: Net Recl

270 ctal cancer (CRC) by the guaiac fecal occult blood test, interval cancers develop in 48% to 55% of th

271 late individual circulating tumor cells from blood, these devices are ineffective at capturing CTC cl

272 mug of leukocyte DNA isolated from 2-3 mL of blood to accurately quantify these two cross-linked addu

273 In vitro exposure of human whole blood to PhNHOH and NOB demonstrated that only sulfinami

274 This blood transcriptome-based model enables assessment of ci

275 Perioperative blood transfusions are associated with shorter survival,

276 ng who received a single unit umbilical cord blood transplantation for non-malignant diseases reporte

277 combination haploidentical single-unit cord blood transplants, we have added 4 Gy TBI to the widely

278 Umbilical cord blood (UCB) is a promising source of stem cells to use i

279 iability and erythrocyte morphology in whole blood under ambient storage.

280 ndard for selecting unrelated umbilical cord blood units for transplantation for non-malignant diseas

281 known to maintain the physiological state of blood vasculature under inflammatory conditions.

282 ed with poor prognosis and increased risk of blood vessel infiltration.

283 ular density and facilitated the recovery of blood vessel perfusion function in a murine hindlimb isc

284 ead to new therapeutic approaches to improve blood vessel regeneration and increase survival and hema

285 iber and resistance analogous to the role of blood vessel tone in regulating blood flow.

286 avasation of sub-nanometre AuNCs from normal blood vessels and enhances their passive targeting to ca

287 , treatment with tPA led to decompression of blood vessels and improved tumor perfusion.

288 ent resulted in an increase in the number of blood vessels and sub-epithelial connective tissue matri

289 C2 in cancer, their role in tumor-associated blood vessels and tumor immunity, and provide an update

290 Pathological proliferation of retinal blood vessels commonly causes vision impairment in proli

291 the structure of tissues, including muscles, blood vessels, and connective tissues, adapts to mechani

292 -GFP were less abundant, concentrated around blood vessels, and round in shape.

293 flex activity, to produce relaxation of some blood vessels.

294 Patients with higher peripheral blood viral loads in primary infection and greater chang

295 ultaneously, we measured changes in cerebral blood volume (CBV) as a proxy of drug effects on neurona

296 on devices by increasing the processed whole blood volume.

297 Peripheral blood was collected from 70 virally suppressed HIV-1-inf

298 port and child report (primary outcome), and blood was collected from children to measure cytokine pr

299 LOY in blood was negatively associated with age (beta=-0.03/10

300 zed and mechanically ventilated, 40 mL/kg of blood was removed yielding marked hypotension and a rise